Arylsulphonamide compounds Cross reference This application claims priority to Australian provisional application no.2021904206, filed on 22 December 2021, the entire contents of which are incorporated herein by reference. Field The present disclosure relates to compounds which treat necroptosis and/or inhibit MLKL, and methods for their use. Background In many diseases, cell death is mediated through apoptotic and/or necrotic pathways. While much is known about the mechanisms of action that control apoptosis, control of necrosis is not as well understood. Understanding the mechanisms in respect of both necrosis and apoptosis in cells is essential to being able to treat conditions, such as neurodegenerative diseases, stroke- coronary heart disease, kidney disease, liver disease, AIDS and the conditions associated with AIDS. Cell death has traditionally been categorized as either apoptotic or necrotic based on morphological characteristics (Wyllie et al., Int. Rev. Cytol.68: 251 (1980)). These two modes of cell death were also initially thought to occur via regulated (caspase-dependent) and non-regulated processes, respectively. More recent studies, however, demonstrate that the underlying cell death mechanisms resulting in these two phenotypes are much more complicated and under some circumstances interrelated. Furthermore, conditions that lead to necrosis can occur by either regulated caspase-independent or non-regulated processes. One regulated caspase-independent cell death pathway with morphological features resembling necrosis, called necroptosis, has been described (Degterev et al., Nat. Chem. Biol.1:112, 2005). This cell death modality can be initiated with various stimuli (e.g., TNF- [alpha] and Fas ligand) and in an array of cell types (e.g., monocytes, fibroblasts, lymphocytes, macrophages, epithelial cells and neurons). Necroptosis may represent a significant contributor to and in some cases predominant mode of cellular demise under pathological conditions involving excessive cell stress, rapid energy loss and massive oxidative species generation, where the highly energy-dependent apoptosis process is not operative. In WO2015/172203, we reported that particular compounds described in US2005/0085637 have been found to be suitable for inhibiting necroptosis. We also discussed particularly suitable compounds for inhibiting necroptosis in WO2016/127213. All publications, patents and patent applications that may be cited herein are hereby incorporated by reference in their entirety. Any discussion of documents, acts, materials, devices, articles or the like which has been included in the present specification is not to be taken as an admission that any or all of these matters form part of the prior art base or were common general knowledge in the field relevant to the present disclosure as it existed before the priority date of each claim of this application. Summary As discussed above, certain compounds described in WO2016/127213, US2005/0085637 and WO2015/172203 have been found to be suitable for inhibiting necroptosis. Surprisingly, the inventors of this invention have now discovered that other types of compounds are also suitable for inhibiting necroptosis. Further, and equally surprising, the compounds described herein target a key effector of the necroptotic pathway, namely mixed lineage kinase domain-like protein (MLKL). In addition, the compounds described herein are potent inhibitors of different MLKL homologues, including human MLKL and murine MLKL. The cross-homologue MLKL potency may provide useful pre-clinical safety and efficacy data. In one aspect, there is provided a compound according to Formula (I) wherein J is selected from the following moieties J1 and J2: A ¹ and A ⁴ are independently selected from N and C; A ² and A ³ are independently selected from N, NR ¹ , CH, O and S; wherein at least one of A ¹ , A ² , A ³ and A ⁴ is selected from N, NR ¹ , O and S; A ⁵ is CH or N; A ⁶ is N or CR ² ; R ¹ and R ³ are independently selected from H and an optionally substituted C1-6-alkyl; R ² is selected from: (i) H, (ii) optionally substituted C _1-4 alkylamido, (iii) optionally substituted C _1-4 alkylaryl, (iv) optionally substituted C _2-4 alkynyl, (v) optionally substituted aryl, (vi) optionally substituted 5- or 6-membered heterocyclyl, (vii) cyano; X is selected from optionally substituted C _1-6 alkyl, optionally substituted haloC _1-6 alkyl, optionally substituted C _2-6 alkynyl, optionally substituted cycloalkyl, optionally substituted halocycloalkyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted C _1-6 alkylcycloalkyl and optionally substituted amino; Y and Z are independently selected from H, R ⁴ and –OR ⁴ ; wherein at least one of Y and Z is H and the remaining one of Y and Z is selected from R ⁴ and –OR ⁴ ; R ⁴ is selected from optionally substituted C _1-6 alkyl, optionally substituted aryl, optionally substituted C _1-6 alkylaryl, optionally substituted heterocyclyl, optionally substituted C _1-6 alkylheterocyclyl, optionally substituted cycloalkyl, optionally substituted C _1-6 alkylC _3-10 cycloalkyl, optionally substituted C _3-10 cycloalkylaryl, optionally substituted C _3-10 cycloalkylheterocyclyl, optionally substituted C _3-10 cycloalkylC _3-10 cycloalkyl, optionally substituted 3-6 membered non-aromatic heterocyclyl-aryl, optionally substituted 3-6 membered non-aromatic heterocyclylC _3-10 cycloalkyl and optionally substituted 3-6 membered non-aromatic heterocyclyl-3-10 membered heterocyclyl; and R ⁵ is selected from H, optionally substituted C _1-6 alkyl, optionally substituted C _3-10 cycloalkyl and optionally substituted aryl. In any aspect or embodiment described herein, the compound of the invention may be provided in the form of a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof. The inventors have found that compounds of Formula (I) are selective inhibitors of MLKL. In some embodiments, when Y is –OR ⁴ , Z is H. In some embodiments, R ² is selected from: (i) H, (ii) optionally substituted C _1-4 alkylamido, (iii) optionally substituted C _1-4 alkylaryl, (iv) optionally substituted C _2-4 alkynyl, (v) optionally substituted aryl, (vi) optionally substituted 5- or 6-membered heterocyclyl. In some embodiments, the compound of the invention is selected from any of compounds 1- 173 described herein. In some embodiments, the compound of the invention is selected from any of compounds 7, 9, 12, 13, 14, 15, 16, 18, 19, 20 and 72. In some embodiments, the compound of the invention is selected from any of compounds 1, 7, 9, 12-16, 18-21, 23-32, 35-46, 48, 50-52, 55-62, 72-89, 92-109, 111, 113, 115-117, and 119-123, preferably any of compounds 19, 29-31, 36, 38, 40-41.75-77, 81, 100-101, 103- 104, 109, 120 and 123. In some embodiments, the compound of the invention is selected from any of compounds 1, 5, 7-9, 11-16, 18-21, 23-32, 35-46, 48, 50-52, 55-62, 66, 69, 70, 72-89, 92-109, 111, 113, 115-117, and 119-123, preferably any of compounds 5, 7-9, 11-13, 15, 18-20, 60, 61, 66, 69, 70 and 72. In some embodiments, the compound of the invention is selected from from any of compounds 3, 11, 13, 19, 29, 30, 46, 79, 80, 81, 97, 98, 99, 103, 104, 109, 113, 116, 120, 121 and 122. In another aspect, there is provided a medicament comprising a compound of the invention. In another aspect, there is provided a pharmaceutical composition comprising a compound of the invention and a pharmaceutically acceptable excipient. In another aspect, there is provided a method of treating necroptosis, comprising administering to a subject in need thereof an effective amount of a compound of the invention. In another aspect, there is provided a method of inhibiting MLKL, comprising contacting a cell with a compound of the invention. Any embodiment herein shall be taken to apply mutatis mutandis to any other embodiment unless specifically stated otherwise. The present disclosure is not to be limited in scope by the specific embodiments described herein, which are intended for the purpose of exemplification only. Functionally-equivalent products, compositions and methods are clearly within the scope of the invention, as described herein. Throughout this specification, unless specifically stated otherwise or the context requires otherwise, reference to a single step, composition of matter, group of steps or group of compositions of matter shall be taken to encompass one and a plurality (i.e. one or more) of those steps, compositions of matter, groups of steps or group of compositions of matter. Definitions Unless otherwise herein defined, the following terms will be understood to have the general meanings which follow. The term “C _1-6 alkyl” refers to optionally substituted straight chain or branched chain hydrocarbon groups having from 1 to 6 carbon atoms. Examples include methyl (Me), ethyl (Et), propyl (Pr), isopropyl (i-Pr), butyl (Bu), isobutyl (i-Bu), sec-butyl (s-Bu), tert-butyl (t-Bu), pentyl, neopentyl, hexyl and the like. Unless the context requires otherwise, the term “C _1-6 alkyl” also encompasses alkyl groups containing one less hydrogen atom such that the group is attached via two positions i.e. divalent. “C _1-4 alkyl” and “C _1-3 alkyl” including methyl, ethyl, propyl, isopropyl, n-butyl, iso-butyl, sec-butyl and tert-butyl are preferred with methyl being particularly preferred. The term “C _2-6 alkenyl” refers to optionally substituted straight chain or branched chain hydrocarbon groups having at least one double bond of either E or Z stereochemistry where applicable and 2 to 6 carbon atoms. Examples include vinyl, 1-propenyl, 1- and 2-butenyl and 2-methyl-2-propenyl. Unless the context requires otherwise, the term “C _2-6 alkenyl” also encompasses alkenyl groups containing one less hydrogen atom such that the group is attached via two positions i.e. divalent. “C _2-4 alkenyl” and “C _2-3 alkenyl” including ethenyl, propenyl and butenyl are preferred with ethenyl being particularly preferred. The term “C _2-6 alkynyl” refers to optionally substituted straight chain or branched chain hydrocarbon groups having at least one triple bond and 2 to 6 carbon atoms. Examples include ethynyl, 1-propynyl, 1- and 2-butynyl, 2-methyl-2-propynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl and 5-hexynyl and the like. Unless the context indicates otherwise, the term “C _2-6 alkynyl” also encompasses alkynyl groups containing one less hydrogen atom such that the group is attached via two positions i.e. divalent. C _2-4 alkynyl or C _2-3 alkynyl are preferred. The term “C _3-10 cycloalkyl” refers to non-aromatic cyclic groups having from 3 to 10 carbon atoms, including cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl and cyclodecyl. It will be understood that cycloalkyl groups may be saturated such as cyclohexyl or unsaturated such as cyclohexenyl. C _3-6 cycloalkyl such as cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl are preferred. Cycloalkyl groups also include polycyclic carbocycles and include fused, bridged and spirocyclic systems. The terms “hydroxy” and “hydroxyl” refer to the group -OH. The term “oxo” refers to the group =O. The term “C _1-6 alkoxy” refers to an alkyl group as defined above covalently bound via an O linkage containing 1 to 6 carbon atoms, such as methoxy, ethoxy, propoxy, isoproxy, butoxy, tert-butoxy and pentoxy. “C _1-4 alkoxy” and “C _1-3 alkoxy” including methoxy, ethoxy, propoxy and butoxy are preferred with methoxy being particularly preferred. The terms “haloC _1-6 alkyl” and “C _1-6 alkylhalo” refer to a C _1-6 alkyl which is substituted with one or more halogens. HaloC _1-3 alkyl groups are preferred, such as for example, -CH ₂ CF ₃ , and - CF ₃ . The terms “haloC _1-6 alkoxy” and “C _1-6 alkoxyhalo” refer to a C _1-6 alkoxy which is substituted with one or more halogens. C _1-3 alkoxyhalo groups are preferred, such as for example, - OCF ₃ . The term “carboxylate” or “carboxyl” refers to the group -COO- or -COOH. The term “ester” refers to a carboxyl group having the hydrogen replaced with, for example a C _1-6 alkyl group (“carboxylC _1-6 alkyl” or “alkylester”), an aryl or aralkyl group (“arylester” or “aralkylester”) and so on. CO ₂ C _1-3 alkyl groups are preferred, such as for example, methylester (CO ₂ Me), ethylester (CO ₂ Et) and propylester (CO ₂ Pr) and includes reverse esters thereof (e.g. –OC(O)Me, -OC(O)Et and –OC(O)Pr). The terms “cyano” and “nitrile” refer to the group -CN. The term “nitro” refers to the group -NO ₂ . The term “amino” refers to the group -NH ₂ . The term “substituted amino” refers to an amino group having at least one hydrogen replaced with, for example a C _1-6 alkyl group (“C _1-6 alkylamino”), an aryl or aralkyl group (“arylamino”, “aralkylamino”) and so on. Substituted amino groups include “monosubstituted amino” (or “secondary amino”) groups, which refer to an amino group having a single hydrogen replaced with, for example a C _1-6 alkyl group, an aryl or aralkyl group and so on. Preferred secondary amino groups include C _1-3 alkylamino groups, such as for example, methylamino (NHMe), ethylamino (NHEt) and propylamino (NHPr). Substituted amino groups also include “disubstituted amino” (or “tertiary amino”) groups, which refer to amino groups having both hydrogens replaced with, for example C _1-6 alkyl groups, which may be the same or different (“dialkylamino”), aryl and alkyl groups (“aryl(alkyl)amino”) and so on. Preferred tertiary amino groups include di(C _1-3 alkyl)amino groups, such as for example, dimethylamino (NMe ₂ ), diethylamino (NEt ₂ ), dipropylamino (NPr ₂ ) and variations thereof (e.g. N(Me)(Et) and so on). The term “aldehyde” refers to the group -C(=O)H. The terms “acyl” and “acetyl” refers to the group –C(O)CH ₃ . The term “ketone” refers to a carbonyl group which may be represented by –C(O)-. The term “substituted ketone” refers to a ketone group covalently linked to at least one further group, for example, a C _1-6 alkyl group (“C _1-6 alkylacyl” or “alkylketone” or “ketoalkyl”), an aryl group (“arylketone”), an aralkyl group (“aralkylketone) and so on. C _1-3 alkylacyl groups are preferred. The term “amido” or “amide” refers to the group -C(O)NH ₂ . The term “substituted amido” or “substituted amide” refers to an amido group having a hydrogen replaced with, for example a C _1-6 alkyl group (“C _1-6 alkylamido” or “C _1-6 alkylamide”), an aryl (“arylamido”), aralkyl group (“aralkylamido”) and so on. C _1-3 alkylamide groups are preferred, such as for example, methylamide (-C(O)NHMe), ethylamide (-C(O)NHEt) and propylamide (-C(O)NHPr) and includes reverse amides thereof (e.g. -NHMeC(O)-, - NHEtC(O)- and –NHPrC(O)-). The term “disubstituted amido” or “disubstituted amide” refers to an amido group having the two hydrogens replaced with, for example a C _1-6 alkyl group (“di(C _1-6 alkyl)amido” or “di(C _{1- 6} alkyl)amide”), an aralkyl and alkyl group (“alkyl(aralkyl)amido”) and so on. Di(C _1-3 alkyl)amide groups are preferred, such as for example, dimethylamide (-C(O)NMe ₂ ), diethylamide (-C(O)NEt ₂ ) and dipropylamide ((-C(O)NPr ₂ ) and variations thereof (e.g. -C(O)N(Me)Et and so on) and includes reverse amides thereof. The term “thiol” refers to the group -SH. The term “C _1-6 alkylthio” refers to a thiol group having the hydrogen replaced with a C _1-6 alkyl group. C _1-3 alkylthio groups are preferred, such as for example, thiolmethyl, thiolethyl and thiolpropyl. The terms “thioxo” refer to the group =S. The term “sulfinyl” refers to the group -S(=O)H. The term “substituted sulfinyl” or “sulfoxide” refers to a sulfinyl group having the hydrogen replaced with, for example a C _1-6 alkyl group (“C _1-6 alkylsulfinyl” or “C _1-6 alkylsulfoxide”), an aryl (“arylsulfinyl”), an aralkyl (“aralkyl sulfinyl”) and so on. C _1-3 alkylsulfinyl groups are preferred, such as for example, -SOmethyl, -SOethyl and -SOpropyl. The term “sulfonyl” refers to the group -SO ₂ H. The term “substituted sulfonyl” refers to a sulfonyl group having the hydrogen replaced with, for example a C _1-6 alkyl group (“sulfonylC _1-6 alkyl”), an aryl (“arylsulfonyl”), an aralkyl (“aralkylsulfonyl”) and so on. SulfonylC _1-3 alkyl groups are preferred, such as for example, - SO ₂ Me, -SO ₂ Et and -SO ₂ Pr. The term “sulfonylamido” or “sulfonamide” refers to the group -SO ₂ NH ₂ . The term “substituted sulfonamido” or “substituted sulphonamide” refers to an sulfonylamido group having a hydrogen replaced with, for example a C _1-6 alkyl group (“sulfonylamidoC _{1- 6} alkyl”), an aryl (“arylsulfonamide”), aralkyl (“aralkylsulfonamide”) and so on. SulfonylamidoC _1-3 alkyl groups are preferred, such as for example, -SO ₂ NHMe, -SO ₂ NHEt and -SO ₂ NHPr and includes reverse sulfonamides thereof (e.g. -NHSO ₂ Me, -NHSO ₂ Et and - NHSO ₂ Pr). The term “disubstituted sufonamido” or “disubstituted sulphonamide” refers to an sulfonylamido group having the two hydrogens replaced with, for example a C _1-6 alkyl group, which may be the same or different (“sulfonylamidodi(C _1-6 alkyl)”), an aralkyl and alkyl group (“sulfonamido(aralkyl)alkyl”) and so on. Sulfonylamidodi(C _1-3 alkyl) groups are preferred, such as for example, -SO ₂ NMe ₂ , -SO ₂ NEt ₂ and -SO ₂ NPr ₂ and variations thereof (e.g. -SO ₂ N(Me)Et and so on) and includes reserve sulfonamides thereof (e.g. – N(Me)SO ₂ Me and so on). The term “sulfate” refers to the group OS(O) ₂ OH and includes groups having the hydrogen replaced with, for example a C _1-6 alkyl group (“alkylsulfates”), an aryl (“arylsulfate”), an aralkyl (“aralkylsulfate”) and so on. C _1-3 sulfates are preferred, such as for example, OS(O) ₂ OMe, OS(O) ₂ OEt and OS(O) ₂ OPr. The term “sulfonate” refers to the group SO ₃ H and includes groups having the hydrogen replaced with, for example a C _1-6 alkyl group (“alkylsulfonate”), an aryl (“arylsulfonate”), an aralkyl (“aralkylsulfonate”) and so on. C _1-3 sulfonates are preferred, such as for example, SO ₃ Me, SO ₃ Et and SO ₃ Pr. The term “aryl” refers to a carbocyclic (non-heterocyclic) aromatic ring or mono-, bi- or tri- cyclic ring system. Poly-cyclic ring systems may be referred to as “aryl” provided at least 1 of the rings within the system is aromatic. The aromatic ring or ring system is generally composed of 6 to 10 carbon atoms. Examples of aryl groups include but are not limited to phenyl, biphenyl, naphthyl and tetrahydronaphthyl.6-membered aryls such as phenyl are preferred. The term “alkylaryl” refers to C _1-6 alkylaryl such as benzyl. The term “alkoxyaryl” refers to C _1-6 alkyloxyaryl such as benzyloxy. The term “heterocyclyl” refers to a moiety obtained by removing a hydrogen atom from a ring atom of a heterocyclic compound which moiety has from 3 to 10 ring atoms (unless otherwise specified), of which 1, 2, 3 or 4 are ring heteroatoms each heteroatom being independently selected from O, S and N. Heterocyclyl groups include monocyclic and polycyclic (such as bicyclic) ring systems, such as fused, bridged and spirocyclic systems, provided at least one of the rings of the ring systm contains at least one heteroatom. In this context, the prefixs 3-, 4-, 5-, 6-, 7-, 8-, 9- and 10- membered denote the number of ring atoms, or range of ring atoms, whether carbon atoms or heteroatoms. For example, the term “3-10 membered heterocylyl”, as used herein, pertains to a heterocyclyl group having 3, 4, 5, 6, 7, 8, 9 or 10 ring atoms. Examples of heterocylyl groups include 5-6-membered monocyclic heterocyclyls and 9-10 membered fused bicyclic heterocyclyls. Examples of monocyclic heterocyclyl groups include, but are not limited to, those containing one nitrogen atom such as aziridine (3-membered ring), azetidine (4-membered ring), pyrrolidine (tetrahydropyrrole), pyrroline (e.g., 3-pyrroline, 2,5-dihydropyrrole), 2H-pyrrole or 3H-pyrrole (isopyrrole, isoazole) or pyrrolidinone (5-membered rings) , piperidine, dihydropyridine, tetrahydropyridine (6-membered rings), and azepine (7-membered ring); those containing two nitrogen atoms such as imidazoline, pyrazolidine (diazolidine), imidazoline, pyrazoline (dihydropyrazole) (5-membered rings), piperazine (6-membered ring); those containing one oxygen atom such as oxirane (3-membered ring), oxetane (4- membered ring), oxolane (tetrahydrofuran), oxole (dihydrofuran) (5-membered rings), oxane (tetrahydropyran), dihydropyran, pyran (6-membered rings), oxepin (7-membered ring); those containing two oxygen atoms such as dioxolane (5-membered ring), dioxane (6- membered ring), and dioxepane (7-membered ring); those containing three oxygen atoms such as trioxane (6-membered ring); those containing one sulfur atom such as thiirane (3- membered ring), thietane (4-membered ring), thiolane (tetrahydrothiophene) (5-membered ring), thiane (tetrahydrothiopyran) (6-membered ring), thiepane (7-membered ring); those containing one nitrogen and one oxygen atom such as tetrahydrooxazole, dihydrooxazole, tetrahydroisoxazole, dihydroisoxazole (5-membered rings), morpholine, tetrahydrooxazine, dihydrooxazine, oxazine (6-membered rings); those containing one nitrogen and one sulfur atom such as thiazoline, thiazolidine (5-membered rings), thiomorpholine (6-membered ring); those containing two nitrogen and one oxygen atom such as oxadiazine (6-membered ring); those containing one oxygen and one sulfur such as: oxathiole (5-membered ring) and oxathiane (thioxane) (6-membered ring); and those containing one nitrogen, one oxygen and one sulfur atom such as oxathiazine (6-membered ring). Heterocyclyls encompass aromatic heterocyclyls and non-aromatic heterocyclyls. Such groups may be substituted or unsubstituted. The term “aromatic heterocyclyl” may be used interchangeably with the term “heteroaromatic” or the term “heteroaryl” or “hetaryl”. The heteroatoms in the aromatic heterocyclyl group may be independently selected from N, S and O. The aromatic heterocyclyl groups may comprise 1, 2, 3, 4 or more ring heteroatoms. In the case of fused aromatic heterocyclyl groups, only one of the rings may contain a heteroatom and not all rings must be aromatic. “Heteroaryl” is used herein to denote a heterocyclic group having aromatic character and embraces aromatic monocyclic ring systems and polycyclic (e.g. bicyclic) ring systems containing one or more aromatic rings. The term aromatic heterocyclyl also encompasses pseudoaromatic heterocyclyls. The term “pseudoaromatic” refers to a ring system which is not strictly aromatic, but which is stabilized by means of delocalization of electrons and behaves in a similar manner to aromatic rings. The term aromatic heterocyclyl therefore covers polycyclic ring systems in which all of the fused rings are aromatic as well as ring systems where one or more rings are non-aromatic, provided that at least one ring is aromatic. In polycyclic systems containing both aromatic and non-aromatic rings fused together, the group may be attached to another moiety by the aromatic ring or by a non- aromatic ring. Examples of heteroaryl groups are monocyclic and bicyclic groups containing from five to ten ring members. The heteroaryl group can be, for example, a five membered or six membered monocyclic ring or a bicyclic structure formed from fused five and six membered rings or two fused six membered rings or two fused five membered rings. Each ring may contain up to about four heteroatoms typically selected from nitrogen, sulphur and oxygen. The heteroaryl ring will contain up to 4 heteroatoms, more typically up to 3 heteroatoms, more usually up to 2, for example a single heteroatom. In one embodiment, the heteroaryl ring contains at least one ring nitrogen atom. The nitrogen atoms in the heteroaryl rings can be basic, as in the case of an imidazole or pyridine, or essentially non-basic as in the case of an indole or pyrrole nitrogen. In general the number of basic nitrogen atoms present in the heteroaryl group, including any amino group substituents of the ring, will be less than five. Aromatic heterocyclyl groups may be 5-membered or 6-membered mono-cyclic aromatic ring systems. Examples of 5-membered monocyclic heteroaryl groups include but are not limited to furanyl, thienyl, pyrrolyl, oxazolyl, oxadiazolyl (including 1,2,3 and 1,2,4 oxadiazolyls and furazanyl i.e.1,2,5-oxadiazolyl), thiazolyl, isoxazolyl, isothiazolyl, pyrazolyl, imidazolyl, triazolyl (including 1,2,3, 1,2,4 and 1,3,4 triazolyls), oxatriazolyl, tetrazolyl, thiadiazolyl (including 1,2,3 and 1,3,4 thiadiazolyls) and the like. Examples of 6-membered monocyclic heteroaryl groups include but are not limited to pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, pyranyl, oxazinyl, dioxinyl, thiazinyl, thiadiazinyl and the like. Examples of 6-membered aromatic heterocyclyls containing nitrogen include pyridyl (1 nitrogen), pyrazinyl, pyrimidinyl and pyridazinyl (2 nitrogens). Aromatic heterocyclyl groups may also be bicyclic or polycyclic heteroaromatic ring systems such as fused ring systems (including purine, pteridinyl, napthyridinyl, 1H thieno[2,3- c]pyrazolyl, thieno[2,3-b]furyl and the like) or linked ring systems (such as oligothiophene, polypyrrole and the like). Fused ring systems may also include aromatic 5-membered or 6- membered heterocyclyls fused to carbocyclic aromatic rings such as phenyl, naphtyl, indenyl, azulenyl, fluorenyl, anthracenyl and the like, such as 5-membered aromatic heterocyclyls containing nitrogen fused to phenyl rings, 5-membered aromatic heterocyclyls containing 1 or 2 nitrogens fused to phenyl ring. A bicyclic heteroaryl group may be, for example, a group selected from: a) a benzene ring fused to a 5- or 6-membered ring containing 1, 2 or 3 ring heteroatoms; b) a pyridine ring fused to a 5- or 6-membered ring containing 1, 2 or 3 ring heteroatoms; c) a pyrimidine ring fused to a 5- or 6-membered ring containing 1 or 2 ring heteroatoms; d) a pyrrole ring fused to a 5- or 6-membered ring containing 1, 2 or 3 ring heteroatoms; e) a pyrazole ring fused to a 5- or 6-membered ring containing 1 or 2 ring heteroatoms; f) an imidazole ring fused to a 5- or 6-membered ring containing 1 or 2 ring heteroatoms; g) an oxazole ring fused to a 5- or 6-membered ring containing 1 or 2 ring heteroatoms; h) an isoxazole ring fused to a 5- or 6- membered ring containing 1 or 2 ring heteroatoms; i) a thiazole ring fused to a 5- or 6- membered ring containing 1 or 2 ring heteroatoms; j) an isothiazole ring fused to a 5- or 6- membered ring containing 1 or 2 ring heteroatoms; k) a thiophene ring fused to a 5- or 6- membered ring containing 1, 2 or 3 ring heteroatoms; I) a furan ring fused to a 5- or 6-membered ring containing 1, 2 or 3 ring heteroatoms; m) a cyclohexyl ring fused to a 5- or 6-membered ring containing 1, 2 or 3 ring heteroatoms; and n) a cyclopentyl ring fused to a 5- or 6-membered ring containing 1, 2 or 3 ring heteroatoms. Particular examples of bicyclic heteroaryl groups containing a five membered ring fused to another five membered ring include but are not limited to imidazothiazole (e.g. imidazo[2,1- b]thiazole) and imidazoimidazole (e.g. imidazo[1,2-a]imidazole). Particular examples of bicyclic heteroaryl groups containing a six membered ring fused to a five membered ring include but are not limited to benzofuran, benzothiophene, benzimidazole, benzoxazole, isobenzoxazole, benzisoxazole, benzothiazole, benzisothiazole, isobenzofuran, indole, isoindole, indolizine, indoline, isoindoline, purine (e.g., adenine, guanine), indazole, pyrazolopyrimidine (e.g. pyrazolo[1 ,5-a]pyrimidine), benzodioxole and pyrazolopyridine (e.g. pyrazolo[1,5-a]pyridine) groups. A further example of a six membered ring fused to a five membered ring is a pyrrolopyridine group such as a pyrrolo[2,3-b]pyridine group. Particular examples of bicyclic heteroaryl groups containing two fused six membered rings include but are not limited to quinoline, isoquinoline, chroman, thiochroman, chromene, isochromene, isochroman, benzodioxan, quinolizine, benzoxazine, benzodiazine, pyridopyridine, quinoxaline, quinazoline, cinnoline, phthalazine, naphthyridine and pteridine groups. Examples of heteroaryl groups containing an aromatic ring and a non-aromatic ring include tetrahydronaphthalene, tetrahydroisoquinoline, tetrahydroquinoline, dihydrobenzothiophene, dihydrobenzofuran, 2,3-dihydro- benzo[1,4]dioxine, benzo[1,3]dioxole, 4,5,6,7- tetrahydrobenzofuran, indoiine, isoindoline and indane groups. Examples of aromatic heterocyclyls fused to carbocyclic aromatic rings may therefore include but are not limited to benzothiophenyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzimidazolyl, indazolyl, benzoxazolyl, benzisoxazolyl, isobenzoxazoyl, benzothiazolyl, benzisothiazolyl, quinolinyl, isoquinolinyl, quinoxalinyl, quinazolinyl, cinnolinyl, benzotriazinyl, phthalazinyl, carbolinyl and the like. The term “non-aromatic heterocyclyl” encompasses optionally substituted saturated and unsaturated rings which contain at least one heteroatom selected from the group consisting of N, S and O. The ring may contain 1, 2 or 3 heteroatoms. The ring may be a monocyclic ring or part of a polycyclic ring system. Polycyclic ring systems include fused rings and spirocycles. Not every ring in a non-aromatic heterocyclic polycyclic ring system must contain a heteroatom, provided at least one ring contains one or more heteroatoms. Non-aromatic heterocyclyls may be 3-7 membered mono-cyclic rings. Examples of 5-membered non-aromatic heterocyclyl rings include 2H-pyrrolyl, 1-pyrrolinyl, 2- pyrrolinyl, 3-pyrrolinyl, pyrrolidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrazolinyl, 2-pyrazolinyl, 3-pyrazolinyl, pyrazolidinyl, 2-pyrazolidinyl, 3-pyrazolidinyl, imidazolidinyl, 3-dioxalanyl, thiazolidinyl, isoxazolidinyl, 2-imidazolinyl and the like. Examples of 6-membered non-aromatic heterocyclyls include piperidinyl, piperidinonyl, pyranyl, dihyrdopyranyl, tetrahydropyranyl, 2H pyranyl, 4H pyranyl, thianyl, thianyl oxide, thianyl dioxide, piperazinyl, diozanyl, 1,4-dioxinyl, 1,4-dithianyl, 1,3,5-triozalanyl, 1,3,5- trithianyl, 1,4-morpholinyl, thiomorpholinyl, 1,4-oxathianyl, triazinyl, 1,4-thiazinyl and the like. Examples of 7-membered non-aromatic heterocyclyls include azepanyl, oxepanyl, thiepanyl and the like. Non-aromatic heterocyclyl rings may also be bicyclic heterocyclyl rings such as linked ring systems (for example uridinyl and the like) or fused ring systems. Fused ring systems include non-aromatic 5-membered, 6-membered or 7-membered heterocyclyls fused to carbocyclic aromatic rings such as phenyl, napthyl, indenyl, azulenyl, fluorenyl, anthracenyl and the like. Examples of non-aromatic 5-membered, 6-membered or 7-membered heterocyclyls fused to carbocyclic aromatic rings include indolinyl, benzodiazepinyl, benzazepinyl, dihydrobenzofuranyl and the like. The term “halo” refers to fluoro, chloro, bromo or iodo. Unless otherwise defined, the term “optionally substituted” or “optional substituent” as used herein refers to a group which may or may not be further substituted with 1, 2, 3, 4 or more groups, preferably 1, 2 or 3, more preferably 1 or 2 groups selected from the group consisting of C _1-6 alkyl, C _2-6 alkenyl, C _2-6 alkynyl, C _3-8 cycloalkyl, hydroxyl, oxo, C _1-6 alkoxy, aryloxy, C _1-6 alkoxyaryl, halo, C _1-6 alkylhalo (such as CF ₃ ), C _1-6 alkoxyhalo (such as OCF ₃ ), carboxyl, esters, cyano, nitro, amino, substituted amino, disubstituted amino, acyl, ketones, substituted ketones, amides, aminoacyl, substituted amides, disubstituted amides, thiol, alkylthio, thioxo, sulfates, sulfonates, sulfinyl, substituted sulfinyl, sulfonyl, substituted sulfonyl, sulfonylamides, substituted sulfonamides, disubstituted sulfonamides, aryl, arC _1-6 alkyl, heterocyclyl and heteroaryl wherein each alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heterocyclyl and groups containing them may be further optionally substituted. Optional substituents in the case of heterocycles containing N may also include but are not limited to C _1-6 alkyl i.e. N-C _1-3 alkyl, more preferably methyl particularly N-methyl. For optionally substituted “C _1-6 alkyl”, “C _2-6 alkenyl” and “C _2-6 alkynyl”, the optional substituent or substituents are preferably selected from halo, aryl, heterocyclyl, C _3-8 cycloalkyl, C _{1- 6} alkoxy, hydroxyl, oxo, aryloxy, haloC _1-6 alkyl, haloC _1-6 alkoxyl and carboxyl. Each of these optional substituents may also be optionally substituted with any of the optional substituents referred to above, where nitro, amino, substituted amino, cyano, heterocyclyl (including non- aromatic heterocyclyl and heteroaryl), C _1-6 alkyl, C _2-6 akenyl, C _2-6 alkynyl, C _1-6 alkoxyl, haloC _{1- 6} alkyl, haloC _1-6 alkoxy, halo, hydroxyl and carboxyl are preferred. It will be understood that suitable derivatives of aromatic heterocyclyls containing nitrogen include N-oxides thereof. In the case of hybrid naming of substituent radicals describing two moieties that may both form a bond attaching the radical to the rest of the compound, such as alkylamino and alkylaryl, no direction in the order of groups is intended, so the point of attachment may be to any of the moieties included in the hybrid radical. For example, the terms “alkylaryl” and “arylalkyl”, are intended to refer to the same group and the point of attachment may be via the alkyl or the aryl moiety (or both in the case of diradical species). The direction of attachment of such a hybrid radical may be denoted by inclusion of a bond, for example, “-alkylaryl” or “arylalkyl-“ denotes that the point of attachment of the radical to the rest of the compound is via the alkyl moiety, and “alkylaryl-“ or “-arylalkyl” denotes that the point of attachment is via the aryl moiety. It will be appreciated that denotes a single or a double bond, depending on the required valency. Unless specifically stated otherwise, where all bonds in a ring are denoted by the ring is intended to be aromatic. As used herein, except where the context requires otherwise, the term "comprise" and variations of the term, such as "comprising", "comprises" and "comprised", are not intended to exclude further additives, components, integers or steps. It must be noted that as used herein and in the appended claims, the singular forms “a”, “an” and “the” include plural reference unless the context clearly dictates otherwise. Thus, for example, a reference to “a salt” may include a plurality of salts and a reference to “at least one heteroatom” may include one or more heteroatoms, and so forth. The term “and/or” can mean “and” or “or”. The term “(s)” following a noun contemplates the singular or plural form, or both. Various features of the invention are described with reference to a certain value, or range of values. These values are intended to relate to the results of the various appropriate measurement techniques, and therefore should be interpreted as including a margin of error inherent in any particular measurement technique. Some of the values referred to herein are denoted by the term “about” to at least in part account for this variability. The term “about”, when used to describe a value, may mean an amount within ±10%, ±5%, ±1% or ±0.1% of that value. Further aspects of the present invention and further embodiments of the aspects described in the preceding paragraphs will become apparent from the following description, given by way of example and with reference to the accompanying drawings. Detailed description of embodiments The invention provides a compound of Formula (I) wherein J is selected from the following moieties J1 and J2: A ¹ , and A4 are independently selected from N and C; A ² and A ³ are independently selected from N, NR ¹ , CH, O and S; wherein at least one of A ¹ , A ² , A ³ and A ⁴ is selected from N, NR ¹ , O and S; A ⁵ is CH or N; A ⁶ is N or CR ² ; R ¹ and R ³ are independently selected from H and an optionally substituted C1-6-alkyl; R ² is selected from: (i) H, (ii) optionally substituted C _1-4 alkylamido, (iii) optionally substituted C1-4alkylaryl, (iv) optionally substituted C _2-4 alkynyl, (v) optionally substituted aryl, (vi) optionally substituted 5- or 6-membered heterocyclyl, (vii) cyano; X is selected from optionally substituted C _1-6 alkyl, optionally substituted haloC _1-6 alkyl, optionally substituted C _2-6 alkynyl, optionally substituted cycloalkyl, optionally substituted halocycloalkyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted C _1-6 alkylcycloalkyl and optionally substituted amino; Y and Z are independently selected from H, R ⁴ and –OR ⁴ ; wherein at least one of Y and Z is H and the remaining one of Y and Z is selected from R ⁴ and –OR ⁴ ; R ⁴ is selected from optionally substituted C _1-6 alkyl, optionally substituted aryl, optionally substituted C _1-6 alkylaryl, optionally substituted heterocyclyl, optionally substituted C _1-6 alkylheterocyclyl, optionally substituted cycloalkyl, optionally substituted C _1-6 alkylC _3-10 cycloalkyl, optionally substituted C _3-10 cycloalkylaryl, optionally substituted C _3-10 cycloalkylheterocyclyl, optionally substituted C _3-10 cycloalkylC _3-10 cycloalkyl, optionally substituted 3-6 membered non-aromatic heterocyclyl-aryl, optionally substituted 3-6 membered non-aromatic heterocyclylC _3-10 cycloalkyl and optionally substituted 3-6 membered non-aromatic heterocyclyl-3-10 membered heterocyclyl; and R ⁵ is selected from H, optionally substituted C _1-6 alkyl, optionally substituted C _3-10 cycloalkyl and optionally substituted aryl. X In some embodiments, X is selected from C _1-6 alkyl, C _2-6 alkynyl, C _3-6 cycloalkyl, aryl, -(CH ₂ ) _n aryl, -(CH ₂ ) _n cycloalkyl, and -N(C _1-4 alkyl) ₂ ; wherein n is 1 or 2, and each alkyl and alkynyl is optionally substituted with one or more groups selected from halo, nitrile, -OR ⁶ , -N(R ⁷ )R ⁸ ; R ⁶ , R ⁷ and R ⁸ are independently selected from H, C _1-6 alkyl and haloC _1-6 alkyl, and wherein each aryl and cycloalkyl is optionally substituted with one or more groups that are independently selected from halo, nitrile, C _1-4 alkyl, C _1-4 alkoxy, haloC _1-4 alkyl and haloC _{1- 4} alkoxy. In some embodiments, X is selected from optionally substituted C _1-4 alkyl, optionally substituted C _2-4 alkynyl, optionally substituted C _1-4 alkylnitrile, optionally substituted haloC _1-4 alkyl, optionally substituted C _3-6 cycloalkyl, optionally substituted C ₁ alkylC _3-6 cycloalkyl, optionally substituted aryl, optionally substituted haloaryl, optionally substituted C ₁ alkylaryl, optionally substituted haloC ₁ alkylaryl, optionally substituted haloC ₁ alkoxyaryl, optionally substituted benzyl, optionally substituted halobenzyl, optionally substituted C ₁ alkylbenzyl, optionally substituted C ₁ alkoybenzyl and optionally substituted haloC ₁ alkoybenzyl. In some embodiments, X is selected from an optionally substituted C _1-4 alkyl, an optionally substituted haloC _1-4 alkyl and a C _3-6 cycloalkyl. In some embodiments, X is selected from an optionally substituted C _1-2 alkyl, an optionally substituted haloC _1-2 alkyl and a C ₃ cycloalkyl. In some embodiments, X is an optionally substituted haloC _1-4 alkyl selected from -CHF ₂ , -CF ₃ , -CH ₂ CF ₃ , -CH ₂ CHF ₂ and -CH ₂ CH ₂ CF ₃ . In some embodiments, X is an optionally substituted haloC _1-2 alkyl. In some embodiments, X is an optionally substituted amino preferably disubstituted amino, such as -N(C _1-4 alkyl) ₂ . In some embodiments, X is –N(CH ₃ ) ₂ . In some embodiments, X is selected from any one of the following groups: methyl, ethyl, isopropyl, tert-butyl, -CHF ₂ , -CF ₃ , -CH ₂ CF ₃ , -CH ₂ CHF ₂ , -CH ₂ CH ₂ CF ₃ , -CH ₂ CH ₂ OCH ₃ , -CH ₂ CH ₂ NH ₂ , -CH ₂ CH ₂ N(CH ₃ ) ₂ , cyclohexyl, cyclopropyl, -N(CH ₃ ) ₂ In some embodiments, X is selected from any one of the following groups: ethyl, difluoromethyl, trifluoroethyl and cyclopropyl. In some embodiments, X is difluoromethyl. In some embodiments, X is a group that has a longest linear chain extending from the sulfur atom depicted in formula (I) by not more than 6, 5, 4, 3 or 2 atoms, preferably 3-6 atoms. By “longest linear chain” it is meant the number of atoms from the point of attachment not including any branching or rings. For example, when X is benzyl, the longest linear chain is 6 atoms which includes the methylene carbon atom, four ring atoms and the hydrogen atom attached to the carbon at the 4-position of the benzyl, and when X is –CH ₂ CF ₃ , the longest linear chain is 3. The longest linear chain in each of these exemplary X-substituents is numbered in the partial formulas shown below: Y and Z In some embodiments, when Y is –OR ⁴ , Z is H. In these embodiments, the compound of formula (I) may be provided as a compound of formula (Ia):

