Title:
AVV VECTOR THAT INCLUDES PROMOTER SPECIFICALLY EXPRESSED IN CEREBROVASCULAR ENDOTHELIAL CELLS AND IS COATED WITH NANO-PEPTIDES TARGETING CEREBROVASCULAR ENDOTHELIAL CELLS, AND USE THEREOF FOR TRANSFER OF GENES SPECIFIC TO CEREBROVASCULAR ENDOTHELIAL CELLS
Document Type and Number:
WIPO Patent Application WO/2024/019425
Kind Code:
A1
Abstract:
The present invention relates to an AAV vector that includes a promoter specifically expressed in cerebrovascular endothelial cells and is coated with nano-peptides targeting cerebrovascular endothelial cells and, to a technique of use thereof for the transfer of genes specific to cerebrovascular endothelial cells.
Inventors:
LEE SEUNG MIN (KR)
Application Number:
PCT/KR2023/010038
Publication Date:
January 25, 2024
Filing Date:
July 13, 2023
Export Citation:
Assignee:
MARKHERZ INC (KR)
International Classes:
C12N15/86; C07K7/06
Foreign References:
| KR20220050073A | 2022-04-22 |
Other References:
LEE SEUNGMIN: "Enhanced recombinant adeno-associated virus(rAAV) in vivo transduction efficacy via surface modified PAMAM nanoparticles precoating", DISSERTATION, LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN, 1 January 2015 (2015-01-01), Ludwig-Maximilians-Universität München, XP093131719, Retrieved from the Internet [retrieved on 20240215]
MERCHAN JUAN A, DEAN JARROD, AZPURUA FEDERICO, SEN SABYASACHI, ZHU YAN, AIKAWA RYUICHI: "Utility of vascular endothelial specific peptides for enhancement of adeno-associated virus-mediated gene transfer", INTERNATIONAL JOURNAL OF BIOMEDICAL SCIENCE, MASTER PUBLISHING GROUP, US, vol. 4, no. 3, 1 September 2008 (2008-09-01), US , pages 217 - 220, XP093131721, ISSN: 1550-9702, DOI: 10.59566/IJBS.2008.4217
HERSH JESSICA, CONDOR CAPCHA JOSÉ MANUEL, IANSEN IRION CAMILA, LAMBERT GUERLINE, NOGUERA MAURICIO, SINGH MOHIT, KAUR AVINASH, DIKI: "Peptide-Functionalized Dendrimer Nanocarriers for Targeted Microdystrophin Gene Delivery", PHARMACEUTICS, MDPI AG, CH, vol. 13, no. 12, 15 December 2021 (2021-12-15), CH , pages 2159, XP093131722, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics13122159
BOZOGLU TARIK, LEE SEUNGMIN, ZIEGLER TILMAN, JURISCH VICTORIA, MAAS SANNE, BAEHR ANDREA, HINKEL RABEA, HOENIG AMELIE, HARIHARAN AN: "Endothelial Retargeting of AAV9 In Vivo", ADVANCED SCIENCE, vol. 9, no. 7, 1 March 2022 (2022-03-01), pages 2103867, XP093131725, ISSN: 2198-3844, DOI: 10.1002/advs.202103867
MERCHAN JUAN A, DEAN JARROD, AZPURUA FEDERICO, SEN SABYASACHI, ZHU YAN, AIKAWA RYUICHI: "Utility of vascular endothelial specific peptides for enhancement of adeno-associated virus-mediated gene transfer", INTERNATIONAL JOURNAL OF BIOMEDICAL SCIENCE, MASTER PUBLISHING GROUP, US, vol. 4, no. 3, 1 September 2008 (2008-09-01), US , pages 217 - 220, XP093131721, ISSN: 1550-9702, DOI: 10.59566/IJBS.2008.4217
HERSH JESSICA, CONDOR CAPCHA JOSÉ MANUEL, IANSEN IRION CAMILA, LAMBERT GUERLINE, NOGUERA MAURICIO, SINGH MOHIT, KAUR AVINASH, DIKI: "Peptide-Functionalized Dendrimer Nanocarriers for Targeted Microdystrophin Gene Delivery", PHARMACEUTICS, MDPI AG, CH, vol. 13, no. 12, 15 December 2021 (2021-12-15), CH , pages 2159, XP093131722, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics13122159
BOZOGLU TARIK, LEE SEUNGMIN, ZIEGLER TILMAN, JURISCH VICTORIA, MAAS SANNE, BAEHR ANDREA, HINKEL RABEA, HOENIG AMELIE, HARIHARAN AN: "Endothelial Retargeting of AAV9 In Vivo", ADVANCED SCIENCE, vol. 9, no. 7, 1 March 2022 (2022-03-01), pages 2103867, XP093131725, ISSN: 2198-3844, DOI: 10.1002/advs.202103867
Attorney, Agent or Firm:
JEON, Jeong Wook (KR)
Download PDF:
Previous Patent: METHOD AND DEVICE FOR BINDING USER AND UE IN MOBILE COMMUNICATION SYSTEM
Next Patent: BATTERY PACK AND VEHICLE INCLUDING SAME
Next Patent: BATTERY PACK AND VEHICLE INCLUDING SAME