Title:
ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING PROBABILISTIC MODELING OF TARGET GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2013/011479
Kind Code:
A3
Abstract:
The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non- transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
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Inventors:
VERHAEGH WILHELMUS FRANCISCUS JOHANNES (NL)
VAN DE STOLPE ANJA (NL)
VAN OOIJEN HENDRIK JAN (NL)
DULLA KALYANA CHAKRAVARTHI (NL)
ALVES DE INDA MARCIA (NL)
HOFFMANN RALF (DE)
VAN DE STOLPE ANJA (NL)
VAN OOIJEN HENDRIK JAN (NL)
DULLA KALYANA CHAKRAVARTHI (NL)
ALVES DE INDA MARCIA (NL)
HOFFMANN RALF (DE)
Application Number:
PCT/IB2012/053686
Publication Date:
March 14, 2013
Filing Date:
July 19, 2012
Export Citation:
Assignee:
KONINKL PHILIPS ELECTRONICS NV (NL)
VERHAEGH WILHELMUS FRANCISCUS JOHANNES (NL)
VAN DE STOLPE ANJA (NL)
VAN OOIJEN HENDRIK JAN (NL)
DULLA KALYANA CHAKRAVARTHI (NL)
ALVES DE INDA MARCIA (NL)
HOFFMANN RALF (DE)
VERHAEGH WILHELMUS FRANCISCUS JOHANNES (NL)
VAN DE STOLPE ANJA (NL)
VAN OOIJEN HENDRIK JAN (NL)
DULLA KALYANA CHAKRAVARTHI (NL)
ALVES DE INDA MARCIA (NL)
HOFFMANN RALF (DE)
International Classes:
C12Q1/68; G16B5/20; G16B20/20; G16B20/30; G16B25/00; G16B40/20
Other References:
M. F. OCHS ET AL: "Detection of Treatment-Induced Changes in Signaling Pathways in Gastrointestinal Stromal Tumors Using Transcriptomic Data", CANCER RESEARCH, vol. 69, no. 23, 1 December 2009 (2009-12-01), pages 9125 - 9132, XP055039908, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-09-1709
BARKER NICK ET AL: "Mining the Wnt pathway for cancer therapeutics", NATURE REVIEWS. DRUG DISCOVERY, vol. 5, no. 12, 1 December 2006 (2006-12-01), NATURE PUBLISHING GROUP, GB, pages 997 - 1014, XP002545380, ISSN: 1474-1784, DOI: 10.1038/NRD2154
L ADAMS ET AL: "Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis", BMC PROCEEDINGS, vol. 5, no. Suppl 4, 1 January 2011 (2011-01-01), pages S6, XP055018507, ISSN: 1753-6561, DOI: 10.1186/1753-6561-5-S4-S6
H. A KESTLER ET AL: "From individual Wnt pathways towards a Wnt signalling network", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B: BIOLOGICAL SCIENCES, vol. 363, no. 1495, 12 April 2008 (2008-04-12), pages 1333 - 1347, XP055018513, ISSN: 0962-8436, DOI: 10.1098/rstb.2007.2251
SU JUNJIE ET AL: "Accurate and reliable cancer classification based on probabilistic inference of pathway activity.", PLOS ONE, vol. 4, no. 12, E8161, December 2009 (2009-12-01), pages 1 - 10, XP002684530, ISSN: 1932-6203
BARKER NICK ET AL: "Mining the Wnt pathway for cancer therapeutics", NATURE REVIEWS. DRUG DISCOVERY, vol. 5, no. 12, 1 December 2006 (2006-12-01), NATURE PUBLISHING GROUP, GB, pages 997 - 1014, XP002545380, ISSN: 1474-1784, DOI: 10.1038/NRD2154
L ADAMS ET AL: "Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis", BMC PROCEEDINGS, vol. 5, no. Suppl 4, 1 January 2011 (2011-01-01), pages S6, XP055018507, ISSN: 1753-6561, DOI: 10.1186/1753-6561-5-S4-S6
H. A KESTLER ET AL: "From individual Wnt pathways towards a Wnt signalling network", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B: BIOLOGICAL SCIENCES, vol. 363, no. 1495, 12 April 2008 (2008-04-12), pages 1333 - 1347, XP055018513, ISSN: 0962-8436, DOI: 10.1098/rstb.2007.2251
SU JUNJIE ET AL: "Accurate and reliable cancer classification based on probabilistic inference of pathway activity.", PLOS ONE, vol. 4, no. 12, E8161, December 2009 (2009-12-01), pages 1 - 10, XP002684530, ISSN: 1932-6203
Attorney, Agent or Firm:
VAN VELZEN, Maaike et al. (Building 44, AE Eindhoven, NL)
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