ATTENUATED MYCOBACTERIUM TUBERCULOSIS VACCINES

WIPO Patent Application WO2003070164

A3

Non-naturally occurring mycobacteria in the Mycobacterium tuberculosis complex are provided. These mycobacteria have a deletion of an RD] region or a region controlling production of a vitamin, and exhibit attenuated virulence in a mammal when compared to the mycobacteria without the deletion. Also provided are non-naturally occurring mycobacteria that have a deletion of a region controlling production of lysine, and mycobacteria comprising two attenuating deletions. Vaccines comprising these mycobacteria are also provided, as are methods of protecting mammals from virulent mycobacteria using the vaccines. Also provided are methods of preparing these vaccines which include the step of deleting an RD I region or a region controlling production of a vitamin from a mycobacterium in the M tuberculosis complex.

JP2020063291	USE OF AMINO ACID SEQUENCES DERIVED FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM
JPH06505143	[Title of the Invention] A nucleic acid probe useful for detecting Mycobacterium tuberculosis.
JP2011524159	Diagnosis method of infection by mycobacterium and reagent for it

JACOBS WILLIAM R JR (US)
HSU TSUNGDA (US)
BARDAROV STOYAN
SAMBANDAMURTHY VASAN (US)

PCT/US2003/002046

February 16, 2006

January 24, 2003

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VERSITY ALBERT EINSTEIN COLLEG (US)

C07K14/35; C12N1/21; C12N9/00; C12N9/88; A61K39/00; (IPC1-7): A61K49/00; A61K48/00; A61K39/00; A61K39/38; A61K39/02; A61K39/04; C07H21/02; C07H21/04

US6221364B1	2001-04-24
US5955077A	1999-09-21
US6271034B1	2001-08-07

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