Title:
AVANAFIL PHOSPHATE COMPOUNDS AS WELL AS PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/231254
Kind Code:
A1
Abstract:
The present invention relates to the technical field of pharmaceutical compounds. Provided are avanafil phosphate compounds, the structural formula thereof being shown as formula I, wherein R in formula I is hydrogen, phenyl, substituted phenyl, alkyl or substituted alkyl. The avanafil phosphate compounds provided by the present invention have good water solubility, long drug action time, and a good slow release effect, thus having wide application prospects in preparation of drugs for treating phosphodiesterase 5-related diseases. The present invention also provides a preparation method for the avanafil phosphate compounds in the above solution, and the preparation method provided by the present invention involves simple steps and easy operation, thus being suitable for large-scale production.
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Inventors:
GU YANFEI (CN)
FENG FEI (CN)
FENG FEI (CN)
Application Number:
PCT/CN2022/122414
Publication Date:
December 07, 2023
Filing Date:
September 29, 2022
Export Citation:
Assignee:
SUZHOU XEON BIOPHARMACEUTICAL LTD (CN)
SUZHOU PHARMOUS BIOPHARM TECH LIMITED COMPANY (CN)
SUZHOU PHARMOUS BIOPHARM TECH LIMITED COMPANY (CN)
International Classes:
C07F9/6558; A61P9/10; A61P9/12; A61P13/08; A61P15/10
Foreign References:
| CN114957332A | 2022-08-30 | |||
| CN104710411A | 2015-06-17 | |||
| CN101100474A | 2008-01-09 | |||
| CN114249788A | 2022-03-29 | |||
| CN112521421A | 2021-03-19 | |||
| CN102229608A | 2011-11-02 |
Other References:
姬勋 等 (JI, XUN ET AL.): "磷酸酯前药在药物研究中的应用 (Application of Phosphates and Phosphonates Prodrugs in Drug Research and Development)", 药学学报 (ACTA PHARMACEUTICA SINICA), vol. 48, no. 5, 31 December 2013 (2013-12-31), XP055866056, DOI: 10.16438/j.0513-4870.2013.05.014
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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