Title:
AROMATIC SUBSTITUENT-CONTAINING (HETERO) ARYL-IMIDAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/017257
Kind Code:
A1
Abstract:
The present application relates to an aromatic substituent-containing heteroaryl- or phenyl-imidazole compound, and a stereoisomer, hydrate, solvate, pharmaceutically-acceptable salt or prodrug thereof. The present application also relates to a method for preparing the aromatic substituent-containing heteroaryl- or phenyl-imidazole compound, and a use of the aromatic substituent-containing heteroaryl- or phenyl- imidazole compound as a soluble epoxide hydrolase inhibitor. The aromatic substituent-containing heteroaryl- or phenyl- imidazole compound herein exhibits extremely high inhibitory activity on soluble epoxide hydrolases, and the IC50 value is even lower at the nanomolar level.
Inventors:
DENG LISHENG (CN)
WU FANGRUI (CN)
MA ZHIXIONG (CN)
WU FANGRUI (CN)
MA ZHIXIONG (CN)
Application Number:
PCT/CN2023/107945
Publication Date:
January 25, 2024
Filing Date:
July 18, 2023
Export Citation:
Assignee:
OPEN SOURCE THERAPEUTICS (CN)
International Classes:
C07D401/04; A61K31/4184; A61K31/4188; A61P7/06; A61P9/04; A61P11/06; A61P25/28; C07D235/18; C07D403/12; C07D413/10
Domestic Patent References:
| WO2021242790A1 | 2021-12-02 | |||
| WO2007043653A1 | 2007-04-19 |
Foreign References:
| CN101535259A | 2009-09-16 | |||
| CN103214456A | 2013-07-24 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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