Title:
ARTIFICIAL RECEPTOR HAVING SHEDDING STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2024/024551
Kind Code:
A1
Abstract:
The present invention provides: an artificial receptor that includes a ligand-binding site, a transmembrane domain that has a shedding structure, and a domain for signal transmission into an immune cell; and a nucleic acid that codes for the artificial receptor.
Inventors:
KANEKO SHIN (JP)
MINAGAWA ATSUTAKA (JP)
MINAGAWA ATSUTAKA (JP)
Application Number:
PCT/JP2023/026123
Publication Date:
February 01, 2024
Filing Date:
July 14, 2023
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N15/62; A61K35/15; A61K35/17; A61P35/00; C12N5/0783; C12N5/10; C12N15/12; C12N15/13
Domestic Patent References:
| WO2017061615A1 | 2017-04-13 | |||
| WO2021100585A1 | 2021-05-27 | |||
| WO2022016119A1 | 2022-01-20 | |||
| WO2021256522A1 | 2021-12-23 |
Foreign References:
| JP2019530456A | 2019-10-24 |
Other References:
KENTO FUJIWARA, TSUNEI AYAKA, KUSABUKA HOTAKA, OGAKI ERIKA, TACHIBANA MASASHI, OKADA NAOKI: "Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold", CELLS, vol. 9, no. 5, 9 May 2020 (2020-05-09), pages 1182, XP055760312, ISSN: 2073-4409, DOI: 10.3390/cells9051182
ZHOU XIAOYU, CAO HANBING, FANG SHAO-YU, CHOW RYAN D., TANG KAIYUAN, MAJETY MEDHA, BAI MEIZHU, DONG MATTHEW B., RENAUER PAUL A., SH: "CTLA-4 tail fusion enhances CAR-T anti-tumor immunity", BIORXIV, 15 March 2023 (2023-03-15), pages 1 - 58, XP093135226, [retrieved on 20240227], DOI: 10.1101/2023.03.14.532655
OLSON MICHAEL L.; MAUSE ERICA R. VANDER; RADHAKRISHNAN SABARINATH V.; BRODY JOSHUA D.; RAPOPORT AARON P.; WELM ALANA L.; ATANACKOV: "Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion", BLOOD CANCER JOURNAL, vol. 36, no. 7, 30 April 2022 (2022-04-30), London, pages 1943 - 1946, XP037895751, ISSN: 0887-6924, DOI: 10.1038/s41375-022-01585-2
HAMIEH MOHAMAD; DOBRIN ANTON; CABRIOLU ANNALISA; VAN DER STEGEN SJOUKJE J.; GIAVRIDIS THEODOROS; MANSILLA-SOTO JORGE; EYQUEM JUSTI: "CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape", NATURE, vol. 568, no. 7750, 27 March 2019 (2019-03-27), pages 112 - 116, XP036746436, DOI: 10.1038/s41586-019-1054-1
ZHOU XIAOYU, CAO HANBING, FANG SHAO-YU, CHOW RYAN D., TANG KAIYUAN, MAJETY MEDHA, BAI MEIZHU, DONG MATTHEW B., RENAUER PAUL A., SH: "CTLA-4 tail fusion enhances CAR-T anti-tumor immunity", BIORXIV, 15 March 2023 (2023-03-15), pages 1 - 58, XP093135226, [retrieved on 20240227], DOI: 10.1101/2023.03.14.532655
OLSON MICHAEL L.; MAUSE ERICA R. VANDER; RADHAKRISHNAN SABARINATH V.; BRODY JOSHUA D.; RAPOPORT AARON P.; WELM ALANA L.; ATANACKOV: "Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion", BLOOD CANCER JOURNAL, vol. 36, no. 7, 30 April 2022 (2022-04-30), London, pages 1943 - 1946, XP037895751, ISSN: 0887-6924, DOI: 10.1038/s41375-022-01585-2
HAMIEH MOHAMAD; DOBRIN ANTON; CABRIOLU ANNALISA; VAN DER STEGEN SJOUKJE J.; GIAVRIDIS THEODOROS; MANSILLA-SOTO JORGE; EYQUEM JUSTI: "CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape", NATURE, vol. 568, no. 7750, 27 March 2019 (2019-03-27), pages 112 - 116, XP036746436, DOI: 10.1038/s41586-019-1054-1
Attorney, Agent or Firm:
MURAOKA, Koichiro et al. (JP)
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