wherein J, A ¹ , A ² , A ³ , A ⁴ , A ⁵ , A ⁶ , n, R ¹ , R ² , R ³ , R ⁴ , R ⁵ and X are as defined for formula (I) or any embodiment thereof. In some embodiments, when Z is –OR ⁴ , Y is H. In these embodiments, the compound of formula (I) may be provided as a compound of formula (Ib): wherein J, A ¹ , A ² , A ³ , A ⁴ , A ⁵ , A ⁶ , n, R ¹ , R ² , R ³ , R ⁴ , R ⁵ and X are as defined for formula (I) or any embodiment thereof. In some embodiments, when Y is –R ⁴ , Z is H. In some embodiments, when Z is –R ⁴ , Y is H. R ⁴ In some embodiments, R ⁴ is selected from C _1-6 alkyl, aryl, cycloalkyl, heterocyclyl, C _1-6 alkylcycloalkyl, C _1-6 alkylaryl and C _1-6 alkylheterocyclyl, wherein each alkyl (including when present as an optional substituent) is optionally substituted with one or more groups independently selected from halo, C _1-4 alkoxy, hydroxy, nitrile, amino, C _1-4 alkylamino, (C _1-4 alkyl) ₂ amino, aryl, cycloalkyl and heterocyclyl; wherein each aryl (including when present as an optional substituent) is optionally substituted with one or more groups independently selected from halo, hydroxy, nitrile, amino, C _{1- 4} alkylamino and (C _1-4 alkyl) ₂ amino, C _1-4 alkyl, C _1-4 alkoxy, haloC _1-4 alkyl, haloC _1-4 alkoxy, aryl, cycloalkyl and heterocyclyl; wherein each cycloalkyl (including when present as an optional substituent) is optionally substituted with one or more groups independently selected from halo, hydroxy, nitrile, amino, C _1-4 alkylamino and (C _1-4 alkyl) ₂ amino, C _1-4 alkyl, C _1-4 alkoxy, haloC _1-4 alkyl, haloC _1-4 alkoxy, aryl, cycloalkyl and heterocyclyl; and wherein each heterocyclyl (including when present as an optional substituent) is optionally substituted with one or more groups independently selected from halo, hydroxy, nitrile, amino, C _1-4 alkylamino and (C _1-4 alkyl) ₂ amino, C _1-4 alkyl, C _1-4 alkoxy, haloC _1-4 alkyl, haloC _1-4 alkoxy, cycloalkyl, heterocyclyl and aryl. In some embodiments, R ⁴ is selected from C _1-6 alkyl, aryl, cycloalkyl, heterocyclyl, C _{1- 6} alkylcycloalkyl, C _1-6 alkylaryl, C _1-6 alkylheterocyclyl, C _3-10 cycloalkylaryl, C _3-10 cycloalkylheterocyclyl, C _3-10 cycloalkylC _3-10 cycloalkyl, 3-6 membered non-aromatic heterocyclyl-aryl, 3-6 membered non-aromatic heterocyclyl-C _3-10 cycloalkyl and 3-6 membered non-aromatic heterocyclyl-3-10 membered heterocyclyl and wherein each cycloalkyl, aryl and heterocyclyl are optionally substituted with one or more groups independently selected from halo, hydroxy, nitrile, amino, C _1-4 alkylamino and (C _1-4 alkyl) ₂ amino, C _1-4 alkyl, C _1-4 alkoxy, haloC _1-4 alkyl and haloC _1-4 alkoxy. In some embodiments, R ⁴ is selected from C _1-6 alkyl, aryl, cycloalkyl, heterocyclyl and -(CH ₂ ) _m R ⁹ , R ⁹ is selected from C _3-10 cycloalkyl, aryl, heterocyclyl, and m is an integer selected from 1 to 6; wherein each cycloalkyl, aryl and heterocyclyl are optionally substituted with one or more groups independently selected from halo, C _1-4 alkyl, C _1-4 alkoxy, haloC _1-4 alkyl and haloC _1-4 alkoxy. In some embodiments, R ⁴ is selected from C _1-4 alkyl, cycloalkyl, haloaryl, -C _1-2 alkylaryl, -C _{1- 2} alkylarylhalo, -C _1-2 alkylC _3-6 cycloalkyl, -C _1-2 alkylheterocyclyl, -C _1-2 alkylarylC ₁ alkylhalo, -C _1-2 alkylarylhaloC ₁ alkyl, -C _1-2 alkylaralkylhalo, -C _1-2 alkylarylhaloalkoxy, cycloalkylaryl, cycloalkylheterocyclyl, cycloalkylcycloalkyl, 3-6 membered non-aromatic heterocyclyl-aryl, 3- 6 membered non-aromatic heterocyclylcycloalkyl and 3-6 membered non-aromatic heterocyclyl-3-10 membered heterocyclyl wherein each alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl and alkoxyl is optionally substituted with a group selected from halo, hydroxy, nitrile, amino, C _1-4 alkylamino and (C _1-4 alkyl) ₂ amino, C _1-4 alkyl, C _1-4 alkoxy, haloC _1-4 alkyl, haloC _1-4 alkoxy and acyl. In some embodiments, R ⁴ is an optionally substituted C ₁ alkylC ₆ aryl. In some embodiments, the C ₁ alkyl moiety is substituted. In some embodiments, the aryl moiety is substituted. In some embodiments, the C ₁ alkylC ₆ aryl moiety may be represented by the following partial formula: wherein R ^a and R ^b are independently selected from H, optionally substituted C _1-4 alkyl, optionally substituted C _1-4 alkoxy, optionally substituted C _1-4 alkylhydroxy, optionally substituted C _{1- 4} alkylnitrile, optionally substituted amino, optionally substituted C _1-4 alkylamino and optionally substituted (C _1-4 alkyl) ₂ amino, or R ^a and R ^b together with the carbon atom to which they are attached form an optionally substituted C _3-6 cycloalkyl or a 3-6 membered non-aromatic heterocyclyl; R ^c is selected from halo and an optionally substituted C _1-4 alkyl; and m is 0, 1 or 2. In some embodiments, R ^a and R ^b are independently selected from H, optionally substituted C _1-4 alkyl, optionally substituted C _1-4 alkoxy, optionally substituted C _1-4 alkylhydroxy, optionally substituted C _1-4 alkylnitrile, optionally substituted C _1-4 alkylamino and optionally substituted (C _1-4 alkyl) ₂ amino. When R ^a and/or R ^b are an optionally substituted C _1-4 alkylamino, either the C _1-4 alkyl or amino moiety may be optionally substituted. In some embodiments, R ^a and R ^b together with the carbon atom to which they are attached form an optionally substituted C _3-6 cycloalkyl or a 3-6 membered non-aromatic heterocyclyl selected from an optionally substituted cyclopropyl, an optionally substituted cyclobutyl, an optionally substituted cyclopentyl, an optionally substituted cyclohexyl, an optionally substituted oxetane and an optionally substituted azetidine. In some embodiments, R ^a and R ^b together with the carbon atom to which they are attached form a 3-6 membered non-aromatic heterocyclyl comprising 1 or 2, preferably 1 heteroatom, preferably selected from O and N. In some embodiments, R ⁵ is selected from H, C _1-6 alkyl, C _3-8 cycloalkyl and aryl. In some embodiments, R ⁵ is selected from H and optionally substituted C _1-6 alkyl. In some embodiments, R ⁵ is selected from H and optionally substituted aryl. In some embodiments, R ⁵ is selected from H, optionally substituted methyl and optionally substituted phenyl. In some embodiments, R ⁵ is H. In some embodiments, m is 0 or 1. In some embodiments, m is 1 or 2. In some embodiments, at least one R ^c is in the para position relative to the benzyl carbon atom. In some embodiments, R ^c is selected from methyl, fluoro and chloro. In some embodiments, R ^a is selected from H and methyl, and R ^b is H. In some embodiments, R ^a and R ^b together with the carbon atom to which they are attached are cyclopropyl. In some embodiments, R ⁴ has partial structure (A): wherein R ^d is selected from H, optionally substituted C _1-4 alkyl, optionally substituted C _1-4 alkoxy, optionally substituted C _1-4 alkoxyC _1-4 alkyl, optionally substituted C _1-4 alkylhydroxy, optionally substituted C _1-4 alkylnitrile, optionally substituted C _1-4 alkylamino and optionally substituted (C _1-4 alkyl) ₂ amino, optionally substituted cycloalkyl and optionally substituted C _{1- 4} alkylcycloalkyl; and R ^e is selected from optionally substituted aryl, optionally substituted C _1-5 alkylaryl, optionally substituted heterocyclyl, optionally substituted C _1-5 alkylheterocyclyl, optionally substituted cycloalkyl, and optionally substituted C _1-5 alkylC _3-10 cycloalkyl. In these embodiments, the compound of formula (I) may be provided as a compound of formula (IV): wherein X, R ³ , R ^d , R ^e , and J are as defined for any compound herein. In some embodiments, R ^d is methyl. In some embodiments, R ^e is selected from optionally substituted aryl, optionally substituted C1-5alkylaryl, optionally substituted heterocyclyl, optionally substituted C1-4alkylheterocyclyl, optionally substituted cycloalkyl, and optionally substituted C _1-4 alkylC _3-10 cycloalkyl. In some embodiments, R ^e is selected from optionally substituted aryl, optionally substituted cycloalkyl and optionally substituted heterocyclyl. In some embodiments, R ^e is selected from optionally substituted aryl and optionally substituted heteroaryl. In some embodiments, R ^d is selected from optionally substituted C1-4alkyl, optionally substituted cycloalkyl and optionally substituted C _1-4 alkylcycloalkyl. In these embodiments, where R ^d and R ^e are not the same group, the partial structure (A) may contain a chiral centre at the carbon to which R ^d and R ^e are attached. Therefore, the carbon atom to which R ^d and R ^e are attached may be enantiomerically enriched. In some embodiments, the carbon atom to which R ^d and R ^e is attached is enriched as the (S) stereoisomer, for example when R ^e has a higher ranking than R ^d in the Cahn-Ingold-Prelog rules for stereochemical assignment. In some embodiments, the carbon atom to which R ^d and R ^e is attached is enriched as the (R) stereoisomer, for example when R ^e has a lower ranking than R ^d the Cahn-Ingold-Prelog rules for stereochemical assignment. In some embodiments, R ^d is selected from optionally substituted C _1-4 alkyl, and the carbon atom to which R ^d and R ^e are attached is enriched in the (S) stereoisomer. In some embodiments, partial structure (A) may have the stereochemical configuration shown in by partial structure (A1): wherein R ^e has a higher ranking than R ^d in the Cahn-Ingold-Prelog rules for stereochemical assignment. The inventors have surprisingly found that compounds with this configuration at this position possess greater MLKL activity than those with other configuration(s). In some cases, when R ^e has a higher ranking than R ^d in the Cahn-Ingold-Prelog rules for stereochemical assignment MLKL activity may be greater than 2-fold more active than the other corresponding stereoisomer, and in some embodiments, may be at least about 5-fold or about 10-fold more active than other corresponding stereoisomer(s) for MLKL inhibition. In some embodiments, the compound is provided as a compound of formula (S): wherein X, J and R ³ are as defined for formula (I) and R ^e and R ^d are as defined for partial formula (A). In some embodiments, R ⁴ is selected from any one of the following groups:

In some embodiments, R ⁴ is selected from any one of the following groups:

In some embodiments, R ⁴ is selected from any one of the following groups: In some embodiments, R ⁴ is selected from any one of the following groups: In some embodiments, R ⁴ is: R ¹ and R ³ In some embodiments, R ¹ and R ³ are H. In some embodiments, R ³ is H and R ¹ is selected from H, methyl and isopropyl, preferably methyl. In some embodiments, R ¹ is selected from H, methyl and isopropyl. In some embodiments, R ¹ is methyl. J1 In some embodiments, J is J1. In these embodiments, the compound of formula (I) may be provided as a compound of formula (II) wherein X, R ² , R ³ , R ⁴ , A ¹ , A ² , A ³ and A ⁴ are as defined for formula (I) or any embodiment thereof. In embodiments where J is J1, the compound of formula (I) may also be provided as a compound of formula (IIe) wherein X, R ² , R ³ , R ⁴ , A ¹ , A ² , A ³ and A ⁴ are as defined for formula (I) or any embodiment thereof. The J1 structure, as shown below (and equivalent structures within other formulas), indicates a conjugated fused aromatic ring system: For instance, in some embodiments J1 may have the following substitution pattern: Similarly, in other embodiments J1 may have the following substitution pattern: In compounds wherein J is J1, at least one of A ¹ , A ² , A ³ and A ⁴ is selected from N, NR ¹ , O and S. In some embodiments, A ³ is selected from N, NR ¹ , O and S. In some embodiments, A ¹ is C or N. In some embodiments, A ¹ is C. In some embodiments, A ² is selected from N and CH. In some embodiments, A ⁴ is selected from C and N. In some embodiments, A ¹ , A ² , A ³ and A ⁴ are selected from the following embodiments: In some embodiments, any one of embodiment nos.1-4 are preferred. In some embodiments, embodiment no.2 is preferred. R ² In some embodiments, R ² is selected from: (i) H (ii) optionally substituted C _1-4 alkylamido, (iii) optionally substituted C _1-4 alkylaryl, (iv) optionally substituted C _2-4 alkynyl, (v) optionally substituted aryl, (vi) optionally substituted 5- or 6-membered heterocyclyl. In some embodiments, R ² is selected from: (i) optionally substituted C _1-4 alkylamido, (ii) optionally substituted C _1-4 alkylaryl, (iii) optionally substituted C _2-4 alkynyl, (iv) optionally substituted aryl, (v) optionally substituted 5- or 6-membered heterocyclyl. In some embodiments, R ² is optionally substituted with one or more group(s) (preferably 1-3 groups) selected from: halo, an optionally substituted C ₁ - ₆ alkyl, an optionally substituted C _{3- 8} cycloalkyl, an optionally substituted C ₁ - ₆ alkyl-N(R ¹¹ ) ₂ , -N(R ¹¹ ) ₂ , an optionally substituted (C ₁ - ₆ alkyl) ₂ amino, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted haloheterocyclyl, an optionally substituted C _1-6 alkylheterocyclyl, an optionally substituted haloC _1-6 alkylheterocyclyl, an optionally substituted C _1- 4alkoxyheterocyclyl, an optionally substituted acylheterocyclyl, an optionally substituted C1- ₄ alkoxy, an optionally substituted C ₁ - ₄ alkyl-OH, an optionally substituted C ₁ - ₄ alkylhalo, an optionally substituted C ₁ - ₄ alkylheterocyclyl, an optionally substituted C ₁ - ₄ alkylC _3-8 cycloalkyl, an optionally substituted C ₁ - ₄ alkylaryl, wherein each R ¹¹ is independently selected from H, optionally substituted C _1-4 alkyl and optionally substituted C _1-4 alkylhalo, or 2 R ¹¹ together with the nitrogen atom to which they are attached form a 3-8 membered heterocyclyl. In some embodiments, R ² is a 5- or 6-membered heterocyclyl optionally substituted with one or more group(s) selected from: halo, an optionally substituted C ₁ - ₆ alkyl, an optionally substituted C _3-8 cycloalkyl, an optionally substituted C ₁ - ₆ alkyl-N(R ¹¹ ) ₂ , -N(R ¹¹ ) ₂ , an optionally substituted (C ₁ - ₆ alkyl) ₂ amino, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted haloheterocyclyl, an optionally substituted C _{1- 6} alkylheterocyclyl, an optionally substituted haloC _1-6 alkylheterocyclyl, an optionally substituted C _1-4 alkoxyheterocyclyl, an optionally substituted acylheterocyclyl, an optionally substituted C ₁ - ₄ alkoxy, an optionally substituted C ₁ - ₄ alkyl-OH, an optionally substituted C ₁ - ₄ alkylhalo, an optionally substituted C ₁ - ₄ alkylheterocyclyl, an optionally substituted C ₁ - ₄ alkylC _3-8 cycloalkyl, an optionally substituted C ₁ - ₄ alkylaryl, wherein each R ¹¹ is independently selected from H, optionally substituted C _1-4 alkyl and optionally substituted C _1-4 alkylhalo, or 2 R ¹¹ together with the nitrogen atom to which they are attached form a 3-8 membered heterocyclyl. In some embodiments, R ² is a 5- or 6-membered heterocyclyl optionally substituted with one or more group(s) selected from: halo, an optionally substituted C ₁ - ₆ alkyl, an optionally substituted C _3-8 cycloalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted C ₁ - ₄ alkoxy, an optionally substituted C ₁ - ₄ alkyl-OH, an optionally substituted C ₁ - ₄ alkylhalo, an optionally substituted C ₁ - ₄ alkylheterocyclyl, an optionally substituted C ₁ - ₄ alkylC _3-8 cycloalkyl, an optionally substituted C ₁ - ₄ alkylaryl; In some embodiments, R ² is H. In some embodiments, R ² is cyano. In some embodiments, R ² is H or cyano. In some embodiments, R ² is optionally substituted C _1-4 alkylamido or optionally substituted C _{2- 4} alkynyl. In some embodiments, R ² is selected from optionally substituted C _1-4 alkylaryl, optionally substituted aryl, and optionally substituted 5- or 6-membered heterocyclyl. In some embodiments, R ² is selected from: (i) optionally substituted aryl, (ii) a 5- or 6-membered heterocyclyl optionally substituted with one or more group(s) selected from: halo, an optionally substituted C ₁ - ₆ alkyl, an optionally substituted C _{3- 8} cycloalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted C ₁ - ₄ alkoxy, an optionally substituted C ₁ - ₄ alkyl-OH, an optionally substituted C ₁ - ₄ alkylhalo, an optionally substituted C ₁ - ₄ alkylheterocyclyl, an optionally substituted C ₁ - ₄ alkylC _3-8 cycloalkyl, an optionally substituted C ₁ - ₄ alkylaryl. In some embodiments, R ² is a 5- or 6-membered heterocylyl selected from: pyrazolyl, pyridyl, tetrahydropyridyl, isozazolyl, pyrimidinyl, piperidinyl and tetrahydropyranyl, and wherein the 5- or 6-membered heterocyclyl is optionally substituted with one or more group(s) selected from: halo, an optionally substituted C ₁ - ₆ alkyl, an optionally substituted C _3-8 cycloalkyl, an optionally substituted C ₁ - ₆ alkyl-N(R ¹¹ ) ₂ , -N(R ¹¹ ) ₂ , an optionally substituted (C ₁ - ₆ alkyl) ₂ amino, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted haloheterocyclyl, an optionally substituted C _{1- 6} alkylheterocyclyl, an optionally substituted haloC _1-6 alkylheterocyclyl, an optionally substituted C _1-4 alkoxyheterocyclyl, an optionally substituted acylheterocyclyl, an optionally substituted C ₁ - ₄ alkoxy, an optionally substituted C ₁ - ₄ alkyl-OH, an optionally substituted C ₁ - ₄ alkylhalo, an optionally substituted C ₁ - ₄ alkylheterocyclyl, an optionally substituted C ₁ - ₄ alkylC _3-8 cycloalkyl, an optionally substituted C ₁ - ₄ alkylaryl, wherein each R ¹¹ is independently selected from H, optionally substituted C _1-4 alkyl and optionally substituted C _1-4 alkylhalo, or 2 R ¹¹ together with the nitrogen atom to which they are attached form a 3-8 membered heterocyclyl. In some embodiments, R ² is a 5- or 6-membered heterocyclyl optionally substituted with one or more substituent(s) selected from: halo, optionally substituted C _1-6 alkyl, optionally substituted C _1-6 alkylamido, optionally substituted C _3-8 cycloalkyl, optionally substituted C _{1- 6} alkylC _3-8 cycloalkyl, optionally substituted haloC _1-6 alkylC _3-8 cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted C _1-6 alkylheterocyclyl, optionally substituted C _1-6 alkoxy, optionally substituted C _1-6 alkyl-OH and optionally substituted C _{1- 6} alkylhalo. In some embodiments, the optionally substituted C _1-6 alkylamido is provided by –C _1- 6alkylC(O)NR ^’ R ^’’ , wherein R’ and R’’ are independently selected from H and optionally substituted C _1-6 alkyl. In some embodiments, any heterocyclyl group of these optional substituents may be a 4-7 membered heterocyclyl (including nonaromatic heterocyclyl and heteroaryl groups). In some embodiments, R ² is a 5- or 6-membered heterocyclyl optionally substituted with one, two or three of any of the optional substituent(s) of R ² described herein. In some embodiments, R ² is a 5- or 6-membered heterocyclyl optionally substituted with one, two or three groups, preferably one or two groups, selected from: methyl, methoxy, methoxyethyl, trifluoromethyl, difluoromethyl, trifluoroethyl, isopropyl, tert-butyl, 2-hydroxyethyl, dimethylamino, cyclopentyl, oxetanyl, tetrahydrofuranyl, piperidinyl, N-methyl-piperidinyl, tetrahydropyranyl and N-methyl-piperazinyl-2-ethyl. In some embodiments, R ² is an optionally substituted 5- or 6-membered heterocyclyl selected from 4-pyridyl, 3-pyridyl, 4-piperidinyl, 1,4-piperazinyl, 4-tetrahydropyranyl, 2H,4H,5H-3- piperidinyl, 3,4-pyrazolyl, 3H,5H,6H-4-tetrahydropyranyl, 2,4-pyrimidinyl and 3,4-isoxazolyl. In some embodiments, R ² is an optionally substituted pyrazolyl, preferably a substituted pyrazolyl, more preferably a mono-substituted pyrazolyl. Preferably, the mono-substituted pyrazolyl is substituted at N. In some embodiments, R ² is a 5- or 6-membered heterocyclyl optionally substituted with one or more group(s) selected from: optionally substituted C ₁ - ₄ alkylhalo, optionally substituted heterocyclyl, optionally substituted C _1-6 alkylheterocyclyl and optionally substituted haloC _{1- 6} alkylheterocyclyl. In these embodiments, the 5- or 6-membered heterocyclyl is preferably selected from pyrazolyl, pyridyl, tetrahydropyridyl, isozazolyl, pyrimidinyl, piperidinyl and tetrahydropyranyl, more preferably pyrazolyl, most preferably N-substituted-pyrazolyl. In some embodiments, R ² is a 5- or 6-membered heterocyclyl optionally substituted with one or more group(s) selected from: optionally substituted C ₁ - ₄ alkylhalo, optionally substituted heterocyclyl, optionally substituted C _1-6 alkylheterocyclyl and optionally substituted haloC _{1- 6} alkylheterocyclyl; wherein the optionally substituted C ₁ - ₄ alkylhalo, optionally substituted heterocyclyl, optionally substituted C _1-6 alkylheterocyclyl and optionally substituted haloC _{1- 6} alkylheterocyclyl; are optionally substituted with one or more substituent(s) selected from C ₁ - ₄ alkyl and C _3-4 cycloalkyl. In these embodiments, the 5- or 6-membered heterocyclyl is preferably selected from pyrazolyl, pyridyl, tetrahydropyridyl, isozazolyl, pyrimidinyl, piperidinyl and tetrahydropyranyl, more preferably pyrazolyl, most preferably N-substituted-pyrazolyl. In some embodiments, R ² is an optionally substituted 6-membered non-aromatic heterocyclyl. In some embodiments, R ² is a 5- or 6-membered heterocyclyl comprising at least 1 nitrogen heteroatom. In some embodiments, R ² is a 5- or 6-membered heterocyclyl comprising at least 1 oxygen heteroatom. In some embodiments, R ² is a 5- or 6-membered heterocyclyl comprising at least 1 nitrogen and at least 1 oxygen heteroatom. In some embodiments, R ² is a 5- or 6-membered heterocyclyl comprising 2 nitrogen heteroatoms. In some embodiments, R ² is an optionally substituted fused heterocyclyl. In some embodiments, R ² is an optionally substituted 5- or 6-membered heteroaryl. In some embodiments, R ² is an optionally substituted pyridyl. In some embodiments, R ² is an optionally substituted isoxazolyl. In some embodiments, R ² is an optionally substituted morpholinyl. In some embodiments, R ² is an optionally substituted pyrimidinyl. In some embodiments, R ² is an optionally substituted pyrrolyl. In some embodiments, R ² is an optionally substituted 1,3-dihydro-2H-benzo[d]imidazol-2-one, preferably including methyl substitution. In some embodiments, R ² is an optionally substituted 1-methylindolinyl-2-one. In some embodiments, R ² is an optionally substituted 1-methyl-1H-indazolyl. In some embodiments, R ² is enriched with one or more of the following minor isotopes: ² H, ³ H, ¹³ C, ¹⁴ C, ¹⁵ N and/or ¹⁷ O, preferably ² H. In some embodiments, R ² is an optionally substituted C _2-4 alkynyl. The C _2-4 alkynyl may optionally be substituted with one or more groups (preferably 1 group) selected from optionally substituted C _3-8 cycloalkyl, optionally substituted haloC _3-8 cycloalkyl, optionally substituted (C _{1- 6} alkyl) _1-3 C _3-8 cycloalkyl, optionally substituted heterocyclyl, optionally substituted halo heterocyclyl, optionally substituted (C _1-6 alkyl) _1-3 heterocyclyl and optionally substituted (C _{1- 6} alkylhalo) _1-3 heterocyclyl. In some embodiments, R ² is an optionally substituted C _2-4 alkynyl. The C _2-4 alkynyl may optionally be substituted with one or more groups (preferably 1 group) selected from optionally substituted C _3-8 cycloalkyl, optionally substituted haloC _3-8 cycloalkyl, optionally substituted (C _{1- 6} alkyl) _1-3 C _3-8 cycloalkyl, optionally substituted heterocyclyl, optionally substituted halo heterocyclyl and optionally substituted (C _1-6 alkyl) _1-3 heterocyclyl. In some embodiments, R ² is selected from: H, cyano, methyl, 3-pyridyl, 4-pyridyl, benzyl,

In some embodiments, R ² is selected from: H, methyl, 3-pyridyl, 4-pyridyl, benzyl,

In some embodiments, R ² comprises a basic moiety (such as an optionally substituted amine including an optionally substituted cyclic amine). In some embodiments, R ² comprises a nitrogen-containing heterocyclyl and the nitrogen atom of these cyclic amines may be optionally substituted with a group selected from C _{1- 6} alkyl and a substituted ketone (such as acyl). In some embodiments, R ² is represented by the following partial formula: -G-(R ¹⁰ ) _w wherein G is selected from: (i) C _1-4 alkylamido, (ii) C _1-4 alkylaryl, (iii) C _2-4 alkynyl, (iv) aryl, (v) 5- or 6-membered heterocyclyl each R ¹⁰ is independently selected from: halo, an optionally substituted C ₁ - ₆ alkyl, an optionally substituted C _3-8 cycloalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted C ₁ - ₄ alkoxy, an optionally substituted C ₁ - ₄ alkyl-OH, an optionally substituted C ₁ - ₄ alkylhalo, an optionally substituted C ₁ - ₄ alkylheterocyclyl, an optionally substituted C ₁ - ₄ alkylC _3-8 cycloalkyl, an optionally substituted C ₁ - ₄ alkylaryl; and w is an integer from 0-3. Accordingly, in some embodiments, the compound is provided as a compound of formula (IIA) or (IIB): wherein A ¹ , A ² , A ³ , A ⁴ , R ³ , R ⁴ , R ^d , R ^e , G, w and R ¹⁰ are as defined herein. In some embodiments, G is a C _2-4 alkynyl. In some embodiments, G is ethynyl and w is 1. In some embodiments, G is a 6-membered heterocyclyl. In these embodiments, G may be a 6-membered non-aromatic heterocyclyl or a 6-membered heteroaryl. In these embodiments, each R ¹⁰ may be independently selected from halo, an optionally substituted C ₁ - ₆ alkyl, an optionally substituted C ₁ - ₄ alkoxy, an optionally substituted C ₁ - ₄ alkylhalo and an optionally substituted (C _1-6 alkyl) ₂ amine. Typically, in these embodiments, w is 1. In some embodiments, G is a 6-membered non-aromatic heterocyclyl comprising a heteroatom selected from N and O. When the heteroatom is N, R ¹⁰ is preferably bonded to an N ring atom. In some embodiments, G is a 5-membered heterocyclyl. In these embodiments, G may be a 5-membered non-aromatic heterocyclyl or a 5-membered heteroaryl. In some embodiments, the 5-membered heterocyclyl may comprise heteroatom(s) selected from N and O. In some embodiments, G is a 5- or 6-membered heterocyclyl comprising at least 1 oxygen heteroatom. In some embodiments, G is a 5- or 6-membered heterocyclyl comprising at least 1 nitrogen and at least 1 oxygen heteroatom. In some embodiments, G is a 5- or 6-membered heterocyclyl comprising 2 nitrogen heteroatoms. In some embodiments, G is an optionally substituted fused heterocyclyl In some embodiments, G is selected from morpholinyl, pyrimidinyl, pyrrolyl, 1,3-dihydro-2H- benzo[d]imidazol-2-one, 1-methylindolinyl-2-one, 1-methyl-1H-indazolyl, pyrazolyl and isoxazolyl. In some embodiments, G is selected from pyrazolyl and isoxazolyl. In some embodiments, G is pyrazolyl. In these embodiments, R ¹⁰ may be bonded to a nitrogen ring atom. In these embodiments, R ² may be represented by the following partial formula: In these embodiments, the compound may be provided as a compound of formula (IIC) or (IID):

wherein A ¹ , A ² , A ³ , A ⁴ , R ³ , R ⁴ , R ^d , R ^e and R ¹⁰ are as defined herein. In some embodiments, R ¹⁰ is selected from C _1-6 alkyl, heterocyclyl, C _1-6 alkyl-OH, C _1-6 alkyl- NH ₂ , C _1-6 alkoxyC _1-6 alkyl, C _3-8 cycloalkyl, wherein the heterocyclyl and C _3-8 cycloalkyl may be further substituted with one or more groups (preferably 1-3 groups, most preferably 1 group) selected from C _1-6 alkyl, haloC _1-6 alkyl, C _1-6 alkoxy, C _1-6 alkyl-OH, C _1-6 alkoxyC _1-6 alkyl, halo, C _1-6 alkyl-NH ₂ , C _1-6 alkylketone (eg acyl) and -NH ₂ . In some embodiments, R ¹⁰ is heterocyclyl or alkylheterocyclyl optionally substituted with one or more groups (preferably 1-3 groups, most preferably 1 group) selected from C _1-6 alkyl, haloC _1-6 alkyl, C _1-6 alkoxy, C _1-6 alkyl-OH, C _1-6 alkoxyC _1-6 alkyl, halo, C _1-6 alkyl-NH ₂ , C _{1- 6} alkylketone (eg acyl) and -NH ₂ . When R ¹⁰ is a group comprising a heterocyclyl moiety, the heterocyclyl may preferably be a 4-8 membered heterocyclyl, preferably comprising one heteroatom selected from N and O, preferably N. In some embodiments, R ¹⁰ is an optionally substituted heterocyclyl selected from an optionally substituted spirocyclic heterocyclyl, optionally substituted fused heterocyclyl or an optionally substituted bridged heterocyclyl. In some embodiments, R ¹⁰ is an optionally substituted heterocyclyl selected from an optionally substituted spirocyclic heterocyclyl or an optionally substituted bridged heterocyclyl. Preferred optional substituents of the spirocyclic, fused and bridged heterocyclyl groups include C _1-6 alkyl and haloC _1-6 alkyl. In some embodiments, R ¹⁰ is enriched with one or more of the following minor isotopes: ² H, 3H, ¹³ C, ¹⁴ C, ¹⁵ N and/or ¹⁷ O, preferably ² H In some embodiments, R ¹⁰ is selected from: methyl, difluoromethyl, trifluoromethyl, methoxy, tert-butyl, phenyl, acyl, dimethylamino, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, hydroxyethyl, methoxyethyl, isopropyl, cyclopentyl, difluorocyclopenyl, piperidinyl, N- methylpiperidinyl, N-acetylpiperidine, azetidinyl, In some embodiments, R ¹⁰ is selected from: methyl, difluoromethyl, trifluoromethyl, methoxy, tert-butyl, phenyl, acyl, dimethylamino, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, hydroxyethyl, methoxyethyl, isopropyl, cyclopentyl, difluorocyclopenyl, piperidinyl, N- methylpiperidinyl, N-acetylpiperidine, azetidinyl,

In some embodiments, R ¹⁰ is selected from C _3-8 cycloalkyl, aryl and 4-8 membered heterocyclyl, each of which may be optionally substituted with 1-3 groups selected from C _{1- 4} alkyl, C _1-4 alkyl-OH, C _1-4 alkyl-NR’R’’, wherein R’ and R’’ are independently selected from H and C _1-4 alkyl, haloC _1-4 alkyl, halo, C _1-4 alkoxy, and C _1-4 alkoxyC _1-4 alkyl. In some embodiments, w is 0 or 1. In some embodiments, w is selected from 0, 1 and 3. In these embodiments, the compound may be provided as a compound of formula (IIF) or (IIG):

wherein A ¹ , A ² , A ³ , A ⁴ , R ³ , R ⁴ , R ^d and R ^e are as defined herein; R ¹² is one or more groups independently selected from H, C _1-6 alkyl, C _2-6 alkenyl, C _2-6 alkynyl, C _3-8 cycloalkyl, hydroxyl, oxo, C _1-6 alkoxy, aryloxy, C _1-6 alkoxyaryl, halo, C _1-6 alkylhalo, C _{1- 6} alkoxyhalo and amino; and R ¹³ is selected from H, C _1-6 alkyl and haloC _1-6 alkyl. In some embodiments, R ¹² is one or more groups independently selected from H, C _1-6 alkyl and C _3-8 cycloalkyl. In some embodiments, R ¹² is one or more groups independently selected from H, C _1-3 alkyl and C _3-4 cycloalkyl; preferably C ₁ alkyl and C ₃ cycloalkyl. In some embodiments, R ¹² substitutes the carbon alpha to the piperidyl nitrogen. In some embodiments, R ¹³ is selected from H, C _1-3 alkyl and haloC _1-3 alkyl; preferably C _1-3 alkyl; more preferably C ₁ alkyl. J2 In some embodiments, J is J2. In these embodiments, the compound of formula (I) may be provided as a compound of formula (III)

