Title:
ASYMMETRIC SYNTHESIS AND USES OF COMPOUNDS IN DISEASE TREATMENTS
Document Type and Number:
WIPO Patent Application WO/2019/041078
Kind Code:
A1
Abstract:
The present application discloses, among other things, asymmetric synthesis a diastereomeric compound of formula (I) (e.g., α-anordrin) or salt thereof. Also provided are methods and compositions for treatment of estrogen deficiency as well as preventing or reducing an estrogen deficiency symptom using a diastereomeric compound of formula (I) (e.g., α-anordrin) or salt thereof alone or in combination with at least one additional agent. Further provided are methods and compositions for reducing a side effect of an additional agent in the context of combination therapy with a diastereomeric compound of formula (I) (e.g., α-anordrin) or salt thereof.
Inventors:
XU WENPING (CN)
YANG JUN (CN)
YANG JUN (CN)
Application Number:
PCT/CN2017/099221
Publication Date:
March 07, 2019
Filing Date:
August 28, 2017
Export Citation:
Assignee:
ZHEJIANG JIACHI PHARMACEUTICAL DEV LTD (CN)
International Classes:
A61K31/56; A61P15/12; A61P19/10
Foreign References:
| CN104208069A | 2014-12-17 | |||
| CN102218069A | 2011-10-19 | |||
| CN1331082A | 2002-01-16 |
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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