Title:
ASSAYS AND REAGENTS FOR CHARACTERIZATION OF MHCI PEPTIDE BINDING
Document Type and Number:
WIPO Patent Application WO/2022/046895
Kind Code:
A3
Abstract:
The present disclosure relates to reagents and methods of making and for detecting MHCI/ligand peptide complexes.
Inventors:
LI JUAN (US)
PHUNG WILSON (US)
SANDOVAL WENDY NOEL (US)
BINDER WHITNEY LAUREN (US)
BLANCHETTE CRAIG (US)
CHAN PAMELA PUI FUNG (US)
DARWISH MARTINE ABRAHAM (US)
PHUNG WILSON (US)
SANDOVAL WENDY NOEL (US)
BINDER WHITNEY LAUREN (US)
BLANCHETTE CRAIG (US)
CHAN PAMELA PUI FUNG (US)
DARWISH MARTINE ABRAHAM (US)
Application Number:
PCT/US2021/047537
Publication Date:
April 28, 2022
Filing Date:
August 25, 2021
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
C07K14/74; C07K7/00; C40B30/04; G01N33/569
Domestic Patent References:
| WO2008039267A2 | 2008-04-03 | |||
| WO2020010261A1 | 2020-01-09 |
Other References:
HADRUP SINE REKER ET AL: "High-throughput T-cell epitope discovery through MHC peptide exchange", ANTIBODY-DRUG CONJUGATES; IN: METHODS IN MOLECULAR BIOLOGY; ISSN 1064-3745; VOL. 263; [METHODS IN MOLECULAR BIOLOGY; ISSN 1064-3745], HUMANA PRESS, US, vol. 524, 1 January 2009 (2009-01-01), pages 383 - 405, XP009184142, ISBN: 978-1-62703-541-5
TOEBES M ET AL: "DESIGN AND USE OF CONDITIONAL MHC CLASS I LIGANDS", NATURE MEDICINE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 12, no. 2, 5 February 2006 (2006-02-05), pages 246 - 251, XP007900182, ISSN: 1078-8956, DOI: 10.1038/NM1360
JOLIEN J. LUIMSTRA ET AL: "A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 215, no. 5, 17 April 2018 (2018-04-17), US, pages 1493 - 1504, XP055540611, ISSN: 0022-1007, DOI: 10.1084/jem.20180156
HOPPES R ET AL: "Technologies for MHC class I immunoproteomics", JOURNAL OF PROTEOMICS, ELSEVIER, AMSTERDAM, NL, vol. 73, no. 10, 10 September 2010 (2010-09-10), pages 1945 - 1953, XP027275232, ISSN: 1874-3919, [retrieved on 20100608]
DARWISH MARTINE ET AL: "complexes", PROTEIN SCIENCE, vol. 30, no. 6, 26 April 2021 (2021-04-26), US, pages 1169 - 1183, XP055868213, ISSN: 0961-8368, Retrieved from the Internet DOI: 10.1002/pro.4082
TOEBES M ET AL: "DESIGN AND USE OF CONDITIONAL MHC CLASS I LIGANDS", NATURE MEDICINE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 12, no. 2, 5 February 2006 (2006-02-05), pages 246 - 251, XP007900182, ISSN: 1078-8956, DOI: 10.1038/NM1360
JOLIEN J. LUIMSTRA ET AL: "A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 215, no. 5, 17 April 2018 (2018-04-17), US, pages 1493 - 1504, XP055540611, ISSN: 0022-1007, DOI: 10.1084/jem.20180156
HOPPES R ET AL: "Technologies for MHC class I immunoproteomics", JOURNAL OF PROTEOMICS, ELSEVIER, AMSTERDAM, NL, vol. 73, no. 10, 10 September 2010 (2010-09-10), pages 1945 - 1953, XP027275232, ISSN: 1874-3919, [retrieved on 20100608]
DARWISH MARTINE ET AL: "complexes", PROTEIN SCIENCE, vol. 30, no. 6, 26 April 2021 (2021-04-26), US, pages 1169 - 1183, XP055868213, ISSN: 0961-8368, Retrieved from the Internet
Attorney, Agent or Firm:
BRAYMAN, Melissa J. et al. (US)
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