wherein X, R ³ , R ⁴ , R ⁵ , A ⁵ and A ⁶ are as defined for formula (I) and any embodiment thereof described herein. In some embodiments, A ⁵ is CH. In some embodiments, A ⁵ is N. In some embodiments, A ⁶ is N. In some embodiments, A ⁶ is CR ² . In some embodiments, A ⁵ is N and A ⁶ is N. In some embodiments, A ⁵ is CH and A ⁶ is N. In some embodiments, A ⁵ is N and A ⁶ is CR ² . In some embodiments, at least one of A ⁵ and A ⁶ is N. In some embodiments, R ⁵ is H. In some embodiments, the compound is selected from compounds 1-173 described herein. In some embodiments, the compound is selected from compounds 1-125 described herein. In some embodiments, the compound is selected from compounds 113, 116, 145, 154, 155, 170 and 171 described herein. Typically, the compounds of the invention may be prepared by techniques known in the art. In another aspect, there is also provided a process for preparing a compound of formula (I) or a salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof. In some embodiments, the process comprises any of the following 4 steps: ● reacting a compound of formula (V) with a compound of formula (VI) wherein X, J and R ⁴ are as defined for formula (I) and LG is a leaving group, such as halo. The leaving group may be any that is capable of activating the sulphonyl moiety of the compound of formula (VI) as an electrophile capable of reacting under appropriate conditions with the free aniline nitrogen of the compound of formula (V). ● reacting a compound of formula (VII) with a compound of formula (VIII) wherein X, R ³ , R ⁴ and J are as defined for formula (I) or any embodiment thereof; E ¹ and E ² are an electrophilic pair suitable to direct a palladium catalysed cross- coupling reaction. In some embodiments, E ¹ and E ² are selected from halo, a boronic acid, a boronic ester and triflate, or a group capable of conversion to any of these moieties, such as hydroxyl, a mixed anhydride, tetrafluorophenyl ether, etc. In some embodiments, E ¹ is halo, and E ² is selected from a boronic acid, a boronic ester and triflate. In some embodiments, E ² is halo, and E ¹ is selected from a boronic acid, a boronic ester and triflate; ● reacting a compound of formula (IX) with a compound of formula (X) wherein X, R ² , R ³ , R ⁴ , A ¹ , A ² , A ³ and A ⁴ are as defined for formula (I) or any embodiment thereof; E ³ and E ⁴ are an electrophilic pair suitable to direct a palladium catalysed cross- coupling reaction. In some embodiments, E ³ and E ⁴ are selected from halo, a boronic acid, a boronic ester and triflate, or a group capable of conversion to any of these moieties, such as hydroxyl, a mixed anhydride, tetrafluorophenyl ether, etc. In some embodiments, E ³ is halo, and E ⁴ is selected from a boronic acid, a boronic ester and triflate. In some embodiments, E ⁴ is halo, and E ³ is selected from a boronic acid, a boronic ester and triflate; ● converting a compound of formula (I) into one of its salts. In some embodiments of the above process, reactive moieties in the compounds of formulas (V)-(X) are functionalised with an appropriate protecting group. Embodiments of these steps are shown in the General Schemes below. The specific reagents and conditions for effecting each of these steps will depend on the specific substituents selected for each reaction partner. The skilled person would readily appreciate how to determine and/or optimise these reagents and conditions. Similarly, where a starting material is not commercially available, the skilled person would be able to design and implement its preparation based on techniques and reactions previously described. Embodiments of these steps are provided in the Examples with reference to specific compounds described herein. Methods In another aspect, there is provided a method for inhibiting necroptosis in a subject in need thereof, the method comprising administering a therapeutically effective amount of a compound according to Formula (I) or a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof. Without wishing to be bound by theory, it is believed that the compounds of the invention treat necroptosis by binding to the ATP-binding site of the pseudokinase domain of Mixed Lineage Kinase Domain-like (MLKL) protein. As used herein, the term "effective amount" means that amount of a drug or pharmaceutical agent that will elicit the biological or medical response of a tissue, system, animal or human that is being sought, for instance, by a researcher or clinician. Furthermore, the term "therapeutically effective amount" means any amount which, as compared to a corresponding subject who has not received such amount, results in improved treatment, healing, prevention, or amelioration of a disease, disorder, or side effect, or a decrease in the rate of advancement of a disease or disorder. The term also includes within its scope amounts effective to enhance normal physiological function. In one embodiment of the present disclosure, administration of a compound according to Formula (I) inhibits a conformational change of MLKL. In another embodiment, the conformational change of MLKL involves release of the four-helix bundle (4HB) domain of MLKL. In another embodiment, administration of the compound inhibits oligomerisation of MLKL. In yet another embodiment, administration of the compound inhibits translocation of MLKL to the cell membrane. In a further embodiment, administration of the compound inhibits a conformational change of MLKL, inhibits oligomerisation of MLKL and inhibits translocation of MLKL to the cell membrane. It is envisaged that some compounds of the present disclosure can bind to MLKL in various species and inhibit necroptosis. As used herein, the term “pseudokinase domain” as understood by a person skilled in the art, means a protein containing a catalytically-inactive or catalytically-defective kinase domain. “Pseudokinase domains” are often referred to as “protein kinase-like domains” as these domains lack conserved residues known to catalyse phosphoryl transfer. It would be understood by a person skilled in the art that although pseudokinase domains are predicted to function principally as catalysis independent protein-interaction modules, several pseudokinase domains have been attributed unexpected catalytic functions. Accordingly, in the present disclosure the term “pseudokinase domain” includes “pseudokinase domains” which lack kinase activity and “pseudokinase domains” which possess weak kinase activity. As used herein, the term “ATP-binding site” as understood by a person skilled in the art, means a specific sequence of protein subunits that promotes the attachment of ATP to a target protein. An ATP binding site is a protein micro-environment where ATP is captured and hydrolyzed to ADP, thereby releasing energy that is utilized by the protein to work by changing the protein shape and/or making the enzyme catalytically active. In pseudokinase domains, the “ATP-binding site” is often referred to as the “pseudoactive site”. The term “ATP-binding site” may also be referred to as a “nucleotide-binding site” as binding at this site includes the binding of nucleotides other than ATP. It would be understood by a person skilled in the art that the term “nucleotide” includes any nucleotide. Exemplary nucleotides include, but are not limited to, AMP, ADP, ATP, AMPPNP, GTP, CTP and UTP. As described herein, inhibition of necroptosis includes both complete and partial inhibition of necroptosis. In one embodiment, inhibition of necroptosis is complete inhibition. In another embodiment, inhibition of necroptosis is partial inhibition. Binding of the compound to the ATP-binding site of the pseudokinase domain of MLKL may inhibit phosphorylation of MLKL by an effector kinase or binding of the compound to the ATP-binding site of the pseudokinase domain of MLKL may not inhibit phosphorylation of MLKL by an effector kinase. The present disclosure demonstrates that compounds that bind to the ATP-binding site of the pseudokinase domain of the MLKL protein, as described herein, can inhibit necroptosis without inhibiting phosphorylation of MLKL by an effector kinase. In one embodiment, binding of the compound to the ATP-binding site of the pseudokinase domain of MLKL does not inhibit phosphorylation of MLKL by an effector kinase. In another embodiment, binding of the compound to the ATP-binding site of the pseudokinase domain of MLKL inhibits phosphorylation of MLKL by an effector kinase. RIP1, RIP3 and MLKL are three proteins implicated in the necroptotic pathway. Upon necroptotic stimulus (e.g. using the combination of TNF, SMAC mimetic and QVD-OPh on suitable cell lines), RIP1 is auto-phosphorylated leading to association with RIP3, which in turn auto-phosphorylates itself. Activated RIP3 phosphorylates MLKL leading to a putative conformational change that triggers its necroptotic activity (Murphy, Immunity, 39, pp 443 – 453, 2013). MLKL acts downstream of RIP1 and RIP3, and is therefore understood to be a key effector of necroptosis. Compounds of this invention may bind to MLKL and block this conformational change or any other key event in its activation. The compounds of the invention may be selective for MLKL. In some embodiments, the compounds of the invention are selective for MLKL over RIP1. In some embodiments, the compounds of the invention are selective for MLKL over RIP3. In some embodiments, the compounds of the invention are selective for MLKL over RIP1 and RIP3. A selective compound may have 5-fold, 10-fold, 50-fold, 100-fold, 500-fold, 1000-fold or greater selectivity for MLKL compared to RIP1 and/or RIP3. Typically, the relative selectivity may be assessed by comparing K _D values for each respective compound binding to the relevant protein (ie MLKL and either or both of RIP1 and RIP3). Suitable assay conditions are described in the Examples below. Compounds selective for MLKL may avoid undesired side- effects associated with RIP1 and/or RIP3 loss of function. In another aspect, there is provided use of a compound of Formula (I) a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof in the preparation of a medicament for the inhibition of necroptosis in a subject. In another aspect, there is provided use of a composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof for the inhibition of necroptosis in a subject. In another aspect, there is provided use of a compound of Formula (I) or a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof for inhibiting necroptosis. In another aspect, there is provided use of a composition comprising a compound of Formula (I) or a salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof for inhibiting necroptosis. In yet another aspect, there is provided a compound according to Formula (I) or a salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof for use in inhibiting necroptosis. In yet another aspect, there is provided a composition comprising a compound according to Formula (I) or a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof for use in inhibiting necroptosis. In some embodiments, the composition is a pharmaceutical composition. In yet another aspect, there is provided a compound according to Formula (I) or a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof when used for inhibiting necroptosis. In yet another aspect, there is provided a composition comprising a compound according to Formula (I) or a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof when used for inhibiting necroptosis. In another aspect, there is provided a method of inhibiting MLKL, comprising contacting a cell with an effective amount of a compound of formula (I) or a salt, solvate, tautomer, N- oxide, stereoisomer and/or prodrug thereof. The salts of the compounds of Formula (I) are preferably pharmaceutically acceptable, but it will be appreciated that non-pharmaceutically acceptable salts also fall within the scope of the present disclosure, for example, as these may be useful as intermediates in the preparation of pharmaceutically acceptable salts or in methods not requiring administration to a subject. The term “pharmaceutically acceptable” may be used to describe any salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof, or any other compound which upon administration to a subject, is capable of providing (directly or indirectly) a compound of Formula (I) or an active metabolite or residue thereof and typically that is not deleterious to the subject. Suitable pharmaceutically acceptable salts include, but are not limited to, salts of pharmaceutically acceptable inorganic acids such as hydrochloric, sulphuric, phosphoric, nitric, carbonic, boric, sulfamic, and hydrobromic acids, or salts of pharmaceutically acceptable organic acids such as acetic, propionic, butyric, tartaric, maleic, hydroxymaleic, fumaric, malic, citric, lactic, mucic, gluconic, benzoic, succinic, oxalic, phenylacetic, methanesulphonic, toluenesulphonic, benzenesulphonic, salicylic, sulphanilic, aspartic, glutamic, edetic, stearic, palmitic, oleic, lauric, pantothenic, tannic, ascorbic and valeric acids. Base salts include, but are not limited to, those formed with pharmaceutically acceptable cations, such as sodium, potassium, lithium, calcium, magnesium, zinc, ammonium, alkylammonium such as salts formed from triethylamine, alkoxyammonium such as those formed with ethanolamine and salts formed from ethylenediamine, choline or amino acids such as arginine, lysine or histidine. General information on types of pharmaceutically acceptable salts and their formation is known to those skilled in the art and is as described in general texts such as “Handbook of Pharmaceutical salts” P.H.Stahl, C.G.Wermuth, 1st edition, 2002, Wiley-VCH. In the case of compounds that are solids, it will be understood by those skilled in the art that the inventive compounds, agents and salts may exist in different crystalline or polymorphic forms, all of which are intended to be within the scope of the present invention and specified formulae. The invention includes all crystalline forms of a compound of Formula (I) including anhydrous crystalline forms, hydrates, solvates and mixed solvates. If any of these crystalline forms demonstrates polymorphism, all polymorphs are within the scope of this invention. Formula (I) is intended to cover, where applicable, solvated as well as unsolvated forms of the compounds. Thus, Formula (I) includes compounds having the indicated structures, including the hydrated or solvated forms, as well as the non-hydrated and non-solvated forms. The compounds of Formula (I) or salts, tautomers, N-oxides, polymorphs or prodrugs thereof may be provided in the form of solvates. Solvates contain either stoichiometric or non- stoichiometric amounts of a solvent, and may be formed during the process of crystallization with pharmaceutically acceptable solvents such as water, alcohols such as methanol, ethanol or isopropyl alcohol, DMSO, acetonitrile, dimethyl formamide (DMF), acetic acid, and the like with the solvate forming part of the crystal lattice by either non-covalent binding or by occupying a hole in the crystal lattice. Hydrates are formed when the solvent is water, alcoholates are formed when the solvent is alcohol. Solvates of the compounds of the present invention can be conveniently prepared or formed during the processes described herein. In general, the solvated forms are considered equivalent to the unsolvated forms for the purposes of the invention. Basic nitrogen-containing groups may be quarternised with such agents as C _1-6 alkyl halide, such as methyl, ethyl, propyl, and butyl chlorides, bromides and iodides; dialkyl sulfates like dimethyl and diethyl sulfate; and others. Nitrogen containing groups may also be oxidised to form an N-oxide. The compound of Formula (I) or salts, tautomers, N-oxides, solvates and/or prodrugs thereof that form crystalline solids may demonstrate polymorphism. All polymorphic forms of the compounds, salts, tautomers, N-oxides, solvates and/or prodrugs are within the scope of the invention. The compound of Formula (I) may demonstrate tautomerism. Tautomers are two interchangeable forms of a molecule that typically exist within an equilibrium. Any tautomers of the compounds of Formula (I) are to be understood as being within the scope of the invention. The compound of Formula (I) may contain one or more stereocentres. All stereoisomers of the compounds of formula (I) are within the scope of the invention. Stereoisomers include enantiomers, diastereomers, geometric isomers (E and Z olephinic forms and cis and trans substitution patterns) and atropisomers. In some embodiments, the compound is a stereoisomerically enriched form of the compound of formula (I) at any stereocentre. The compound may be enriched in one stereoisomer over another by at least about 60, 70, 80, 90, 95, 98 or 99%. The compound of Formula (I) or its salts, tautomers, solvates, N-oxides, and/or stereoisomers, may be isotopically enriched with one or more of the isotopes of the atoms present in the compound. For example, the compound may be enriched with one or more of the following minor isotopes: ² H, ³ H, ¹³ C, ¹⁴ C, ¹⁵ N and/or ¹⁷ O, preferably ² H. An isotope may be considered enriched when its abundance is greater than its natural abundance. A "prodrug" is a compound that may not fully satisfy the structural requirements of the compounds provided herein, but is modified in vivo, following administration to a subject or patient, to produce a compound of formula (I) provided herein. For example, a prodrug may be an acylated derivative of a compound as provided herein. Prodrugs include compounds wherein hydroxy, carboxy, amine or sulfhydryl groups are bonded to any group that, when administered to a mammalian subject, cleaves to form a free hydroxy, carboxy, amino, or sulfhydryl group, respectively. Examples of prodrugs include, but are not limited to, acetate, formate, phosphate and benzoate derivatives of alcohol and amine functional groups within the compounds provided herein. Prodrugs of the compounds provided herein may be prepared by modifying functional groups present in the compounds in such a way that the modifications are cleaved in vivo to generate the parent compounds. Prodrugs include compounds wherein an amino acid residue, or a polypeptide chain of two or more (eg, two, three or four) amino acid residues which are covalently joined to free amino, and amido groups of compounds of Formula (I). The amino acid residues include the 20 naturally occurring amino acids commonly designated by three letter symbols and also include, 4-hydroxyproline, hydroxylysine, demosine, isodemosine, 3-methylhistidine, norvlin, beta-alanine, gamma-aminobutyric acid, citrulline, homocysteine, homoserine, ornithine and methionine sulfone. Prodrugs also include compounds wherein carbonates, carbamates, amides and alkyl esters which are covalently bonded to the above substituents of Formula (I) through the carbonyl carbon prodrug sidechain. Pharmaceutical compositions may be formulated from compounds according to Formula (I) for any appropriate route of administration including, for example, oral, rectal, nasal, vaginal, topical (including transdermal, buccal, ocular and sublingual), parenteral (including subcutaneous, intraperitoneal, intradermal, intravascular (for example, intravenous), intramuscular, spinal, intracranial, intrathecal, intraocular, periocular, intraorbital, intrasynovial and intraperitoneal injection, intracisternal injection as well as any other similar injection or infusion techniques), inhalation, insufflation, infusion or implantation techniques (e.g., as sterile injectable aqueous or non-aqueous solutions or suspensions). In certain embodiments, compositions in a form suitable for oral use or parenteral use are preferred. Suitable oral forms include, for example, tablets, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, or syrups or elixirs. For intravenous, intramuscular, subcutaneous, or intraperitoneal administration, one or more compounds may be combined with a sterile aqueous solution which is preferably isotonic with the blood of the recipient. Such formulations may be prepared by dissolving solid active ingredient in water containing physiologically compatible substances such as sodium chloride or glycine, and having a buffered pH compatible with physiological conditions to produce an aqueous solution, and rendering said solution sterile. The formulations may be present in unit or multi-dose containers such as sealed ampoules or vials. Examples of components are described in Martindale – The Extra Pharmacopoeia (Pharmaceutical Press, London 1993), and Remington: The Science and Practice of Pharmacy, 21st Ed., 2005, Lippincott Williams & Wilkins. All methods include the step of bringing the active ingredient, for example a compound defined by Formula (I), or a pharmaceutically acceptable salt or prodrug thereof, into association with the carrier which constitutes one or more accessory ingredients. In general, the pharmaceutical compositions are prepared by uniformly and intimately bringing the active ingredient, for example a compound defined by Formula (I), or a pharmaceutically acceptable salt or prodrug thereof, into association with a liquid carrier or a finely divided solid carrier or both, and then, if necessary, shaping the product into the desired formulation. In the pharmaceutical composition the active object compound is included in an amount sufficient to produce the desired effect. In some embodiments, the method of the invention comprises administering a pharmaceutical comprising a compound of Formula (I) or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier, diluent and/or excipient. In the context of this specification the term “administering” and variations of that term including “administer” and “administration”, includes contacting, applying, delivering or providing a compound or composition of the invention to an organism, or a surface by any appropriate means. For the inhibition of necroptosis, the dose of the biologically active compound according to the invention may vary within wide limits and may be adjusted to individual requirements. Active compounds according to the present invention are generally administered in a therapeutically effective amount. The daily dose may be administered as a single dose or in a plurality of doses. The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the subject treated and the particular mode of administration. It will be understood, however, that the specific dose level for any particular subject will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex and diet of the subject, time of administration, route of administration, and rate of excretion, drug combination (i.e. other drugs being used to treat the subject), and the severity of the particular disorder undergoing therapy. Such treatments may be administered as often as necessary and for the period of time judged necessary by the treating physician. A person skilled in the art will appreciate that the dosage regime or therapeutically effective amount of the compound of formula (I) to be administered may need to be optimized for each individual. It will also be appreciated that different dosages may be required for treating different disorders. An effective amount of an agent is that amount which causes a statistically significant decrease in necroptosis. For in vitro analysis, the necroptosis inhibition may be determined by assays used to measure TSQ-induced necroptosis, as described in the biological tests defined herein. The terms “treating”, “treatment” and “therapy” are used herein to refer to curative therapy, prophylactic therapy and preventative therapy. Thus, in the context of the present disclosure the term “treating” encompasses curing, ameliorating or tempering the severity of necroptosis and/or associated diseases or their symptoms. “Preventing” or "prevention" means preventing the occurrence of the necroptosis or tempering the severity of the necroptosis if it develops subsequent to the administration of the compounds or pharmaceutical compositions of the present invention. “Subject” includes any human or non-human animal. Thus, in addition to being useful for human treatment, the compounds of the present invention may also be useful for veterinary treatment of mammals, including companion animals and farm animals, such as, but not limited to dogs, cats, horses, cows, sheep, and pigs. The term “inhibit” is used to describe any form of inhibition that results in prevention, reduction or otherwise amelioration of necroptosis and/or MLKL function, including complete and partial inhibition. The compounds of the present invention may be administered along with a pharmaceutical carrier, diluent and/or excipient as described above. The methods of the present disclosure can be used to prevent or treat the following disease(s), condition(s) and/or disorder(s) in a subject: ● diseases of the bones, joints, connective tissue and of cartilage, such as osteoporosis, osteomyelitis including chronic recurrent multifocal osteomyelitis, arthritises including for example osteoarthritis, rheumatoid arthritis and psoriatic arthritis, avascular necrosis, progressive fibrodysplasia ossificans, rickets, Cushing's syndrome; ● muscular diseases such as muscular dystrophy, such as for example Duchenne's muscular dystrophy, myotonic dystrophies, myopathies and myasthenias; ● diseases of the skin, such as dermatitis, eczema, psoriasis, aging or even alterations of scarring; ● cardiovascular diseases such as cardiac and/or vascular ischemia, myocardial infarction, ischemic cardiopathy, chronic or acute congestive heart failure, cardiac dysrythmia, atrial fibrillation, ventricular fibrillation, paroxystic tachycardia, congestive heart failure, hypertrophic cardiopathy, anoxia, hypoxia, secondary effects due to therapies with anti-cancer agents; ● circulatory diseases such as atherosclerosis, arterial scleroses and peripheral vascular diseases, strokes including cerebrovascular strokes, aneurisms; ● haematological and vascular diseases such as: anemia, aplastic anemia, vascular amyloidosis, haemorrhages, drepanocytosis, red cell fragmentation syndrome, neutropenia, leukopenia, medullar aplasia, pantocytopenia, thrombocytopenia, haemophilia; ● lung diseases including pneumonia, asthma; obstructive chronic diseases of the lungs such as for example chronic obstructive pulmonary disease (COPD), chronic bronchitis and emphysema; ● diseases of the gastro-intestinal tract, such as ulcers; inflammatory bowel diseases (IBD), including Crohn’s disease, ulcerative colitis; ● diseases of the liver such as for example hepatitis particularly hepatitis of viral origin or having as causative agent other infectious agents, auto-immune hepatitis, fulminating hepatitis, inflammatory hepatitis, certain hereditary metabolic disorders, Wilson's disease, cirrhoses, non-alcoholic fatty liver disease (NAFLD) including non- alcoholic hepatic steatosis and/or non-alcoholic steatohepatitis (NASH), diseases of the liver due to toxins and to drugs such as drug-induced liver injury, ethanol (or alcohol)-induced liver disease; ● diseases of the pancreas such as for example acute or chronic pancreatitis; ● metabolic diseases such as diabetes, including diabetes mellitus, pre-diabetes and insipid diabetes; thyroiditis; ● diseases of the kidneys such as acute renal disorders (such as acute kidney injury (AKI), including ischaemic reperfusion injury (IRI)) or glomerulonephritis; ● viral and bacterial infections such as septicemia; ● severe intoxications by chemicals, toxins or drugs; ● degenerative diseases associated with the Acquired Immune Deficiency Syndrome (AIDS); ● disorders associated with aging such as the syndrome of accelerated aging; ● inflammatory diseases such as Terminal ileitis including Crohn's disease, rheumatoid polyarthritis, TNF-induced systemic inflammatory syndrome; ● auto-immune diseases such as erythematous lupus (including systemic lupus erythematosus), cleavage-resistant RIPK1-induced autoinflammatory (CRIA) syndrome; ● dental disorders such as those resulting in degradation of tissues such as for example periodontitis; ● ophthalmic diseases or disorders including diabetic retinopathies, glaucoma, macular degenerations, retinal degeneration, retinitis pigmentosa, retinal holes or tears, retinal detachment, retinal ischemia, acute retinopathies associated with trauma, inflammatory degenerations, post-surgical complications, medicinal retinopathies, cataract, cone cell degeneration; ● disorders of the audition tracts, such as otosclerosis and deafness induced by antibiotics; ● Ischemic reperfusion injury, including retinal ischaemic reperfusion injury; ● Neuronal loss, including Alzheimer’s disease and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS; also referred to as motor neuron disease (MND) and Charcot disease); ● diseases associated with mitochondria (mitochondrial pathologies), such as Friedrich's ataxia, congenital muscular dystrophy with structural mitochondrial abnormality, certain myopathies (MELAS syndrome, MERFF syndrome, Pearson's syndrome), MIDD (mitochondrial diabetes and deafness) syndrome, Wolfram's syndrome, dystonia; ● cancer and metastasis including but not limited to cancers of the lung and bronchus, including non-small cell lung cancer (NSCLC), squamous lung cancer, brochioloalveolar carcinoma (BAC), adenocarcinoma of the lung, and small cell lung cancer (SCLC); prostate cancer, including androgen-dependent and androgen- independent prostate cancer; breast cancer, including metastatic breast cancer; pancreatic cancer; cancers of the colon and rectum; thyroid cancer; cancers of the liver and intrahepatic bile duct; hepatocellular cancer; gastric cancer; endometrial cancer; melanoma; cancers of the kidney, renal pelvis, urinary bladder, uterine corpus and uterine cervix; ovarian cancer, including progressive epithelial or primary peritoneal cancer; multiple myeloma; oesophageal cancer, including squamous cell carcinoma and adenocarcinoma of the oesophagus; acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML), including accelerated CML and CML blast phase (CML-BP); lymphocytic leukemia; myeloid leukemia; acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); Hodgkin's disease (HD); non- Hodgkin's lymphoma (NHL), including follicular lymphoma and mantle cell lymphoma; B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL); T-cell lymphoma; multiple myeloma (MM); amyloidosis; Waldenstrom's macroglobulinemia; myelodysplastic syndromes (MDS), including refractory anemia (RA), refractory anemia with ringed siderblasts (RARS), (refractory anemia with excess blasts (RAEB), and RAEB in transformation (RAEB-T); and myeloproliferative syndromes; cancers of the brain, including glioma/glioblastoma, anaplastic oligodendroglioma, and adult anaplastic astrocytoma; neuroendocrine cancers, including metastatic neuroendocrine tumors; cancers of the head and neck, including , e.g., squamous cell carcinoma of the head and neck, and nasopharyngeal cancer; cancers of the oral cavity, pharynx and small intestine; bone cancer; soft tissue sarcoma; and villous colon adenoma; and ● diseases of the central nervous system (CNS), such as multiple sclerosis (MS). In some embodiments, the methods of the present disclosure may be for treating and/or preventing any one or more of the diseases, conditions and/or disorders disclosed herein. For example, in some embodiments, there is provided a method for treating and/or preventing any one or more of: retinal ischaemic reperfusion injury, chronic recurrent multifocal osteomyelitis, aplastic anaemia, CRIA, ethanol-induced liver disease, NASH, inflammatory hepatitis, acute kidney injury, IRI, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, stroke, systemic lupus erythematosus, myocardial infarction, diabetes, Crohn’s disease, inflammatory bowel disease and COPD, comprising administering to a subject in need thereof an effective amount of a compound of the invention or a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof. The methods can also be used for protecting cells, tissues and/or transplanted organs, whether before, during (removal, transport and/or re-implantation) or after transplantation. In some embodiments, the compound of the invention may be administered in combination with a further active pharmaceutical ingredient (API). The API may be any that is suitable for treating any of the diseases, conditions and/or disorders associated with necroptosis, such as those described herein. The compound of the invention may be co-formulated with the further API in any of the pharmaceutical compositions described herein, or the compound of the invention may be administered in a concurrent, sequential or separate manner. Concurrent administration includes administering the compound of the invention at the same time as the other API, whether coformulated or in separate dosage forms administered through the same or different route. Sequential administration includes administering, by the same or different route, the compound of the invention and the other API according to a resolved dosage regimen, such as within about 0.5, 1, 2, 3, 4, 5, or 6 hours of the other. When sequentially administered, the compound of the invention may be administered before or after administration of the other API. Separate administration includes administering the compound of the invention and the other API according to regimens that are independent of each other and by any route suitable for either active, which may be the same or different. The methods may comprise administering the compound of Formula (I) in any pharmaceutically acceptable form. In some embodiments, the compound of Formula (I) is provided in the form of a pharmaceutically acceptable salt, solvate, N-oxide, polymorph, tautomer or prodrug thereof, or a combination of these forms in any ratio. The methods may also comprise administering a pharmaceutical composition comprising the compound of formula (I) or a pharmaceutically acceptable salt, solvate, N-oxide, polymorph, tautomer or prodrug thereof to the subject in need thereof. The pharmaceutical composition may comprise any pharmaceutically acceptable carrier, diluent and/or excipient described herein. The compounds of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof, as defined herein, may be administered by any suitable means, for example, orally, rectally, nasally, vaginally, topically (including buccal and sub-lingual), parenterally, such as by subcutaneous, intraperitoneal, intravenous, intramuscular, or intracisternal injection, inhalation, insufflation, infusion or implantation techniques (e.g., as sterile injectable aqueous or non-aqueous solutions or suspensions). The compounds of the invention may be provided as pharmaceutical compositions including those for oral, rectal, nasal, topical (including buccal and sub-lingual), parenteral administration (including intramuscular, intraperitoneal, sub-cutaneous and intravenous), or in a form suitable for administration by inhalation or insufflation. The compounds of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof, together with a conventional adjuvant, carrier or diluent, may thus be placed into the form of pharmaceutical compositions and unit dosages thereof, and in such form may be employed as solids, such as tablets or filled capsules, or liquids as solutions, suspensions, emulsions, elixirs or capsules filled with the same, all for oral use, or in the form of sterile injectable solutions for parenteral (including subcutaneous) use. Also provided is a kit of parts, comprising in separate parts: ● a compound of Formula (I) or a pharmaceutically acceptable salt, solvate, N- oxide, polymorph, tautomer or prodrug thereof; and ● instructions for its use in any of the methods of the invention. Examples The compounds, compositions, kits and methods described herein are described by the following illustrative and non-limiting examples. CHEMISTRY Synthesis Compounds of the invention, including salts thereof, can be prepared using known organic synthesis techniques and can be synthesized according to any of numerous possible synthetic routes. The reactions for preparing compounds of the invention can be carried out in suitable solvents, which can be readily selected by one of skill in the art of organic synthesis. Suitable solvents can be substantially nonreactive with the starting materials (reactants), the intermediates, or products at the temperatures at which the reactions are carried out, e.g., temperatures which can range from the solvent's freezing temperature to the solvent's boiling temperature. A given reaction can be carried out in one solvent or a mixture of more than one solvent. Depending on the particular reaction step, suitable solvents for a particular reaction step can be selected by the skilled artisan. Preparation of compounds of the invention can involve the protection and deprotection of various chemical groups. The need for protection and deprotection, and the selection of appropriate protecting groups, can be readily determined by one skilled in the art. The chemistry of protecting groups can be found, for example, in T.W. Greene and P.G.M. Wuts, Protective Groups in Organic Synthesis, 3rd. Ed., Wiley & Sons, Inc., New York (1999), which is incorporated herein by reference in its entirety. Reactions can be monitored according to any suitable method known in the art. For example, product formation can be monitored by spectroscopic means, such as nuclear magnetic resonance spectroscopy (e.g., 1H or 13C), infrared spectroscopy, spectrophotometry (e.g., UV-visible), or mass spectrometry, or by chromatography such as high-performance liquid chromatography (HPLC) or thin layer chromatography. The expressions, “ambient temperature,” “room temperature,” and “RT”, as used herein, are understood in the art, and refer generally to a temperature, e.g. a reaction temperature, that is about the temperature of the room in which the reaction is carried out, for example, a temperature from about 20 ºC to about 30 ºC. Compounds of the invention can be prepared according to numerous preparatory routes known in the literature. Example synthetic methods for preparing compounds of the invention are provided in the Schemes below. General chemistry methods Definitions:

LCMS methodology Electrospray mass spectroscopy (MS) was carried out using the following method. Method A (5 minutes): LC model: Method A 1200 (Pump type: Binary Pump, Detector type: DAD) MS model: Method A G6110A Quadrupole. Column: Xbridge-C18, 2.5 μm, 2.1×30 mm. Column temperature: 30 ºC. Acquisition of wavelength: 214 nm, 254 nm. Mobile phase: A: 0.07% HCOOH aqueous solution, B: MeOH. Run time: 5 min. MS: Ion source: ES+ (or ES-). MS range: 50~900 m/z. Fragmentor: 60. Drying gas flow: 10 L/min. Nebulizer pressure: 35 psi. Drying gas temperature: 350 ºC. Vcap: 3.5 kV. Method B (3.5 minutes): LC model: Method A 1200 (Pump type: Binary Pump, Detector type: DAD) MS model: Method A G6110A Quadrupole. Column: Xbridge-C18, 2.5 μm, 2.1×30 mm. Column temperature: 30 ºC. Acquisition of wavelength: 214 nm, 254 nm. Mobile phase: A: 0.07% HCOOH aqueous solution, B: MeOH. Run time: 5 min. MS: Ion source: ES+ (or ES-). MS range: 50~900 m/z. Fragmentor: 60. Drying gas flow: 10 L/min. Nebulizer pressure: 35 psi. Drying gas temperature: 350 ºC. Vcap: 3.5 kV. Method C: (8 minutes) LC model: Waters 2695 alliance (Pump: Quaternary Pump, Detector: 2996 Photodiode Array Detector) MS model: Micromass ZQ LC: Column: Xbridge-C18, 3.5μm, 2.1×50 mm Column temperature: 20 ºC. Acquisition of wavelength: 214 nm, 254 nm Mobile phase: A: 0.05% HCOOH aqueous solution, B: CAN Run time: 8 min MS: Ion source: ES+ (or ES-) MS range: 100~1000 m/z Capillary: 3 kv Cone: 40 V Extractor: 3 V Drying gas flow: 800 L/hr cone: 50 L/hr Desolvation temperature: 500℃ Source temperature: 120 ºC Method D: Mass detector: Agilent G6120B MSD Pump: 1260 Infinity G1312B Binary pump Autosampler: 1260 Infinity G1367E HiPALS Detector: 1260 Infinity G4212B DAD Column: Poroshell 120 EC-C18, 2.1 x 30mm 2.7 Micron Column temperature: 30 °C Injection volume: 2 µL Flowrate: 1.0 ml/min Solvent A: Water 0.1% Formic Acid Solvent B: Acetonitrile 0.1% Formic Acid Gradient: 5-100% B over 3.8 min Acquisition time: 4.1 min Detection: 254 nm and 254 nm Ion source: Single Quadrupole Ion Mode: API-ES Drying gas temperature: 350 °C Capillary voltage (V): 4000 (positive) Capillary voltage (V): 4000 (negative) Scan Range: 100- 1000 Step size: 0.1 sec Method E: Mass detector: Agilent G6120B MSD Pump: 1260 Infinity G1312B Binary pump Autosampler: 1260 Infinity G1367E HiPALS Detector: 1260 Infinity G4212B DAD Column: Atlantis T3, 3uM, 100A, 3.0 x 50mm Column temperature: 30 °C Injection volume: 1 µL Flowrate: 1.0 ml/min Solvent A: Water 0.1% Formic Acid Solvent B: Acetonitrile 0.1% Formic Acid Gradient: 5-50% B over 3.0 min Acquisition time: 4.1 min Detection: 214 and 254nm Ion source: Single Quadrupole Ion Mode: API-ES Drying gas temperature: 350 °C Capillary voltage (V): 4000 (positive) Capillary voltage (V): 4000 (negative) Scan Range: 100-1000 Step size: 0.1 sec Preparative HPLC Method A: Instrument type: VARIAN 940 LC. Pump type: Binary Pump. Detector type: PDA. LC conditions: Column: Waters SunFire prep C18 OBD, 5 μm, 19×100 mm. Acquisition wavelength: 214 nm, 254 nm. Mobile Phase: A: 0.07% TFA aqueous solution (or 0.1% HCOOH aqueous solution), B: MeOH (or CH ₃ CN). Method B: Waters ZQ 3100 –Mass Detector, Waters 2545-Pump, Waters SFO System Fluidics Organizer, Waters 2996 Diode Array Detector, Waters 2767 Sample Manager. LC conditions: Column: Xbridge TM prep C18 OBD 5µm 19 x 100mm, Solvent A: Water 0.1% Formic Acid, Solvent B: Acetonitrile 0.1% Formic Acid, Gradient: variable, Flow rate: 20 ml/min, Detection: 100-600 nm MS conditions: Ion Source: Single-quadrupole, Ion Mode: ES positive, Source Temp: 150°C, Desolvation Temp: 350 °C, Detection: Ion counting, Capillary (KV)-3.00, Cone (V): 30, Extractor (V):3, RF Lens (V): 0.1, Scan Range: 100-1000 Amu, Scan Time: 0.5 sec, Acquisition time: 20min Gas Flow: Desolvation L/hr-650, Cone L/hr-100 Method C: Waters ZQ 3100 –Mass Detector, Waters 2545-Pump, Waters SFO System Fluidics Organizer, Waters 2996 Diode Array Detector, Waters 2767 Sample Manager. LC conditions: Column: Xbridge TM prep C18 OBD 5µm 19 x 100mm, Solvent A: Water, Solvent B: Acetonitrile, Gradient: variable, Flow rate: 20 ml/min, Detection: 100-600 nm MS conditions: Ion Source: Single-quadrupole, Ion Mode: ES positive, Source Temp: 150°C, Desolvation Temp: 350 °C, Detection: Ion counting, Capillary (KV)-3.00, Cone (V): 30, Extractor (V):3, RF Lens (V): 0.1, Scan Range: 100-1000 Amu, Scan Time: 0.5 sec, Acquisition time: 20min Gas Flow: Desolvation L/hr-650, Cone L/hr-100. NMR Nuclear magnetic resonance spectra were recorded on a Bruker 400 MHz or 300 MHz for ¹ H nuclei as specified. Samples were recorded in deuterated solvent as specified, and data acquired at 25 °C. Chemical shifts are reported in ppm on the δ scale and referenced to the appropriate solvent peak. In reporting spectral data, the following abbreviations have been used: s, singlet; bs, broad singlet; d, doublet; t, triplet; q, quartet; m, multiplet. Synthesis of Intermediates A Intermediate A1: 3-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-4-amine Step 1: 4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine To a solution of 4-chloro-1H-pyrazolo[4,3-c]pyridine (25 g, 162 mmol) in DMF (200 mL) was added NIS (43.6 g, 194 mmol) and the mixture was stirred at 85 °C overnight. The mixture was diluted with water (2,500 mL) and the solids were filtered to give the title product (43.0 g, 94%) as a yellow solid. LCMS (Method A): 2.99 min, m/z: 279.9 [M+H] ⁺ . Step 2: 4-chloro-3-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridine To a pre-cooled solution of 4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine (43 g, 153 mmol) in DMF (200 mL) at 0°C was added NaH (60% in oil, 18.4 g, 765 mmol). The mixture was stirred at 0 °C under N ₂ for 10 min. Iodomethane (32.5 g, 229 mmol) was then added slowly and the mixture and stirred at rt for 1 h. Water (2,000 mL) was added and the product was extracted with EtOAc (2 x 1000mL). The combined organics were dried over MgSO ₄ , concentrated under reduced pressure and the residue was purified by column chromatography (DCM/PE = 4/1, v/v) to give the title product (23.5 g, 52%) as a white solid. LCMS (Method A): 3.42 min, m/z: 293.8 [M+H] ⁺ . Step 3: 3-iodo-N-(4-methoxybenzyl)-1-methyl-1H-pyrazolo[4,3-c]pyridi n-4-amine To a solution of 4-chloro-3-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridine (23.5 g, 80.0 mmol) in 1- butanol (200 mL) was added (4-methoxyphenyl)methanamine (44.0 g, 320 mmol) and the mixture was stirred at 110°C overnight. The mixture was concentrated under reduced pressure before the addition of water (2,000 mL). The precipitate was filtered off to give the title product (33.0 g) as a white solid. LCMS (Method A): 2.58 min, m/z: 395.0 [M+H] ⁺ . Step 4: 3-iodo-1-methyl-1Hpyrazolo[4,3-c]pyridin-4-amine A solution of 3-iodo-N-[(4-methoxyphenyl)methyl]-1-methyl-1H-pyrazolo[4,3- c]pyridin-4- amine (33 g, 83.7 mmol) in TFA (60 mL) was stirred at 70 °C overnight. The mixture was concentrated under reduced pressure and the residue was partitioned between an aqueous solution of Na ₂ CO ₃ (250 mL) and DCM (250 mL). The organics were washed with water, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (16.4 g, 71% over 2 steps) as a white solid. LCMS (Method A): 0.91 min, m/z: 275.0 [M+H] ⁺ . Intermediate A2: 3-iodo-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-4-amine Step 1: 4-chloro-3-iodo-1-isopropyl-1H-pyrazolo[4,3-c]pyridine To a mixture of 4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine (6 g, 21.4 mmol) and Cs ₂ CO ₃ (20.8 g, 64.1 mmol) in acetonitrile (200 mL) was added 2-bromopropane (5.26 g, 42.8 mmol) and the reaction mixture was stirred at 70 °C overnight. Water (200 mL) was added, and the product was extracted with EtOAc (2 x 100 mL). The combined organics were dried over Na ₂ SO ₄ , concentrated under reduced pressure and the residue was purified by column chromatography (PE/EtOAc = 4/1 to 1/4, v/v) to give the title product (4 g, 58%) as a yellow solid. LCMS (Method A): 2.60 min, m/z: 322.0 [M+H] ⁺ . Step 2: 3-iodo-1-isopropyl-N-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyr idin-4-amine To a solution of 4-chloro-3-iodo-1-isopropyl-1H-pyrazolo[4,3-c]pyridine (4 g, 12.4 mmol) in 1- butanol (40 mL) was added (4-methoxyphenyl)methanamine (8.50 g, 62.0 mmol) and the mixture was stirred at 110 °C overnight. The reaction mixture was concentrated under reduced pressure and the residue partitioned between water (200 mL) and EtOAc (200 mL). The layers were separated, and the aqueous layer was further extracted with EtOAc (100 mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the crude product (2 g, 38%) as a brown oil. LCMS (Method A): 2.95 min, m/z: 423.1 [M+H] ⁺ . Step 3: 3-iodo-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-4-amine A solution of 3-iodo-1-isopropyl-N-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyr idin-4-amine (3.7 g, 8.76 mmol) in TFA (20 mL) was stirred at 70 °C overnight. The mixture was concentrated under reduced pressure and the residue was partitioned between an aqueous solution of Na ₂ CO ₃ (250 mL) and DCM (250 mL). The organics were washed with water, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (500 mg, 19%) as a yellow solid. LCMS (Method A): 1.83 min, m/z: 303.0 [M+H] ⁺ . Intermediate A3: 3-iodopyrazolo[1,5-a]pyrazin-4-amine Step 1: N-(2,2-dimethoxyethyl)-1H-pyrazole-5-carboxamide A mixture of 1H-pyrazole-5-carboxylic acid (10 g, 89.2 mmol) and carbonyldiimidazole (15.9 g, 98.1 mmol) in 1,4-dioxane (100 ml) was stirred at 50 °C under N ₂ for 1 hour before the addition of 2,2-dimethoxyethan-1-amine (10.3 g, 98.1 mmol), and the reaction mixture was stirred at 50 °C overnight. The reaction mixture was concentrated under reduced pressure and the residue was poured into water (500 mL). The aqueous solution was adjusted to pH = 5 with 1 M HCl and the organics were extracted with EtOAc (2 x 250 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (15 g, 84%) as a white solid. LCMS (Method A):3.32 min; m/z: 222.1 [M+H] ⁺ . Step 2: 7-hydroxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one A solution of N-(2,2-dimethoxyethyl)-1H-pyrazole-5-carboxamide (15 g, 75.2 mmol) in DCM (100 ml) and TFA (100 ml) was stirred at RT overnight. The reaction mixture was concentrated under reduced pressure to give the title product (12 g, 100%) as a brown oil. Step 3: pyrazolo[1,5-a]pyrazin-4(5H)-one A solution of 7-hydroxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (12 g, 78.3 mmol) in polyphosphoric acid (50 mL) was stirred at 145 °C for 5 hours. The reaction mixture was adjusted to pH = 10 with an aqueous NaOH solution. The mixture was concentrated under reduced pressure and the residue was purified by column chromatography (DCM/MeOH = 20/1, v/v) to give the title product (6.1 g, 58%) as a brown solid. ¹ H NMR (400 MHz, DMSO- d ₆ ): δ 11.23 (s, 1H), 7.89 (s, 1H), 7.68 (d, J = 5.8 Hz, 1H), 7.00 (s, 1H), 6.86 (d, J = 11.5 Hz, 1H). Step 4: 4-chloropyrazolo[1,5-a]pyrazine A solution of pyrazolo[1,5-a]pyrazin-4(5H)-one (6.1 g, 45.1 mmol) in POCl ₃ (50 mL) and DMF (4 drops) was stirred at 130 °C overnight. The reaction mixture was slowly poured into ice water (300 mL), then adjusted to pH = 10 with an aqueous NaOH solution. The organics were extracted with EtOAc (2 x 100 mL) and the combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 10/1, v/v) to give the title product (3.6 g, 85%) as a white solid. ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 8.86 (d, J = 5.6 Hz, 1H), 8.26 (s, 1H), 7.75 (d, J = 4.7 Hz, 1H), 7.05 (d, J = 0.9 Hz, 1H). Step 5: 4-chloro-3-iodopyrazolo[1,5-a]pyrazine To a solution of 4-chloropyrazolo[1,5-a]pyrazine (3.6 g, 23.4 mmol) in DMF (100 mL) was added NIS (10.5 g, 46.8 mmol) and the reaction was stirred at 85 °C overnight. The reaction mixture was poured into water (100 mL) and the solids were filtered, washed with water and dried under reduced pressure to give the title product (4.9 g, 75%) as a white solid. ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 8.93 (d, J = 4.7 Hz, 1H), 8.37 (s, 1H), 7.75 (d, J = 4.7 Hz, 1H). Step 6: 3-iodopyrazolo[1,5-a]pyrazin-4-amine To a solution of 4-chloro-3-iodopyrazolo[1,5-a]pyrazine (4.9 g, 17.5 mmol) in MeOH (50 mL) was added a solution of ammonia in MeOH (7M, 100 mL) and the mixture was stirred at 110 °C in a sealed tube overnight. The mixture was concentrated under reduced pressure and the residue was purified by column chromatography (DCM/MeOH = 50/1, v/v) to give the title product (3.00 g, 11.5 mmol) as a white solid. ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 8.08 (d, J = 4.7 Hz, 1H), 8.02 (d, J = 11.8 Hz, 1H), 7.26 (t, J = 4.7 Hz, 1H), 6.68 (d, J = 37.2 Hz, 2H). Synthesis of Intermediates B Intermediate B1: (S)-1,1-difluoro-N-(2-(1-(4-fluorophenyl)ethoxy)-4-(4,4,5,5- tetramethyl- 1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide Step 1: (S)-4-bromo-2-(1-(4-fluorophenyl)ethoxy)-1-nitrobenzene To a solution of (1S)-1-(4-fluorophenyl)ethan-1-ol (40 g, 285 mmol) in THF (600 mL) was added NaH (60% in oil, 57.1 g, 1425 mmol) and the mixture was stirred at 0 °C under N ₂ for 30 min.4-Bromo-2-fluoro-1-nitrobenzene (62.6 g, 285 mmol) was then added, and the mixture was stirred at RT overnight. The reaction mixture was diluted with water (500 mL) and extracted with EtOAc (3 x 500 mL). The combined organics were washed with water and brine, dried (Na ₂ SO ₄ ) and concentrated under reduced pressure to give the crude product (70 g, 72%) as a yellow oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 7.80 (d, J = 8.4 Hz, 1H), 7.54 (d, J = 2.0 Hz, 1H), 7.48 (q, J = 4.8 Hz, 2H), 7.26 (dd, J = 8.8, 2.0 Hz, 1H), 7.20 (t, J = 8.8 Hz, 1H), 5.89 (q, J = 6.4 Hz, 1H), 1.54 (d, J = 6.0 Hz, 3H). Step 2: 4-bromo-2-[(1S)-1-(4-fluorophenyl)ethoxy]aniline To a solution of 4-bromo-2-[(1S)-1-(4-fluorophenyl)ethoxy]-1-nitrobenzene (70 g, 205 mmol) in MeOH (500 mL), was added Zn dust (67.0 g, 1025 mmol) followed by sat. aq. NH ₄ Cl (170 mL). The mixture was stirred at 60 °C for 6 h, then diluted with water (500 mL) and extracted with EtOAc (3 x 500 mL). The combined organics were washed with water and brine, dried (Na ₂ SO ₄ ) and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 100/1, v/v) to give the title product (40 g, 63%) as a brown oil. LCMS (method A): 4.13 min, m/z: 311.0, 312.0 [M+H] ⁺ . Step 3: N-{4-bromo-2-[(1S)-1-(4-fluorophenyl)ethoxy]phenyl}-1,1- difluoromethanesulfonamide To a solution of 4-bromo-2-[(1S)-1-(4-fluorophenyl)ethoxy]aniline (40 g, 128 mmol) in DCM (200 mL) and pyridine (40.5 g, 512 mmol) was added difluoromethanesulfonyl chloride (24.9 g, 166 mmol). After stirring at RT overnight, the residue was diluted with water (500 mL) and extracted with DCM (3 x 500 mL). The combined organics were washed with brine, dried (Na ₂ SO ₄ ) and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 100/1, v/v) to give the title product (39 g, 72%) as a brown oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 10.43 (s, 1H), 7.57 (q, J = 4.8 Hz, 2H), 7.21-7.15 (m, 3H), 7.07-7.04 (m, 2H), 6.98 (t, J = 52.4 Hz, 1H), 5.65 (q, J = 6.4 Hz, 1H), 1.54 (d, J = 6.0 Hz, 3H). Step 4: (S)-1,1-difluoro-N-(2-(1-(4-fluorophenyl)ethoxy)-4-(4,4,5,5- tetramethyl-1,3,2- dioxaborolan-2-yl)phenyl)methanesulfonamide To a solution of N-{4-bromo-2-[(1S)-1-(4-fluorophenyl)ethoxy]phenyl}-1,1- difluoromethanesulfonamide (39 g, 91.9 mmol) in dioxane (300 mL), was added KOAc (26.9 g, 275 mmol), B ₂ pin ₂ (34.7 g, 137 mmol) and Pd(dppf)Cl ₂ (2.01 g, 2.75 mmol). The mixture was stirred at 100 ^o C under N ₂ overnight, then concentrated under reduced pressure. The residue was diluted with water (500 mL) and extracted with EtOAc (3 x 500 mL). The combined organics were washed with water and brine, dried (Na ₂ SO ₄ ) and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 50/1, v/v) to give the desired product (41 g, 94%) as a yellow oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 10.41 (s, 1H), 7.58 (q, J = 4.8 Hz, 2H), 7.27 (d, J = 7.6 Hz, 1H), 7.20-7.16 (m, 3H), 7.12 (s, 1H), 6.98 (t, J = 52.4 Hz, 1H), 5.63 (q, J = 6.4 Hz, 1H), 1.54 (d, J = 6.4 Hz, 3H), 1.25 (d, J = 4.8 Hz, 12H). The following intermediates B were similarly prepared from the appropriate aryl or heteroaryl alcohol (step 1) according to the preparation of (S)-1,1-difluoro-N-(2-(1-(4- fluorophenyl)ethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborol an-2- yl)phenyl)methanesulfonamide (intermediate B1)

