Title:
AZAQUINOLINONE COMPOUND AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/046158
Kind Code:
A1
Abstract:
Provided are an azaquinolinone compound, an isomer, a solvate, a deuterated derivative or a pharmaceutically acceptable salt of the compound. In addition, also provided are a drug using the compound, the isomer, the solvate, the deuterated derivative and the salt thereof as active ingredients, and the use thereof in the preparation of a drug for diseases associated with PARP-1, such as cancer.
Inventors:
ZHANG WENYAN (CN)
Application Number:
PCT/CN2022/121293
Publication Date:
March 30, 2023
Filing Date:
September 26, 2022
Export Citation:
Assignee:
ZHANG WENYAN (CN)
International Classes:
C07D471/04; A61K31/496; A61K31/498; A61P35/00; C07D401/14
Domestic Patent References:
| WO2021013735A1 | 2021-01-28 | |||
| WO2021260092A1 | 2021-12-30 | |||
| WO2022222995A1 | 2022-10-27 | |||
| WO2022222921A1 | 2022-10-27 | |||
| WO2022225934A1 | 2022-10-27 | |||
| WO2022228387A1 | 2022-11-03 |
Foreign References:
| CN102341394A | 2012-02-01 | |||
| CN115232121A | 2022-10-25 |
Other References:
JOHANNES, J. W. ET AL.: "Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, no. 19, 27 September 2021 (2021-09-27), XP093028792, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01012
Attorney, Agent or Firm:
JJS INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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