Title:
ASYNCHRONOUS MAGNETIC BEAD ROTATION SENSING SYSTEMS AND METHODS
Document Type and Number:
WIPO Patent Application WO/2012/027747
Kind Code:
A3
Abstract:
Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles.
Inventors:
MCNAUGHTON BRANDON H (US)
KINNUNEN PAIVO (US)
KOPELMAN RAOUL (US)
HUNT ALAN (US)
CLARKE ROY C (US)
SINN IRENE (US)
ELBEZ REMY (US)
ALBERTSON THEODORE (US)
KINNUNEN PAIVO (US)
KOPELMAN RAOUL (US)
HUNT ALAN (US)
CLARKE ROY C (US)
SINN IRENE (US)
ELBEZ REMY (US)
ALBERTSON THEODORE (US)
Application Number:
PCT/US2011/049571
Publication Date:
June 14, 2012
Filing Date:
August 29, 2011
Export Citation:
Assignee:
UNIV MICHIGAN (US)
MCNAUGHTON BRANDON H (US)
KINNUNEN PAIVO (US)
KOPELMAN RAOUL (US)
HUNT ALAN (US)
CLARKE ROY C (US)
SINN IRENE (US)
ELBEZ REMY (US)
ALBERTSON THEODORE (US)
MCNAUGHTON BRANDON H (US)
KINNUNEN PAIVO (US)
KOPELMAN RAOUL (US)
HUNT ALAN (US)
CLARKE ROY C (US)
SINN IRENE (US)
ELBEZ REMY (US)
ALBERTSON THEODORE (US)
International Classes:
C12Q1/02; C12M1/42; G01N27/72; G01N33/50
Foreign References:
| US20080220411A1 | 2008-09-11 |
Other References:
MCNAUGHTON, B. H. ET AL.: "Sudden breakdown in linear response of a rotationally driven magnetic microparticle and application to physical and chemical microsensing", JOURNAL OF PHYSICAL CHEMISTRY., vol. 110, no. 38, 28 September 2006 (2006-09-28), pages 18958 - 18964
JANSSEN, X. J. ET AL.: "Controlled torque on supserparamagnetic beads for functional biosensors", BIOSENSORS AND BIOELECTRONICS., vol. 24, no. 7, 14 October 2008 (2008-10-14), pages 1937 - 1941
KINNUNEN, P. ET AL.: "Monitoring the growth and drug susceptibility of individual bacteria using asynchronous magnetic bead rotation sensors", BIOSENSORS AND BIOELECTRONICS., vol. 26, no. 5, 14 October 2010 (2010-10-14), pages 2751 - 2755
JANSSEN, X. J. ET AL.: "Controlled torque on supserparamagnetic beads for functional biosensors", BIOSENSORS AND BIOELECTRONICS., vol. 24, no. 7, 14 October 2008 (2008-10-14), pages 1937 - 1941
KINNUNEN, P. ET AL.: "Monitoring the growth and drug susceptibility of individual bacteria using asynchronous magnetic bead rotation sensors", BIOSENSORS AND BIOELECTRONICS., vol. 26, no. 5, 14 October 2010 (2010-10-14), pages 2751 - 2755
Attorney, Agent or Firm:
STEPHENS, Paul, B. (Gerstein & Borun LLP233 S. Wacker Drive,6300 Willis Towe, Chicago IL, US)
Download PDF:
Previous Patent: RUPTURE DISK
Next Patent: METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR DETECTING CUSTOMER PRESENCE TO INITIATE THE ORDERI...
Next Patent: METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR DETECTING CUSTOMER PRESENCE TO INITIATE THE ORDERI...