Title:
ARTIFICIAL PROTEIN AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2024/048683
Kind Code:
A1
Abstract:
The present invention provides a novel substance that suitably functions as an Met agonist. The present invention provides an artificial protein that includes an antibody Fc region, where an amino acid represented by SEQ ID NO: 1 is inserted into the Fc region (in SEQ ID NO: 1, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, and X11 each independently represents an amino acid, and n1 and n2 are each independently an integer from 0 to 6). (X1)n1YX3X4FYYNYX 5X6X7WX8X9X10X11(X2)n2 (SEQ ID NO: 1)
Inventors:
SAKO YUSUKE (JP)
HIRAI HIDENORI (JP)
MATSUMOTO KUNIO (JP)
SAKAI KATSUYA (JP)
HIRAI HIDENORI (JP)
MATSUMOTO KUNIO (JP)
SAKAI KATSUYA (JP)
Application Number:
PCT/JP2023/031626
Publication Date:
March 07, 2024
Filing Date:
August 30, 2023
Export Citation:
Assignee:
MIRABIOLOGICS INC (JP)
UNIV NAT CORP KANAZAWA (JP)
UNIV NAT CORP KANAZAWA (JP)
International Classes:
C07K19/00; A61K38/00; A61K47/68; A61P1/16; A61P3/06; A61P9/00; A61P9/10; A61P9/14; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P21/00; A61P37/06; C07K7/08; C07K16/00
Domestic Patent References:
| WO2019026920A1 | 2019-02-07 | |||
| WO2020027224A1 | 2020-02-06 |
Other References:
KENICHIRO ITO, KATSUYA SAKAI, YOSHINORI SUZUKI, NAOYA OZAWA, TOMOHISA HATTA, TOHRU NATSUME, KUNIO MATSUMOTO, HIROAKI SUGA: "Artificial human Met agonists based on macrocycle scaffolds", NATURE COMMUNICATIONS, vol. 6, pages 6373, XP055362332, DOI: 10.1038/ncomms7373
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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