Synthesis of Intermediates AB Intermediate A1B1 : N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)- 1-(4-fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonam ide Step 1: N-(4-{4-amino-1-methyl-1Hpyrazolo[4,3-c]pyridin-3-yl}-2-[(1S )-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (Compound 17) To a solution of 3-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-4-amine (8 g, 29.1 mmol) in degassed 1,4-dioxane and H ₂ O (4/1, 150 mL) was added 1,1-difluoro-N-{2-[(1S)-1-(4- fluorophenyl)ethoxy]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborol an-2- yl)phenyl}methanesulfonamide (15.0 g, 32.0 mmol), Na ₂ CO ₃ (6.16 g, 58.2 mmol) and Pd(dppf)Cl ₂ (1.18 g, 1.45 mmol) and the mixture was stirred at 100 °C overnight. The mixture was cooled to RT and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 40/1, v/v) to give the title product (12.0 g, 84%) as a yellow solid. LCMS (Method A): 2.92 min, m/z: 492.2 [M+H] ⁺ . Step 2: N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide To a solution of N-(4-{4-amino-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-[(1 S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (12 g, 24.4 mmol) in DMF (150 mL) was added NIS (6.57 g, 29.2 mmol) and the mixture was stirred at 85 °C overnight. Water (1500 mL) was added and the solids were filtered off, washed with water (200mL), and dried under reduced pressure. The solids were further purified by column chromatography (PE/EA = 1/1, v/v) to give the title product (8.00 g, 53%) as a yellow solid. LCMS (Method A): 3.35 min, m/z: 618.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 8.00 (s, 1H), 7.56 (q, J = 4.8 Hz, 2H), 7.40 (dd, J = 8.8, 2.0 Hz, 1H), 7.18-7.10 (m, 4H), 7.02 (t, J = 52.4 Hz, 1H), 5.85 (s, 2H), 5.64 (q, J = 6.4 Hz, 1H), 4.24 (s, 3H), 1.58 (d, J = 6.4 Hz, 3H). Intermediate A2B1: (S)-N-(4-(4-amino-7-iodo-1-isopropyl-1H-pyrazolo[4,3-c]pyrid in-3-yl)-2- (1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfona mide

Step 1: (S)-N-(4-(4-amino-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl )-2-(1-(4- fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfonamide (Compound 53) To a solution of 3-iodo-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-amine (500 mg, 1.65 mmol) in degassed 1,4-dioxane/water (4/1, 20 mL) were added 1,1-difluoro-N-{2- [(1S)-1-(4- fluorophenyl)ethoxy]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborol an-2- yl)phenyl}methanesulfonamide (1.16 g, 1.82 mmol), Na ₂ CO ₃ (98.9 mg, 0.9334 mmol) and Pd(dppf)Cl ₂ (38.1 mg, 0.04667 mmol) and the mixture was stirred at 100 °C overnight. The mixture was cooled to RT and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 40/1, v/v) to give the title product (950 mg, >100%) as a yellow solid. LCMS (Method A): 3.17 min, m/z: 520.2 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO- d6): δ 11.32 (s, 1H), 7.76 (d, J =6.8 Hz, 1H), 7.57 (t, J =8.4 Hz, 2H), 7.40 (d, J =8.0 Hz, 1H), 7.20-7.09 (m, 5H), 7.00 (t, J = 52.4 Hz, 1H), 6.55 (s, 2H), 5.64 (q, J = 5.6 Hz, 1H), 4.95-4.89 (m, 1H), 1.58 (d, J = 6.0 Hz, 3H), 1.45 (q, J = 4.8 Hz, 6H). Step 2: (S)-N-(4-(4-amino-7-iodo-1-isopropyl-1H-pyrazolo[4,3-c]pyrid in-3-yl)-2-(1-(4- fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfonamide To a solution of N-{4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-3-yl ]-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl}-1,1-difluoromethanesulfonamide (980 mg, 1.88 mmol) in DMF (30 mL) was added NIS (1.05 g, 4.70 mmol) and the mixture was stirred at 85 ^o C overnight. Water (300 mL) was added and the solids were filtered, washed with water (200mL) and dried under reduced pressure. The solids were further purified by column chromatography (DCM/MeOH = 200/1, v/v) to give the title product (450 mg, 37%) as a brown solid. LCMS (Method A): 3.65 min, m/z: 646.1 [M+H] ⁺ . Intermediate A3B1: (S)-N-(4-(4-amino-7-bromopyrazolo[1,5-a]pyrazin-3-yl)-2-(1-( 4- fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfonamide Step 1: (S)-N-(4-(4-aminopyrazolo[1,5-a]pyrazin-3-yl)-2-(1-(4-fluoro phenyl)ethoxy)phenyl)- 1,1-difluoromethanesulfonamide (Compound 22) A mixture of 3-iodopyrazolo[1,5-a]pyrazin-4-amine (2.3 g, 8.84 mmol), 1,1-difluoro-N-{2-[(1S)- 1-(4-fluorophenyl)ethoxy]-4-(4,4,5,5-tetramethyl-1,3,2-dioxa borolan-2- yl)phenyl}methanesulfonamide (4.16 g, 8.84 mmol), Pd(dppf)Cl ₂ (1.43 g, 1.76 mmol) and Na ₂ CO ₃ (1.86 g, 17.6 mmol) in degassed 1,4-dioxane/H ₂ O (4/1, 100 mL) was stirred at 100 °C under N ₂ overnight. The mixture was poured into water (100 mL) and extracted with EtOAc (2 x 70 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 80/1, v/v) to give the title product (3 g, 71%) as a brown solid. LCMS (Method A): 4.62 min, m/z: 478.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 10.45 (s, 1H), 8.02 (d, J = 4.7 Hz, 1H), 7.89 (s, 1H), 7.58 (dd, J = 8.7, 5.6 Hz, 2H), 7.34 (d, J = 8.0 Hz, 1H), 7.30 (d, J = 4.7 Hz, 1H), 7.17 (t, J = 8.9 Hz, 2H), 7.05-6.88 (m, 3H), 5.99 (s, 2H), 5.68 (q, J = 6.2 Hz, 1H), 1.58 (d, J = 6.3 Hz, 3H). Step 2: (S)-N-(4-(4-amino-7-bromopyrazolo[1,5-a]pyrazin-3-yl)-2-(1-( 4-fluorophenyl)ethoxy) phenyl)-1,1-difluoromethanesulfonamide To a solution of (S)-N-(4-(4-aminopyrazolo[1,5-a]pyrazin-3-yl)-2-(1-(4-fluoro phenyl)ethoxy) phenyl)-1,1-difluoromethanesulfonamide (300 mg, 628 µmol) in DMF (10 mL) was added NBS (122 mg, 690 µmol) and the reaction was stirred at room temperature for 1h. The mixture was poured into water (100 mL) and extracted with EtOAc (4 x 50 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH = 50/1, v/v) to give the title product (100 mg, 28%) as a brown solid.

General Procedure A for the Suzuki reaction between intermediate A1B1 and boronate esters A mixture of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (1 eq), boronate ester (1.1 eq), Na ₂ CO ₃ (3 eq) and Pd(dppf)Cl ₂ (0.1eq) in degassed 1,4- dioxane/H ₂ O (4/1, 0.2 M) was stirred at 80 to 100 °C under N ₂ overnight (or at 80 °C for 2h or 4h under MW irradiation). The mixture was diluted with water and extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH) or by prep-TLC (DCM/MeOH) to give the title products. The following compounds were prepared following the General procedure A with intermediate A1B1 and corresponding boronate esters

H H

General procedure B for the Suzuki reaction followed by acidic deprotection between intermediate A1B1 and Boc protected boronate esters A mixture of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (1 eq), Boc protected boronate ester (1.1 eq), Na ₂ CO ₃ (3 eq) and Pd(dppf)Cl ₂ (0.1eq) in degassed 1,4- dioxane/H ₂ O (4/1, 0.2 M) was stirred at 100 °C under N ₂ overnight (or at 80 °C for 2h under MW irradiation). The mixture was diluted with water and extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH) to give the Boc protected products. The solids were dissolved in HCOOH neat (2M) and the reaction mixture was stirred at RT for 30 min or until completion. The reaction mixture was concentrated under reduced pressure and the residue was adjusted to pH=8 with a saturated aqueous Na ₂ CO ₃ solution. The residue was further diluted with water and the organics were extracted with EtOAc (3 times). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH) followed by preparative HPLC (neutral condition method C) if needed to give the desired products The following compounds were prepared following the General procedure B

Synthesis of boronate ester intermediates E Intermediate E1: 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl)-1- (2,2,2-trifluoroethyl)piperidine Step 1: tert-butyl 4-(benzyloxy)piperidine-1-carboxylate To a solution of tert-butyl 4-hydroxypiperidine-1-carboxylate (1 g, 4.96 mmol) in dry DMF (10 mL) at 0 °C was added NaH (60% in oil, 238 mg, 9.92 mmol). The mixture was stirred at 0 °C for 30 mins, then (chloromethyl)benzene (755 mg, 5.95 mmol) was added and the mixture was stirred at RT overnight. The reaction mixture was partitioned between water (10 mL) and EtOAc (10 mL). The aqueous layer was extracted with EtOAc (3 x 30 mL) and the combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 10/1, v/v) to give the title product (1.30 g,92%) as a colourless oil. ¹ HNMR (400 MHz, CD ₃ OD): 7.27-7.18 (m, 5H), 4.48 (s, 2H), 3.73-3.67 (m, 2H), 3.51-3.46 (m, 1H), 3.06-3.00 (m, 2H), 1.80-1.75 (m, 2H), 1.55-1.48 (m, 2H), 1.38 (s, 9H). Step 2: 4-(benzyloxy)piperidine hydrochloride To a solution of tert-butyl 4-(benzyloxy)piperidine-1-carboxylate (1.3 g, 4.46 mmol) in dioxane (5 mL) was added HCl in dioxane (4M, 10 mL) and the reaction mixture was stirred at RT overnight. The solution was concentrated under reduced pressure to give the title product (2.10 g, 100%) as a white solid. ¹ HNMR (400 MHz, MeOD-d ₄ ): 7.38-7.26 (m, 5H), 4.58 (s, 2H), 3.81-3.76 (m, 1H), 3.37-3.31 (m, 2H), 3.16-3.10 (m, 2H), 2.08-2.01 (m, 2H), 1.97-1.91 (m, 2H). Step 3: 4-(benzyloxy)-1-(2,2,2-trifluoroethyl)piperidine To a solution of 4-(benzyloxy)piperidine hydrochloride (2.1 g, 9.22 mmol) in DMF (15 mL) was added 1,1,1-trifluoro-2-iodoethane (5.79 g, 27.6 mmol) and K ₂ CO ₃ (3.81 g, 27.6 mmol). The reaction mixture was stirred at 130 °C for 1.5 h under microwave irradiation. The reaction mixture was partitioned between water (10 mL) and EtOAc (10 ml), and the aqueous layer was extracted with EtOAc (2 x 20 mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 10/1, v/v) to give the title product (896 mg, 36%) as a yellow oil. ¹ HNMR (400 MHz, MeOD-d ₄ ): 7.36-7.24 (m, 5H), 4.54 (s, 2H), 3.50-3.43 (m, 1H), 3.07-2.99 (m, 2H), 2.92-2.87 (m, 2H), 2.51-2.45 (m, 2H), 1.95-1.89 (m, 2H), 1.70-1.61 (m, 2H). Step 4: 1-(2,2,2-trifluoroethyl)piperidin-4-ol To a solution of 4-(benzyloxy)-1-(2,2,2-trifluoroethyl)piperidine (890 mg, 3.25 mmol) in MeOH (10 mL) was added Pd(OH) ₂ (91.2 mg). The mixture was stirred at 55 °C under H ₂ overnight. The reaction mixture was filtered, and the organics were concentrated under reduced pressure to give the title product (590 mg, 98%) as colorless oil. ¹ HNMR (400 MHz, CDCl ₃ ): 3.72-3.67 (m, 1H), 3.00-2.91 (m, 2H), 2.90-2.85 (m, 2H), 2.51-2.44 (m, 2H), 1.91-1.84 (m, 2H), 1.64- 1.55 (m, 2H). Step 5: 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl)-1-(2,2,2- trifluoroethyl)piperidine To a solution of 1-(2,2,2-trifluoroethyl)piperidin-4-ol (590 mg, 3.22 mmol) in DCM (10 mL) was added Et ₃ N (1.45 g, 14.4 mmol), followed by MsCl (1.10 g, 9.66 mmol), and the mixture was stirred at RT overnight. The mixture was partitioned between water (10 mL) and DCM (10 mL) and the organic layer was washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the crude mesylate (880 mg, 100%) as a yellow oil. ¹ HNMR (400 MHz, CDCl ₃ ): 4.78-4.73 (m, 1H), 3.13 (s, 1H), 3.01-2.94 (m, 7H), 2.90-2.85 (m, 2H), 2.64-2.60 (m, 2H), 2.05-1.99 (m, 2H), 1.94-1.88 (m, 2H). The crude mesylate was dissolved in DMF (10 mL), and 4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrazole (465 mg, 2.40 mmol), Cs ₂ CO ₃ (1.30 g, 4.00 mmol) and KI (44.3 mg, 267 µmol) were added. The reaction mixture was stirred at 100 °C in a sealed tube overnight. Water (10 mL) was added, and the mixture was extracted with EtOAc (2 x 40 mL). The combined organics were washed with water and brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by prep-TLC (PE/EtOAc = 70/30, v/v) to give the title product (70.0 mg, 7%) as a colourless oil. LCMS (method A): 1.36 min, m/z: 360.2 [M+H] ⁺ . Intermediate E2: 1-methyl-4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-y l)-1H-pyrazol- 1-yl)ethyl)piperazine Step 1: 1-(2-bromoethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2 -yl)-1H-pyrazole To a solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (500 mg, 2.57 mmol) in DMSO (5 mL) was added KOH (1.43 g, 25.6 mmol). After stirring at RT for 1 h, 1,2- dibromoethane (9.63 g, 51.3 mmol) was added. The mixture was stirred at RT overnight, then diluted with water (10 mL) and extracted with EtOAc (3 x 15 mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 5/1, v/v) to give the title product (320 mg, 41%) as a colourless oil. LCMS (Method A): 2.03 min, m/z 301.1/303.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d6): 7.99 (s, 1H), 7.62 (s, 1H), 4.52 (d, J = 6.4 Hz, 2H), 3.85 (d, J = 6.0 Hz, 2H), 1.26 (s, 12H). Step 2: 1-methyl-4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-y l)-1H-pyrazol-1- yl)ethyl)piperazine To a solution of 1-(2-bromoethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2 -yl)-1H-pyrazole (100 mg, 332 µmol) in MeCN (3 mL) were added 1-methylpiperazine (49.8 mg, 498 µmol) and Cs ₂ CO ₃ (216 mg, 664 µmol). The mixture was stirred at 90 °C for 6h. Water (10 mL) was added, and the organics were extracted with EtOAc (3 x 15mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (60.0 mg, 56%) as a light-yellow oil, which was used directly without further purification. LCMS (Method B): 1.43 min, m/z: 321.3 [M+H] ⁺ . Intermediate E3: 1-(2-(3,3-dimethylazetidin-1-yl)ethyl)-4-(4,4,5,5-tetramethy l-1,3,2- dioxaborolan-2-yl)-1H-pyrazole Step 1: 1-(2-(3,3-dimethylazetidin-1-yl)ethyl)-4-(4,4,5,5-tetramethy l-1,3,2-dioxaborolan-2-yl)- 1H-pyrazole To a solution of 1-(2-bromoethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2 -yl)-1H-pyrazole (100 mg, 332 µmol) in MeCN (3 mL) was added cesium carbonate (540 mg, 1.66 mmol) and 3,3-dimethylazetidine hydrochloride (60.5 mg, 498 µmol). The reaction mixture was refluxed for 4 h. The mixture was cooled to RT, filtered, and the residue was washed with MeCN (2 x 3mL). The combined filtrates were concentrated under reduced pressure to give the title product (105 mg, >100%) as a light-yellow solid. Used directly in the next step without further purification. LCMS (Method A): 0.32 min; m/z: 307.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.88 (s, 1H), 7.54 (s, 1H), 4.04-4.01 (m, 2H), 2.81-2.80 (m, 4H), 2.72 (t, J = 6.4 Hz, 2H), 1.26- 1.24 (m, 12H), 1.12 (s, 6H). Intermediate E4: N-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H- pyrazol-1-yl)ethan-1-amine Step 1: N-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H-pyrazol-1-yl)ethan-1- amine To a solution of 1-(2-bromoethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2 -yl)-1H-pyrazole (100 mg, 332 μmol) in MeCN (3 mL) were added methylamine hydrochloride (44.1 mg, 664 μmol), Cs ₂ CO ₃ (540 mg, 1.66 mmol) and KI (5.51 mg, 33.2 μmol) at RT. The reaction mixture was refluxed for 4 h under N ₂ atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title product (118 mg, >100%) as a yellow oil. Used as crude in the next step. LCMS (Method A): 0.30 min; m/z 169.9 [M+H] ⁺ . Intermediate E5: N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)-1H- pyrazol-1-yl)ethan-1-amine Step 1: N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)-1H-pyrazol-1- yl)ethan-1-amine To a solution of 1-(2-bromoethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2 -yl)-1H-pyrazole (100 mg, 0.332 mmol) in MeCN (3 mL) were added dimethylamine (22.4 mg, 0.498 mmol), Cs ₂ CO ₃ (540 mg, 1.66 mmol) and KI (5.51 mg, 0.033 mmol) at RT. The reaction mixture was stirred at 90 °C for 4 h under N2. The solids were removed by filtration, washed with EtOAc (5mL) and the combined organics were concentrated under reduced pressure to afford the title product (120 mg, >100%) as a black oil. Used directly as crude in the next step. LCMS (Method A): 0.45 min, m/z 266.1 [M+H] ⁺ . Intermediate E6: 8-methyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H-pyrazol-1- yl]-8-azabicyclo[3.2.1]octane Step 1: 8-methyl-8-azabicyclo[3.2.1]octan-3-yl methanesulfonate A mixture of 8-methyl-8-azabicyclo[3.2.1]octan-3-ol (3 g, 21.2 mmol) and Et ₃ N (5.57 g, 55.1 mmol) in DCM (30 mL) was stirred at 0 °C. MsCl (3.14 g, 27.5 mmol) was added at 0 °C and the reaction mixture was stirred at RT for 2 h. The mixture was poured into water (40 mL) and extracted with EtOAc (40 mL x 2). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the crude title product (2.00 g, 9.11 mmol) as an orange solid. Used as crude in the next step. LCMS (Method A): 0.72 min, m/z 219.9 [M+H] ⁺ . Step 2: 8-methyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H-pyrazol-1-yl]-8- azabicyclo[3.2.1]octane A mixture of 8-methyl-8-azabicyclo[3.2.1]octan-3-yl methanesulfonate (500 mg, 2.27 mmol), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (440 mg, 2.27 mmol) and K ₂ CO ₃ (941 mg, 6.81 mmol) in MeCN (10 mL) was stirred at 80 °C for 12 h. The reaction mixture was concentrated under reduced pressure and the residue was poured into water (40 mL) and extracted with EtOAc (40 mL x 2). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc; 4/1 to 1/4) to give the title product (200 mg, 28%) as a brown solid. LCMS (Method B): 2.58 min, m/z 318.2 [M+H] ⁺ Intermediate E7: 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrrole-2- carbonitrile Step 1: 4-bromo-1-methyl-1H-pyrrole-2-carbonitrile To a solution of 1-methyl-1H-pyrrole-2-carbonitrile (500 mg, 4.71 mmol) in DMF (5 mL) was added NBS (838 mg, 4.71 mmol). The reaction mixture was stirred at RT overnight. The mixture was poured into water (20 mL) and extracted with EtOAc (50 mL x 2). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (PE:EtOAc; 4:1) to give the title product (700 mg, 80%) as a white solid. ¹ H NMR (400 MHz, CDCl ₃ ): 6.81 (s, 1H), 6.76 (s, 1H), 3.77 (s, 3H). Step 2: 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrrole-2-carbonitrile To a solution of 4-bromo-1-methyl-1H-pyrrole-2-carbonitrile (300 mg, 1.62 mmol), B ₂ pin ₂ (431 mg, 1.70 mmol) and AcOK (476 mg, 4.86 mmol) in degassed 1,4-dioxane (10 mL) was added Pd(dppf)Cl2 (74.1 mg, 81.0 µmol). The mixture was stirred at 100 °C under N2 overnight. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (PE:EtOAc; 2:1) to give the title product (200 mg, 53%) as a white solid. No mass ion Intermediate E8: 2-{3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyr azol-1- yl]oxetan-3-yl}acetonitrile Step 1: 2-{3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyr azol-1-yl]oxetan-3- yl}acetonitrile To a mixture of 2-(oxetan-3-ylidene)acetonitrile (200 mg, 2.10 mmol) and 4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (520 mg, 2.68 mmol) in MeCN (15 mL) was added DBU (639 mg, 4.20 mmol) and the reaction mixture was stirred at 60 °C for 18 h. The mixture was concentrated under reduced pressure and the residue was diluted with water (20 mL) and extracted with EtOAc (3 x 20 mL). The combined organics were washed with brine (50 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by Prep-TLC (PE:EtOAc; 4:1) to give the title product (250 mg, 41%) as a yellow oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): 8.30 (s, 1H), 7.76 (s, 1H), 5.01 (d, J = 7.2 Hz, 2H), 4.74 (d, J = 7.2 Hz, 2H), 3.61 (s, 2H), 1.27 (s, 12H). Intermediate E9: N-isopropyl-N-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxabo rolan-2-yl)- 1H-pyrazol-1-yl)propan-1-amine Step 1: 2-chloro-N-isopropyl-N-methylpropanamide To a solution of methyl(propan-2-yl)amine (1 g, 13.6 mmol) in DCM (14 mL) was added Et ₃ N (2.28 g, 22.6 mmol) followed by 2-chloropropanoyl chloride (1.43 g, 11.3 mmol) at 0 °C. The solution was stirred at 0 °C for 1 h under N ₂ . The solution was diluted with EtOAc (50 mL), washed with water (10 mL) and brine (3 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (1.70 g, 76%) as a white oil. LCMS (Method C): 0.74 min; m/z: 163.9 [M+H] ⁺ Step 2: 2-(4-bromo-1H-pyrazol-1-yl)-N-isopropyl-N-methylpropanamide To a solution of 2-chloro-N-methyl-N-(propan-2-yl)propanamide (1.56 g, 9.53 mmol) in DMF (25 mL) were added 4-bromo-1H-pyrazole (1.16 g, 7.94 mmol) and K ₂ CO ₃ (3.28 g, 23.8 mmol) at RT. The solution was stirred at 130 °C overnight under N ₂ . The solution was diluted with water (25 mL) and the organics were extracted with EtOAc (2 x 10 mL). The combined organics were washed with water (10 mL) and brine (10 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAC; 5:1) to give the title product (2.00 g, 76%) as a colourless oil. LCMS (Method C): 1.20 min; m/z: 275.9 [M+H] ⁺ Step 3: 2-(4-bromo-1H-pyrazol-1-yl)-N-isopropyl-N-methylpropan-1-ami ne To a solution of 2-(4-bromo-1H-pyrazol-1-yl)-N-methyl-N-(propan-2-yl)propenam ide (500 mg, 1.82 mmol) in THF (8 mL) was added LiAlH ₄ (138 mg, 3.64 mmol) at RT. The solution was stirred at RT for 1 h under N ₂ . The solution was diluted with water (25 mL) and the organics were extracted with EtOAC (2 x 10 mL). The combined organics were washed with water (10 mL) and brine (10 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (DCM:MeOH; 100/1) to give the title product (205 mg, 43%) as a white solid. LCMS (Method C): 0.29 min; m/z 259.9 [M+H] ⁺ Step 4: methyl(propan-2-yl){2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxabor olan-2-yl)-1H-pyrazol-1- yl]propyl}amine To a solution of 2-(4-bromo-1H-pyrazol-1-yl)-N-isopropyl-N-methylpropan-1-ami ne (100 mg, 384 µmol) in 1,4-dioxane (4 mL) were added B ₂ pin ₂ (146 mg, 576 µmol), Pd(dppf)Cl ₂ (28.0 mg, 38.4 µmol) and AcOK (94.2 mg, 960 µmol). The solution was stirred at 100 °C for 8 h under N ₂ . The solution was concentrated and the crude was purified by silica gel column chromatography (PE/EtOAc = 1/1) to give the title compound (18.0 mg, 15%) as a white oil. LCMS (method C): 0.36 min; m/z: 307.9 [M+H] ⁺ Intermediate E10: 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1- yl)cyclopropane-1-carbonitrile Step 1: 2-(4-iodo-1H-pyrazol-1-yl)acetonitrile To a solution of 4-iodo-1H-pyrazole (1 g, 5.15 mmol) in DMF (10 mL) were added K ₂ CO ₃ (1.42 g, 10.3 mmol) and 2-bromoacetonitrile (678 mg, 5.66 mmol) at RT. The reaction mixture was stirred at 50 °C overnight. The reaction mixture was extracted with EtOAc (2 x 30mL) and the combined rganics were washed with water and brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (PE:EtOAc; 5:1) to give title product (1.10 g, 92%) as a white solid. ¹ HNMR (400 MHz, DMSO- d ₆ ): 8.02 (s,1H), 7.68 (s, 1H), 5.49 (s, 2H). Step 2: 1-(4-iodo-1H-pyrazol-1-yl)cyclopropane-1-carbonitrile To a solution of 2-(4-iodo-1H-pyrazol-1-yl)acetonitrile (1.1 g, 4.72 mmol) in DMSO (8 mL) was added NaH (60% in oil, 451 mg, 18.8 mmol) at 0°C and the mixture was stirred at 0°C for 30 mins.1,2-dibromoethane (2.64 g, 14.1 mmol) in DMSO (2 mL) was added dropwise and the reaction was stirred at RT for 8 h. The reaction was quenched with water (10 mL) and the organics were extracted with EtOAc (30 mL x 2). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (PE: EtOAc; 10/1) to give title product (274 mg, 22%) as yellow oil. LCMS (method E): 0.95 min; m/z: 259.9 [M+H] ⁺ Step 3: 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl)cyclopropane-1- carbonitrile To a solution of 1-(4-iodo-1H-pyrazol-1-yl)cyclopropane-1-carbonitrile (255 mg, 984 μmol) in degassed DMSO (10 mL) were added B ₂ (pin) ₂ (373 mg, 1.47 mmol), Pd(dppf)Cl2 (71.9 mg, 98.3 μmol) and AcOK (289 mg, 2.95 mmol) at RT and the reaction mixture was stirred at 80 °C for 3 h. The mixture was partitioned between H ₂ O (10mL) and EtOAc (10 mL), and the layers were separated. The aqueous fraction was extracted with EtOAc (30 mL x 2). The combined organics were washed with water and brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (PE: EtOAc; 20/1 to 5/1) to give title product (150 mg, 59%) as a white solid. LCMS (Method E): 1.03 min; m/z: 259.9 [M+H] ⁺ Intermediate E11: 1-(methyl-d3)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2 -yl)-1H- pyrazol-1-yl)piperidine Step 1: 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl)piperidine A solution of tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1- yl]piperidine-1-carboxylate (377 mg, 999 μmol) in HCOOH (2 mL) was stirred at RT for 1 h. The mixture was concentrated under reduced pressure to give the title compound as a formate salt (270 mg, 97%) as a colorless oil. LCMS (Method A): 2.17 min, m/z 278.1 [M+H] ⁺ Step 2: 1-(methyl-d3)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2 -yl)-1H-pyrazol-1- yl)piperidine To a solution of 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl]piperidine (270 mg, 974 μmol) in MeCN (5 mL) was added K ₂ CO ₃ (134 mg, 974 μmol) and CD ₃ I (141 mg, 974 μmol). The reaction mixture was stirred at 80 °C for 2 h. The mixture was poured into water (5 mL) and extracted with EtOAc (3 x 5 mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (290 mg, >100%) as a white solid. Used as crude in the next step. LCMS (Method A): 2.09 min, m/z 295.1 [M+H] ⁺ Intermediate E12: tert-butyl 3-methyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H- pyrazol-1-yl)piperidine-1-carboxylate Step 1: tert-butyl 3-methyl-5-(tosyloxy)piperidine-1-carboxylate To a solution of tert-butyl 3-hydroxy-5-methylpiperidine-1-carboxylate (575 mg, 2.67 mmol) in DCM (10 mL) and pyridine (10 mL) was added TsCl (610 mg, 3.20 mmol). After stirring at RT overnight, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc; 25/1) to give the title product (800 mg, 81%) as a white solid. LCMS (Method A): 4.28 min; 392.2 [M+Na] ⁺ Step 2: tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)-5-methylpiperidine-1-carboxylate To a solution of tert-butyl 3-methyl-5-(tosyloxy)piperidine-1-carboxylate (500 mg, 1.35 mmol) in DMF (10 mL) were added 4-bromo-1H-pyrazole (257 mg, 1.75 mmol) and Cs ₂ CO ₃ (1.31 g, 4.05 mmol). After stirring at 100 °C overnight under N ₂ , the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc; 5/1) to give the title product (230 mg, 50%) as a colorless oil. LCMS (Method A): 4.19 min; m/z: 288.0, 290.0 [M+H] ⁺ Step 3: tert-butyl 3-methyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H-pyrazol-1- yl)piperidine-1-carboxylate To a solution of tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)-5-methylpiperidine-1-carboxylate (200 mg, 0.581 mmol) in DME (10 mL) were added AcOK (113 mg, 1.16 mmol), B ₂ pin ₂ (221 mg, 871 μmol) and Pd(dppf)Cl ₂ (42.4 mg, 58.0 μmol). After stirring at 100 °C overnight under N ₂ , the mixture was concentrated under reduced pressure. The residue was diluted with water (100 mL) and extracted with EtOAc (100 mL x 3). The combined organic phases were washed with water and brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (400 mg, >100%) as a black oil. Used as crude in the next step. LCMS (Method A): 3.50 min; m/z: 392.3 [M+H] ⁺ Intermediate E13: tert-butyl 2-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyraz ol-1- yl)methyl)pyrrolidine-1-carboxylate Step 1: tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate To a solution of (pyrrolidin-2-yl)methanol (500 mg, 4.94 mmol) in DCM (5 mL) was added Et ₃ N (2.49 g, 24.7 mmol) followed by Boc ₂ O (1.29 g, 5.92 mmol). The reaction mixture was stirred at RT for 16 h. The solvents were removed under reduced pressure and the residue was purified by silica gel column chromatography (PE:EA, 1:1) to give the title product (850 mg, 85%) as a yellow oil. Step 2: tert-butyl 2-{[(4-methylbenzenesulfonyl)oxy]methyl}pyrrolidine-1-carbox ylate To a solution of tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate (850 mg, 4.22 mmol) in DCM (5 mL) were added TsCl (2.40 g, 12.6 mmol) and Et ₃ N (2.56 g, 25.3 mmol). The mixture was stirred at RT overnight. Water (10 mL) was added and the organics were extracted with DCM (2 x 10mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EA, 4:1) to give the title product (1.40 g, 93%) as a yellow oil. Step 3: tert-butyl 2-[(4-bromo-1H-pyrazol-1-yl)methyl]pyrrolidine-1-carboxylate To a solution of tert-butyl 2-{[(4-methylbenzenesulfonyl)oxy]methyl}pyrrolidine-1-carbox ylate (1.4 g, 3.93 mmol) in DMF (10 mL) were added Cs ₂ CO ₃ (3.80 g, 11.7 mmol) and 4-bromo-1H- pyrazole (692 mg, 4.71 mmol). The reaction mixture was stirred at 100 °C for 16 h. Water (10 mL) was added and the organics were extracted with EtOAc (2 x 20mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EA, 2:1) to give the title product (1.30 g, 100%) as a colorless oil. Step 4: tert-butyl 2-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyraz ol-1- yl)methyl)pyrrolidine-1-carboxylate To a solution of tert-butyl 2-[(4-bromo-1H-pyrazol-1-yl)methyl]pyrrolidine-1-carboxylate (1.3 g, 3.93 mmol) in DME (10 mL) were added AcOK (1.14 g, 11.7 mmol), B ₂ (pin) ₂ (1.19 g, 4.71 mmol) and Pd(dppf)Cl2 (287 mg, 393 μmol). The reaction mixture was stirred at 100 °C for 16 h under N ₂ . The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (PE:EtOAc, 3:1) to give the title compound (1.0 g, 67%) as a colorless oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.82 (s, 1H), 7.58 (s, 1H), 4.22- 4.13 (m, 3H), 3.20-3.10 (m, 2H), 1.75-1.69 (m, 4H), 1.41-1.37 (m, 9H), 1.24 (s, 12 H) Intermediate E14: 6-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl]-2- azaspiro[3.3]heptane-2-carboxylate Step 1: tert-butyl 6-[(4-methylbenzenesulfonyl)oxy]-2-azaspiro[3.3]heptane-2-ca rboxylate To a solution of tert-butyl 6-hydroxy-2-azaspiro [3.3]heptane-2-carboxylate (3.0 g, 14.0 mmol) in DCM/pyridine (4/1, 100 mL) was added Ts Cl (2.93 g, 15.4 mmol). The mixture was stirred at RT for 12 h. Water (50 mL) was added and the organics were extracted with EtOAc (3 x 50 mL). The combined organics were washed with brine (50 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (PE:EA; 5:1) to give the title product (3.00 g, 58%) as a white solid. Step 2: tert-butyl 6-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl)-2- azaspiro[3.3]heptane-2-carboxylate To a solution of tert-butyl 6-[(4-methylbenzenesulfonyl)oxy]-2-azaspiro[3.3]heptane-2- carboxylate (1.2 g, 3.26 mmol) in DMF (40 mL) were added Cs ₂ CO ₃ (2.12 g, 6.52 mmol) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (632 mg, 3.26 mmol), and the mixture was stirred at 100 °C overnight. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (PE:EA; 3:1) to give the title product (800 mg, 63%) as a yellow solid. Intermediate E15: tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1- yl]azepane-1-carboxylate Step 1: tert-butyl 4-((methylsulfonyl)oxy)azepane-1-carboxylate To a 0 °C solution of tert-butyl 4-hydroxyazepane-1-carboxylate (860 mg, 3.99 mmol) in DCM (10 mL) were added Et ₃ N (808 mg, 7.98 mmol) and MsCl (684 mg, 5.98 mol). The reaction was stirred at room temperature for 1 h under N ₂ . Water (10 mL) was added and the organics were extracted with DCM (3 x 15 mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title compound (1.1 g, 94%) as a yellow oil. ¹ HNMR: (400 MHz, DMSO-d ₆ ): 3.36-3.32(m, 3H), 3.22 (brs, 2H), 3.16 (s, 3H), 2.00-1.95 (m, 1H), 1.84-1.77 (m, 4H), 1.64-1.61(m, 1H), 1.40 (s, 9H). Step 2: tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)azepane-1-carboxylate To a solution of tert-butyl 4-(methanesulfonyloxy)azepane-1-carboxylate (1.1 g, 3.74 mmol) in DMF (15 mL) were added Cs ₂ CO ₃ (3.64 g, 11.2 mmol) and 4-bromo-1H-pyrazole (549 mg, 3.74 mmol) at RT. The reaction mixture was refluxed for 4 h. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (PE:EtOAc; 5:1) to give the title product (1.0 g, 77%) as a yellow oil. LCMS (method A): 1.20 min; m/z 287.7, 289.7 [M+H-tBu] ⁺ . ¹ HNMR: (400 MHz, DMSO-d ₆ ): 8.03 (s, 1H), 7.51 (s, 1H), 4.32-4.26 (m, 1H), 3.60-3.52 (m, 1H), 3.38-3.36 (m, 2H), 3.23-3.17 (m, 1H), 2.03-1.81 (m, 5H), 1.61-1.62 (m,1H), 1.41 (s, 9H). Step 3: tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl]azepane- 1-carboxylate A mixture of tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)azepane-1-carboxylate (700 mg, 2.03 mmol), AcOK (595 mg, 6.08 mmol), B ₂ (pin) ₂ (771 mg, 3.04 mmol) and Pd(dppf)Cl ₂ (147 mg, 202 µmol) in degassed 1,4-dioxane (15 mL) was stirred at 80 °C for 8 h under N ₂ . The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc; 5:1) to give the title compound (700 mg, 1.78 mmol) as a yellow oil. LCMS (method A): 1.80 min; m/z 391.9 [M+H] ⁺ Intermediate E16: 1-(1-methylpyrrolidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dio xaborolan-2- yl)-1H-pyrazole Step 1: 1-(1-methylpyrrolidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dio xaborolan-2-yl)-1H- pyrazole A mixture of 1-(pyrrolidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborola n-2-yl)-1H-pyrazole (200 mg, 760 µmol), formaldehyde (184 mg, 2.28 mmol) and NaBH(OAc) ₃ (1.28 g, 6.07 mmol) in DCM (10 mL) was stirred at RT overnight. The mixture was poured into water and extracted with EtOAc (50 mL x 3). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (PE/EA: 95/5) to give the title product (140 mg, 67%) as a yellow oil. LCMS (Method A): 3.04 min; m/z 278.2 [M+H] ⁺ Intermediate E17: 1-(1-isopropylazetidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-di oxaborolan-2- yl)-1H-pyrazole Step 1: tert-butyl 3-((methylsulfonyl)oxy)azetidine-1-carboxylate To a mixture of tert-butyl 3-hydroxyazetidine-1-carboxylate (5.0 g, 28.9 mmol) and Et ₃ N (8.75 g, 86.60 mmol) in DCM (50 mL) at 0 °C was added MsCl (4.94 g, 43.30mmol) and the reaction was stirred at 0 °C for 3 h. Water (20 mL) was added and the organics were extracted with DCM (2 x 20mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title compound (7.2 g, >100%) as a white solid. LCMS (Method C): 1.07 min; m/z 195.8 [M+H-tbu] ⁺ Step 2: tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate To a solution of tert-butyl 3-((methylsulfonyl)oxy)azetidine-1-carboxylate (7.2 g, 28.65 mmol) in DMF (200 ml) were added Cs ₂ CO ₃ (27.9 g, 85.95 mmol) and 4-bromo-1H-pyrazole (4.63 g, 31.51 mmol) and the reaction mixture was stirred at 80 °C for 3 h. Water (200 mL) was added and the organics were extracted with EtOAc (2 x 100mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc; 5/1) to give the title compound (7.7 g). LCMS (Method C): 0.79 min; m/z 245.0 [M+H-tbu] ⁺ Step 3: tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl)azetidine -1-carboxylate To a mixture of tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate (7.7 g, 25.48 mmol), Pd(dppf)Cl ₂ (1.86 g, 2.55 mmol) and AcOK (7.49 g, 76.44 mmol) in degassed 1,4- dioxane (500 mL) was added B ₂ (pin) ₂ (9.71 g, 38.22 mmol) and the reaction was stirred at 100 °C for 6 h under N ₂ . The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (PE:EtOAc; 3:1) to give the title compound (8.2 g) as a colorless oil. LCMS (Method C): 1.04 min; m/z 293.5 [M+H-tbu] ⁺ Step 4: 1-(azetidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)-1H-pyrazole hydrochloride To a solution of tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1- yl)azetidine-1-carboxylate (8.2 g, 23.47 mmol ) in 1,4-dioxane (10 mL) was added HCl (4M in 1,4-dioxane; 20mL) and the reaction mixture was stirred at RT for 4 h. The reaction mixture was concentrated under reduced pressure to afford the title product (6.7 g) as a yellow oil. LCMS (Method C): 0.76 min; m/z 250.2 [M+H] ⁺ Step 5: 1-(1-isopropylazetidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-di oxaborolan-2-yl)-1H-pyraz ole To a solution of 1-(azetidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)-1H-pyrazole (500 mg, 2.00 mmol) in MeCN (10 mL) were added 2-iodopropane (1.01 g, 6.00 mmol) and K ₂ CO ₃ (276 mg, 2.00 mmol) and the reaction was stirred at 45 °C overnight. Water (10 mL) was added and the organics were extracted with EtOAc (2 x 40 mL). The combined organics were washed with water and brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (DCM:MeOH; 50/1) to give the title product (70 mg) as a colorless oil. LCMS (Method C): 0.44 min; m/z 292.1 [M+H] ⁺ Intermediate E18: 1-(1-methylazetidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxa borolan-2-yl)- 1H-pyrazole Step 1: tert-butyl 3-oxoazetidine-1-carboxylate A mixture of azetidin-3-one hydrochloride (1 g, 9.29 mmol), Boc ₂ O (3.03 g, 13.9 mmol) and Et ₃ N (2.81 g, 27.8 mmol) in DCM (40 mL) was stirred at RT overnight. The mixture was washed with brine (2 x 20 mL) and concentrated under reduced pressure to give the title product (1.17 g, 73.5%) as a yellow oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): 4.67 (s, 4H), 1.42 (s, 9H). Step 2: tert-butyl 3-hydroxyazetidine-1-carboxylate A mixture of tert-butyl 3-oxoazetidine-1-carboxylate (6.77 g, 39.5 mmol) and NaBH ₄ (2.98 g, 79.0 mmol) in MeOH (80 mL) was stirred at RT for 30 min. The mixture was concentrated under reduced pressure to give the title product (4.30 g, 63%) as a yellowish oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): 5.62 (d, J = 6.5 Hz, 1H), 4.36 (qt, J = 6.7, 4.5 Hz, 1H), 4.03-3.92 (m, 2H), 3.57 (dd, J = 9.2, 4.5 Hz, 2H), 1.36 (s, 9H). Step 3: tert-butyl 3-[(4-methylbenzenesulfonyl)oxy]azetidine-1-carboxylate A mixture of tert-butyl 3-hydroxyazetidine-1-carboxylate (2 g, 11.5 mmol), TsCl (2.28 g, 12.0 mmol) and Et ₃ N (2.32 g, 23.0 mmol) in DCM (5 mL) was stirred at RT overnight. The reaction mixture was washed with brine (50 mL x 2), dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (1.25 g, 33%) as a colorless oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.81 (d, J = 8.4 Hz, 2H), 7.50 (d, J = 8.2 Hz, 2H), 5.08 (tt, J = 6.6, 3.9 Hz, 1H), 4.13-4.00 (m, 2H), 3.81-3.67 (m, 2H), 2.43 (s, 3H), 1.34 (s, 9H). Step 4: tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1-yl]azetidine-1- carboxylate A mixture of tert-butyl 3-[(4-methylbenzenesulfonyl)oxy]azetidine-1-carboxylate (1.45 g, 4.42 mmol), Cs ₂ CO ₃ (2.88 g, 8.84 mmol) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrazole (1.28 g, 6.63 mmol) in DMF (40 mL) was stirred at 110 °C overnight. The mixture was poured into water (150 mL) and extracted with EtOAc (2 x 100 mL). The combined organics were washed with brine (2 x 100 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc; 10:1) to give the title product (750 mg, 49%) as a yellow oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): 8.07 (s, 1H), 7.70 (s, 1H), 5.22 (ddd, J = 13.2, 8.0, 5.3 Hz, 1H), 4.26 (t, J = 8.3 Hz, 2H), 4.11 (s, 2H), 1.40 (s, 9H), 1.25 (s, 12H). Step 5: 1-(azetidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)-1H-pyrazole A mixture of tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazo l-1- yl]azetidine-1-carboxylate (500 mg, 1.43 mmol) in aqueous HCl (1M, 2 mL) was stirred at RT for 1 h. The reaction mixture was concentrated under reduced pressure to give the title product (350 mg, 1.40 mmol, 98.3%) as a yellow oil. LCMS (Method A): 1.03 min, m/z 250.0 [M+H] ⁺ . Step 6: 1-(1-methylazetidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxa borolan-2-yl)-1H-pyrazole A mixture of 1-(azetidin-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)-1H-pyrazole (500 mg, 1.40 mmol), paraformaldehyde (337 mg, 4.19 mmol) and NaBH(OAc) ₃ (2.37 g, 11.2 mmol) in DCM (30 mL) was stirred at RT for 45 min. The solution was diluted with DCM (30 mL) before the addition of sat. aq. NaHCO ₃ (30 mL). The aqueous layer was extracted with a DCM/MeOH mixture (9:1; 3 x 10 mL). The combined organic layers were concentrated under reduced pressure to give the title product (70 mg, 19%) as a yellow solid. LCMS (Method A): 1.39 min, m/z 264.1 [M+H] ⁺ . Intermediate E19: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(1-(2,2,2- trifluoroethyl)azetidin-3-yl)-1H-pyrazole Step 1: tert-butyl 3-(benzyloxy)azetidine-1-carboxylate To a 0 °C solution of tert-butyl 3-hydroxyazetidine-1-carboxylate (5 g, 28.9 mmol) in DMF (50 mL) was added NaH (60% in oil, 2.3 g, 57.8 mmol). The solution was stirred at 0°C for 1 h. benzyl chloride (4.4 g, 34.7 mmol) was added to the solution at 0 °C and the reaction mixture was stirred at RT for 2 h. Water (250 mL) was added and the organics were extracted with EtOAc (2 x 300 mL). The combined organic layers were washed with brine (500 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure to afford the title product (7.1 g, 93%) as a white solid. LCMS (Method C): 1.53 min; m/z 208 [M+H-tBu] ⁺ Step 2: 3-(benzyloxy)azetidine To a solution of tert-butyl 3-(benzyloxy)azetidine-1-carboxylate (4.8 g, 18.2 mmol) in DCM (30 mL) was added TFA (10 mL) and the solution was stirred at RT for 2 h. The solution was concentrated under reduced pressure and the residue was dissolved in MeOH (3 mL). The pH was adjust to pH = 8 with the addition of sat. aq. NaHCO ₃ . The organics were extracted with DCM (2 x 50 mL), and the combined organics were washed with brine (100 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (4.10 g, >100%) as a colorless oil. Used as crude in the next step. ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.36-7.35 (m, 5H), 4.46 (s, 2H), 4.43-4.38 (m, 1H), 4.03-3.98 (m, 2H), 3.77-3.74 (m, 2H). Step 3: 3-(benzyloxy)-1-(2,2,2-trifluoroethyl)azetidine To a solution of 3-(benzyloxy)azetidine (200 mg, 1.22 mmol) and 1,1,1-trifluoro-2-iodoethane (768 mg, 3.66 mmol) in DMF (3 mL) was added K ₂ CO ₃ (337 mg, 2.44 mmol) and the reaction was stirred at 130 °C for 90 min. Water (20 mL) was added, and the organics were extracted with EtOAc (3 x 20 mL). The combined organics were washed with water (50 mL) and brine (50 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc; 10:1) to give the title compound (80mg, 27%) as a light yellow oil. LCMS (Method A): 1.82 min; m/z: 246.0 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.37-7.29 (m, 5H), 4.39 (s, 2H), 4.19-4.15 (m, 1H), 3.60-3.57 (m, 2H), 3.22-3.08 (m, 4H). Step 4: 1-(2,2,2-trifluoroethyl)azetidin-3-ol To a solution of 3-(benzyloxy)-1-(2,2,2-trifluoroethyl)azetidine (130 mg, 530 μmol) in MeOH (10 mL) was added Pd(OH) ₂ (37.2 mg, 265 μmol) and the reaction mixture was stirred under H ₂ overnight. The mixture was filtered over Celite, and the filtrate was concentrated under reduced pressure to afford the title product (80.0 mg, 97%) as a colorless oil. ¹ H NMR (400 MHz, DMSO-d ₆ ): 5.37 (s, 1H), 4.23-4.19 (m, 1H), 3.61-3.58 (m, 2H), 3.17-3.09 (m, 2H), 3.00- 2.96 (m, 2H). Step 5: 1-(2,2,2-trifluoroethyl)azetidin-3-yl methanesulfonate To a 0 °C solution of 1-(2,2,2-trifluoroethyl)azetidin-3-ol (80 mg, 515 μmol) in DCM (5 mL) were added Et ₃ N (103 mg, 1.02 mmol) and MsCl (70.7 mg, 618 μmol). The solution was stirred at RT for 1 h, then poured into water (10 mL) and extracted with DCM (2 x 20mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (100 mg, 83%) as a light yellow oil. LCMS (Method C): 0.72 min; m/z: 233.8 [M+H] ⁺ Step 6: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[1-(2,2,2- -trifluoroethyl)azetidin-3- yl]-1H-pyrazole To a solution of 1-(2,2,2-trifluoroethyl)azetidin-3-yl methanesulfonate (500 mg, 2.14 mmol) in DMF (2 mL) were added Cs ₂ CO ₃ (1.04g, 3.21 mmol), KI (935 mg, 0.21 mmol) and 4-(4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (372 mg, 1.92 mmol), and the reaction was stirred at 80 °C for 2 h. Water (10 mL) was added and the organics were extraxted with EtOAc (2 x 10 mL). The combined organics were washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EA; 5:1 to 1:1) to give the title product (130 mg, 20%) as a colourless oil. LCMS (Method C): 1.25 min; m/z: 331.9 [M+H] ⁺ Intermediate E20: N-methyl-N-(propan-2-yl)-2-[4-(4,4,5,5-tetramethyl-1,3,2-dio xaborolan-2- yl)-1Hpyrazol-1-yl]propenamide Step 1: give 2-chloro-N-methyl-N-(propan-2-yl)propanamide To a solution of methyl(propan-2-yl)amine (1 g, 13.6 mmol) in DCM (14 mL) were added Et ₃ N (2.28 g, 22.6 mmol) and 2-chloropropanoyl chloride (1.43 g, 11.3 mmol) at 0 °C. The solution was stirred at 0°C for 1h under N ₂ . The solution was partitioned between water (20 mL) and DCM (20mL), then the organics were collected, wash with brine (10 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE/EtOAc; 5/1) to give the title product (1.46 g, 66%) as a white oil. Step 2: N-methyl-N-(propan-2-yl)-2-[4-(4,4,5,5-tetramethyl-1,3,2-dio xaborolan-2-yl)-1H- pyrazol-1-yl]propanamide To a solution of 2-chloro-N-methyl-N-(propan-2-yl)propanamide (1.45 g, 8.86 mmol) in DMF (25 mL) were added K ₂ CO ₃ (3.05 g, 22.1 mmol) and 4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1Hpyrazole (1.43 g, 7.38 mmol). The solution was stirred at 130 °C overnight under N ₂ . Water (20 mL) was added and the organics were extracted with EtOAC (2 x 10 mL). The combined organics were washed with brine (10 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE/EtOAC, 5/1) to give the title product (1.46 g, 51%) as a white solid. Intermediate E21: tert-butyl 2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)- 1H-pyrazol-1-yl)piperidine-1-carboxylate Step 1: tert-butyl 2,2-dimethyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate To a mixture of tert-butyl 5-hydroxy-2,2-dimethylpiperidine-1-carboxylate (50 mg, 218 μmol) in DCM (5 mL) were added Et ₃ N (51.7 mg, 654 μmol) and MsCl (29.8 mg, 261 μmol), and the mixture was stirred at RT overnight. The mixture was poured into water (10 mL) and the organics were extracted with EtOAc (3 x 10 mL). The combined organics were washed with brine (10 mL) and concentrated under reduced pressure to give the title compound (60.0 mg, 89%) as a colorless oil. Step 2: tert-butyl 2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)-1H-pyrazol- 1-yl)piperidine-1-carboxylate A mixture of tert-butyl 2,2-dimethyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate (370 mg, 1.20 mmol), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (242 mg, 1.25 mmol) and Cs ₂ CO ₃ (779 mg, 2.40 mmol) in DMF (15 mL) was stirred at 90 °C overnight. The mixture was poured into water (20 mL) and extracted with EtOAc (10 mL x 2). The combined organic phases were dried over Na ₂ SO ₄ and concentrated. The residue was purified by prep-TLC (DCM/MeOH = 99/1) to give the title product as a yellow solid. Intermediate E22: N,N-dimethyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)-1H- pyrazol-1-yl]cyclopentan-1-amine Step 1: 3-hydroxycyclopentyl 4-methylbenzene-1-sulfonate A mixture of cyclopentane-1,3-diol (1g, 9.79 mmol), Et ₃ N (3.95 g, 39.1 mmol) and TsCl (1.94 g, 10.2 mmol) in DCM (5 mL) was stirred at 0 °C for 2 h. The mixture was diluted with H ₂ O (100 mL) and extracted with EtOAc (3 x 200 mL). The combined organic layers were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc= 2:1) to afford the title product (1.20 g, 48%) as a yellow oil. LCMS (Method A): 2.93 min, m/z 279.0 [M+Na] ⁺ Step 2: 3-(4-bromo-1H-pyrazol-1-yl)cyclopentan-1-ol A mixture of 3-hydroxycyclopentyl 4-methylbenzene-1-sulfonate (1.2g, 4.68 mmol), Cs ₂ CO ₃ (2.77 g, 4.68 mmol) and 4-bromo-1H-pyrazole (687 mg, 4.68 mmol) in DMF (30 mL) was stirred at 50 °C overnight. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with water (30 mL) and extracted with EtOAc (3 x 30mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by Prep-TLC (DCM/MeOH = 20/1) to give the title product (750 mg, 69%) as a yellow solid. LCMS (Method A): 4.25 min; m/z 231.0 [M+H] ⁺ Step 3: 3-(4-bromo-1H-pyrazol-1-yl)cyclopentyl 4- methylbenzene-1-sulfonate A mixture of 3-(4-bromo-1H-pyrazol-1-yl)cyclopentan-1-ol (750 mg, 3.24 mmol), Et ₃ N (1.30 g, 12.9 mmol) and TsCl (739 mg, 3.88 mmol) in DCM (5 mL) was stirred at 0 °C for 2 h. The mixture was diluted with H ₂ O (100 mL) and extracted with EtOAc (3 x 200 mL). The combined organic layers were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc = 2:1) to afford the title product (100 mg, 8%) as a yellow oil. LCMS (Method A): 2.93 min, m/z 386.0 [M+H] ⁺ . Step 4: 3-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylcyclopentan-1-amine To a mixture of 3-(4-bromo-1H-pyrazol-1-yl)cyclopentyl 4-methylbenzene-1-sulfonate (100 mg, 259 μmol) and K ₂ CO ₃ (253 mg, 777 μmol) in DMF (3 mL) was added dimethylamine (1.2 eq) and the mixture was stirred at 80 °C overnight. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with water (30 mL) and extracted with EtOAc (3 x 30mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by Prep-TLC (DCM/MeOH = 20/1) to give the title product (110mg, >100%) as a yellow solid. LCMS (Method B): 1.00 min; m/z 258.0 [M+H] ⁺ . Step 5: N,N-dimethyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)-1H-pyrazol-1- yl]cyclopentan-1-amine A mixture of 3-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylcyclopentan-1-amine (110 mg, 426 μmol), B ₂ (pin) ₂ (129 mg, 511 μmol), Pd(dppf)Cl ₂ (31.1 mg, 42.6 μmol) and AcOK (83.6 mg, 852 μmol) in degassed 1,4-dioxane (2 mL) was stirred at 100 °C under N ₂ overnight. The mixture was concentrated under reduced pressure and the residue was purified by Prep-TLC (DCM/MeOH = 20/1) to give the title product (60mg, 46%) as a yellow solid. LCMS (Method B): 3.5 min; m/z 306.0 [M+H] ⁺ Synthesis of halogenopyrazole intermediates F Intermediate F1: tert-butyl (3aR,6aS)-5-(4-bromo-1H-pyrazol-1-yl)- octahydrocyclopenta[c]pyrrole-2-carboxylate Step 1: tert-butyl (3aR,6aS)-5-hydroxy-octahydrocyclopenta[c]pyrrole-2-carboxyl ate To a solution of tert-butyl (3aR,6aS)-5-oxo-octahydrocyclopenta[c]pyrrole-2-carboxylate (2.3 g, 10.2 mmol) in MeOH (50 mL) was added NaBH ₄ (1.92 g, 50.9 mmol) and the mixture was stirred at 60 °C overnight. The mixture was concentrated under reduced pressure and the residue was partitioned between DCM (10 mL) and H ₂ O (10 mL). The organic phase was removed and the aqueous was extracted with DCM (2 x 25ml). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (2.20 g, 95%) as a yellow oil. LCMS: (Method A): 2.70 min; m/z: 228.1 [M+H] ⁺ Step 2: tert-butyl (3aR,6aS)-5-(methanesulfonyloxy)-octahydrocyclopenta[c]pyrro le-2- carboxylate To a solution of tert-butyl (3aR,6aS)-5-hydroxy-octahydrocyclopenta[c]pyrrole-2-carboxyl ate (2.2 g, 9.67 mmol) and Et ₃ N (2.93 g, 29.0 mmol) in DCM (50 mL) was added MsCl (1.65 g, 14.5 mmol). The mixture was stirred at RT for 1 h. The organics were extracted with DCM (2 x 100 mL), and the combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (3.00 g, >100%) as a yellow oil. LCMS: (Method A), 3.22 min; m/z: 306.1 [M+H] ⁺ . Step 3: tert-butyl (3aR,6aS)-5-(4-bromo-1H-pyrazol-1-yl)-octahydrocyclopenta[c] pyrrole-2- carboxylate To a mixture of tert-butyl (3aR,6aS)-5-(methanesulfonyloxy)-octahydrocyclopenta[c]pyrro le-2- carboxylate (3 g, 9.82 mmol) and Cs ₂ CO ₃ (6.38 g, 19.6 mmol) in MeCN (60 mL) was added 4-bromo-1H-pyrazole (2.16 g, 14.7 mmol) and the mixture was stirred at 80 °C overnight. The mixture was concentrated under reduced pressure and the residue was partitioned in DCM (10 mL) and H ₂ O (10 mL). The organic phase was collected and the aqueous was extracted with DCM (2 x 25ml). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (PE/EtOAc = 1/1) to give the title product (2.17g, 62%) as a yellow solid. LCMS: (Method A), 2,19 min; m/z: 378.1, 380.1 [M+Na] ⁺ The following intermediate F13 were prepared according to the synthesis of intermediate F1 with 4-iodo-1H-pyrazole and tert-butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate Intermediate F2: 7-(4-bromo-1H-pyrazol-1-yl)-4-methyl-4-azaspiro[2.5]octane Step 1: of tert-butyl 7-hydroxy-4-azaspiro[2.5]octane-4-carboxylate To a solution of tert-butyl 7-oxo-4-azaspiro[2.5]octane-4-carboxylate (25 g, 110 mmol) in MeOH (400 mL) was added NaBH ₄ (12.4 g, 330 mmol) and the mixture was stirred at RT overnight. The mixture was concentrated under reduced pressure and the residue was diluted with EtOAc (200 mL). The organics were washed with water (3 x 200 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (26.0 g, >100%) as a colourless oil. Used as crude in the next step. LCMS: (Method A): 1.29 min, m/z 250.2 [M+Na] ⁺ Step 2: tert-butyl 7-(methanesulfonyloxy)-4-azaspiro[2.5]octane-4-carboxylate To a solution of tert-butyl 7-hydroxy-4-azaspiro[2.5]octane-4-carboxylate (26 g, 114 mmol) and Et ₃ N (34.5 g, 342 mmol) in DCM (300 mL) was added MsCl (15.5 g, 136 mmol) and the mixture was stirred at RT for 1 h. The mixture was washed with water (3 x 200 mL), then the organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (34.0 g, 97%) as a yellow oil. LCMS: (Method A): 2.04 min, m/z 328.2 [M+Na] ⁺ Step 3: tert-butyl 7-(4-bromo-1H-pyrazol-1-yl)-4-azaspiro[2.5]octane-4-carboxyl ate A mixture of tert-butyl 7-(methanesulfonyloxy)-4-azaspiro[2.5]octane-4-carboxylate (34 g, 111 mmol), 4-bromo-1H-pyrazole (19.5 g, 133 mmol) and Cs ₂ CO ₃ (72.3 g, 222 mmol) in MeCN (350 mL) was stirred at 80 °C overnight. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (PE/EA = 20/1 to 1/1) to give the title product (28.0 g, 71%) as a colourless oil. LCMS: (Method A): 1.90 min, m/z 378.2, 380.2 [M+Na] ⁺ Step 4: 7-(4-bromo-1H-pyrazol-1-yl)-4-azaspiro[2.5]octane A solution of tert-butyl 7-(4-bromo-1H-pyrazol-1-yl)-4-azaspiro[2.5]octane-4-carboxyl ate (28 g, 78.5 mmol) in HCl in dioxane (4M, 60 mL) was stirred at RT for 1 h. The reaction mixture was concentrated under reduce pressure to give the title product as a HCl salt (26.0 g) as a white solid. LCMS: (Method A) 0.93 min, m/z 256.1, 258.1[M+H] ⁺ Step 5: 7-(4-bromo-1H-pyrazol-1-yl)-4-methyl-4-azaspiro[2.5]octane To a solution of 7-(4-bromo-1H-pyrazol-1-yl)-4-azaspiro[2.5]octane (26 g, 101 mmol) and (CH ₂ O) _n (15.2 g, 505 mmol) in DCM (300 mL ) was added NaBH(OAc) ₃ (31.9 g, 151 mmol) and the mixture was stirred at RT for 1 h. H ₂ O (100mL) was added and the organics were separated. The organic layer was washed with water (2 x 100 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (20.0 g, 73%) as a colorless oil. LCMS: (Method A) 0.64 min, m/z 270.2, 272.2 [M+H] ⁺

