Title:
AZAPHILONE COMPOUND AND USE THEREOF IN PREPARATION OF ANTI-TUMOR DRUGS
Document Type and Number:
WIPO Patent Application WO/2023/160112
Kind Code:
A1
Abstract:
Provided is a use of an azaphilone compound of formula (I) in the preparation of drugs for treating or preventing diseases, including but not limited to tumors, autoimmune diseases, infectious diseases and aging, and a method for treating the diseases by using the compounds. The present invention further relates to a novel azaphilone compound as an NK activator.
Inventors:
LI DEHAI (CN)
LI JING (CN)
SUN CHUNXIAO (CN)
WU YU (CN)
GU QIANQUN (CN)
QI XIN (CN)
ZHU TIANJIAO (CN)
CHE QIAN (CN)
ZHANG GUOJIAN (CN)
LI JING (CN)
SUN CHUNXIAO (CN)
WU YU (CN)
GU QIANQUN (CN)
QI XIN (CN)
ZHU TIANJIAO (CN)
CHE QIAN (CN)
ZHANG GUOJIAN (CN)
Application Number:
PCT/CN2022/137267
Publication Date:
August 31, 2023
Filing Date:
December 07, 2022
Export Citation:
Assignee:
OCEAN UNIV CHINA (CN)
International Classes:
A61K31/4741; A61K31/365; A61P35/00; C07D311/76; C07D491/048; C07D493/04
Foreign References:
| CN110407847A | 2019-11-05 | |||
| US20220016075A1 | 2022-01-20 |
Other References:
TANG JIA-LIN, ZHOU ZONG-YUAN, YANG TAO, YAO CAN, WU LIN-WEI, LI GUO-YOU: "Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 67, no. 8, 27 February 2019 (2019-02-27), US , pages 2175 - 2182, XP093063772, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.8b05628
YOUN UI JOUNG, SRIPISUT TAWANUN, PARK EUN-JUNG, KONDRATYUK TAMARA P., FATIMA NIGHAT, SIMMONS CHARLES J., WALL MARISA M., SUN DIANQ: "Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 25, no. 21, 1 November 2015 (2015-11-01), Amsterdam NL , pages 4719 - 4723, XP093085713, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2015.08.063
YASUHIDE MUROGA, YAMADA TAKESHI, NUMATA ATSUSHI, TANAKA REIKO: "Chaetomugilins, new selectively cytotoxic metabolites, produced by a marine fish-derived Chaetomium species", THE JOURNAL OF ANTIBIOTICS, vol. 61, no. 10, 8 September 2008 (2008-09-08), pages 615 - 622, XP093085714
LI XIANG; TIAN YE; YANG SHENG-XIANG; ZHANG YA-MEI; QIN JIAN-CHUN: "Cytotoxic azaphilone alkaloids fromChaetomium globosumTY1", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 23, no. 10, 21 March 2013 (2013-03-21), Amsterdam NL , pages 2945 - 2947, XP028582251, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.03.044
ZHANG XIAO-YAN, TAN XIANG-MEI, YU MENG, YANG JIAN, SUN BING-DA, QIN JIAN-CHUN, GUO LAN-PING, DING GANG: "Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae)", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM , NL, vol. 185, 1 May 2021 (2021-05-01), Amsterdam , NL , pages 112701, XP093085715, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2021.112701
WANG WEIYI, YANG JING, LIAO YAN-YAN, CHENG GANG, CHEN JING, CHENG XIANG-DONG, QIN JIANG-JIANG, SHAO ZONGZE: "Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 83, no. 4, 24 April 2020 (2020-04-24), US , pages 1157 - 1166, XP093085716, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.9b01165
SUN CHUNXIAO, GE XUEPING, MUDASSIR SHAH, ZHOU LUNING, YU GUIHONG, CHE QIAN, ZHANG GUOJIAN, PENG JIXING, GU QIANQUN, ZHU TIANJIAO, : "New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus Chaetomium globosum HDN151398", MARINE DRUGS, vol. 17, no. 5, 28 April 2019 (2019-04-28), pages 253, XP093085717, DOI: 10.3390/md17050253
YOUN UI JOUNG, SRIPISUT TAWANUN, PARK EUN-JUNG, KONDRATYUK TAMARA P., FATIMA NIGHAT, SIMMONS CHARLES J., WALL MARISA M., SUN DIANQ: "Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 25, no. 21, 1 November 2015 (2015-11-01), Amsterdam NL , pages 4719 - 4723, XP093085713, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2015.08.063
YASUHIDE MUROGA, YAMADA TAKESHI, NUMATA ATSUSHI, TANAKA REIKO: "Chaetomugilins, new selectively cytotoxic metabolites, produced by a marine fish-derived Chaetomium species", THE JOURNAL OF ANTIBIOTICS, vol. 61, no. 10, 8 September 2008 (2008-09-08), pages 615 - 622, XP093085714
LI XIANG; TIAN YE; YANG SHENG-XIANG; ZHANG YA-MEI; QIN JIAN-CHUN: "Cytotoxic azaphilone alkaloids fromChaetomium globosumTY1", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 23, no. 10, 21 March 2013 (2013-03-21), Amsterdam NL , pages 2945 - 2947, XP028582251, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.03.044
ZHANG XIAO-YAN, TAN XIANG-MEI, YU MENG, YANG JIAN, SUN BING-DA, QIN JIAN-CHUN, GUO LAN-PING, DING GANG: "Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae)", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM , NL, vol. 185, 1 May 2021 (2021-05-01), Amsterdam , NL , pages 112701, XP093085715, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2021.112701
WANG WEIYI, YANG JING, LIAO YAN-YAN, CHENG GANG, CHEN JING, CHENG XIANG-DONG, QIN JIANG-JIANG, SHAO ZONGZE: "Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 83, no. 4, 24 April 2020 (2020-04-24), US , pages 1157 - 1166, XP093085716, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.9b01165
SUN CHUNXIAO, GE XUEPING, MUDASSIR SHAH, ZHOU LUNING, YU GUIHONG, CHE QIAN, ZHANG GUOJIAN, PENG JIXING, GU QIANQUN, ZHU TIANJIAO, : "New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus Chaetomium globosum HDN151398", MARINE DRUGS, vol. 17, no. 5, 28 April 2019 (2019-04-28), pages 253, XP093085717, DOI: 10.3390/md17050253
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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