Title:
ARTIFICIAL ANTIGEN-PRESENTING CELL PREPARED FROM HLA-NULL CELL LINE BY USING MULTIPLEX CRISPR-CAS9 SYSTEM AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/101796
Kind Code:
A1
Abstract:
The present invention relates to an artificial antigen-presenting cell prepared from HLA-null cell line using a multiplex CRISPR-Cas9 system and the use thereof and, more particularly, to a novel artificial antigen-presenting cell which includes ability to present antigens of HLA class I and a co-stimulatory molecule group transferred from an HLA-A,-B,-C-null cell line generated using a multiplex CRISPR-Cas9 system and to stimulate T cells, and the use thereof as an immunotherapeutic agent and in treating tumors, pathogen infections, and autoimmune diseases.
Inventors:
KIM TAI GYU (KR)
SOHN HYUN JUNG (KR)
HONG CHEOL HWA (KR)
SOHN HYUN JUNG (KR)
HONG CHEOL HWA (KR)
Application Number:
PCT/KR2017/014027
Publication Date:
June 07, 2018
Filing Date:
December 01, 2017
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C12N15/63; C07K14/74; C12N5/0783; C12N9/22; C12N15/85
Domestic Patent References:
| WO2016183041A2 | 2016-11-17 |
Foreign References:
| US20060034810A1 | 2006-02-16 |
Other References:
SUHOSKI, MEGAN M.: "Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules", MOLECULAR THERAPY, vol. 15, no. 5, 2007, pages 981 - 988, XP009091356, DOI: doi:10.1038/mt.sj.6300134
BUTLER, MARCUS 0. ET AL: "Long-lived antitumor CD 8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell", CLINICAL CANCER RESEARCH, vol. 13, no. 6, 2007, pages 1857 - 1867, XP055606917
ZENG, WANYONG: "Artificial antigen-presenting cells expressing CD 80, CD70, and 4-1BB ligand efficiently expand functional T cells specific to tumor-associated antigens", IMMUNOBIOLOGY, vol. 219, no. 8, 2014, pages 583 - 592, XP028868244, DOI: doi:10.1016/j.imbio.2014.03.003
HONG, CHEOL-HWA: "Antigen presentation by individually transferred HLA Class I genes in HLA-A, HLA-B, HLA-C null human cell line generated using the multiplex CRISPR-Cas9 system", JOURNAL OF IMMUNOTHERAPY, vol. 40, no. 6, 8 July 2017 (2017-07-08), pages 201 - 210
BUTLER, MARCUS 0. ET AL: "Long-lived antitumor CD 8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell", CLINICAL CANCER RESEARCH, vol. 13, no. 6, 2007, pages 1857 - 1867, XP055606917
ZENG, WANYONG: "Artificial antigen-presenting cells expressing CD 80, CD70, and 4-1BB ligand efficiently expand functional T cells specific to tumor-associated antigens", IMMUNOBIOLOGY, vol. 219, no. 8, 2014, pages 583 - 592, XP028868244, DOI: doi:10.1016/j.imbio.2014.03.003
HONG, CHEOL-HWA: "Antigen presentation by individually transferred HLA Class I genes in HLA-A, HLA-B, HLA-C null human cell line generated using the multiplex CRISPR-Cas9 system", JOURNAL OF IMMUNOTHERAPY, vol. 40, no. 6, 8 July 2017 (2017-07-08), pages 201 - 210
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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