The following intermediates F3-F10 were prepared according to the synthesis of intermediate F2 Intermediate F11 and F12: (R)-4-(4-bromo-1H-pyrazol-1-yl)-1,2,2-trimethylpiperidine and (S)-4-(4-bromo-1H-pyrazol-1-yl)-1,2,2-trimethylpiperidine (R)-4-(4-bromo-1H-pyrazol-1-yl)-1,2,2-trimethylpiperidine and (S)-4-(4-bromo-1H-pyrazol-1- yl)-1,2,2-trimethylpiperidine were obtained by chiral SFC purification of the racemic mixture (4-(4-bromo-1H-pyrazol-1-yl)-2,2-dimethylpiperidine-1-carbox ylate (obtained from tert-butyl 4- (4-(4-amino-3-(4-((difluoromethyl)sulfonamido)-3-((S)-1-(4-f luorophenyl)ethoxy)phenyl)-1- methyl-1H-pyrazolo[4,3-c]pyridin-7-yl)-1H-pyrazol-1-yl)-2,2- dimethylpiperidine-1-carboxylate step 4 compound 13, following the synthesis of intermediate F2 step 4 and 5). Instrument SFC-150mgm, column: YMC Cellulose-SC (20*250 mm, 5 um), temperature: 30 °C, Mobile phase: CO2/IPA[0.5%NH3(7M in MeOH)]=95/5, Flow rate: 40 ml/min, Back pressure: 100 bar. Peak 1 = 0.89 min, Peak 2 = 1.09 min The enantiomeric excess was calculated on UPCC (Waters), Column: YMC Cellulose-SC (4.6*100mm 3um), Temperature: 40 °C, Mobile phase: CO ₂ /IPA [1.0% NH ₃ (7M in MeOH)] = 90/10, Flow rate: 3 mL/min. Both enantiomers have an enantiomeric excess >98% ee. Intermediate F13 and F14: (R)-7-(4-bromo-1H-pyrazol-1-yl)-4-methyl-4-azaspiro[2.5]octa ne and (S)-7-(4-bromo-1H-pyrazol-1-yl)-4-methyl-4-azaspiro[2.5]octa ne (R)-7-(4-bromo-1H-pyrazol-1-yl)-4-methyl-4-azaspiro[2.5]octa ne and (S)-7-(4-bromo-1H- pyrazol-1-yl)-4-methyl-4-azaspiro[2.5]octane were obtained by chiral HPLC purification of the racemic 7-(4-bromo-1H-pyrazol-1-yl)-4-methyl-4-azaspiro[2.5]octane (intermediate F2). Column：CHIRALCEL® AD-H; Column size: 21.2 ×250 mm, 5 μm; mobile phase : n- Hexane/Ethanol/Dietylamine= 70/30/0.1 (v/v/v); flow rate: 20 mL/min; temperature: 35℃. The enantiomeric excess was calculated :CHIRALCEL®AD-H, column size: 0.46 cm I.D. ×25 cm L ×5 μm, injection : 5μL, mobile phase : n-Hexane/Ethanol/Dietylamine = 70/30/0.1 (v/v/v), flow rate : 1.0 mL/min, sample solution:1.1 mg/mL in MeOH/EtOH = 1/1 (v/v). Peak 1 = 4.72 min, Peak 2 = 9.64 min. Both enantiomers have an enantiomeric excess >99% ee.

General procedure A2 for the Sonogashira reaction between intermediate A1B1 and alkynes To a solution of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (1 eq.), CuI (1 eq.), Et ₃ N (3 eq) and the alkyne (2 eq) in degassed DMF (0.2 M) was added Pd(dppf)Cl ₂ (0.1 eq) and the mixture was stirred at 130 °C under MW for 1h, or until reaction completion as checked by TLC. The mixture was concentrated under reduced pressure and the residue was purified by column chromatography (DCM/MeOH) or prep-TLC to give the title compound as a yellow solid. The following compounds were prepared following the General procedure A2

General procedure A3 for the Suzuki reaction between intermediate A2B1 and boronate esters A mixture of (S)-N-(4-(4-amino-7-iodo-1-isopropyl-1H-pyrazolo[4,3-c]pyrid in-3-yl)-2-(1-(4- fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfonamide (1 eq), boronate ester (1.1 eq), Na ₂ CO ₃ (3 eq) and Pd(dppf)Cl ₂ (0.1 eq) in degassed 1,4-dioxane/H ₂ O (4/1, 0.2 M) was stirred at 100 ^o C overnight under N ₂ . The mixture was diluted with water and the organics were extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH) to give the title product as a yellow solid. The following compounds were prepared following the General procedure A3

General procedure A4 for the Suzuki reaction between intermediate A3B1 and boronate esters A mixture of (S)-N-(4-(4-amino-7-bromopyrazolo[1,5-a]pyrazin-3-yl)-2-(1-( 4- fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfonamide (1 eq), boronate ester (1.1 eq), Na ₂ CO ₃ (3 eq) and Pd(dppf)Cl ₂ (0.1 eq) in degassed 1,4-dioxane/H ₂ O (4/1, 0.2 M) was stirred at 100 °C overnight under N ₂ . The mixture was diluted with water and the organics were extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH or PE/EtOAc) to give the title product as a yellow solid. The following compounds were prepared following the General procedure A4

