Title:
ARYL CARBOXYLIC ACID COMPOUND AND USE THEREOF IN PREPARATION OF MRGPR X4 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/098210
Kind Code:
A1
Abstract:
The present invention relates to the technical field of drug research and development, and specifically relates to an aryl carboxylic acid compound, in particular to a use of the aryl carboxylic acid compound in the preparation of an Mrgpr X4 inhibitor. The present invention provides a novel compound having an aryl carboxylic acid structure. The compound has a good inhibitory effect on an Mrgpr X4 receptor and has good application prospects in the treatment of pain, pruritus, cholestatic pruritus, drug side effects, autoimmune diseases, multiple sclerosis and other diseases, and can be used in the preparation of drugs for preventing or treating pruritus, and the compound has excellent safety and in-vivo pharmacokinetic properties.
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Inventors:
TANG CHANGHUA (CN)
DING YUYANG (CN)
DENG JIANYANG (CN)
CAI CHUNMAN (CN)
LIU WENTAO (CN)
TANG DAOPENG (CN)
YU ZHICHENG (CN)
ZHAO JINGLI (CN)
YAN KECHI (CN)
ZUO LIAN (CN)
WANG TINGCHUN (CN)
DING YUYANG (CN)
DENG JIANYANG (CN)
CAI CHUNMAN (CN)
LIU WENTAO (CN)
TANG DAOPENG (CN)
YU ZHICHENG (CN)
ZHAO JINGLI (CN)
YAN KECHI (CN)
ZUO LIAN (CN)
WANG TINGCHUN (CN)
Application Number:
PCT/CN2022/130381
Publication Date:
May 16, 2024
Filing Date:
November 07, 2022
Export Citation:
Assignee:
SHENZHEN BORUI PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07D207/08; A61K31/397; A61K31/402; A61K31/4025; A61K31/451; A61P17/04; A61P29/00; C07D205/04; C07D211/34; C07D401/06; C07D405/04
Domestic Patent References:
| WO2021211839A1 | 2021-10-21 | |||
| WO2022051634A1 | 2022-03-10 |
Foreign References:
| CN113939288A | 2022-01-14 | |||
| CN112469699A | 2021-03-09 | |||
| US20220340530A1 | 2022-10-27 |
Other References:
DATABASE REGISTRY 21 June 2015 (2015-06-21), ANONYMOUS: "Benzoic acid, 4-(1-phenyl-2-pyrrolidinyl)- (CA INDEX NAME)", XP093169591, retrieved from STNext Database accession no. 1785602-75-6
DATABASE REGISTRY 14 June 2015 (2015-06-14), ANONYMOUS: "Benzoic acid, 3-(1-phenyl-2-pyrrolidinyl)- (CA INDEX NAME)", XP093169594, retrieved from STNext Database accession no. 1779992-32-3
NISHA ADHIKARI: "Caffeic acid phenethyl ester inhibits pseudo-allergic reactions via inhibition of MRGPRX2/MrgprB2-dependent mast cell degranulation", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 45, no. 9, 2 October 2022 (2022-10-02), KR , pages 644 - 657, XP093169543, ISSN: 0253-6269, DOI: 10.1007/s12272-022-01405-2
DATABASE REGISTRY 14 June 2015 (2015-06-14), ANONYMOUS: "Benzoic acid, 3-(1-phenyl-2-pyrrolidinyl)- (CA INDEX NAME)", XP093169594, retrieved from STNext Database accession no. 1779992-32-3
NISHA ADHIKARI: "Caffeic acid phenethyl ester inhibits pseudo-allergic reactions via inhibition of MRGPRX2/MrgprB2-dependent mast cell degranulation", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 45, no. 9, 2 October 2022 (2022-10-02), KR , pages 644 - 657, XP093169543, ISSN: 0253-6269, DOI: 10.1007/s12272-022-01405-2
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)
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