Title:
ARYL FORMAMIDE COMPOUND, PREPARATION METHOD FOR SAME, AND MEDICINAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/063205
Kind Code:
A1
Abstract:
An aryl formamide compound, a preparation method for same, and medicinal uses thereof. Specifically, related are a compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, uses thereof serving as a P2X3 receptor antagonist, and uses in treating and/or preventing P2X3 receptor activity-related diseases, such as chronic cough, pain, endometriosis, and overactive bladder. The definitions of the substituents in formula (I) are identical to the definitions in the description. ![]()
Inventors:
YIN HUIJUN (CN)
YAN XU (CN)
ZONG LIBIN (CN)
LIU GUOBIAO (CN)
ZHANG SHOULIANG (CN)
CHEN BIN (CN)
LU JIAWEI (CN)
WANG ZHUO (CN)
LI RUI (CN)
YAN XU (CN)
ZONG LIBIN (CN)
LIU GUOBIAO (CN)
ZHANG SHOULIANG (CN)
CHEN BIN (CN)
LU JIAWEI (CN)
WANG ZHUO (CN)
LI RUI (CN)
Application Number:
PCT/CN2021/120150
Publication Date:
March 31, 2022
Filing Date:
September 24, 2021
Export Citation:
Assignee:
THE NAT INSTITUTES OF PHARMACEUTICAL R&D CO LTD (CN)
International Classes:
C07D417/14; A61K31/416; A61K31/426; A61K31/506; A61K31/536; A61P1/04; A61P11/00; A61P13/00; A61P25/00; A61P29/00; C07D405/14; C07D413/14
Domestic Patent References:
| WO2021059136A1 | 2021-04-01 | |||
| WO2020260463A1 | 2020-12-30 | |||
| WO2020239951A1 | 2020-12-03 | |||
| WO2010111058A1 | 2010-09-30 | |||
| WO2010111060A1 | 2010-09-30 |
Foreign References:
| CN102803245A | 2012-11-28 | |||
| CN101528717A | 2009-09-09 | |||
| CN107207507A | 2017-09-26 | |||
| CN106029660A | 2016-10-12 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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