Compounds 79 and 80 Step 1: tert-butyl 4-(2-{4-amino-3-[4-(difluoromethanesulfonamido)-3-[(1S)-1-(4 - fluorophenyl)ethoxy]phenyl]-1-methyl-1H-pyrazolo[4,3-c]pyrid in-7-yl}ethynyl)piperidine-1- carboxylate Following general procedure A2 with tert-butyl 4-ethynylpiperidine-1-carboxylate, the title compound (88%) was obtained as a yellow solid. Step 2: (S)-N-(4-(4-amino-1-methyl-7-(piperidin-4-ylethynyl)-1H-pyra zolo[4,3-c]pyridin-3-yl)- 2-(1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfo namide (Compound 79) To a solution of tert-butyl 4-(2-{4-amino-3-[4-(difluoromethanesulfonamido)-3-[(1S)-1-(4 - fluorophenyl)ethoxy]phenyl]-1-methyl-1H-pyrazolo[4,3-c]pyrid in-7-yl}ethynyl)piperidine-1- carboxylate (300 mg, 429 μmol) in HCO ₂ H (2 mL) was stirred at RT for 1 h. The reaction mixture was concentrated under reduced pressure and the residue was adjusted to pH=8 with sat. aq. Na ₂ CO ₃ . The residue was diluted with water (5 mL) and the organics were extracted with EtOAc (3 x 5 mL). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH: 95/5) to give the title product (140 mg, 54%) as a white solid. LCMS (Method A): 2.83 min, m/z 599.1 [MH] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.80 (s, 1H), 7.64-7.53 (m, 1H), 7.50 (q, J = 4 Hz, 2H), 7.34 (d, J = 8 Hz, 1H), 7.12 (t, J = 8 Hz, 1H), 6.90 (d, J = 8 Hz, 1H), 7.18-7.10 (m, 1H), 6.84 (s, 1H), 6.33 (t, J = 52 Hz, 1H), 6.00 (s, 2H), 5.63 (q, J = 8 Hz, 1H), 4.15 (s, 3H), 3.23 (s, 2H), 3.00 (s, 3H), 2.04 (s, 2H), 1.76 (s, 2H), 1.50 (d, J = 6.2 Hz, 3H) Step 3: (S)-N-(4-(4-amino-1-methyl-7-((1-methylpiperidin-4-yl)ethyny l)-1H-pyrazolo[4,3- c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difl uoromethanesulfonamide (Compound 80) To a solution of N-(4-{4-amino-1-methyl-7-[2-(piperidin-4-yl)ethynyl]-1H-pyra zolo[4,3- c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)ethoxy]phenyl)-1,1 -difluoromethanesulfonamide (120 mg, 0.2 mmol) in DCM (10 mL) were added paraformaldehyde (11.9 mg, 0.4 mmol) and NaBH(OAc) ₃ (127 mg, 0.6 mmol), and the reaction mixture was stirred at RT overnight. The mixture was concentrated under reduced pressure and the residue was purified by prep-TLC (MeOH/DCM: 1/20) to give the title compound (40 mg, 32%) as a yellow solid. LCMS (Method A): 2.80 min, m/z 613.3 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 10.96 (s, 1H), 7.88 (s, 1H), 7.57 (q, J = 4 Hz, 2H), 7.40 (d, J = 8 Hz, 1H), 7.18-7.10 (m, 4H), 7.13 (t, J = 52 Hz, 1H), 6.11 (s, 2H), 5.65 (q, J = 4 Hz, 1H), 4.22 (s, 3H), 3.16 (s, 2H), 2.89 (s, 1H), 2.70 (s, 3H), 2.18-1.98 (m, 4H), 1.57 (d, J = 6.2 Hz, 3H), 1.23 (s, 2H). Compound 91: (S)-N-(4-(4-amino-1-methyl-7-(5-methyl-4,5,6,7-tetrahydropyr azolo[1,5- a]pyrazin-3-yl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluo rophenyl)ethoxy)phenyl)-1,1- difluoromethanesulfonamide Step 1: (S)-N-(4-(4-amino-1-methyl-7-(5-methyl-4,5,6,7-tetrahydropyr azolo[1,5-a]pyrazin-3- yl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)eth oxy)phenyl)-1,1- difluoromethanesulfonamide To a solution of (S)-N-(4-(4-amino-1-methyl-7-(4,5,6,7-tetrahydropyrazolo[1,5 -a]pyrazin-3-yl)- 1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy) phenyl)-1,1- difluoromethanesulfonamide (Compound 90, 34 mg, 55.4 µmol) in DCM (5 mL) were added paraformaldehyde (5.37 mg, 66.4 µmol) and NaBH(OAc) ₃ (58.7 mg, 277 µmol). The reaction mixture was stirred at RT for 45 min before sat. aq. NaHCO ₃ (10 mL) was added, and the aqueous layer was extracted with EtOAc (3 x 10 mL). The combined organics were concentrated under reduced pressure and the residue was purified by silica gel column chromatography (DCM:MeOH; 10:1) to give the title compound (10 mg, 29%) as a yellow solid. LCMS (Method B): 2.85 min; m/z: 627.2 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.60 (s, 1H), 7.53 (d, J = 8.1 Hz, 1H), 7.48 (dd, J = 8.4, 5.4 Hz, 3H), 7.16 (d, J = 8.1 Hz, 1H), 7.10-7.02 (m, 3H), 5.56 (q, J = 6.2 Hz, 1H), 4.29 (t, J = 5.5 Hz, 2H), 3.70 (s, 3H), 3.57 (s, 2H), 3.04 (t, J = 5.4 Hz, 2H), 2.48 (s, 3H), 1.69 (d, J = 6.3 Hz, 3H). The following compounds were prepared similarly to compound 91 Compound 54 and Compound 55 Step 1: (S)-N-(4-(4-amino-1-methyl-7-(1,2,5,6-tetrahydropyridin-3-yl )-1H-pyrazolo[4,3- c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difl uoromethanesulfonamide (Compound 54) To a solution of tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6- dihydropyridine- 1(2H)-carboxylate (1 g, 3.23 mmol) in 1,4-dioxane (15 mL) was added a 2M HCl in dioxane (10 mL) and the mixture was stirred at RT for 10 min. The solution was concentrated under reduced pressure to give a white solid. The solids were dissolved in degassed 1,4- dioxane/H ₂ O (4/1, 10 mL) and (S)-N-(4-(4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin- 3-yl)-2-(1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difluoromethan esulfonamide (700 mg, 1.13 mmol), Na ₂ CO ₃ (358 mg, 3.38 mmol) and Pd(dppf)Cl ₂ (92.2 mg, 113 µmol) were added. The solution was then stirred at 100 ^o C for 12 h. The reaction mixture was concentrated under reduced pressure, and the residue was poured into water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organics were dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH = 10/1) to give the title product (300 mg, 46%) as a brown solid. LCMS (Method A): 2.63 min, m/z: 573.2 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 10.85 (s, 1H), 7.54 (dd, J = 8.7, 5.6 Hz, 2H), 7.48 (s, 1H), 7.37 (d, J = 8.1 Hz, 1H), 7.15 (t, J = 8.9 Hz, 2H), 7.06-6.98 (m, 2H), 5.87 (s, 1H), 5.64 (q, J = 6.3 Hz, 1H), 3.97 (s, 3H), 3.52 (s, 2H), 2.99 (s, 2H), 2.61 (s, 3H), 2.47 (s, 2H), 1.55 (d, J = 6.3 Hz, 3H). Step 2: (S)-N-(4-(4-amino-1-methyl-7-(1-methyl-1,2,5,6-tetrahydropyr idin-3-yl)-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phe nyl)-1,1- difluoromethanesulfonamide (Compound 55) A mixture of (S)-N-(4-(4-amino-1-methyl-7-(1,2,5,6-tetrahydropyridin-3-yl )-1H-pyrazolo[4,3- c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difl uoromethanesulfonamide (20 mg, 34.9 µmol) and paraformaldehyde (20.8 mg, 348 µmol) in MeOH (3 mL) was stirred at RT for 12 h. NaBH ₃ (CN) (8.73 mg, 139 µmol) was added and the mixture was stirred at RT for 20 min. The rection mixture was poured into water (40 mL) and the organics were extracted with EtOAc (2 x 40 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 15/1) to give the title product (10.0 mg, 49%) as a brown solid. LCMS (Method A): 3.73 min, m/z: 611.2 [M+Na] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 10.85 (s, 1H), 7.54 (dd, J = 8.7, 5.6 Hz, 2H), 7.48 (s, 1H), 7.37 (d, J = 8.1 Hz, 1H), 7.15 (t, J = 8.9 Hz, 2H), 7.06-6.98 (m, 2H), 5.87 (s, 1H), 5.64 (q, J = 6.3 Hz, 1H), 3.97 (s, 3H), 3.52 (s, 2H), 2.99 (s, 2H), 2.61 (s, 3H), 2.47 (s, 2H), 1.55 (d, J = 6.3 Hz, 3H). Compound 42: (S)-N-(4-(4-amino-1-methyl-7-(1-methylpiperidin-4-yl)-1H-pyr azolo[4,3- c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difl uoromethanesulfonamide Step 1: (S)-N-(4-(4-amino-1-methyl-7-(1-methylpiperidin-4-yl)-1H-pyr azolo[4,3-c]pyridin-3-yl)- 2-(1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfo namide A mixture of (S)-N-(4-(4-amino-1-methyl-7-(1-methyl-1,2,3,6-tetrahydropyr idin-4-yl)-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phe nyl)-1,1- difluoromethanesulfonamide (90 mg, 153 µmol), NaBH ₄ (11.5 mg, 306 µmol) and AcOH (27.5 mg, 459 µmol) in THF (10 mL) was stirred at 45 °C overnight. HCl (1 M, 5 mL) was added, and the reaction mixture was stirred for 5 min. The reaction mixture was adjusted to pH = 8 with sat. aq. Na ₂ CO ₃ and the organics were extracted with EtOAc (2 x 30 mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated. The residue was purified by prep- TLC (DCM/MeOH = 15/1) to give the title product (7 mg, 7%) as a white solid. LCMS (Method A): 3.30 min, m/z 589.2 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCl ₃ ): 7.86 (s, 1H), 7.69 (d, J = 8.2 Hz, 1H), 7.34-7.29 (m, 2H), 7.15 (d, J = 8.2 Hz, 1H), 7.08 (t, J = 8.6 Hz, 2H), 6.92 (s, 1H), 6.35 (t, J = 53.6 Hz, 1H), 5.72 (s, 2H), 5.43 (q, J = 6.1 Hz, 1H), 4.21 (s, 3H), 3.26 (d, J = 8.1 Hz, 2H), 2.99 (s, 2H), 2.74 (s, 3H), 2.22 (d, J = 15.3 Hz, 1H), 2.00 (s, 2H), 1.82 (s, 2H), 1.70 (d, J = 6.4 Hz, 3H). Compound 40: (S)-N-(4-(4-amino-1-methyl-7-(pyrimidin-4-yl)-1H-pyrazolo[4, 3-c]pyridin-3- yl)-2-(1-(4-fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanes ulfonamide Step 1: (S)-N-(4-(4-amino-1-methyl-7-(pyrimidin-4-yl)-1H-pyrazolo[4, 3-c]pyridin-3-yl)-2-(1-(4- fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfonamide To a solution of (S)-N-(4-(4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin- 3-yl)-2-(1-(4- fluorophenyl)ethoxy)phenyl)-1,1-difluoromethanesulfonamide (70 mg, 113 μmol) in degassed MePh (2 mL) were added Pd(PPh ₃ ) ₄ (13.0 mg, 11.3 μmol), KF (32.8 mg, 565 μmol) and 4- (tributylstannyl)pyrimidine (41.7 mg, 113 μmol), and the mixture was stirred at 130 °C with μW irradiation for 2 h. The mixture was concentrated under reduced pressure and the residue was purified by Prep TLC (DCM/MeOH = 40/1) to give the title product (7.0 mg, 11%) as a yellow solid. LCMS (method C): 3.30 min, m/z 570.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCl ₃ ): 9.30 (s, 1H), 8.81 (d, J = 5.2Hz, 1H), 7.92 (s, 1H), 7.68 (d, J = 8.4Hz, 1H), 7.59 (d, J = 4.4 Hz,1H), 7.32 (q, J = 4.4 Hz, 2H), 7.21 (dd, J = 8.4, 1.6 Hz, 1H), 7.07-7.02 (m, 3H), 6.35 (t, J = 53.6 Hz, 1H), 5.47 (q, J = 6.4 Hz, 1H), 5.13 (s, 2H), 3.95 (s, 3H), 1.69 (d, J = 6.4Hz, 3H). Compound 109: (S)-N-(4-(7-(1-(1-acetylpiperidin-4-yl)-1H-pyrazol-4-yl)-4-a mino-1-methyl- 1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy) phenyl)-1,1- difluoromethanesulfonamide Step 1: (S)-N-(4-(7-(1-(1-acetylpiperidin-4-yl)-1H-pyrazol-4-yl)-4-a mino-1-methyl-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phe nyl)-1,1- difluoromethanesulfonamide To a solution of compound 59 (150 mg, 234 μmol) and Et ₃ N (70.9 mg, 702 μmol) in DCM (10 mL) was added AcCl (18.3 mg, 234 μmol). The reaction mixture was stirred at RT for 10 min. The mixture was concentrated under reduced pressure and the residue was purified by prep- TLC (DCM:MeOH; 20:1) to give the title product (80.0 mg, 50%) as a yellow solid. LCMS (Method A) 2.88 min; m/z 683.2 [M+H] ⁺ . ¹ H NMR (400MHz, DMSO-d ₆ ): 7.99 (s, 1H), 7.61 (s, 1H), 7.59-7.55 (m, 3H), 7.43-7.41 (d, J = 8 Hz, 1H), 7.18-7.14 (m, 4H), 6.99 (t, J = 52 Hz, 1H), 5.82 (s, 2H), 5.66 (q, J = 4 Hz, 1H), 4.55-4.44 (m, 2H), 3.70 (s, 3H), 2.80-2.74 (m, 1H), 2.15- 2.11 (m, 2H), 2.05 (s, 3H),1.99-1.80 (m, 2H), 1.60 (d, J = 8 Hz, 3H). Compound 89: (S)-N-(4-(4-amino-7-(1-(1-(aminomethyl)cyclopropyl)-1H-pyraz ol-4-yl)-1- methyl-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl) ethoxy)phenyl)-1,1- difluoromethanesulfonamide Step 1: (S)-N-(4-(4-amino-7-(1-(1-(aminomethyl)cyclopropyl)-1H-pyraz ol-4-yl)-1-methyl-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phe nyl)-1,1- difluoromethanesulfonamide To a 0 °C solution of N-(4-{4-amino-7-[1-(1-cyanocyclopropyl)-1H-pyrazol-4-yl]-1-m ethyl-1H- pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)ethox y]phenyl)-1,1- difluoromethanesulfonamide 96 (30 mg, 48.1 µmol) in dry THF (2 mL) was added LiAlH ₄ (3.65 mg, 96.2 µmol). The reaction mixture was stirred at RT for 1 h under N ₂ , then concentrated under reduced pressure. The residue was purified by prep-TLC (DCM:MeOH; 98:2) to give the title product (15.0 mg, 50%) as yellow solid. LCMS (Method E): 0.34 min, m/z: 627.3 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.99 (s,1H), 7.71 (s, 1H), 7.53-7.49 (m, 3H), 7.36-7.34 (m, 1H), 7.13 (t, J = 8.4 Hz, 2H), 6.95-6.87 (m, 2H), 6.40 (t, J = 14.4 Hz, 1H), 5.65 (brs, 3H), 3.72 (s, 3H), 3.27 (s, 2H), 1.52-1.23 (m, 7H). Compound 141: N-{4-[4-amino-1-methyl-7-(morpholin-4-yl)-1H-pyrazolo[4,3-c] pyridin-3-yl]- 2-[(1S)-1-(4-fluorophenyl)ethoxy]phenyl}-1,1-difluoromethane sulfonamide Step 1: N-{4-[4-amino-1-methyl-7-(morpholin-4-yl)-1H-pyrazolo[4,3-c] pyridin-3-yl]-2-[(1S)-1- (4-fluorophenyl)ethoxy]phenyl}-1,1-difluoromethanesulfonamid e A mixture of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (300 mg, 485 μmol), morpholine (422 mg, 4.85 mmol) and K ₂ CO ₃ (200 mg, 1.45 mmol) in ethylene glycol (3 mL) was stirred at 130 °C overnight. The reaction mixture was concentrated under reduced pressure and the crude mixture was purified by Prep-TLC (DCM/MeOH: 99/1) to give the title compound (8 mg, 3%) as a yellow solid. LCMS (Method A): 3.04 min, m/z: 577.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCl ₃ ): 7.67 (d, J = 8.2 Hz, 1H), 7.50 (s, 1H), 7.35-7.29 (m, 2H), 7.16 (dd, J = 8.2, 1.8 Hz, 1H), 7.07-6.99 (m, 3H), 6.35 (t, J = 53.6 Hz, 1H), 5.83 (s, 2H), 5.46 (q, J = 6.3 Hz, 1H), 4.35 (s, 3H), 3.97 (d, J = 9.4 Hz, 2H), 3.82-3.67 (m, 2H), 3.00 (d, J = 16.7 Hz, 4H), 1.68 (d, J = 6.4 Hz, 3H). Compound 133: N-(4-{4-amino-7-cyano-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-y l}-2-[(1S)-1- (4-fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamid e Step 1: N-(4-{4-amino-7-cyano-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-y l}-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide A mixture of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (50 mg, 80.9 μmol), CuI (15.4 mg, 80.9 μmol) and Zn(CN) ₂ (9.49 mg, 80.9 μmol) in NMP (4 mL) was stirred at 130 °C under N ₂ overnight. The reaction was poured into EtOAc (20 mL), then the organics were washed with water (20 mL x 3) and brine (10 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by Prep-TLC (DCM/MeOH = 15/1) to give the title product (7 mg, 17%) as a brown solid. LCMS (Method A): 3.69 min, m/z 517.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCl ₃ ): 8.21 (s, 1H), 7.70 (d, J = 8.5 Hz, 1H), 7.32 (t, J = 6.9 Hz, 2H), 7.18 (d, J = 8.5 Hz, 1H), 7.06 (t, J = 8.4 Hz, 2H), 7.01 (s, 1H), 6.35 (t, J = 52 Hz, 1H), 5.47 (q, J = 6.6 Hz, 1H), 5.30 (s, 2H), 4.27 (s, 3H), 1.71 (d, J = 6.4 Hz, 3H). Compound 44: (S)-N-(4-(4-amino-1-methyl-7-(1-(tetrahydro-2H-pyran-4-yl)-1 H-pyrazol-4-yl)- 1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy) phenyl)-2,2,2-trifluoroethane-1- sulfonamide Step 1: (S)-3-(3-(1-(4-fluorophenyl)ethoxy)-4-nitrophenyl)-1-methyl- 1H-pyrazolo[4,3- c]pyridin-4-amine A mixture of 3-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-4-amine (4 g, 14.5 mmol), (S)-2-(3-(1- (4-fluorophenyl)ethoxy)-4-nitrophenyl)-4,4,5,5-tetramethyl-1 ,3,2-dioxaborolane (5.61 g, 14.5 mmol), K2CO3 (6.01 g, 43.5 mmol) and Pd(dppf)Cl2 (1.18 g, 1.45 mmol) in degassed 1,4- dioxane/H ₂ O (4/1, 125 mL) was stirred at 100 °C for 10 h under N ₂ . The mixture was concentrated under reduced pressure and the residue was purified by column chromatography (PE/EtOAc = 4:1 to 1:4) to give the title product (5.2 g, 88%) as a yellow solid. LCMS (Method A): 3.31 min, m/z: 408.4 [M+H] ⁺ . Step 2: (S)-3-(3-(1-(4-fluorophenyl)ethoxy)-4-nitrophenyl)-7-iodo-1- methyl-1H-pyrazolo[4,3- c]pyridin-4-amine A mixture of (S)-3-(3-(1-(4-fluorophenyl)ethoxy)-4-nitrophenyl)-1-methyl- 1H-pyrazolo[4,3- c]pyridin-4-amine (2.5 g, 6.13 mmol) and NIS (2.74 g, 12.2 mmol) in DMF (50 mL) was stirred at 85 °C for 6 h under N ₂ . The mixture was concentrated under reduced pressure and the residue was purified by column chromatography (PE/EtOAc = 4:1 to 1:4) to give the title product (1.1 g, 33%) as a yellow solid. LCMS (Method A): 3.51 min, m/z: 534.3 [M+H] ⁺ . Step 3: (S)-3-(3-(1-(4-fluorophenyl)ethoxy)-4-nitrophenyl)-1-methyl- 7-(1-(tetrahydro-2H- pyran-4-yl)-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-4-ami ne A mixture of (S)-3-(3-(1-(4-fluorophenyl)ethoxy)-4-nitrophenyl)-7-iodo-1- methyl-1H- pyrazolo[4,3-c]pyridin-4-amine (1.1 g, 2.06 mmol), 1-(tetrahydro-2H-pyran-4-yl)-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (573 mg, 2.06 mmol), K ₂ CO ₃ (854 mg, 6.18 mmol) and Pd(dppf)Cl ₂ (168 mg, 206 µmol) in 1,4-dioxane/H ₂ O (4/1, 25 mL) was stirred at 100 °C for 10 h under N ₂ . The mixture was concentrated under reduced pressure and the residue was purified was purified by column chromatography (PE/EtOAc = 4:1 to 1:4) to give the title product (0.9 g, 76%) as a yellow solid. LCMS (Method A): 3.10 min, m/z: 558.6 [M+H] ⁺ . Step 4: (S)-3-(4-amino-3-(1-(4-fluorophenyl)ethoxy)phenyl)-1-methyl- 7-(1-(tetrahydro-2H- pyran-4-yl)-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-4-ami ne A mixture of (S)-3-(3-(1-(4-fluorophenyl)ethoxy)-4-nitrophenyl)-1-methyl- 7-(1-(tetrahydro-2H- pyran-4-yl)-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-4-ami ne (0.9 g, 1.61 mmol) and Zn dust (525 mg, 8.04 mmol) in MeOH (18 mL) and sat. aq. NH4Cl (6 mL) was stirred at 60 °C for 8 h. The mixture was poured into water (20 mL) and the organics were extracted with DCM (2 x 10 mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 1:4 to 1:10) to give the title product (330 mg 39%) as a white solid. LCMS (Method A): 2.85 min, m/z: 528.6 [M+H] ⁺ . Step 5: (S)-N-(4-(4-amino-1-methyl-7-(1-(tetrahydro-2H-pyran-4-yl)-1 H-pyrazol-4-yl)-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)ethoxy)phe nyl)-2,2,2-trifluoroethane-1- sulfonamide A solution of (S)-3-(4-amino-3-(1-(4-fluorophenyl)ethoxy)phenyl)-1-methyl- 7-(1-(tetrahydro- 2H-pyran-4-yl)-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-4- amine (100 mg, 189 µmol) and 2,2,2-trifluoroethanesulfonyl chloride (51.6 mg, 283 µmol) in DCM (2.5 mL) and pyridine (0.5 mL) was stirred at 35 °C for 10 h. The mixture was concentrated under reduced pressure and the residue was purified by column chromatography (DCM/MeOH = 20/1) to give the title product (7 mg, 6%) as a white solid. LCMS (Method A): 3.17 min, m/z: 674.7 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCl ₃ ): 7.71 (d, J = 8.2 Hz, 1H), 7.62 (s, 1H), 7.58 (s, 1H), 7.54 (s, 1H), 7.36-7.28 (m, 2H), 7.25-7.20 (m, 1H), 7.11-7.00 (m, 3H), 5.47 (q, J = 6.4 Hz, 1H), 4.43 (tt, J = 10.4, 4.8 Hz, 1H), 4.15 (dt, J = 11.8, 3.1 Hz, 2H), 3.92 (q, J = 8.7 Hz, 2H), 3.77 (s, 3H), 3.59 (td, J = 11.6, 2.8 Hz, 2H), 2.26-2.09 (m, 4H), 1.69 (d, J = 6.4 Hz, 3H). The following compounds were prepared similarly to the synthesis of (S)-N-(4-(4-amino-1- methyl-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-1H-p yrazolo[4,3-c]pyridin-3-yl)-2-(1- (4-fluorophenyl)ethoxy)phenyl)-2,2,2-trifluoroethane-1-sulfo namide (compound 44) with the indicated sulfonyl chloride in step 5.

General procedure FA for the cross coupling reaction between intermediate A1B1 and halogenopyrazoles F A mixture of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (1 eq), halogenopyrazole (1.0 eq), B ₂ (pin) ₂ (2 eq), Pd(OAc) ₂ (0.2 eq) bis(adamantan-1-yl)(butyl)phosphane (0.4 eq) and K ₂ CO ₃ (2 eq) were dissolved in degassed 1,4-dioxane/H ₂ O (4/1, 0.2 M) and the solution was stirred at 100 °C under N ₂ overnight (or at 80 °C for 2 h under μW irradiation). The mixture was diluted with water and extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH or EtOAc/PE) or prep TLC (DCM/MeOH) The following compounds were prepared following the General procedure FA

General procedure FB for the Cross coupling reaction followed by acidic deprotection between intermediate A1B1 and Boc protected halogenopyrazoles F A mixture of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (1 eq), halogenopyrazole (1.0 eq), B ₂ (pin) ₂ (2 eq), Pd(OAc) ₂ (0.2 eq) bis(adamantan-1-yl)(butyl)phosphane (0.4 eq) and K ₂ CO ₃ (2 eq) were dissolved in degassed 1,4-dioxane/H ₂ O (4/1, 0.2 M) and the solution was stirred at 100 °C under N ₂ overnight (or at 80 °C for 2 h under μW irradiation). The mixture was diluted with water and extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH or EtOAc/PE) or prep-TLC (DCM/MeOH) The solids were dissolved in HCOOH neat (2 M) and the reaction mixture was stirred at RT for 30 min or until completion. The reaction mixture was concentrated under reduced pressure and the residue was adjusted to pH=8 with sat. aq. Na2CO3. The residue was further diluted with water and the organics were extracted with EtOAc (3 times). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH) followed by preparative HPLC (neutral condition method C) if needed to give the desired products The following compounds were prepared following the General procedure FB

Compound 120: N-(4-{4-amino-7-[1-(3,3-difluorocyclopentyl)-1H-pyrazol-4-yl ]-1-methyl-1H- pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)ethox y]phenyl)-1,1- difluoromethanesulfonamide Step 1: 3-(4-iodo-1H-pyrazol-1-yl)cyclopentan-1-one To a mixture of 4-iodo-1H-pyrazole (500 mg, 2.57 mmol) and cyclopent-2-en-1-one (316 mg, 3.85 mmol) in DCM (10 mL) was added ScCl ₃ (77.7 mg, 514 µmol). The reaction mixture was stirred at RT for 4 h. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (PE/EtOAc 95/5 to 20/80) to give the title product (657 mg, 93%) as a clear oil. LCMS (Method A): 3.21 min, m/z 277.0 [M+H] ⁺ Step 2: 1-(3,3-difluorocyclopentyl)-4-iodo-1H-pyrazole To a 0 °C solution of 3-(4-iodo-1H-pyrazol-1-yl)cyclopentan-1-one (1.43 g, 5.17 mmol) in anhydrous DCM (10 mL) was added DAST (2.49 g, 15.5 mmol) in a dropwise manner, and the reaction mixture was allowed to warm to RT and stirred overnight under N ₂ . The reaction mixture was quenched with 1.5 M KH ₂ PO ₄ (10mL) and the organics were extracted 3 times with EtOAc. The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE/EtOAc 95/5 to 20/80) to give the title product (978 mg, 63%) as a clear oil. Step 3: N-(4-{4-amino-7-[1-(3,3-difluorocyclopentyl)-1H-pyrazol-4-yl ]-1-methyl-1H- pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)ethox y]phenyl)-1,1- difluoromethanesulfonamide A mixture of 1-(3,3-difluorocyclopentyl)-4-iodo-1H-pyrazole (47.9 mg, 161 µmol), N-(4-{4- amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S )-1-(4-fluorophenyl)ethoxy] phenyl)-1,1-difluoromethanesulfonamide (1 eq), Pd(OAc) ₂ (3.61 mg, 16.1 µmol), K ₂ CO ₃ (22.2 mg, 161 µmol), Butyldi-1-adamantylphosphine (11.5 mg, 32.3 µmol) and B ₂ Pin ₂ (40.8 mg, 161 µmol) in degassed 1,4-dioxane (4 mL) and H ₂ O (1 mL) was heated at 100 °C for 12 h under N ₂ . The solvents were evaporated, and the residue was purified by silica gel column chromatography (PE/EtOAc 80/20 to 20/80) to give the title product (5.00 mg, 9%) as a yellow solid. LCMS (Method A): 3.86 min, m/z 662.0 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 8.03 (s, 1H), 7.66 (s, 1H), 7.60-7.55 (m, 2H), 7.54 (d, J = 1.7 Hz, 1H), 7.40 (d, J = 8.0 Hz, 1H), 7.20-7.10 (m, 4H), 7.10-6.85 (m, 1H), 5.75 (s, 2H), 5.65 (q, J = 6.3 Hz, 1H), 5.00 (p, J = 7.4 Hz, 1H), 2.80-2.70 (m, 1H), 2.64 (dd, J = 15.7, 7.5 Hz, 1H), 2.37 (dddd, J = 19.1, 9.7, 6.0, 4.0 Hz, 2H), 2.28-2.16 (m, 2H), 1.58 (d, J = 6.3 Hz, 3H). Compound 113: N-(4-(4-amino-1-methyl-7-(1-(1,2,2-trimethylpiperidin-4-yl)- 1H-pyrazol-4- yl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-((S)-1-(4-fluorophenyl )ethoxy)phenyl)-1,1- difluoromethanesulfonamide Step 1: tert-butyl 4-hydroxy-2,2-dimethylpiperidine-1-carboxylate To a solution of tert-butyl 2,2-dimethyl-4-oxopiperidine-1-carboxylate (1 g, 4.39 mmol) in MeOH (20 mL) was added NaBH ₄ (495 mg, 13.1 mmol). The reaction mixture was stirred at RT overnight. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (PE/EtOAc: 90/10 to 10/90) to give the title product (740 mg) as yellow oil. Step 2: tert-butyl 4-(methanesulfonyloxy)-2,2-dimethylpiperidine-1-carboxylate To a solution of tert-butyl 4-hydroxy-2,2-dimethylpiperidine-1-carboxylate (740 mg, 3.22mmol) in DCM (5 mL) were added Et ₃ N (764 mg, 9.66 mmol) and MsCl (553 mg, 4.83mmol). The mixture was stirred at RT for 16 h. The mixture was poured into water (20 mL) and the organics were extracted with EtOAc (3 x 50 mL). The combined organics were washed with brine (50 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (900 mg, 2.92 mmol) as a colourless oil. Used as crude in the next step. LCMS (Method A): 3.96 min, m/z 674.4 [M+H] ⁺ Step 3: tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)-2,2-dimethylpiperidine-1-carboxy late A mixture of tert-butyl 4-(methanesulfonyloxy)-2,2-dimethylpiperidine-1-carboxylate (900 mg, 2.92 mmol), 4-bromo-1H-pyrazole (557 mg, 3.79 mmol) and Cs ₂ CO ₃ (2.84 g, 8.76 mmol) in DMF (20 mL) was stirred at 100 °C overnight. The mixture was poured into water (50 mL) and the organics were extracted with EtOAc (50 mL x 2). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by prep-TLC (PE/EtOAc; 10/1) to give the title product (420 mg, 40 %) as a white solid. Step 4: tert-butyl 4-(4-(4-amino-3-(4-((difluoromethyl)sulfonamido)-3-((S)-1-(4 - fluorophenyl)ethoxy)phenyl)-1-methyl-1H-pyrazolo[4,3-c]pyrid in-7-yl)-1H-pyrazol-1-yl)-2,2- dimethylpiperidine-1-carboxylate To a mixture of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (344 mg, 558 µmol) and tert- butyl 4-(4-bromo-1H-pyrazol-1-yl)-2,2-dimethylpiperidine-1-carboxy late (200 mg, 558 µmol) in degassed 1,4-dioxane (8 mL) and H ₂ O (2 mL) were added Pd(OAc) ₂ (24.9 mg, 111 µmol), K ₂ CO ₃ (153 mg, 1.11 mmol), butyldi-1-adamantylphosphine (79.9 mg, 223 µmol) and B ₂ pin ₂ (281 mg, 1.11 mmol). The mixture was stirred at 100 ^o C for 12 h under N ₂ . The mixture was poured into water (50 mL) and the organics were extracted with EtOAc (50 mL x 2). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (DCM/MeOH = 95/5) to give the title product (170 mg, 39%) as a yellow solid. LCMS (Method A): 3.57 min, m/z 769.1 [M+H] ⁺ Step 5: N-(4-(4-amino-7-(1-(2,2-dimethylpiperidin-4-yl)-1H-pyrazol-4 -yl)-1-methyl-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-((S)-1-(4-fluorophenyl)ethoxy )phenyl)-1,1- difluoromethanesulfonamide A solution of tert-butyl 4-(4-{4-amino-3-[4-(difluoromethanesulfonamido)-3-[(1S)-1-(4 - fluorophenyl)ethoxy]phenyl]-1-methyl-1H-pyrazolo[4,3-c]pyrid in-7-yl}-1H-pyrazol-1-yl)-2,2- dimethylpiperidine-1-carboxylate (150 mg, 195 μmol) in HCOOH (3 mL) was stirred at RT for 4 h under N ₂ . The mixture was adjusted to pH=8 with the addition of sat. aq. Na ₂ CO ₃ and concentrated under reduced pressure. The solids were washed with EtOAc (2 x 5 mL) and dried under reduced pressure to give the title product (120 mg, 92%) as a white solid. LCMS (Method A): 2.73 min, m/z 670.1 [M+H] ⁺ Step 6: N-(4-(4-amino-1-methyl-7-(1-(1,2,2-trimethylpiperidin-4-yl)- 1H-pyrazol-4-yl)-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-((S)-1-(4-fluorophenyl)ethoxy )phenyl)-1,1- difluoromethanesulfonamide A mixture of N-(4-{4-amino-7-[1-(2,2-dimethylpiperidin-4-yl)-1H-pyrazol-4 -yl]-1-methyl-1H- pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)ethox y]phenyl)-1,1- difluoromethanesulfonamide (120 mg, 179.4 μmol), paraformaldehyde (72.7 mg, 897 µmol) and NaBH(OAc) ₃ (190 mg, 897 µmol) in MeOH (5 mL) was stirred at RT for 45 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (DCM/MeOH; 95/5) to give the title product (30 mg, 25%) as a yellow solid. LCMS (Method A): 2.88 min, m/z 683.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.93 (s, 1H), 7.62 (s, 1H), 7.56-7.50 (m, 2H), 7.50 (d, J = 1.5 Hz, 1H), 7.36 (d, J = 8.1 Hz, 1H), 7.18- 7.12 (m, 2H), 7.01 (dd, J = 8.1, 1.9 Hz, 1H), 6.96 (d, J = 1.9 Hz, 1H), 6.65 (s, 1H), 5.66 (s, 2H), 5.64 (d, J = 6.3 Hz, 1H), 4.58 (dd, J = 10.9, 5.4 Hz, 1H), 3.67 (s, 3H), 3.13-3.02 (m, 3H), 2.19- 2.11 (m, 2H), 2.10-2.07 (m, 1H), 2.04-1.92 (m, 1H), 1.54 (d, J = 6.3 Hz, 3H), 1.29 (s, 3H), 1.24 (s, 3H). The following compound was prepared similarly to compound 113

Compound 104: N-(4-{4-amino-1-methyl-7-[1-(1,6,6-trimethylpiperidin-3-yl)- 1H-pyrazol-4-yl]- 1H-pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)et hoxy]phenyl)-1,1- difluoromethanesulfonamide Step 1: N-(4-{4-amino-7-[1-(6,6-dimethylpiperidin-3-yl)-1H-pyrazol-4 -yl]-1-methyl-1H- pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)ethox y]phenyl)-1,1- difluoromethanesulfonamide Following General procedure B for the Suzuki reaction followed by acidic deprotection between intermediate A1B1 and tert-butyl 2,2-dimethyl-4-[4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate (Intermediate E21, 100 mg, 246 μmol), the title compound (20 mg,19%) was obtained as a colorless oil. LCMS (Method A): 2.71 min, m/z 335.2 [M+2H] ²⁺ Step 2: N-(4-{4-amino-1-methyl-7-[1-(1,6,6-trimethylpiperidin-3-yl)- 1H-pyrazol-4-yl]-1H- pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)ethox y]phenyl)-1,1- difluoromethanesulfonamide A mixture of N-(4-{4-amino-7-[1-(6,6-dimethylpiperidin-3-yl)-1H-pyrazol-4 -yl]-1-methyl-1H- pyrazolo[4,3-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophenyl)ethox y]phenyl)-1,1- difluoromethanesulfonamide (30 mg, 44.8 μmol), paraformaldehyde (5.43 mg, 67.2 μmol) and NaBH(OAc) ₃ (47.4 mg, 224 μmol) in MeOH (5 mL) was stirred at RT for 45 min. The mixture was diluted with sat. aq. NaHCO ₃ (30 mL) and DCM (30 mL). The aqueous layer was extracted with a DCM/MeOH mixture (9/1; 3 x 10 mL). The combined organic layers were concentrated under reduced pressure and the residue was purified by silica gel column chromatography (DCM/MeOH 97/3) to give the title product (10.0 mg, 19%) as a yellow solid. LCMS (Method A): 2.64 min; m/z 683.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.65 (d, J = 3.6 Hz, 2H), 7.56 (m, 2H), 7.34-7.26 (m, 2H), 7.20 (dd, J = 2.0, 8.0 Hz, 1H), 7.06-7.01 (m, 3H), 6.35 (t, J = 53.6 Hz, 1H), 5,47 (q, J = 2,4Hz, 1H), 3.75 (s, 3H), 3,30-3,22 (m, 2 H), 2,56 (s, 3H), 2,30-2.12 (m, 4 H), 1,80-1,76 (m, 1H), 1,69 (d, J = 6.4 Hz, 3H), 1.29 (s, 6H). Compound 111: (R)-N-(4-(4-amino-1-methyl-7-(1-(tetrahydro-2H-pyran-4-yl)-1 H-pyrazol-4- yl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)-2- methoxyethoxy)phenyl)-1,1- difluoromethanesulfonamide (R)-N-(4-(4-amino-1-methyl-7-(1-(tetrahydro-2H-pyran-4-yl)-1 H-pyrazol-4-yl)-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)-2-methoxy ethoxy)phenyl)-1,1- difluoromethanesulfonamide was obtained by chiral HPLC purification of the racemic mixture (compound 102). The separation was performed on a UniChiral CND-5H (column size 21.2 mm I.D. × 250 mm L) using n-Hexane/Ethanol/TFA = 50/50/0.1 as the mobile phase and flow rate 25 mL/min at 25 °C. Product retention time = 5.38 min. The residue was adjusted to pH=8 with sat. aq. Na ₂ CO ₃ solution. The residue was further diluted with water and the organics were extracted with EtOAc (3 times). The combined organics were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The enantiomeric excess was calculated on UniChiral CND-5H,4.6*250 mm (50%n- hexane/50%Ethanol/0.1%TFA, flow rate 1 mL/min, injection 10 μL, temperature 30 °C, retention time 5.38 min) ee>98% LCMS (Method A): 3.10 min, m/z 672.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCl ³ ): 7.80 (d, J = 8.3 Hz, 1H), 7.58 (s, 1H), 7.56 (s, 1H), 7.41 (dd, J = 8.5, 5.2 Hz, 2H), 7.28-7.27 (m, 1H), 7.12 (t, J = 8.6 Hz, 2H), 6.86 (d, J = 1.5 Hz, 1H), 6.40 (t, J = 53.5 Hz, 1H), 4.96 (dd, J = 9.6, 2.7 Hz, 1H), 4.43 (tt, J = 10.2, 4.8 Hz, 1H), 4.19-4.11 (m, 2H), 3.76 (s, 3H), 3.58 (t, J = 2.8 Hz, 4H), 3.55 (s, 3H), 2.17-2.09 (m, 4H). Compound 112: (S)-N-(4-(4-amino-1-methyl-7-(1-(tetrahydro-2H-pyran-4-yl)-1 H-pyrazol-4- yl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)-2- methoxyethoxy)phenyl)-1,1- difluoromethanesulfonamide (S)-N-(4-(4-amino-1-methyl-7-(1-(tetrahydro-2H-pyran-4-yl)-1 H-pyrazol-4-yl)-1H- pyrazolo[4,3-c]pyridin-3-yl)-2-(1-(4-fluorophenyl)-2-methoxy ethoxy)phenyl)-1,1- difluoromethanesulfonamide was obtained by chiral HPLC purification of the racemic mixture (compound 102). The separation was performed on a UniChiral CND-5H (column size 21.2 mm I.D. × 250 mm L) using n-Hexane/Ethanol/TFA = 50/50/0.1 as the mobile phase and flow rate 25 mL/min at 25 °C. Product retention time = 7.14 min. The residue was adjusted to pH=8 with sat. aq. Na2CO3 solution. The residue was further diluted with water and the organics were extracted with EtOAc (3 times). The combined organics were washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The enantiomeric excess was calculated on UniChiral CND-5H,4.6*250 mm (50%n- hexane/50%Ethanol/0.1%TFA, flow rate 1 mL/min, injection 10 μL, temperature 30 °C, retention time 5.38 min) ee>98% LCMS (Method A): 3.12 min, m/z 672.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCl ₃ ): 7.80 (d, J = 8.3 Hz, 1H), 7.68 (s, 1H), 7.60 (s, 1H), 7.41 (dd, J = 8.5, 5.2 Hz, 2H), 7.28-7.27 (m, 1H), 7.10 (t, J = 8.6 Hz, 2H), 6.86 (d, J = 1.5 Hz, 1H), 6.37 (t, J = 53.5 Hz, 1H), 4.99 (dd, J = 9.6, 2.7 Hz, 1H), 4.43 (tt, J = 10.2, 4.8 Hz, 1H), 4.19-4.11 (m, 2H), 3.76 (s, 3H), 3.58 (t, J = 2.8 Hz, 4H), 3.55 (s, 3H), 2.17-2.09 (m, 4H). Further exemplary compounds prepared by the method similar to those described herein are detailed in Table below

Intermediate C: ,1-difluoro-N-{2-[(4-fluorophenyl)methoxy]-4-(4,4,5,5-tetram ethyl-1,3,2- dioxaborolan-2-yl)phenyl}methanesulfonamide Step 1: 4-bromo-2-((4-fluorobenzyl)oxy)-1-nitrobenzene A mixture of 5-bromo-2-nitrophenol (10 g, 45.8 mmol), K ₂ CO ₃ (12.6 g, 91.6 mmol), and 1- (bromomethyl)-4-fluorobenzene (8.65 g, 45.8 mmol) in MeCN (100 mL) was stirred at 70 °C under N ₂ for 16 h. The mixture was diluted with H ₂ O (100 mL) and extracted with EtOAc (3 x 200 mL). The combined organic layers were dried (Na ₂ SO ₄ ) and then concentrated under reduced pressure to give the title product (15.0 g, 100%) as a white solid. Step 2: 4-bromo-2-((4-fluorobenzyl)oxy)aniline To a solution of 4-bromo-2-((4-fluorobenzyl)oxy)-1-nitrobenzene (15 g, 45.9 mmol) in MeOH (300 mL) and sat. aq. NH ₄ Cl (100 mL), was added Zn dust (14.9 g, 229 mmol) and the reaction mixture was stirred at 60 °C for 4 h. The mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was partitioned between H ₂ O (250 mL) and EtOAc (300 mL) and the organic layer was separated, dried (Na ₂ SO ₄ ) and then concentrated under reduced pressure to give the title product (13.0 g, 96%) as a black oil. LCMS (method A): 4.24 min, m/z: 296.0 [M+H] ⁺ . Step 3：N-{4-bromo-2-[(4-fluorophenyl)methoxy]phenyl}-1,1-difluo romethanesulfonamide To a solution of 4-bromo-2-[(4-fluorophenyl)methoxy]aniline (8.2 g, 27.6 mmol) in DCM (10 mL) were added pyridine (6.54 g, 82.8 mmol) and difluoromethanesulfonyl chloride (4.98 g, 33.1 mmol), and the resulting mixture was stirred at RT overnight. The reaction mixture was concentrated under reduced pressure and the residue was purified by column chromatography (PE/EtOAc = 30/1) to give the title product (7.77 g, 69%) as a white solid. Step 4 ： 1,1-difluoro-N-{2-[(4-fluorophenyl)methoxy]-4-(4,4,5,5-tetra methyl-1,3,2- dioxaborolan-2-yl)phenyl}methanesulfonamide A mixture of N-{4-bromo-2-[(4-fluorophenyl)methoxy]phenyl}-1,1-difluorome thanesulfonamide (7.77 g, 18.9 mmol), B ₂ (pin) ₂ (5.25 g, 20.7 mmol), AcOK (3.70 g, 37.8 mmol) and Pd(dppf)Cl ₂ (1.38 g, 1.89 mmol) in degassed 1,4-dioxane (100 mL) was stirred at 100 °C overnight under N ₂ . The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (PE/EtOAc = 10/1) to give the title product (7.14 g, 82%) as a white solid. Intermediate AC: N-(4-(4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl )-2-((4- fluorobenzyl)oxy)phenyl)-1,1-difluoromethanesulfonamide Step 1: N-(4-{4-amino-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-[(4 -fluorophenyl)methoxy] phenyl)-1,1-difluoromethanesulfonamide (Compound 10) A mixture of methyl 3-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-4-amine (100 mg, 0.365 mmol), 1,1-difluoro-N-{2-[(4-fluorophenyl)methoxy]-4-(4,4,5,5-tetra methyl-1,3,2-dioxaborolan-2- yl)phenyl}methanesulfonamide (166 mg, 0.365 mmol), Na ₂ CO ₃ (77.3 mg, 0.7296 mmol) and Pd(dppf)Cl ₂ (29.7 mg, 0.03648 mmol) in 1,4-dioxane/H ₂ O (4/1, 7.5 mL) was stirred at 100 ^o C for 16 h under N ₂ . The mixture was poured into water (100 mL) and extracted with EtOAc (2 x 50 mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated. The residue was purified by column chromatography (DCM/MeOH = 20/1) to give the title product (130 mg, 75%) as a grey solid. LCMS (Method A): 3.04 min, m/z: 478.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.81 (d, J = 8.0 Hz, 1H), 7.64-7.60 (m, 2H), 7.45-7.40 (m, 2H), 7.28-7.24 (m, 3H), 7.03-6.76 (m, 2H), 6.33 (s, 2H), 5.23 (s, 2H), 4.03 (s, 3H). Step 2: N-(4-(4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl )-2-((4-fluorobenzyl) oxy)phenyl)-1,1-difluoromethanesulfonamide A mixture of N-(4-{4-amino-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-[(4 -fluorophenyl) methoxy]phenyl)-1,1-difluoromethanesulfonamide (1.28 g, 2.68 mmol), NIS (661 mg, 2.94 mmol) in DMF (15 mL) was stirred at 85 °C for 16 h under N ₂ . The mixture was poured into water (100 mL) and extracted with EtOAc (2 x 50 mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 20/1) to give the title product (550 mg, 34%) as a yellow solid. LCMS (Method A): 3.60 min, m/z: 604.2 [M+H] ⁺ . General procedure C for the Suzuki reaction between intermediate AC and boronate esters A mixture of N-(4-(4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl )-2-((4- fluorobenzyl)oxy)phenyl)-1,1-difluoromethanesulfonamide (1 eq), boronate ester (1.1 eq), Na ₂ CO ₃ (3 eq) and Pd(dppf)Cl ₂ (0.1 eq) in degassed 1,4-dioxane/H ₂ O (4/1, 0.2 M) was stirred at 100 °C overnight under N ₂ . The mixture was diluted with water and the organics were extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH) to give the title product as a yellow solid. The following compounds were prepared following the General procedure C

Intermediate D: N-(2-((4-fluorobenzyl)oxy)-4-(4,4,5,5-tetramethyl-1,3,2-diox aborolan- 2- yl)phenyl)ethanesulfonamide Step 1: N-(4-bromo-2-((4-fluorobenzyl)oxy)phenyl)ethanesulfonamide A mixture of 4-bromo-2-((4-fluorobenzyl)oxy)aniline (13 g, 43.8 mmol), EtSO ₂ Cl (8.43 g, 65.6 mmol), pyridine (50 mL) and CHCl ₃ (50 mL) was stirred at RT for 3 h. The mixture was concentrated under reduced pressure and the crude residue was purified by column chromatography (PE/EtOAc = 1/1) to give the title product (12.5 g, 73%) as a yellow solid. LCMS (method A): 4.24 min, m/z: 410.0 [M+H] ⁺ . Step 2: N-(2-((4-fluorobenzyl)oxy)-4-(4,4,5,5-tetramethyl-1,3,2-diox aborolan- 2-yl)phenyl) ethanesulfonamide A mixture of N-(4-bromo-2-((4-fluorobenzyl)oxy)phenyl)ethanesulfonamide (12.5 g, 32.1 mmol) Pd(dppf)Cl ₂ (1.46 g, 1.60 mmol), AcOK (6.29 g, 64.2 mmol) and B ₂ pin ₂ (8.96 g, 35.2 mmol) in degassed 1,4-dioxane (200 mL) was stirred at 100 °C for 16 h under N ₂ . The mixture was concentrated under reduced pressure and the crude residue was purified by column chromatography (PE/EtOAc = 2/1) to give the title product (14.8 g, >100%) as a brown solid. LCMS (method A): 4.51 min, m/z: 453.2 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 8.99 (s, 1H), 7.63-7.60 (m, 2H), 7.38-7.32 (m, 2H), 7.28-7.21 (m, 3H), 5.15 (s, 2H), 3.03 (q, J = 7.2 Hz, 2H), 1.29 (s, 12H), 1.11 (t, J = 7.2 Hz, 3H). Intermediate AD: N-(4-(4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl )-2-((4- fluorobenzyl)oxy)phenyl)ethanesulfonamide Step 1: N-(4-{4-amino-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-[(4 -fluorophenyl)methoxy] phenyl)ethane-1-sulfonamide A mixture of 3-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-4-amine (50 mg, 182 µmol), N-{2-[(4- fluorophenyl)methoxy]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaboro lan-2-yl)phenyl}ethane-1- sulfonamide (94.8 mg, 218 µmol), Pd(dppf)Cl ₂ (14.8 mg, 18.2 µmol) and Na ₂ CO ₃ (57.8 mg, 546 µmol) in degassed 1,4-dioxane/H ₂ O (4/1, 10 mL) was stirred at 100 °C for 1 h under μW. The mixture was poured into water (10 mL) and extracted with EtOAc (2 x 10 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by Prep-TLC (DCM/MeOH = 20/1) to give the title product (20 mg, 24%) as a brown solid. Step 2： N-(4-(4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl )-2-((4-fluorobenzyl) oxy)phenyl)ethanesulfonamide A mixture of N-(4-{4-amino-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-[(4 -fluorophenyl) methoxy]phenyl)ethane-1-sulfonamide (3.5 g, 7.68 mmol) and NIS (3.44 g, 15.3 mmol) in DMF (100 mL) was stirred at 85 °C overnight. The mixture was poured into water (100 mL) and the organics were extracted with EtOAc (2 x 50 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EtOAc = 4/1 to 1/4, v/v) to give the title product (1.5 g, 47%) as a yellow solid. General procedure D for the Suzuki reaction between intermediate AD and boronate esters/boronic acids A mixture of N-(4-(4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl )-2-((4- fluorobenzyl)oxy)phenyl)ethanesulfonamide (1 eq), boronate ester/boronic acid (1.1 eq), Na ₂ CO ₃ (3 eq) and Pd(dppf)Cl ₂ (0.1eq) in degassed 1,4-dioxane/H ₂ O (4/1, 0.2 M) was stirred at 100 ^o C overnight under N2. The mixture was diluted with water and the organics were extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH) to give the desired product as a yellow solid. The following compounds were prepared following the General procedure D

