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Title:
AZAQUINOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/232069
Kind Code:
A1
Abstract:
An azaquinolinone compound having a structure of the following formula (I) as an enzyme inhibitor for the poly(ADP-ribose)polymerase (PARP) family, and a pharmaceutically acceptable salt, a stereoisomer, a tautomer or an N-oxide drug thereof, a preparation method therefor and the use thereof.

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Inventors:
SONG LIQIANG (CN)
WANG QIONG (CN)
MAN YI (CN)
SUN LING (CN)
ZHANG YI (CN)
XIANG YONGZHE (CN)
LI LI (CN)
CHEN HONG (CN)
WANG YING (CN)
Application Number:
PCT/CN2023/097403
Publication Date:
December 07, 2023
Filing Date:
May 31, 2023
Export Citation:
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Assignee:
CHENGDU EASTON BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07D401/14; A61K31/336; A61K31/498; A61K41/00; A61P35/00; C07D403/14; C07D471/04
Domestic Patent References:
WO2022222921A12022-10-27
WO2022228387A12022-11-03
WO2022261777A12022-12-22
WO2023046034A12023-03-30
WO2023046149A12023-03-30
WO2023046158A12023-03-30
WO2023051716A12023-04-06
WO2023051807A12023-04-06
WO2023051812A12023-04-06
WO2023109521A12023-06-22
WO2023118085A12023-06-29
Foreign References:
US20220009901A12022-01-13
US20220348574A12022-11-03
Other References:
JOHANNES. J. W. ET AL.: "Discovery of 5-14-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3- yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, no. 19, 30 September 2021 (2021-09-30), pages 14498 - 14512, XP093028792, DOI: 10.1021/acs.jmedchem.1c01012
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