Title:
ARSENIC COMPOUND-BASED TUMOR VACCINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/066080
Kind Code:
A1
Abstract:
An arsenic compound-based tumor vaccine, a preparation method therefor, and an application thereof. The arsenic compound-based tumor vaccine comprises tumor cells treated by an arsenic compound, may activate an anti-tumor immune response, and may not only effectively prevent the occurrence of tumors, but may also significantly delay the rapid development of existing tumors in vivo. The arsenic compound-based tumor vaccine may also be combined with an immune checkpoint blockade therapy to achieve synergistic interaction. A key molecule and a signaling pathway for determining the immunogenicity and tumor prevention and control effect of the tumor vaccine identify a plurality of important biomarkers which may be used for curative effect prediction. An effective combination therapeutic drug is also provided when the key molecule or signaling pathway is deficient, underexpressed, or poorly activated.
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Inventors:
MA YUTING (CN)
CHEN JINFENG (CN)
YANG HENG (CN)
CHEN JINFENG (CN)
YANG HENG (CN)
Application Number:
PCT/CN2022/139780
Publication Date:
April 04, 2024
Filing Date:
December 16, 2022
Export Citation:
Assignee:
SUZHOU INST OF SYSTEMS MEDICINE (CN)
International Classes:
A01N59/22; A61K31/436; A61P35/00; A61P35/04; C12N5/0786
Domestic Patent References:
| WO2004096244A1 | 2004-11-11 |
Foreign References:
| CN115634287A | 2023-01-24 | |||
| CN108379569A | 2018-08-10 | |||
| CN113181351A | 2021-07-30 | |||
| CN1282218A | 2001-01-31 | |||
| CN105435228A | 2016-03-30 | |||
| US20130156790A1 | 2013-06-20 | |||
| CN103816535A | 2014-05-28 |
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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