Compound 64: N-(4-(4-Aminopyrazolo[1,5-a]pyrazin-3-yl)-2-((4-fluorophenyl )methoxy) phenyl)ethane-1-sulfonamide Step 1: N-(4-(4-Aminopyrazolo[1,5-a]pyrazin-3-yl)-2-((4-fluorophenyl )methoxy)phenyl) ethane-1-sulfonamide To a mixture of 3-iodopyrazolo[1,5-a]pyrazin-4-amine (20 mg, 0.08 mmol), N-(2-((4- fluorophenyl)methoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaboro lan-2-yl)phenyl)ethane-1- sulfonamide (36.8 mg, 0.08 mmol) and Na ₂ CO ₃ (16.3 mg, 0.15 mmol) in 1,4-dioxane/water (4/1, 2 mL) was added Pd(dppf)Cl ₂ (5.62 mg, 8 μmol), and the reaction was heated at 120 °C with μW irradiation for 1 h. The mixture was filtered over Celite, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (0-100% EtOAc:c-Hex) to give the title product (5.6 mg, 17%) as a brown solid. LCMS (Method D): 1.45 min, m/z 442.2 [M+H] ⁺ . ¹ H NMR (300 MHz, CDCl ₃ ): 7.88 (d, J = 5.0 Hz, 1H), 7.84 (s, 1H), 7.66 (d, J = 8.2 Hz, 1H), 7.37 (dd, J = 8.7, 5.3 Hz, 2H), 7.31 (d, J = 5.0 Hz, 1H), 7.13-7.07 (m, 4H), 5.12 (s, 2H), 3.15 (q, J = 7.4 Hz, 2H), 1.36 (t, J = 7.4 Hz, 3H). Compound 63: N-(4-(8-Aminoimidazo[1,5-a]pyrazin-1-yl)-2-((4-fluorophenyl) methoxy) phenyl) ethane-1-sulfonamide Step 1: N-((3-Chloropyrazin-2-yl)methyl)formamide A solution of 1-(3-chloropyrazin-2-yl)methanamine hydrochloride (1.0 g, 5.55 mmol) in HC(OMe) ₃ (6.06 mL, 55.5 mmol) was heated at 110 °C under an atmosphere of N ₂ overnight. The mixture was concentrated in vacuo and the residue was taken up in DCM. The organic phase was washed with water and brine, dried over MgSO ₄ and concentrated in vacuo to give the title product (772 mg, 81%) as a yellow solid. LCMS (Method E): 0.33 min, m/z 172.0 [M+H] ⁺ . ¹ H NMR (300 MHz, CDCl ₃ ): 8.46 (d, J = 2.6 Hz, 1 H), 8.38 (d, J = 1.0 Hz, 1 H), 8.35- 8.33 (m, 1 H), 6.94 (bs, 1 H), 4.76-4.74 (m, 2 H). Step 2: 8-Chloroimidazo[1,5-a]pyrazine A solution of N-((3-chloropyrazin-2-yl)methyl)formamide (0.83 g, 4.83 mmol) in MeCN (20 mL) was cooled to 0 °C before POCl ₃ (1.34 mL, 14.4 mmol) was added dropwise. The reaction was stirred at 0 °C for 5 min before DMF (2 drops) was added. The reaction was warmed to RT and stirred overnight. The mixture was concentrated in vacuo and the residue was diluted with water. The pH was adjusted to ~8 with sat. aq. NaHCO ₃ and the aqueous mixture was extracted with DCM. The combined organics were dried over MgSO ₄ and concentrated in vacuo to give the title product (631 mg, 85%) as a pink solid. LCMS (Method D): 0.62 min, m/z 154.2 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.70 (d, J = 0.6 Hz, 1 H), 8.39 (dd, J = 4.9, 1.0 Hz, 1 H), 7.88 (d, J = 1.0 Hz, 1 H), 7.41 (d, J = 4.9 Hz, 1 H). Step 3: 8-Chloro-1-iodoimidazo[1,5-a]pyrazine To a solution of 8-chloroimidazo[1,5-a]pyrazine (150 mg, 0.98 mmol) in DMF (20 mL) was added NIS (240 mg, 1.07 mmol) and the reaction was stirred at RT overnight. The mixture was diluted with water (40 mL) and extracted with EtOAc (2 x 50 mL). The combined organics were dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-5% MeOH:DCM) to give the title product (51.9 mg, 19%) as a pale-yellow solid. LCMS (Method D): 1.15 min, m/z 280.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.68 (s, 1 H), 8.43 (d, J = 4.9 Hz, 1 H), 7.40 (d, J = 4.9 Hz, 1 H). Step 4: 1-Iodoimidazo[1,5-a]pyrazin-8-amine To a solution of 8-chloro-1-iodoimidazo[1,5-a]pyrazine (50 mg, 0.18 mmol) in MeOH (1 mL) was added 7M NH ₃ in MeOH (3 mL) and the reaction was heated at 100 °C in a sealed tube overnight. Once cooled, the mixture was concentrated in vacuo and the residue was purified by column chromatography (0-10% MeOH:DCM) to give the title product (24.9 mg, 54%) as a yellow solid. LCMS (Method D): 0.21 min, m/z 261.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO- d ₆ ): 8.35 (s, 1 H), 7.23 (d, J = 4.9 Hz, 1 H), 6.98 (d, J = 4.9 Hz, 1 H), 6.58 (bs, 2 H). Step 5: N-(4-(8-Aminoimidazo[1,5-a]pyrazin-1-yl)-2-((4-fluorophenyl) methoxy)phenyl) ethane-1-sulfonamide To a mixture of 1-iodoimidazo[1,5-a]pyrazin-8-amine (50 mg, 0.19 mmol), N-(2-((4- fluorophenyl)methoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaboro lan-2-yl)phenyl)ethane-1- sulfonamide (92.0 mg, 0.21 mmol) and Na ₂ CO ₃ (40.7 mg, 0.38 mmol) in degassed 1,4- dioxane/water (4/1, 3 mL) was added Pd(dppf)Cl ₂ (14.0 mg, 19.2 μmol), and the reaction was heated at 120 °C with μW irradiation for 1 h. The mixture was filtered over Celite, and the filtrate was concentrated in vacuo. The residue was purified by column chromatography (0- 5% MeOH:DCM), followed by prep-HPLC (method B, gradient 30-60% MeCN) to give the title product (12.1 mg, 14%) as an orange solid (formate salt). LCMS (Method D): 1.26 min, m/z 442.2 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 9.06 (s, 1 H), 8.43 (s, 1 H), 8.14 (s, 1 H), 7.70 (d, J = 4.8 Hz, 1 H), 7.64-7.59 (m, 2 H), 7.40 (d, J = 8.1 Hz, 1 H), 7.36 (s, 1 H), 7.27- 7.16 (m, 3 H), 7.04 (d, J = 4.8 Hz, 1 H), 6.13 (s, 2 H), 5.19 (s, 2 H), 3.04 (q, J = 7.3 Hz, 2 H), 1.15 (t, J = 7.3 Hz, 3 H). Compound 2: N-(4-amino-3-(4-(ethylsulfonamido)-3-((4-fluorobenzyl)oxy)ph enyl)-1-methyl- 1H-pyrazolo[4,3-c]pyridin-7-yl)acetamide Step 1: 3-iodo-7-nitro-1H-pyrazolo[4,3-c]pyridin-4-amine To a solution of 3-iodo-1H-pyrazolo[4,3-c]pyridin-4-amine (500 mg, 1.92 mmol) in H2SO4 (50 mL) was added HNO ₃ (238 µL, 5.76 mmol) and the solution was stirred at 25 ^o C overnight. The reaction mixture was poured into water (150 mL) and adjusted to pH = 8 with an aq. NaOH solution. The mixture was extracted with EtOAc (250 mL x 3) and the combined organics were washed with water and brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure to give the title product (270 mg, 46%) as a yellow solid. LCMS (method A): 2.34 min, m/z: 305.9 [M+H] ⁺ . Step 2: 3-iodo-1-methyl-7-nitro-1H-pyrazolo[4,3-c]pyridin-4-amine A mixture of 3-iodo-7-nitro-1H-pyrazolo[4,3-c]pyridin-4-amine (160 mg, 0.52 mmol), K ₂ CO ₃ (72.3 mg, 0.52 mmol) and iodomethane (74.4 mg, 0.52 mmol) in DMF (4 mL) was stirred at RT overnight. Water (20 mL) was added and the solids were filtered. The filter cake was washed with water (5 mL) and dried under reduced pressure to give the title product (160 mg 96%). LCMS (method A): 3.14 min, m/z: 319.9 [M+H] ⁺ . Step 3: N-(4-{4-amino-1-methyl-7-nitro-1H-pyrazolo[4,3-c]pyridin-3-y l}-2-[(4-fluorophenyl) methoxy]phenyl)ethane-1-sulfonamide A mixture of 3-iodo-1-methyl-7-nitro-1H-pyrazolo[4,3-c]pyridin-4-amine (190 mg, 0.59 mmol), N-{2-[(4-fluorophenyl)methoxy]-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)phenyl} ethane-1-sulfonamide (259 mg, 0.60 mmol), Pd(dppf)Cl ₂ (24.3 mg, 0.03 mmol) and K ₂ CO ₃ (245 mg, 1.78 mmol) in degassed 1,4-dioxane/H ₂ O (4/1, 2.5 mL ) was stirred at 100 °C overnight. The mixture was poured into water (20 mL) and extracted with EtOAc (2 x 50 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EA = 1/1) to give the title product (200 mg 67%) as a yellow solid. LCMS (method A): 3.78 min, m/z: 501.1 [M+H] ⁺ . Step 4: N-(4-{4,7-diamino-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl}-2 -[(4-fluorophenyl) methoxy]phenyl)ethane-1-sulfonamide A mixture of N-(4-{4-amino-1-methyl-7-nitro-1H-pyrazolo[4,3-c]pyridin-3-y l}-2-[(4-fluorophenyl) methoxy]phenyl)ethane-1-sulfonamide (125 mg, 0.25 mmol) and Zn dust (81.0 mg, 1.24 mmol) in MeOH (5 mL) and aqueous NH ₄ Cl (5 mL) was stirred at 60 °C for 2 h. The reaction mixture was poured into water (50 mL) and the organics were extracted with EtOAc (2 x 50 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH = 10/1) to give the title product (27 mg, 23%) as a brown solid. LCMS (Method A): 2.97 min, m/z: 471.1 [M+H] ⁺ . Step 5: N-(4-amino-3-(4-(ethylsulfonamido)-3-((4-fluorobenzyl)oxy)ph enyl)-1-methyl-1H- pyrazolo[4,3-c]pyridin-7-yl)acetamide To a solution of N-(4-{4,7-diamino-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl}-2 -[(4- fluorophenyl)methoxy]phenyl)ethane-1-sulfonamide (27 mg, 0.057 mmol), AcOH (3.44 mg, 57 μmol) and DIEA (22.2 mg, 0.17 mmol) in DMF (1 mL) was added HATU (30.5 mg, 0.12 mmol), and the reaction was stirred at RT for 6 h. The mixture was poured into water (10 mL) and extracted with EtOAc (3 x 50 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH = 20/1) to give the title product (8 mg, 27%) as a brown solid. LCMS (Method B): 2.80 min, m/z: 513.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 9.60 (s, 1H), 9.08 (bs, 1H), 7.64 - 7.60 (m, 2H), 7.46-7.44 (m, 2H), 7.35 (d, J = 1.6 Hz, 1H), 7.26-7.19 (m, 3H), 5.78 (s, 2H), 5.20 (s, 2H), 3.99 (s, 3H), 3.05 (q, J = 7.6 Hz, 2H), 2.09 (s, 3H), 1.15 (t, J = 7.2 Hz, 3H). Intermediate BB: N-(4-{4-amino-7-iodofuro[3,2-c]pyridin-3-yl}-2-[(1S)-1-(4-fl uorophenyl) ethoxy]phenyl)-1,1-difluoromethanesulfonamide Step 1: 3-bromofuro[3,2-c]pyridin-4-amine A solution of 3-bromo-4-chlorofuro[3,2-c]pyridine (1 g, 4.30 mmol) in aq. NH ₃ (200 mL) and 1,4-dioxane (20 mL) was stirred at 150 °C for 36 h in a sealed tube. The mixture was concentrated under reduced pressure and the residue was purified by column chromatography (PE/EA = 5/1) to give the title product (400 mg, 44%) as a white solid. LCMS (Method A): 0.89 min, m/z: 212.9, 214.9 [M+H] ⁺ . Step 2: N-(4-{4-aminofuro[3,2-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophe nyl)ethoxy]phenyl)-1,1- difluoromethanesulfonamide To a solution of 3-bromofuro[3,2-c]pyridin-4-amine (350 mg, 1.64 mmol) in degassed 1,4- dioxane/H ₂ O (4/1, 20 mL) were added 1,1-difluoro-N-{2-[(1S)-1-(4-fluorophenyl)ethoxy]-4- (4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)phenyl}methanesulfonamide (772 mg, 0.542 mmol), Na ₂ CO ₃ (396 mg, 3.74 mmol) and Pd(dppf)Cl ₂ (152 mg, 0.187 mmol). The reaction was stirred at 100 ^o C under N ₂ overnight. The mixture was concentrated under reduced pressure and the residue was diluted with water (50 mL). The organics were extracted with EtOAc (2 x 50 mL), dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 50/1) to give the title product (400 mg, 51%) as a black solid. LCMS (Method A): 3.02 min, m/z: 478.1 [M+H] ⁺ . Step 3: N-(4-{4-amino-7-iodofuro[3,2-c]pyridin-3-yl}-2-[(1S)-1-(4-fl uorophenyl)ethoxy]phenyl)- 1,1-difluoromethanesulfonamide To a solution of N-(4-{4-aminofuro[3,2-c]pyridin-3-yl}-2-[(1S)-1-(4-fluorophe nyl)ethoxy] phenyl)-1,1-difluoromethanesulfonamide (400 mg, 0.838 mmol) in DMF (5 mL) was added NIS (375 mg, 1.67 mmol). After stirring at 85 °C for 4 h under N ₂ , the mixture was concentrated in vacuo. The residue was diluted with water (50 mL) and the organics were extracted with EtOAc (3 x 50 mL). The combined organics were washed with water and brine, dried over Na ₂ SO ₄ and concentrated in vacuo. The residue was purified by prep-TLC (DCM/MeOH = 25/1) to give the title product (90 mg, 18%) as a black solid. LCMS (Method A): 3.82 min, m/z: 604.0 [M+H] ⁺ . General procedure B1 for the Suzuki reaction between intermediate BB and boronate esters A mixture of N-(4-{4-amino-7-iodofuro[3,2-c]pyridin-3-yl}-2-[(1S)-1-(4-fl uorophenyl)ethoxy] phenyl)-1,1-difluoromethanesulfonamide (1 eq), boronate ester (1.1 eq), Na ₂ CO ₃ (3 eq) and Pd(dppf)Cl ₂ (0.1 eq) in degassed 1,4-dioxane/H ₂ O (4/1, 0.2 M) was stirred at 100 °C overnight under N ₂ . The mixture was diluted with water and the organics were extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH) to give the title product as a yellow solid. The following compounds were prepared following the General procedure B1

Intermediate BC: N-(4-{4-amino-7-iodofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophe nyl)methoxy] phenyl)-1,1-difluoromethanesulfonamide Step 1: 3-{4-amino-3-[(4-fluorophenyl)methoxy]phenyl}furo[3,2-c]pyri din-4-amine To a solution of 3-bromofuro[3,2-c]pyridin-4-amine (400 mg, 1.87 mmol) in degassed 1,4- dioxane/H ₂ O (4/1, 20 mL) were added 2-[(4-fluorophenyl)methoxy]-4-(4,4,5,5-tetramethyl- 1,3,2-dioxaborolan-2-yl)aniline (641 mg, 0.5418 mmol), Na ₂ CO ₃ (396 mg, 3.74 mmol) and Pd(dppf)Cl ₂ (152 mg, 0.187 mmol). After stirring at 100 °C overnight under N ₂ , the mixture was concentrated under reduced pressure. The residue was diluted with water (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 50/1) to give the title product (460 mg, 70%) as a brown oil. LCMS (Method A): 2.89 min, m/z: 350.1 [M+H] ⁺ . Step 2: N-(4-{4-aminofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophenyl)met hoxy]phenyl)-1,1- difluoromethanesulfonamide To a solution of 3-{4-amino-3-[(4-fluorophenyl)methoxy]phenyl}furo[3,2-c]pyri din-4-amine (480 mg, 1.37 mmol) in DCM (10 mL) and pyridine (541 mg, 6.85 mmol) was added difluoromethanesulfonyl chloride (550 µL, 2.05 mmol). After stirring at RT overnight, the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 50/1) to give the title product (240 mg, 38%) as a yellow solid. LCMS (Method A): 3.22 min, m/z: 464.1 [M+H] ⁺ . Step 3: N-(4-{4-amino-7-iodofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophe nyl)methoxy]phenyl)-1,1- difluoromethanesulfonamide To a solution of N-(4-{4-aminofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophenyl)met hoxy]phenyl)-1,1- difluoromethanesulfonamide (120 mg, 0.259 mmol) in DMF (3 mL) was added NIS (116 mg, 0.518 mmol). After stirring at 85 °C for 6 h under N ₂ , the mixture was diluted with water (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 25/1) to give the title product (20 mg, 13%) as a yellow solid. LCMS (Method A): 3.78 min, m/z: 590.0 [M+H] ⁺ . General procedure B2 for the Suzuki reaction between intermediate BC and boronate esters A mixture of N-(4-{4-amino-7-iodofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophe nyl)methoxy]phenyl)- 1,1-difluoromethanesulfonamide (1 eq), boronate ester (1.1 eq), Na ₂ CO ₃ (3 eq) and Pd(dppf)Cl ₂ ·CH ₂ Cl ₂ (0.1 eq) in degassed 1,4-dioxane/H ₂ O (4/1, 0.2 M) was stirred at 100 °C overnight under N ₂ . The mixture was diluted with water and the organics were extracted with EtOAc (3 x). The combined organics were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH) to give the title product as a yellow solid. The following compounds were prepared following the General procedure B2

Compound 3: N-(4-(4-amino-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-y l)furo[3,2- c]pyridin-3-yl)-2-((4-fluorobenzyl)oxy)phenyl)ethanesulfonam ide Step 1: N-(4-{4-aminofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophenyl)met hoxy]phenyl) ethane- 51-sulfonamide To a solution of 3-{4-amino-3-[(4-fluorophenyl)methoxy]phenyl}furo[3,2-c]pyri din-4-amine (420 mg, 1.20 mmol) in DCM (20 mL) and pyridine (510 µL, 5.99 mmol) was added EtSO ₂ Cl (230 mg, 1.79 mmol). The solution was stirred at RT overnight before being diluted with water (50 mL) and extracted with EtOAc (3 x 50 mL). The combined organics 10 were washed with brine, dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 50/1) to give the title product (400 mg, 76%) as a yellow solid. LCMS (Method A): 3.04 min, m/z: 442.1 [M+H] ⁺ . Step 2: N-(4-{4-amino-7-iodofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophe nyl)methoxy]phenyl) ethane-1-sulfonamide 15 To a solution of N-(4-{4-aminofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophenyl)met hoxy] phenyl)ethane-1-sulfonamide (200 mg, 0.45 mmol) in DMF (5 mL) was added NIS (203 mg, 0.91 mmol). After stirring at 85 °C for 6 h under N ₂ , the mixture was concentrated under reduced pressure. The residue was diluted with water (50 mL) and the organics were extracted with EtOAc (3 x 50 mL). The combined organics were dried over Na ₂ SO ₄ 20 and concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH = 25/1) to give the title product (80 mg, 31%) as a yellow solid. LCMS (Method A): 3.63 min, m/z: 568.0 [M+H] ⁺ . Step 3: N-(4-(4-amino-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-y l)furo[3,2-c]pyridin- 3-yl)-2-((4-fluorobenzyl)oxy)phenyl)ethanesulfonamide 25 To a solution of N-(4-{4-amino-7-iodofuro[3,2-c]pyridin-3-yl}-2-[(4-fluorophe nyl) methoxy]phenyl)ethane-1-sulfonamide (50 mg, 88 μmol) in degassed 1,4-dioxane/H ₂ O (4/1, 1.25 mL) were added 1-(tetrahydro-2H-pyran-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrazole (24.0 mg, 88 μmol), Pd(dppf) ₂ Cl ₂ (7.19 mg, 8.8 μmol) and Na ₂ CO ₃ (18.6 mg, 0.1762 mmol). After stirring at 100 °C for 1 h with μW irradiation, the 30 mixture was concentrated under reduced pressure. The residue was diluted with water (5 mL) and the organics were extracted with EtOAc (2 x 5mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by chromatography on silica gel (DCM/MeOH = 20/1) to give the title product (30 mg, 58%) as a brown solid. LCMS (Method A): 3.13 min, m/z: 592.2 [M+H] ⁺ . ¹ H NMR (400 5 MHz, DMSO-d ₆ ): 9.10 (s, 1H), 8.30 (s, 1H), 8.23 (s, 1H), 8.07 (s, 1H), 8.01 (s, 1H), 7.63 (t, J = 5.6 Hz, 2H), 7.43 (d, J = 8.0 Hz, 1H), 7.33 (s, 1H), 7.24 (t, J = 9.2 Hz, 2H), 7.12 (d, J = 8.0 Hz, 1H), 5.58 (s, 2H), 5.21 (s, 2H), 4.51-4.46 (m, 1H), 3.99 (d, J = 8.8 Hz, 2H), 3.52-3.46 (m, 2H), 3.02 (q, J = 7.6 Hz, 2H), 2.04-1.98 (m, 4H), 1.15 (t, J = 7.2 Hz, 3H). 10 The following compound was similarly prepared following step 3 of Compound 3

Compound 11: N-(4-(4-amino-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-y l)furo[3,2-c] pyridin-3-yl)-2-((4-fluorobenzyl)oxy)phenyl)-2,2,2-trifluoro ethane-1-sulfonamide Step 1: 3-{3-[(4-fluorophenyl)methoxy]-4-nitrophenyl}furo[3,2-c]pyri din-4-amine To a solution of 3-bromofuro[3,2-c]pyridin-4-amine (570 mg, 2.67 mmol) in degassed 1,4- dioxane/H ₂ O (4/1, 30 mL) were added 2-{3-[(4-fluorophenyl)methoxy]-4-nitrophenyl}-4,4,5,5- tetramethyl-1,3,2-dioxaborolane (996 mg 2.67 mmol), Na ₂ CO ₃ (396 mg, 3.74 mmol) and Pd(dppf)Cl2 (152 mg, 0.19 mmol). After stirring at 100 °C overnight under N2, the mixture was concentrated under reduced pressure and the residue was purified by column chromatography (DCM/MeOH = 100/1) to give the title product (610 mg, 60%) as a yellow solid. LCMS (Method A): 3.13 min, m/z: 380.1 [M+H] ⁺ . Step 2: 3-{3-[(4-fluorophenyl)methoxy]-4-nitrophenyl}-7-iodofuro[3,2 -c]pyridin-4-amine To a solution of 3-{3-[(4-fluorophenyl)methoxy]-4-nitrophenyl}furo[3,2-c]pyri din-4-amine (550 mg, 1.44 mmol) in DMF (11 mL) was added NIS (647 mg, 2.88 mmol). After stirring at 85 °C for 4 h under N ₂ , the reaction mixture was concentrated under reduced pressure. The residue was diluted with water (50 mL) and the organics were extracted with EtOAc (3 x 50 mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (PE/EA = 1/1) to give the title product (530 mg, 73%) as a brown solid. LCMS (Method A): 4.01 min, m/z: 506.0 [M+H] ⁺ . Step 3: 3-{3-[(4-fluorophenyl)methoxy]-4-nitrophenyl}-7-[1-(oxan-4-y l)-1H-pyrazol-4-yl]furo[3,2- c]pyridin-4-amine To a solution of 3-{3-[(4-fluorophenyl)methoxy]-4-nitrophenyl}-7-iodofuro[3,2 -c]pyridin-4-amine (200 mg, 396 μmol) in degassed 1,4-dioxane/H ₂ O (4/1, 5 mL) were added 1- (oxan-4-yl)-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (110 mg, 396 μmol), Pd(dppf)Cl ₂ (32.3 mg, 39.6 μmol) and Na ₂ CO ₃ (83.9 mg, 0.79 mmol). After stirring at 100 °C for 2 h with μW irradiation, the mixture was concentrated under reduced pressure. The residue was diluted with water (5 mL) and the organics were extracted with EtOAc (3 x 5 mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 20/1) to give the title product (45 mg, 22%) as a yellow solid. LCMS (Method A): 3.40 min, m/z: 530.2 [M+H] ⁺ . Step 4: 3-{4-amino-3-[(4-fluorophenyl)methoxy]phenyl}-7-[1-(oxan-4-y l)-1H-pyrazol-4-yl]furo[3,2- c]pyridin-4-amine To a solution of 3-{3-[(4-fluorophenyl)methoxy]-4-nitrophenyl}-7-[1-(oxan-4-y l)-1H-pyrazol-4- yl]furo[3,2-c]pyridin-4-amine (45 mg, 0.085 mmol) in MeOH (6 mL) was added sat. aq. NH ₄ Cl (2 mL) followed by Zn dust (27.7 mg, 0.425 mmol). After stirring at 60 °C overnight, the reaction mixture was concentrated under reduced pressure. The residue was diluted with water (5 mL) and extracted with EtOAc (3 x 5 mL). The combined organic phases were dried over Na ₂ SO ₄ and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 20/1) to give the title product (40 mg, 94%) as a yellow solid. LCMS (Method A): 3.16 min, m/z: 500.2 [M+H] ⁺ . Step 5: N-(4-(4-amino-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-y l)furo[3,2-c]pyridin-3-yl)-2- ((4-fluorobenzyl)oxy)phenyl)-2,2,2-trifluoroethane-1-sulfona mide To a solution of 3-{4-amino-3-[(4-fluorophenyl)methoxy]phenyl}-7-[1-(oxan-4-y l)-1H-pyrazol-4- yl]furo[3,2-c]pyridin-4-amine (50 mg, 0.1 mmol) in DCM (5 mL) and pyridine (40.2 µL, 0.5 mmol) was added 2,2,2-trifluoroethane-1-sulfonyl chloride (18.2 mg, 0.1 mmol). After stirring at RT overnight, the mixture was concentrated under reduced pressure and the residue was purified by column chromatography (DCM/MeOH = 20/1) to give the title product (30 mg, 47%) as a yellow solid. LCMS (Method A): 3.32 min, m/z: 646.2 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-d ₆ ): 9.92 (s, 1H), 8.29 (s, 1H), 8.22 (s, 1H), 8.09 (s, 1H), 8.01 (s, 1H), 7.60 (t, J =8.0 Hz, 2H), 7.40 (d, J =1.0 Hz, 1H), 7.34 (s, 1H), 7.23 (t, J = 8.0 Hz, 2H), 7.15 (d, J = 8.0 Hz, 1H), 5.59 (s, 2H), 5.21 (s, 2H), 4.51 - 4.44 (m, 1H), 4.29 (q, J = 9.6 Hz, 2H), 3.98 (d, J = 11.2 Hz, 4H), 2.01 (s, 4H). Compound 62: N-(4-(3-Amino-1H-indazol-4-yl)-2-((4-fluorophenyl)methoxy)ph enyl)ethane-1- sulfonamide Step 1: 4-Bromo-1H-indazol-3-amine To a solution of 2-bromo-6-fluorobenzonitrile (200 mg, 1.00 mmol) in EtOH (2 mL) was added NH ₂ NH ₂ ·H ₂ O (241 µL, 4.99 mmol) and the reaction was heated at reflux for 12 h. Water was added, and the mixture was chilled on ice. The precipitate was collected via filtration and air-dried to give the title product (195 mg, 92%) as a white solid. LCMS (Method D): 1.07 min, m/z 214.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 7.26 (dd, J = 7.5, 1.6 Hz, 1H), 7.13-7.05 (m, 2H), 5.13 (s, 2H). Step 2: N-(4-(3-Amino-1H-indazol-4-yl)-2-((4-fluorophenyl)methoxy)ph enyl)ethane-1- sulfonamide To a mixture of 4-bromo-1H-indazol-3-amine (50 mg, 0.24 mmol), N-(2-((4-fluorophenyl) methoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phen yl)ethane-1-sulfonamide (112 mg, 0.26 mmol) and Na ₂ CO ₃ (49.9 mg, 0.47 mmol) in 1,4-dioxane/H ₂ O (4/1, 5 mL) was added Pd(dppf)Cl ₂ (17.2 mg, 0.02 mmol), and the reaction was heated at 100 °C with μW irradiation for 30 min. The mixture was filtered over Celite, and the filtrate was concentrated in vacuo. The residue was purified by column chromatography (0-5% MeOH:DCM) to give the title compound (89.9 mg, 87%) as a brown solid. LCMS (Method D): 1.88 min, m/z 441.2 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 9.06 (s, 1H), 7.61 (dd, J = 8.8, 5.6 Hz, 2H), 7.40 (d, J = 8.1 Hz, 1H), 7.21-7.29 (m, 5H), 7.04 (dd, J = 8.1, 1.8 Hz, 1H), 6.82 (dd, J = 3.8, 3.8 Hz, 1H), 5.21 (s, 2H), 4.34 (s, 2H), 3.04 (q, J = 7.3 Hz, 2H), 1.16 (t, J = 7.3 Hz, 3H). Compound 67: N-(4-(3-Amino-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((4-fluoroph enyl)methoxy) phenyl)-2,2,2-trifluoroethane-1-sulfonamide Step 1: 2-Chloro-4-iodopyridine-3-carbonitrile To a solution of 2-chloro-4-iodopyridine-3-carbaldehyde (1.0 g, 3.73 mmol) in THF (11 mL) were added 25% NH ₄ OH (11 mL, 69.9 mmol) and I ₂ (1.04 g, 4.10 mmol), and the reaction was stirred at RT for 18 h. The reaction was quenched by the addition of sat. NaHSO ₃ and extracted with EtOAc. The organic phase was washed with brine, dried over MgSO ₄ and concentrated in vacuo to give the title compound (970 mg, 98%) as a yellow solid. LCMS (Method D): 1.54 min, m/z 264.8 [M+H] ⁺ . ¹ H NMR (300 MHz, CDCl ₃ ): 8.18 (d, J = 5.3 Hz, 1H), 7.83 (d, J = 5.3 Hz, 1H). Step 2: 2-Chloro-4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)pyridi ne-3-carbonitrile To a mixture of 2-chloro-4-iodopyridine-3-carbonitrile (970 mg, 3.66 mmol), 2-(3-((4- fluorophenyl)methoxy)-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3 ,2-dioxaborolane (1.50 g, 4.02 mmol) and Na ₂ CO ₃ (775 mg, 7.32 mmol) in 1,4-dioxane/water (9/1, 37 mL) was added Pd(dppf)Cl ₂ ·CH ₂ Cl ₂ (298 mg, 0.37 mmol), and the reaction was heated at 100 °C under N ₂ for 20 h. Once cooled, the mixture was concentrated in vacuo and the residue was partitioned between EtOAc (50 mL) and water (50 mL). The phases were separated, and the aqueous phase was extracted with EtOAc (3 x 50 mL). The combined organics were washed with brine, dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-50% EtOAc: n-Hep) to give the title compound (1.08 g, 77%) as a yellow solid. LCMS (Method D): 2.52 min, molecular ion not observed. ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.82 (d, J = 5.2 Hz, 1H), 8.12 (d, J = 8.3 Hz, 1H), 7.83 (d, J = 1.6 Hz, 1H), 7.80 (d, J = 5.2 Hz, 1H), 7.54 - 7.48 (m, 2H), 7.46 (d, J = 1.6 Hz, 1H), 7.26 (dd, J = 8.9 Hz, 2H), 5.34 (s, 2H). Step 3: 4-(3-((4-Fluorophenyl)methoxy)-4-nitrophenyl)-1H-pyrazolo[3, 4-b]pyridin-3-amine To a solution of 2-chloro-4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)pyridi ne-3-carbonitrile (1.05 g, 2.73 mmol) in i-PrOH (27 mL) was added NH ₂ NH ₂ ·H ₂ O (264 µL, 5.46 mmol) and the reaction was heated at 80 °C with μW irradiation for 1 h. Once cooled, the precipitate was collected via filtration to give the title product (878 mg, 85%) as an orange solid. LCMS (Method D): 1.97 min, m/z 380.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 12.45 (bs, 1H), 8.46 (d, J = 4.7 Hz, 1H), 8.06 (d, J = 8.3 Hz, 1H), 7.67 (d, J = 1.6 Hz, 1H), 7.52 (dd, J = 8.8, 5.5 Hz, 2H), 7.35 (dd, J = 8.3, 1.6 Hz, 1H), 7.26 (dd, J = 8.8 Hz, 2H), 7.03 (d, J = 4.7 Hz, 1H), 5.39 (s, 2H), 4.76 (s, 2H). Step 4: 4-(4-Amino-3-((4-fluorophenyl)methoxy)phenyl)-1H-pyrazolo[3, 4-b]pyridin-3-amine To a solution of 4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)-1H-pyrazolo[3, 4-b]pyridin-3-amine (878 mg, 2.31 mmol) in EtOH:THF:H ₂ O (4:4:1, 36 mL) were added Fe (642 mg, 11.5 mmol) and NH ₄ Cl (123 mg, 2.31 mmol), and the reaction was heated at reflux overnight. Whilst hot, the mixture was filtered over Celite and the pad was rinsed with EtOH. The combined filtrates were concentrated in vacuo and the residue was purified by column chromatography (0-20% MeOH:DCM) to give the title product (445 mg, 55%) as a yellow glass. LCMS (Method D): 1.50 min, m/z 350.2 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 12.16 (s, 1H), 8.29 (d, J = 4.8 Hz, 1H), 7.57 (dd, J = 8.8, 5.6 Hz, 2H), 7.72 (dd, J = 8.8 Hz, 2H), 7.16 (d, J = 1.8 Hz, 1H), 6.99 (dd, J = 8.0, 1.8 Hz, 1H), 6.84 (d, J = 4.8 Hz, 1H), 6.81 (d, J = 8.0 Hz, 1H), 5.17 (s, 2H), 4.61 (s, 2H). Step 5: N-(4-(3-Amino-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((4-fluoroph enyl)methoxy) phenyl)- 2,2,2-trifluoroethane-1-sulfonamide To a solution of 4-(4-amino-3-((4-fluorophenyl)methoxy)phenyl)-1H-pyrazolo[3, 4-b]pyridin-3- amine (103.5 mg, 0.29 mmol) in CHCl ₃ (3 mL) were added pyridine (71.1 µL, 0.88 mmol) and 2,2,2-trifluoroethanesulfonyl chloride (80.7 mg, 0.44 mmol), and the reaction was stirred under N ₂ overnight. The mixture was concentrated in vacuo and the residue was purified by column chromatography (0-10% MeOH:DCM) followed by prep-HPLC purification (method B, gradient 30-60% MeCN) to give the title compound (13.3 mg, 9%) as a yellow solid. LCMS (Method D): 1.93 min, m/z 496.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 12.33 (s, 1H), 9.94 (s, 1H), 8.40 (d, J = 4.7 Hz, 1H), 7.65-7.55 (m, 2H), 7.44 (d, J = 8.1 Hz, 1H), 7.40 (d, J = 1.8 Hz, 1H), 7.29-7.15 (m, 3H), 6.95 (d, J = 4.7 Hz, 1H), 5.24 (s, 2H), 4.67 (s, 2H), 4.33 (q, J = 9.8 Hz, 2H). Compound 66: N-(4-(3-Amino-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((4-fluoroph enyl)methoxy) phenyl)-1,1-difluoromethanesulfonamide Step 1: N-(4-(3-Amino-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((4-fluoroph enyl)methoxy) phenyl)-1,1- difluoromethanesulfonamide To a solution of 4-(4-amino-3-((4-fluorophenyl)methoxy)phenyl)-1H-pyrazolo[3, 4-b]pyridin-3- amine (90 mg, 0.26 mmol) in pyridine (2.5 mL) was added difluoromethanesulfonyl chloride (45.6 µL, 0.52 mmol), and the reaction was stirred at RT under N ₂ overnight. The mixture was concentrated in vacuo and the residue was azeotropically distilled with MePh. The residue was purified by column chromatography (0-20% MeOH:DCM) followed by prep-HPLC purification (Method B, gradient 30-60% MeCN) to give the title product (3.50 mg, 3%) as a yellow solid. LCMS (Method D): 1.78 min, m/z 464.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 10.54 (s, 1H), 8.38 (d, J = 4.8 Hz, 1H), 7.59 (dd, J = 8.6, 5.6 Hz, 2H), 7.41 (d, J = 8.1 Hz, 1H), 7.33 (s, 1H), 7.23 (t, J = 8.9 Hz, 2H), 7.15 (d, J = 7.6 Hz, 1H), 6.93 (d, J = 4.8 Hz, 1H), 5.22 (s, 2H), 4.62 (s, 2H). Compound 72: N-(4-(3-Amino-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((1S)-1-(4-f luorophenyl) ethoxy) phenyl)-1,1-difluoromethanesulfonamide Step 1: N-(4-(2-Chloro-3-cyanopyridin-4-yl)-2-((1S)-1-(4-fluoropheny l)ethoxy)phenyl)-1,1- difluoromethanesulfonamide To a mixture of 2-chloro-4-iodopyridine-3-carbonitrile (150 mg, 0.57 mmol), 1,1-difluoro-N-(2- ((1S)-1-(4-fluorophenyl)ethoxy)-4-(4,4,5,5-tetramethyl-1,3,2 -dioxaborolan-2-yl)phenyl) methanesulfonamide (294 mg, 0.62 mmol) and Na ₂ CO ₃ (119 mg, 1.13 mmol) in 1,4-dioxane/water (9/1, 6 mL) was added Pd(dppf)Cl ₂ ·CH ₂ Cl ₂ (46.3 mg, 0.06 mmol), and the reaction was heated at 100 °C under N ₂ for 23 h. Once cooled, the mixture was concentrated in vacuo and the residue was partitioned between EtOAc (20 mL) and water (20 mL). The phases were separated, and the aqueous phase was extracted with EtOAc (3 x 20 mL). The combined organic fractions were washed with brine, dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-50% EtOAc:n-Hep) to give the title product (214 mg, 78%) as a yellow solid. LCMS (Method D): 2.46 min, m/z 482.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 10.61 (s, 1H), 8.70 (d, J = 4.1 Hz, 1H), 7.61-7.57 (m, 3H), 7.43 (d, J = 8.2 Hz, 1H), 7.31 (d, J = 1.8 Hz, 1H), 7.21-7.15 (m, 3H), 7.04 (t, J = 52.3 Hz, 1H), 5.70 (q, J = 6.2 Hz, 1H), 1.59 (d, J = 6.2 Hz, 3H). Step 2: N-(4-(3-Amino-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((1S)-1-(4-f luorophenyl) ethoxy)phenyl)- 1,1-difluoromethanesulfonamide To a solution of N-(4-(2-chloro-3-cyanopyridin-4-yl)-2-((1S)-1-(4-fluoropheny l) ethoxy)phenyl)- 1,1-difluoromethanesulfonamide (210 mg, 0.44 mmol) in i-PrOH (5 mL) was added NH ₂ NH ₂ ·H ₂ O (63.1 µL, 1.30 mmol), and the reaction was heated at 80 °C with μW irradiation for 1 h. Once cooled, the mixture was diluted with water (25 mL) and extracted with EtOAc (3 x 25 mL). The combined organics were washed with brine, dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-10% MeOH:DCM) to give the title product (145 mg, 70%) as a yellow solid. LCMS (Method D): 1.86 min, m/z 478.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 10.51 (s, 1H), 8.35 (d, J = 4.7 Hz, 1H), 7.58 (dd, J = 8.7, 5.5 Hz, 2H), 7.40 (d, J = 8.0 Hz, 1H), 7.18 (d, J = 8.9 Hz, 2H), 7.15-7.07 (m, 2H), 7.03 (t, J = 51.6 Hz, 1H), 6.77 (d, J = 4.7 Hz, 1H), 5.72 (q, J = 6.3 Hz, 1H), 4.47 (s, 2H), 1.59 (d, J = 6.3 Hz, 3H). Compound 65: N-(4-(3-amino-1H-pyrazolo[4,3-c]pyridin-4-yl)-2-((4-fluoroph enyl)methoxy) phenyl)-2,2,2-trifluoroethane-1-sulfonamide

