Title:
ASGPR CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2023/288033
Kind Code:
A8
Abstract:
The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface asialoglycoprotein receptor (ASGPR). The cell surface ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.
Inventors:
BUSCH BRETT (US)
ERNST JUSTIN (US)
PACKARD GARRICK (US)
LEWIS JASON (US)
TURTLE ERIC (US)
ERNST JUSTIN (US)
PACKARD GARRICK (US)
LEWIS JASON (US)
TURTLE ERIC (US)
Application Number:
PCT/US2022/037227
Publication Date:
June 22, 2023
Filing Date:
July 14, 2022
Export Citation:
Assignee:
LYCIA THERAPEUTICS INC (US)
International Classes:
A61K47/54; A61P35/00
Attorney, Agent or Firm:
FOULDS, Glenn, J. et al. (US)
Download PDF:
Previous Patent: FLUID HANDLING SYSTEMS WITH FUNCTION CHECKS
Next Patent: SPATIALIZED AUDIO CHAT IN A VIRTUAL METAVERSE
Next Patent: SPATIALIZED AUDIO CHAT IN A VIRTUAL METAVERSE