Title:
ASSAYS TO DETECT COMPOUNDS THAT BIND THE SARS-COV-2 SPIKE PROTEIN
Document Type and Number:
WIPO Patent Application WO/2021/236937
Kind Code:
A3
Abstract:
Microparticle-based in vitro assays that detect antibodies that bind the SARS-CoV-2 spike protein and that detect binding between the SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 (hACE2) are described. The assays can quantify inhibition of such binding by either human serum/plasma or drug candidates. The assay is compatible with high-throughput screening systems.
Inventors:
SMITH STEPHEN EDWARD PAUCHA (US)
Application Number:
PCT/US2021/033420
Publication Date:
December 23, 2021
Filing Date:
May 20, 2021
Export Citation:
Assignee:
SEATTLE CHILDRENS HOSPITAL D/B/A SEATTLE CHILDRENS RES INSTITUTE (US)
International Classes:
A61K31/70; A61P31/14; G01N33/58
Domestic Patent References:
| WO2011147850A1 | 2011-12-01 |
Foreign References:
| US20070148784A1 | 2007-06-28 | |||
| US7659085B2 | 2010-02-09 |
Other References:
CHEN XIANGYU, LI REN, PAN ZHIWEI, QIAN CHUNFANG, YANG YANG, YOU RENRONG, ZHAO JING, LIU PINGHUANG, GAO LEIQIONG, LI ZHIRONG, HUANG: "Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor", CELLULAR AND MOLECULAR IMMUNOLOGY, NATURE, vol. 17, no. 6, 27 March 2020 (2020-03-27), pages 647 - 649, XP037153212
AMANAT ET AL.: "A serological assay to detect SARS-CoV-2 seroconversion in humans", NATURE MEDICINE, vol. 26, 12 May 2020 (2020-05-12), pages 1033 - 1036, XP037191537, DOI: 10.1038/s41591-020-0913-5
BLOOM: "Software for the analysis and visualization of deep mutational scanning data", BMC BIOINFORMATICS, vol. 16, no. 168, 2015, pages 1 - 13, XP021222403
AMANAT ET AL.: "A serological assay to detect SARS-CoV-2 seroconversion in humans", NATURE MEDICINE, vol. 26, 12 May 2020 (2020-05-12), pages 1033 - 1036, XP037191537, DOI: 10.1038/s41591-020-0913-5
BLOOM: "Software for the analysis and visualization of deep mutational scanning data", BMC BIOINFORMATICS, vol. 16, no. 168, 2015, pages 1 - 13, XP021222403
Attorney, Agent or Firm:
WINGER, C. Rachal et al. (US)
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