Title:
ASCORBIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1991/003471
Kind Code:
A1
Abstract:
A drug effective in preventing and ameliorating dysfunctions of organs caused by active oxygen species and active organic radical species, comprising an ascorbic acid derivative of general formula (I) as the active ingredient in order to solve the problem of in vivo unstableness of conventional drugs, wherein R2 represents a group selected from among alkylcarbonyl (lower alkyl) groups wherein the terminal alkyl group has 7 to 15 carbon atoms, alkyl groups having 9 to 17 carbon atoms, and alkoxycarbonyl (lower alkyl) groups wherein the terminal alkoxy group has 7 to 20 carbon atoms. Ascorbic acid derivatives of the above general formula, wherein R2 represents an alkylcarbonyl (lower alkyl) group wherein the terminal alkyl group has 7 to 15 carbon atoms are new substances, and this invention discloses these new substances and a method of producing the same.
Inventors:
SATOH TOSHIO (JP)
NIIRO YASUNORI (JP)
KAKEGAWA HISAO (JP)
MATSUMOTO HITOSHI (JP)
NIIRO YASUNORI (JP)
KAKEGAWA HISAO (JP)
MATSUMOTO HITOSHI (JP)
Application Number:
PCT/JP1990/001157
Publication Date:
March 21, 1991
Filing Date:
September 11, 1990
Export Citation:
Assignee:
NIPPON HYPOX LAB INC (JP)
International Classes:
C07D307/62; (IPC1-7): A61K31/375; C07D307/62
Foreign References:
| JPS58131978A | 1983-08-06 | |||
| JPH01228977A | 1989-09-12 |
Other References:
Journal of Medicional Chemistry Vol. 31, No. 4, p. 739-8, (1988), K. KATO et al. "Studies on Scavengers of Active Oxigen Species. 1" A Compound wherein R2 in the formula (1A) is an alkyl group having 18 carbon atoms is described as the compound No. 9.
See also references of EP 0444199A4
See also references of EP 0444199A4
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