Title:
ARYLPROPIONIC ACID DERIVATIVE AND EMULSION PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/115511
Kind Code:
A1
Abstract:
The present application relates to an arylpropionic acid derivative and an emulsion preparation thereof. The arylpropionic acid derivative is a compound with a structural formula (1) prepared by carrying out derivatization on carboxyl of a loxoprofen active metabolite, such that the solubility of the compound in an oil solution is increased and the compound is further prepared into an emulsion preparation. The problem of compatibility of opioid drugs such as morphine hydrochloride is effectively solved. The present application has important significance for clinically and effectively controlling the use dosage of addictive drugs such as morphine.
Inventors:
YE HAI (CN)
ZHOU WENLIANG (CN)
XU YING (CN)
LV TIAN (CN)
MIN TAO (CN)
CHEN XINGRAN (CN)
ZHOU WENLIANG (CN)
XU YING (CN)
LV TIAN (CN)
MIN TAO (CN)
CHEN XINGRAN (CN)
Application Number:
PCT/CN2021/141083
Publication Date:
June 29, 2023
Filing Date:
December 24, 2021
Export Citation:
Assignee:
NANJING HERON PHARMACEUTICAL SCIENCE AND TECH CO LTD (CN)
International Classes:
C07C69/732; A61K31/216; A61P29/00; C07C69/73
Domestic Patent References:
| WO2022052936A1 | 2022-03-17 | |||
| WO2014065577A1 | 2014-05-01 |
Foreign References:
| CN111635309A | 2020-09-08 | |||
| US4407823A | 1983-10-04 | |||
| CN111635315A | 2020-09-08 | |||
| CN106661061A | 2017-05-10 | |||
| CN1069484A | 1993-03-03 | |||
| CN102333754A | 2012-01-25 |
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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