Step 1: 4-Chloro-2-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)pyridi ne-3-carbonitrile To a mixture of 2,4-dichloropyridine-3-carbonitrile (692 mg, 4.0 mmol), 2-(3-((4-fluorophenyl) methoxy)-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborol ane (1.64 g, 4.40 mmol) and Na ₂ CO ₃ (847 mg, 8.00 mmol) in 1,4-dioxane:water (9:1, 40 mL) was added Pd(dppf)Cl ₂ (292 mg, 0.4 mmol), and the reaction was heated at 100 °C under N ₂ for 18 h. Once cooled, the mixture was diluted with EtOAc, filtered over Celite and concentrated in vacuo. The residue was purified by column chromatography (0-50% EtOAc:c-Hex) to give the title compound & it’s regioisomer (5:2, 1.02 g, 48%) as a white solid. LCMS (Method D): 2.47 min, m/z 384.0 [M+H] ⁺ . Step 2: 4-(3-((4-Fluorophenyl)methoxy)-4-nitrophenyl)-1H-pyrazolo[4, 3-c]pyridin-3-amine To a mixture of 4-chloro-2-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)pyridi ne-3-carbonitrile & it’s regioisomer (191 mg, 0.5 mmol) in i-PrOH (5 mL) was added NH ₂ NH ₂ ·H ₂ O (48.4 µL, 1.0 mmol), and the reaction was heated at 80 °C with μW irradiation for 1 h. Once cooled, the precipitate was collected via filtration to give the title product (133 mg, 70%) as a yellow solid. LCMS (Method D): 1.46 min, m/z 380.9 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 12.34 (s, 1H), 8.29 (d, J = 5.9 Hz, 1H), 8.06 (d, J = 8.3 Hz, 1H), 7.77 (d, J = 1.6 Hz, 1H), 7.55-7.47 (m, 3H), 7.33 (d, J = 5.9 Hz, 1H), 7.26 (dd, J = 8.9 Hz, 2H), 5.38 (s, 2H), 4.96 (s, 2H). Step 3: 4-(4-Amino-3-((4-fluorophenyl)methoxy)phenyl)-1H-pyrazolo[4, 3-c]pyridin-3-amine To a solution of 4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)-1H-pyrazolo[4, 3-c]pyridin-3-amine (210 mg, 0.55 mmol) in EtOH:THF:H ₂ O (4:4:1, 18 mL) were added Fe (154 mg, 2.76 mmol) and NH4Cl (29.6 mg, 0.55 mmol), and the reaction was heated at reflux overnight. Whilst hot, the mixture was filtered over Celite and the pad was rinsed with EtOH. The combined filtrates were concentrated in vacuo and the residue was purified by column chromatography (0-20% MeOH:DCM) to give the title product (127 mg, 66%) as a yellow glass. LCMS (Method D): 1.21 min, m/z 350.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 12.33 (bs, 1H), 8.13 (d, J = 6.2 Hz, 1H), 7.57 (dd, J = 8.9, 5.6 Hz, 2H), 7.32 (d, J = 1.8 Hz, 1H), 7.25-7.19 (m, 3H), 7.12 (dd, J = 8.0, 1.8 Hz, 1H), 6.82 (d, J = 8.0 Hz, 1H), 5.28 (s, 2H), 5.16 (s, 2H), 4.94 (s, 2H). Step 4: N-(4-(3-amino-1H-pyrazolo[4,3-c]pyridin-4-yl)-2-((4-fluoroph enyl)methoxy) phenyl)-2,2,2- trifluoroethane-1-sulfonamide To a solution of 4-(4-amino-3-((4-fluorophenyl)methoxy)phenyl)-1H-pyrazolo [4,3-c]pyridin-3- amine (120 mg, 0.34 mmol) in pyridine (3.43 mL) was added 2,2,2-trifluoroethanesulfonyl chloride (125 mg, 0.69 mmol), and the reaction was stirred at RT under N ₂ overnight. The mixture was concentrated in vacuo and the residue was azeotropically distilled with MePh. The residue was purified by column chromatography (0-20% MeOH:DCM) followed by prep-HPLC purification (method B, gradient 30-60% MeCN) to give the title product (13.4 mg, 8%) as a yellow solid (as a formate salt). LCMS (Method D): 1.50 min, m/z 496.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 12.35 (s, 2H), 9.90 (s, 1H), 8.24 (d, J = 6.0 Hz, 1H), 8.13 (s, 1H), 7.66-7.56 (m, 2H), 7.51 (d, J = 1.8 Hz, 1H), 7.44 (d, J = 8.1 Hz, 1H), 7.31 (dd, J = 8.1, 1.8 Hz, 1H), 7.29-7.18 (m, 3H), 5.23 (s, 2H), 4.88 (s, 2H), 4.35 (q, J = 9.9 Hz, 2H). Compound 68: N-(4-(3-amino-1H-pyrazolo[4,3-c]pyridin-4-yl)-2-((4-fluoroph enyl)methoxy) phenyl)-1,1-difluoromethanesulfonamide Step 1: N-(4-(3-amino-1H-pyrazolo[4,3-c]pyridin-4-yl)-2-((4-fluoroph enyl)methoxy) phenyl)-1,1- difluoromethanesulfonamide To a solution of 4-(4-amino-3-((4-fluorophenyl)methoxy)phenyl)-1H-pyrazolo [4,3-c]pyridin-3- amine (160.3 mg, 0.46 mmol) in CHCl ₃ (4.57 mL) were added pyridine (109 µL, 1.37 mmol) and difluoromethanesulfonyl chloride (60.7 µL, 0.69 mmol), and the reaction was stirred at RT under N ₂ overnight. The mixture was concentrated in vacuo and the residue was purified by column chromatography (0-10% MeOH:DCM) followed by prep-HPLC purification (method B, gradient 30-60% MeCN) to give the title product (5.34 g, 3%) as a yellow solid. LCMS (Method D): 1.98 min, m/z 464.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.62 (d, J = 5.8 Hz, 1H), 7.64 (d, J = 5.8 Hz, 1H), 7.58 (dd, J = 8.7, 5.6 Hz, 2H), 7.28 (d, J = 1.9 Hz, 1H), 7.26-7.16 (m, 2H), 7.07 (dd, J = 8.0, 1.8 Hz, 1H), 6.82 (d, J = 8.1 Hz, 1H), 5.89 (s, 2H), 5.30 (s, 2H), 5.14 (s, 2H). Compound 69: N-(4-(3-Amino-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-2-((4-fluoro phenyl)methoxy) phenyl)-1,1-difluoromethanesulfonamide

Step 1: N-(4-(6-Amino-5-cyanopyrimidin-4-yl)-2-((4-fluorophenyl) methoxy)phenyl)-1,1- difluoromethanesulfonamide To a mixture of 4-amino-6-chloropyrimidine-5-carbonitrile (76.0 mg, 0.49 mmol), 1,1-difluoro-N- (2-((4-fluorophenyl)methoxy)-4-(4,4,5,5-tetramethyl-1,3,2-di oxaborolan-2-yl)phenyl) methanesulfonamide (225 mg, 0.49 mmol) and Na ₂ CO ₃ (104 mg, 0.98 mmol) in dioxane:H ₂ O (9:1, 5.0 mL) was added and Pd(dppf)Cl ₂ ·CH ₂ Cl ₂ (40.1 mg, 0.05 mmol), and the reaction was heated at 100 °C under N ₂ for 24 h. Once cooled, the mixture was diluted with water (20 mL) and extracted with EtOAc (3 x 20 mL). The combined organics were washed with brine, dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-100% EtOAc:n- Hep) to give the title product (93.1 mg, 42%) as a yellow solid. LCMS (Method D): 1.92 min, m/z 450.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 10.61 (s, 1H), 8.60 (d, J = 2.8 Hz, 1H), 7.94 (bs, 2H), 7.63-7.58 (m, 3H), 7.49 (dd, J = 8.2, 1.9 Hz, 1H), 7.42 (d, J = 8.2 Hz, 1H), 7.27-7.21 (m, 2H), 6.96 (t, J = 52.4 Hz, 1H), 5.21 (s, 2H). Step 2: N-(4-(6-Chloro-5-cyanopyrimidin-4-yl)-2-((4-fluorophenyl)met hoxy)phenyl)-1,1- difluoromethanesulfonamide To a solution of N-(4-(6-amino-5-cyanopyrimidin-4-yl)-2-((4-fluorophenyl)meth oxy) phenyl)-1,1- difluoromethanesulfonamide (93.1 mg, 0.21 mmol) in MeCN (2.0 mL) were added CuCl ₂ (55.6 mg, 0.41 mmol) and Isoamyl nitrite (55.6 µL, 0.41 mmol), and the reaction was heated at 65 °C for 5 h. Once cooled, the mixture was acidified to pH 3 with 1 M HCl and extracted with DCM (10 mL). The organic phase was dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-50% EtOAc:n-Hep) to give the title product (26.0 mg, 27%) as a yellow solid. LCMS (Method D): 2.45 min, m/z 469.0 [M+H] ⁺ . ¹ H NMR (300 MHz, CDCl ₃ ): 9.12 (s, 1H), 7.87-7.75 (m, 3H), 7.44-7.40 (m, 2H), 7.30 (s, 1H), 7.13 (dd, J = 8.7 Hz, 2H), 6.31 (t, J = 53.5 Hz, 1H), 5.21 (s, 2H). Step 3: N-(4-(3-Amino-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-2-((4-fluoro phenyl)methoxy) phenyl)- 1,1-difluoromethanesulfonamide To a solution of N-(4-(6-chloro-5-cyanopyrimidin-4-yl)-2-((4-fluorophenyl)met hoxy) phenyl)-1,1- difluoromethanesulfonamide (26 mg, 0.06 mmol) in i-PrOH (554 µL) was added NH ₂ NH ₂ ·H ₂ O (5.37 µL, 0.11 mmol) and the reaction was heated at 80 °C in a sealed tube for 1 h. Once cooled, the precipitate was collected via filtration to give the title product (4.20 mg, 16%) as a yellow solid. LCMS (Method D): 1.68 min, m/z 465.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 9.29 (s, 1H), 8.59 (s, 1H), 7.58 (ddd, J = 8.6, 5.5, 2.6 Hz, 2H), 7.52 (d, J = 2.0 Hz, 1H), 7.44 (dd, J = 8.3, 2.0 Hz, 1H), 7.38 (d, J = 8.3 Hz, 1H), 7.26-7.16 (m, 2H), 6.61 (t, J = 53.8 Hz, 1H), 5.12 (s, 2H). Compound 70: N-(4-(3-Amino-6-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((4 -fluorophenyl) methoxy)phenyl)-1,1-difluoromethanesulfonamide Step 1: 3-((4-Fluorophenyl)methoxy)-4-nitrobenzaldehyde To a solution of 3-hydroxy-4-nitrobenzaldehyde (2.0 g, 11.9 mmol) in MeCN (24 mL) were added K ₂ CO ₃ (1.96 g, 14.2 mmol) and 4-fluorobenzyl bromide (1.54 mL, 12.4 mmol), and the reaction was heated at reflux for 2 h. Once cooled, water (100 mL) was added and the mixture was extracted with Et ₂ O (4 x 50 mL). The combined organics were washed with brine, dried over MgSO ₄ and concentrated in vacuo to give the title product (7.33 g, 99%) as a pale yellow solid. LCMS (Method D): 2.24 min, m/z 276.0 [M+H] ⁺ . ¹ H NMR (300 MHz, CDCl ₃ ): 10.03 (s, 1H), 7.94 (d, J = 8.1 Hz, 1H), 7.63 (d, J = 1.5 Hz, 1H), 7.56 (dd, 8.1, 1.5 Hz, 1H), 7.46-7.41 (m, 2H), 7.12- 7.06 (m, 2H), 5.26 (s, 2H). Step 2: 4-(3-((4-Fluorophenyl)methoxy)-4-nitrophenyl)-6-methyl-2-oxo -1,2-dihydropyridine-3- carbonitrile To a suspension of AcONH ₄ (2.23 g, 29.0 mmol) in n-BuOH (15 mL) were added acetone (267 µL, 3.63 mmol), methyl 2-cyanoacetate (319 µL, 3.63 mmol) and 3-((4-fluorophenyl)methoxy)-4- nitrobenzaldehyde (1.0 g, 3.63 mmol), and the reaction was heated at reflux for 3 h. Once cooled, the precipitate was collected via filtration, washed with EtOH and n-Hep, and air-dried to give the title product (351 mg, 26%) as a pale orange solid. LCMS (Method D): 1.99 min, m/z 378.8 [M- H]-. ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.04 (d, J = 8.4 Hz, 1H), 7.65 (d, J = 1.6 Hz, 1H), 7.53-7.49 (m, 2H), 7.34 (dd, J = 8.4, 1.6 Hz, 1H), 7.28-7.22 (m, 2H), 6.36 (s, 1H) 5.33 (s, 2H), 2.33 (s, 3H). Step 3: 2-Chloro-4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)-6-met hylpyridine-3-carbonitrile A mixture of 4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)-6-methyl-2-oxo -1,2-dihydropyridine-3- carbonitrile (0.43 g, 1.13 mmol, from multiple iterations) and PCl ₅ (470 mg, 2.26 mmol) in POCl ₃ (5 mL) was heated at reflux for 5 h. Once cooled, the mixture was poured into ice-water and neutralised with sat. NaHCO ₃ . The precipitate was collected via filtration, washed with water and dried under vacuum for 15 h to give the title product (425 mg, 95%) as a light orange solid. LCMS (Method D): 2.64 min, m/z 398.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.09 (d, J = 8.3 Hz, 1H), 7.81 (d, J = 1.6 Hz, 1H), 7.70 (s, 1H), 7.54-7.49 (m, 2H), 7.45 (dd, J = 8.3, 1.6 Hz, 1H), 7.28-7.23 (m, 2H), 5.34 (s, 2H), 2.63 (s, 3H). Step 4: 4-(4-Amino-3-((4-fluorophenyl)methoxy)phenyl)-2-chloro-6-met hylpyridine-3-carbonitrile To a solution of 2-chloro-4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)-6-met hylpyridine-3- carbonitrile (425 mg, 1.06 mmol) in EtOH (10.6 mL) was added SnCl ₂ ·2H ₂ O (1.19 g, 5.30 mmol) in portions, and the reaction was heated at 70 °C under N ₂ for 2 h. Once cooled, the mixture was poured into NH ₄ OH (25%, 25 mL) and extracted with EtOAc (3 x 25 mL). The combined organics were washed with brine (2 x 25 mL), dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-10% MeOH:DCM) to give the title product (94.7 mg, 24%) as a brown solid. LCMS (Method D): 2.45 min, m/z 368.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 7.59-7.54 (m, 3H), 7.30 (d, J = 2.0 Hz, 1H), 7.24-7.14 (m, 3H), 6.78 (d, J = 8.2 Hz, 1H), 5.48 (s, 2H), 5.15 (s, 2H), 2.54 (s, 3H). Step 5: N-(4-(2-Chloro-3-cyano-6-methylpyridin-4-yl)-2-((4-fluorophe nyl)methoxy) phenyl)-1,1- difluoromethanesulfonamide To a solution of 4-(4-amino-3-((4-fluorophenyl)methoxy)phenyl)-2-chloro-6-met hyl pyridine-3- carbonitrile (90 mg, 0.24 mmol) in CHCl ₃ (2.5 mL) were added pyridine (98.2 µL, 1.22 mmol) and difluoromethanesulfonyl chloride (43.3 µL, 0.49 mmol), and the reaction was stirred at RT under N ₂ overnight. The mixture was concentrated in vacuo and the residue was azeotropically distilled with MePh. The residue was purified by column chromatography (0-50% EtOAc:n-Hep) to give the title product (65.9 mg, 56%) as a yellow solid. LCMS (Method D): 2.80 min, m/z 480.8 [M-H]- . ¹ H NMR (300 MHz, DMSO-d ₆ ): 7.72-7.64 (m, 3H), 7.57-7.52 (m, 3H), 7.49 (t, J = 51.5 Hz, 1H), 7.44 (dd, J = 8.2, 1.9 Hz, 1H), 7.26 (dd, J = 8.9 Hz, 2H), 5.29 (s, 2H), 2.62 (s, 3H). Step 6: N-(4-(3-Amino-6-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((4 -fluorophenyl)methoxy) phenyl)-1,1-difluoromethanesulfonamide To a solution of N-(4-(2-chloro-3-cyano-6-methylpyridin-4-yl)-2-((4-fluorophe nyl)methoxy) phenyl)-1,1-difluoromethanesulfonamide (65 mg, 0.13 mmol) in i-PrOH (2 mL) was added NH ₂ NH ₂ ·H ₂ O (12.9 µL, 0.27 mmol) and the reaction was heated at 80 °C with μW irradiation for 1 h. Once cooled, the mixture was partitioned between EtOAc (10 mL) and water (10 mL). The phases were separated, and the aqueous fraction was extracted with EtOAc (2 x 10 mL). The combined organics were washed with brine (10 mL), dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-10% MeOH:DCM) to give the title product (16.3 mg, 25%) as a yellow solid. LCMS (Method D): 1.83 min, m/z 478.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 12.14 (s, 1H), 10.48 (s, 1H), 7.61 (dd, J = 8.5, 5.7 Hz, 2H), 7.42 (d, J = 8.0 Hz, 1H), 7.38 (d, J = 1.8 Hz, 1H), 7.25 (t, J = 8.9 Hz, 2H), 7.18 (dd, J = 8.1, 1.8 Hz, 1H), 6.94 (t, J = 52.7 Hz, 1H), 6.85 (s, 1H), 5.25 (s, 2H), 4.55 (s, 2H), 2.54 (s, 3H). Compound 71: N-(4-(3-Amino-6-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((4 -fluorophenyl) methoxy)phenyl)-1,1-difluoromethanesulfonamide Step 1: 4-(3-((4-Fluorophenyl)methoxy)-4-nitrophenyl)-2-oxo-6-phenyl -1,2-dihydropyridine-3- carbonitrile To a suspension of AcONH ₄ (2.23 g, 29.0 mmol) in n-BuOH (15 mL) were successively added acetophenone (423 µL, 3.63 mmol), methyl 2-cyanoacetate (319 µL, 3.63 mmol) and 3-((4- fluorophenyl)methoxy)-4-nitrobenzaldehyde (1.0 g, 3.63 mmol), and the reaction was heated at reflux for 3 h. Once cooled, the precipitate was collected via filtration, washed with EtOH and n- Hep, and air-dried to give the title product (687 mg, 43%) as a pale orange solid. LCMS (Method D): 2.38 min, m/z 442.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.07 (d, J = 8.3 Hz, 1H), 7.90 (d, J = 7.9 Hz, 2H), 7.78 (d, J = 1.7 Hz, 1H), 7.59-7.46 (m, 6 H), 7.29-7.21 (m, 2 H), 6.90 (d, J = 1.7 Hz, 1H) 5.37 (s, 2H). Step 2: 2-Chloro-4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)-6-phe nylpyridine-3-carbonitrile A mixture of 4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)-2-oxo-6-phenyl -1,2-dihydropyridine-3- carbonitrile (680 mg, 1.54 mmol) and PCl ₅ (641 mg, 3.08 mmol) in POCl ₃ (7 mL) was heated at reflux for 5 h. Once cooled, the mixture was poured into ice-water and neutralised with sat. NaHCO ₃ . The precipitate was collected via filtration, washed with water and dried under vacuum for 15 h to give the title product (703 mg, 99%) as a pale yellow solid. LCMS (Method D): 2.37 min, molecular ion not observed. ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.08 (d, J = 8.3 Hz, 1H), 7.91 (d, J = 7.0 Hz, 2H), 7.79 (d, J = 1.6 Hz, 1H), 7.60-7.47 (m, 6H), 7.28-7.22 (m, 2H), 6.92 (s, 1H) 5.37 (s, 2H). Step 3: 4-(4-Amino-3-((4-fluorophenyl)methoxy)phenyl)-2-chloro-6-phe nylpyridine-3-carbonitrile To a solution of 2-chloro-4-(3-((4-fluorophenyl)methoxy)-4-nitrophenyl)-6-phe nylpyridine-3- carbonitrile (700 mg, 1.52 mmol) in EtOH (15 mL) was added SnCl ₂ ·2H ₂ O (1.73 g, 7.70 mmol) in portions, and the reaction was heated at 70 °C under N ₂ for 2 h. Once cooled, the mixture was poured into NH ₄ OH (25%, 25 mL) and extracted with EtOAc (3 x 50 mL). The combined organics were washed with brine (2 x 50 mL), dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-10% MeOH:DCM) to give the title product (48.5 mg, 7%) as a yellow glass. LCMS (Method D): 3.04 min, m/z 430.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO- d ₆ ): 8.21-8.18 (m, 2H), 8.08 (s, 1H), 7.61-7.54 (m, 5H), 7.41 (d, J = 2.0 Hz,1H), 7.29 (dd, J = 8.2, 2.0 Hz, 1H), 7.25-7.19 (m, 2H), 6.82 (d, J = 8.2 Hz, 1H) 5.52 (s, 2H), 5.19 (s, 2H). Step 4: N-(4-(2-Chloro-3-cyano-6-phenylpyridin-4-yl)-2-((4-fluorophe nyl)methoxy) phenyl)-1,1- difluoromethanesulfonamide To a solution of 4-(4-amino-3-((4-fluorophenyl)methoxy)phenyl)-2-chloro-6-phe nylpyridine-3- carbonitrile (45 mg, 0.10 mmol) in CHCl ₃ (1.0 mL) were added pyridine (42.0 µL, 0.52 mmol) and difluoromethanesulfonyl chloride (18.4 µL, 0.21 mmol), and the reaction was stirred at RT under N ₂ overnight. The mixture was concentrated in vacuo and the residue was azeotropically distilled with MePh. The residue was purified by column chromatography (0-20% EtOAc:n-Hep) to give the title product (48.5 mg, 85%) as a yellow solid. LCMS (Method D): 3.21 min, m/z 544.8 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 8.34 (s, 1H), 8.28-8.25 (m, 2H), 7.79 (d, J = 1.8 Hz, 1H), 7.69 (dd, J = 8.1, 5.3 Hz, 1H), 7.60-7.53 (m, 7H), 7.51 (t, J = 51.5 Hz, 1H), 7.29-7.23 (m, 2H), 5.33 (s, 2H). Step 5: N-(4-(3-Amino-6-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-2-((4 -fluorophenyl)methoxy) phenyl)-1,1-difluoromethanesulfonamide To a solution of N-(4-(2-chloro-3-cyano-6-phenylpyridin-4-yl)-2-((4-fluorophe nyl)methoxy) phenyl)-1,1-difluoromethanesulfonamide (48 mg, 0.09 mmol) in i-PrOH (1.0 mL) was added NH ₂ NH ₂ ·H ₂ O (8.55 µL, 0.18 mmol) and the reaction was heated at 80 °C with μW irradiation for 1 h. Once cooled, the mixture was partitioned between EtOAc (10 mL) and water (10 mL). The phases were separated, and the aqueous fraction was extracted with EtOAc (2 x 10 mL). The combined organics were washed with brine (10 mL), dried over MgSO ₄ and concentrated in vacuo. The residue was purified by column chromatography (0-10% MeOH:DCM) to give the title product (6.50 mg, 14%) as a yellow solid. LCMS (Method D): 2.35 min, m/z 540.0 [M+H] ⁺ . ¹ H NMR (300 MHz, DMSO-d ₆ ): 12.40 (s, 1H), 10.53 (s, 1H), 8.16 (dd, J = 8.3, 1.7 Hz, 2H), 7.64-7.55 (m, 2H), 7.52-7.46 (m, 6H), 7.31-7.22 (m, 3H), 6.95 (t, J = 52.7 Hz, 1H), 5.29 (s, 2H), 4.65 (s, 2H). Compound 173: 4-(4-{4-amino-3-[4-(difluoromethanesulfonamido)-3-[(1S)-1-(4 - fluorophenyl)ethoxy]phenyl]-1-methyl-1H-pyrazolo[4,3-c]pyrid in-7-yl}-1H-pyrazol-1- yl)cyclohexane-1-carboxylic acid Step 1: tert-butyl 4-hydroxycyclohexane-1-carboxylate To a 0 °C solution of tert-butyl 4-oxocyclohexane-1-carboxylate (3 g, 15.1 mmol) in MeOH (20 mL) was added NaBH ₄ (2.85 g, 75.5 mmol) in portions, and the mixture was stirred at 0 °C for 1h. The mixture was concentrated under reduced pressure, then diluted with H ₂ O (60 mL) and extracted with Et ₂ O (3 x 80 mL). The combined organics were concentrated under reduced pressure to afford the title product (3.08 g, >100%) as yellow oil. Step 2: tert-butyl 4-(methanesulfonyloxy)cyclohexane-1-carboxylate To a 0 °C mixture of tert-butyl 4-hydroxycyclohexane-1-carboxylate (4.36 g, 21.7 mmol) and Et3N (10.9 g, 108 mmol) in MeCN (40 mL) was slowly added a solution of MsCl (4.97 g, 43.4 mmol) in MeCN (15 mL), and the reaction was stirred at 0 °C for 1h. The mixture was concentrated under reduced pressure, then diluted with H ₂ O (120 mL) and extracted with EtOAc (3 x 150 mL). The combined organics were concentrated under reduced pressure to afford the title product (6.62 g, >100%) as yellow oil. Step 3: tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)cyclohexane-1-carboxylate A mixture of tert-butyl 4-(methanesulfonyloxy)cyclohexane-1-carboxylate (6.11 g, 21.9 mmol), Cs ₂ CO ₃ (21.3 g, 65.6 mmol) and 4-bromo-1H-pyrazole (3.21 g, 21.9 mmol) in MeCN (60 mL) was stirred at 80 °C overnight. The mixture was concentrated under reduced pressure, then diluted with H ₂ O (100 mL) and extracted with EtOAc (3 x 120 mL). The combined organics were concentrated under reduced pressure and purified by column chromatography (PE:EA = 30/1 to 20/1) to afford the title product (4.07 g, 56%) as a white solid. LCMS (Method B): 2.68 min, m/z 329.1, 331.1 [M+H] ⁺ . Step 4: tert-butyl 4-(4-{4-amino-3-[4-(difluoromethanesulfonamido)-3-[(1S)-1-(4 -fluorophenyl) ethoxy]phenyl]-1-methyl-1H-pyrazolo[4,3-c]pyridin-7-yl}-1H-p yrazol-1-yl)cyclohexane-1- carboxylate A mixture of N-(4-{4-amino-7-iodo-1-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl }-2-[(1S)-1-(4- fluorophenyl)ethoxy]phenyl)-1,1-difluoromethanesulfonamide (850 mg, 1.37 mmol), tert-butyl 4- (4-bromo-1H-pyrazol-1-yl)cyclohexane-1-carboxylate (583 mg, 1.78 mmol), B ₂ pin ₂ (1.08 g, 4.26 mmol), Pd(OAc) ₂ (260 mg, 1.16 mmol), butyldi-1-adamantylphosphine (695 mg, 1.94 mmol) and K ₂ CO ₃ (803 mg, 5.81 mmol) in 1,4-Dioxane/H ₂ O (4/1, 30 mL) was stirred at 80 °C under N ₂ for 2.5 h. The mixture was concentrated under reduced pressure, then diluted with H ₂ O (80 mL) and extracted with EtOAc (3 x 100 mL). The combined organics were concentrated under reduced pressure, and the residue was purified by column chromatography (DCM/MeOH = 70/1 to 60:1) to afford the title product (488 mg, 24% ) as a black solid. LCMS (Method B): 2.37 min, m/z 740.3 [M+H] ⁺ . Step 5: 4-(4-{4-amino-3-[4-(difluoromethanesulfonamido)-3-[(1S)-1-(4 -fluorophenyl)ethoxy] phenyl]-1-methyl-1H-pyrazolo[4,3-c]pyridin-7-yl}-1H-pyrazol- 1-yl)cyclohexane-1-carboxylic acid A solution of tert-butyl 4-(4-{4-amino-3-[4-(difluoromethanesulfonamido)-3-[(1S)-1-(4 -fluoro phenyl)ethoxy]phenyl]-1-methyl-1H-pyrazolo[4,3-c]pyridin-7-y l}-1H-pyrazol-1-yl)cyclohexane-1- carboxylate (488 mg, 0.66 mmol) in HCOOH (15 mL) was stirred at RT under N ₂ for 4 h. The mixture was concentrated under reduced pressure and the residue was purified by Prep-TLC (DCM/MeOH = 10/1) to give the title product (80 mg, 18%) as a black solid. LCMS (Method B): 1.93 min; 682.2 [M-H]-. ¹ H NMR (400 MHz, DMSO-d ₆ ): 7.98 (s, 1H), 7.62-7.53 (m, 4H), 7.40 (d, J = 8.0 Hz, 1H), 7.20-7.08 (m, 4H), 5.97 (s, 2H), 5.65 (q, J = 6.3 Hz, 1H), 4.27 (dd, J = 8.9, 4.4 Hz, 1H), 3.69 (s, 3H), 2.62-2.55 (m, 1H), 2.48 (s, 1H), 2.12 (s, 1H), 2.00 (dt, J = 25.2, 8.5 Hz, 5H), 1.58 (d, J = 6.2 Hz, 3H), 1.23 (s, 1H). BIOLOGY IN VITRO ASSAY Binding affinity of the test compounds for human MLKL (full length), mouse MLKL (full length), human RIPK1 and human RIPK3 was determined using the KINOMEscan™ technology developed by DiscoverX (USA; http://www.discoverx.com). The assay was conducted according to manufacturer instructions. Protocol Description Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24- well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 phage from a frozen stock (multiplicity of infection = 0.4) and incubated with shaking at 32 °C until lysis (90-150 minutes). The lysates were centrifuged (6,000 x g) and filtered (0.2 μm) to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DNA for qPCR detection. Streptavidin-coated magnetic beads were treated with biotinylated small molecule ligands for 30 minutes at room temperature to generate affinity resins for kinase assays. The liganded beads were blocked with excess biotin and washed with blocking buffer (SeaBlock (Pierce), 1% BSA, 0.05% Tween 20, 1 mM DTT) to remove unbound ligand and to reduce non-specific phage binding. Binding reactions to screen test compounds for kinase binding activity were assembled by combining kinases, liganded affinity beads, and test compounds in 1x binding buffer (20% SeaBlock, 0.17x PBS, 0.05% Tween 20, 6 mM DTT). All reactions were performed in polypropylene 384-well plates in a final volume of 20 µL. The assay plates were incubated at room temperature with shaking for 1 hour and the affinity beads were washed with wash buffer (1x PBS, 0.05% Tween 20). The beads were then re- suspended in elution buffer (1x PBS, 0.05% Tween 20, 0.5 μM non-biotinylated affinity ligand) and incubated at room temperature with shaking for 30 minutes. The kinase concentration in the eluates was measured by qPCR. Compound Handling An 11-point 3-fold serial dilution of each test compound was prepared in 100% DMSO at 100x final test concentration and subsequently diluted to 1x in the assay (final DMSO concentration = 1%). Most K _D s were determined using a compound top concentration = 30,000 nM. If the initial KD determined was < 0.5 nM (the lowest concentration tested in the initial serial dilution), the measurement was repeated with a further 11 point 3-fold serial dilution starting at 3,000 nM. Binding Constants (K _D s) K _D for each test compound was calculated with a standard dose-response curve using the Hill equation (equation (1)): The Hill Slope was set to -1. Curves were fitted using a non-linear least square fit with the Levenberg-Marquardt algorithm. Refs: • Fabian, M.A. et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat. Biotechnol.23, 329-336 (2005). • Karaman, M.W. et al. A quantitative analysis of kinase inhibitor selectivity. Nat. Biotechnol.26, 127-132 (2008). • Hill, A.V. The possible effects of the aggregation of the molecules of hemoglobin on its dissociation curves. J. Physiol. (Lond.).40, iv-vii (1910). • Levenberg, K. A method for the solution of certain non-linear problems in least squares. Q. Appl. Math.2, 164-168 (1944). The results of the in vitro screening of the compounds described above are shown below in Tables 20 and 21. Table 20: Results of binding assay for compounds of the invention against human MLKL, human RIPK1 and human RIPK3. Binding affinity is measured by the equilibrium dissociation constant (K _D ). The smaller the K _D value, the greater the binding affinity of the ligand for its target. Activity is provided as follows: ++++ = K _D < 1 nM +++ = 1 nM < K _D < 100 nM ++ = 100 nM < K _D < 10,000 nM + = K _D > 10,000 nM Table 21: Results of binding assay for compounds of the invention against mouse MLKL. Binding affinity is measured by the equilibrium dissociation constant (K _D ). The smaller the K _D value, the greater the binding affinity of the ligand for its target. Activity is provided as follows: ++++ = K _D < 1 nM +++ = 1 nM < KD < 100 nM ++ = 100 nM < K _D < 10,000 nM + = K _D > 10,000 nM CELLULAR ASSAY: Screening compounds for inhibition of TSQ induced necroptosis, 384 well plate format. Cell Line ID: U937 human histiocytic leukemia cell line. Cell Concentration (cells/well): Final cell density is 20000 cells per well. Cell growth medium: HT-RPMI medium + 7.4% Fetal Bovine Serum (FBS). Cells are cultured in Corning 150cm ² tissue culture flasks with vented caps at 37 °C/5% CO ₂ . Incubation: Plates were incubated at 37 °C/5% CO ₂ in a humidified incubator for 48 hours following addition of compounds and death stimuli (TSQ cocktail). Compound concentration: 36 µM starting concentration, 1:3 dilution, 10 point DMSO final concentration (% v/v): 0.3%. Compounds in TSQ cocktail (T: TNF; S: Smac mimetic; Q: Q-VD-OPh) and their final concentrations: hTNF-Fc (100 ng/ml) – produced by standard procedures as shown in Bossen et al., J. Biol. Chem., 2006, 281(20), 13964-13971. Compound A (500 nM) - Smac mimetic, Tetralogic and SYNthesis med chem Q-VD-OPh (10 μM) – MP Biomedicals Assay experimental outline The cellular assay was carried out according to the following steps: 1. Each well was prepared by sequential addition of: a. DMSO (control; columns 1-2 and 23-24) or compound in DMSO – addition was performed using acoustic transfer of nL volumes of stock compound to give final test concentrations of 36,12, 4, 1.3, 0.44, 0.148, 0.049, 0.016, 0.005 and 0.002 µM. All wells were backfilled with DMSO to a final total volume in the well of 100 nL. b. Following compound/DMSO addition in step (a), 40 µL of cell suspension (5 x 10 ⁵ cells/mL) was added to provide a final cell concentration of 20,000 cells per well, and c. Following cell addition in step (b), 10 µL of 5x TSQ cocktail (except to positive controls; columns 1 and 23) was added to each well. 2. After 48 hours, plate was removed from the 37°C incubator and equilibrated to room temperature for 45 minutes. 3. 15 µL of room temperature CellTitre-Glo2 ^TM (Promega ^TM ) was added to each well. 4. Shook plates for 2 minutes (~600 rpm) and incubated at room temperature for 15 minutes to allow signal to stabilise. 5. Read luminescence readout on a plate reader. Analysis: Percent viability was calculated for each compound according to equation (2): % viability = 100 x ((RawData – NSA)/(TA-NSA) (2) wherein RawData is the readout of any cell containing a compound of the invention. TA is the total activity provided by the luminescence readout from DMSO only wells (columns 2 and 24) = 100% viability. NSA is the non-specific activity provided by DMSO+TSQ wells (columns 1 and 23) = 0% viability Curve fitting: 10-point titration curves are fitted with the 4-parameter logistic nonlinear regression model and the IC ₅₀ reported is the inflection point of the curve Analysis: Data was loaded into Dotmatics ^TM and visualised using the Tibco® Spotfire ^TM software. 10 point titration curves were fitted with the 4 parameter logistic nonlinear regression model and the IC ₅₀ reported reflect the inflection point of the curve for curve fitting. Interpretation of results: Assay involving the TSQ cocktail (T: TNF; S: Smac mimetic; Q: Q-VD-OPh): TSQ treatment ensures that cells specifically undergo necroptotic cell death. TNF activates the TNF receptor, Smac mimetic directs the signal away from proinflammatory signaling and toward the RIPK1/RIPK3-mediated cell death pathways, and Q-VD-OPh ensures that the apoptotic response is blocked leaving only the programmed necrosis response. The compounds’ activity (solution in DMSO) tested in this TSQ-induced assay was evaluated by determining the number of viable cells in culture by measuring the amount of ATP present as measured by CelltiterGlo. Counter screen: In parallel, all compounds were tested for their ability to affect cell viability. The same U937 cells were treated with compound in DMSO without the TSQ cocktail. This counter screen enabled evaluation of off-target effects. In this case, cell viability was measured by CelltiterGlo. The results of the cellular screening of the compounds described above are shown below in Table 22. Table 22: Table showing the results of cell-based assays performed, analysed as the half maximal inhibitory concentration (IC ₅₀ ), being the concentration of the test compound needed to inhibit TSQ induced necroptosis by 50%. The lower the IC _50, the more potent the compound. Activity is provided as follows: ++++ = IC ₅₀ < 10 nM +++ = 10 nM < IC ₅₀ < 1,000 nM ++ = 1,000 nM < IC ₅₀ < 10,000 nM + = IC ₅₀ > 10,000 nM CELLULAR ASSAY: Screening compounds for inhibition of TSI induced necroptosis in , 384 well plate format. Cell Line ID: Immortalised Mouse Dermal Fibroblasts (MDFs). Cell Concentration (cells/well): Final cell density is 2200 cells per well. Cell growth medium: DMEM medium + 7.4% Fetal Bovine Serum (FBS). Cells are cultured in Corning 150cm ² tissue culture flasks with vented caps at 37°C/10% CO ₂ . Incubation: Plates were incubated for 30 minutes following addition of compounds and then 3 hours incubation with death stimuli (TSI cocktail) at 37°C/10% CO ₂ in a humidified incubator. Compound concentration: 36 µM starting concentration, 1:3 dilution, 10 point DMSO final concentration (% v/v): 0.3%. Compounds in TSI cocktail (T: TNF; S: Smac mimetic; I: IDN-6556) and their final concentrations: rhTNF (100ng/ml) Compound A (500 nM) - Smac mimetic, Tetralogic and SYNthesis med chem IDN-6556 (10 μM) – Selleckchem (S7775) Assay experimental outline The cellular assay was carried out according to the following steps: 1. Each well was prepared by sequential addition of: a. 40µL of cell suspension (5.5 x 10 ⁴ cells/mL) was added to each well to provide a final cell concentration of 2,200 cells per well. b. After 24 hours, DMSO (control; columns 1-2 and 23-24) or compound in DMSO – addition was performed using acoustic transfer of nL volumes of stock compound to give final test concentrations of 36,12, 4, 1.3, 0.44, 0.148, 0.049, 0.016, 0.005 and 0.002 µM. All wells were backfilled with DMSO to a final total volume in the well of 100nL. c. Following compound/DMSO addition in step (b), Plates were incubated for 30 minutes at 37°C/10% CO ₂ in a humidified incubator and then 10 µL of 5x TSI cocktail (except to positive controls; columns 2 and 24) was added to each well. 2. After 3 hours, plate was removed from the 37°C incubator and equilibrated to room temperature for 15 minutes. 3. 15 µL of room temperatured CellTitre-Glo2 ^TM (Promega ^TM ) was added to each well. 4. Shook plates for 2 minutes (~600 rpm) and incubated at room temperature for 15 minutes to allow signal to stabilise. 5. Read luminescence readout on a plate reader. Analysis: Percent viability was calculated for each compound according to equation (2): %viability=100x((RawData-NSA)/(TANSA) (2) Wherein RawData is the readout of any cell containing a compound of the invention. TA is the total activity provided by the luminescence readout from DMSO only wells (columns 2 and 24) = 100% viability. NSA is the non-specific activity provided by DMSO+TSI wells (columns 1 and 23) = 0% viability Curve fitting: 10-point titration curves are fitted with the 4-parameter logistic nonlinear regression model and the IC ₅₀ reported is the inflection point of the curve Analysis: Data was loaded into Dotmatics ^TM and visualised using the Tibco® Spotfire ^TM software.10 point titration curves were fitted with the 4 parameter logistic nonlinear regression model and the IC50 reported reflect the inflection point of the curve for curve fitting. Interpretation of results: Assay involving the TSI cocktail (T: TNF; S: Smac mimetic; I: IDN-6556): TSI treatment ensures that cells specifically undergo necroptotic cell death. TNF activates the TNF receptor, Smac mimetic directs the signal away from proinflammatory signaling and toward the RIPK1/RIPK3-mediated cell death pathways, and IDN-6556 (Caspase inhibitor) ensures that the apoptotic response is blocked leaving only the programmed necrosis response. The compounds’ activity (solution in DMSO) tested in this TSI-induced assay was evaluated by determining the number of viable cells in culture by measuring the amount of ATP present as measured by CelltiterGlo. The results of the cellular screening of the compounds described above are shown below in Table 23. Table 23: Table showing the results of cell-based assays performed, analysed as the half maximal inhibitory concentration (IC ₅₀ ), being the concentration of the test compound needed to inhibit TSI induced necroptosis by 50%. The lower the IC _50, the more potent the compound. Activity is provided as follows: ++++ = < 100nM +++ = 100 nM < IC ₅₀ < 1,000 nM ++ = 1,000 nM < IC ₅₀ < 10,000 nM

It will be appreciated by persons skilled in the art that numerous variations and/or modifications may be made to the above-described embodiments, without departing from the broad general spirit and scope of the present disclosure. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive.