Title:
AZA AND AZA (N-OXY) ANALOGS OF GLYCINE/NMDA RECEPTAZA AND AZA (N-OXY) ANALOGS OF GLYCINE/NMDA RECEPTOR ANTAGONISTS OR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO1996022990
Kind Code:
A3
Abstract:
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome, treating or preventing adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, inducing anesthesia, and treating or preventing opiate tolerance are disclosed by administering to an animal in need of such treatment or prevention a substituted or unsubstituted pyridine and pyridine (N-oxide) analogs of 4-hydroxydihydroquinolones, tetrahydroquinoline-trione-oximes and quinoxalones, tautomers and pharmaceutically acceptable salts thereof, which have high binding to the glycine receptor.
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Inventors:
KEANA JOHN F W
CAI SUI XIONG
MARTIN VLADIMIR V
ZHOU ZHANG-LIN
NAVRATIL JAMES M
CAI SUI XIONG
MARTIN VLADIMIR V
ZHOU ZHANG-LIN
NAVRATIL JAMES M
Application Number:
PCT/US1995/016575
Publication Date:
October 10, 1996
Filing Date:
December 21, 1995
Export Citation:
Assignee:
OREGON STATE (US)
ACEA PHARM INC (US)
ACEA PHARM INC (US)
International Classes:
C07D241/44; A61K31/4375; A61K31/444; A61K31/498; A61K31/519; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/18; A61P25/22; A61P25/28; A61P25/36; A61P43/00; C07D241/52; C07D471/04; C07D475/00; C07D487/04; (IPC1-7): C07D471/04; A61K31/44
Domestic Patent References:
| WO1994027605A1 | 1994-12-08 | |||
| WO1994020470A1 | 1994-09-15 |
Foreign References:
| US5268378A | 1993-12-07 | |||
| US5252584A | 1993-10-12 | |||
| EP0459561A2 | 1991-12-04 |
Other References:
See also references of EP 0805809A2
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