ASYMMETRIC SYNTHESIS OF QUINAZOLIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS

Title:

ASYMMETRIC SYNTHESIS OF QUINAZOLIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2001070707

Kind Code:

A3

Abstract:

This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.

Inventors:

PARSONS RODNEY L
DOROW ROBERTA L
DAVULCU AKIN H
FORTUNAK JOSEPH M
HARRIS GREGORY D
KAUFFMAN GOSS S
NUGENT WILLIAM A
RADESCA LILIAN A

Application Number:

PCT/US2001/007865

Publication Date:

March 07, 2002

Filing Date:

March 13, 2001

Export Citation:

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Assignee:

DU PONT PHARM CO (US)

International Classes:

C07D239/80; (IPC1-7): C07D239/80

Domestic Patent References:

WO1998045276A2

1998-10-15

Foreign References:

US5434152A

1995-07-18

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