Title:
AT2R AGONIST
Document Type and Number:
WIPO Patent Application WO/2023/193733
Kind Code:
A1
Abstract:
The present disclosure relates to the field of medicine. Specifically, provided in the present disclosure are a compound represented by formula I, and a tautomer, a stereoisomer, a hydrate, a solvate, and a pharmaceutically acceptable salt or a prodrug thereof. The compound can be used as an agonist of an AT2 receptor,
Inventors:
ZHANG XUEJUN (CN)
ZANG YANG (CN)
DING XIAOHUA (CN)
GAO ZHENXING (CN)
QIAN LINA (CN)
LI QUN (CN)
YANG HUI (CN)
LI LIE (CN)
YANG JUN (CN)
ZANG YANG (CN)
DING XIAOHUA (CN)
GAO ZHENXING (CN)
QIAN LINA (CN)
LI QUN (CN)
YANG HUI (CN)
LI LIE (CN)
YANG JUN (CN)
Application Number:
PCT/CN2023/086425
Publication Date:
October 12, 2023
Filing Date:
April 06, 2023
Export Citation:
Assignee:
WUHAN HUMANWELL INNOVATIVE DRUG RES AND DEVELOPMENT CENTER LIMITED COMPANY (CN)
International Classes:
C07D409/10; A61K31/4439; A61K31/506; A61P9/00; A61P11/00; A61P13/12; C07D401/14; C07D409/14
Domestic Patent References:
| WO2021053344A1 | 2021-03-25 | |||
| WO2004046141A1 | 2004-06-03 |
Foreign References:
| GB2605148A | 2022-09-28 | |||
| CN101193886A | 2008-06-04 |
Other References:
MAHALINGAM, A.K. ET AL.: "Selective Angiotensin II AT2 Receptor Agonists with Reduced CYP 450 Inhibition", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, no. 12, 9 April 2010 (2010-04-09), XP027072378, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2010.03.064
WANNBERG, J. ET AL.: "N-(Methyloxycarbonyl)Thiophene Sulfonamides as High Affinity AT2 Receptor Ligands", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 29, 7 November 2020 (2020-11-07), XP086455878, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2020.115859
MURUGAIAH, A.M.S. ET AL.: "From the First Selective Non-Peptide AT2 Receptor Agonist to Structurally Related Antagonists", J. MED. CHEM., vol. 55, no. 5, 16 January 2012 (2012-01-16), XP055817970, ISSN: 0022-2623, DOI: 10.1021/jm2015099
WANNBERG, J. ET AL.: "N-(Methyloxycarbonyl)Thiophene Sulfonamides as High Affinity AT2 Receptor Ligands", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 29, 7 November 2020 (2020-11-07), XP086455878, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2020.115859
MURUGAIAH, A.M.S. ET AL.: "From the First Selective Non-Peptide AT2 Receptor Agonist to Structurally Related Antagonists", J. MED. CHEM., vol. 55, no. 5, 16 January 2012 (2012-01-16), XP055817970, ISSN: 0022-2623, DOI: 10.1021/jm2015099
Attorney, Agent or Firm:
ZHIFAN & PARTNERS (CN)
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