ARTERIAL ENDOTHELIAL FUNCTION MEASUREMENT METHOD AND APPARATUS

WIPO Patent Application WO2005079189

A3

A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

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MALTZ JONATHAN S (US)
BUDINGER THOMAS F (US)

PCT/US2004/029737

February 02, 2006

September 10, 2004

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UNIV CALIFORNIA (US)
MALTZ JONATHAN S (US)
BUDINGER THOMAS F (US)

A61B8/08; (IPC1-7): A61B8/02

US6398734B1	2002-06-04
US6592520B1	2003-07-15

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