Title:
B-BIPHENYL SULFONAMIDE COMPOUNDS AS ION CHANNEL MODULATORS
Document Type and Number:
WIPO Patent Application WO/2010/056527
Kind Code:
A3
Abstract:
The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (IA) or (IB): as further described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.
Inventors:
ABELMAN MATTHEW (US)
ELZEIN ELFATIH (US)
JIANG ROBERT (US)
KALLA RAO (US)
KOBAYASHI TETSUYA (US)
LI XIAOFEN (US)
PERRY THAO (US)
ZABLOCKI JEFF (US)
ELZEIN ELFATIH (US)
JIANG ROBERT (US)
KALLA RAO (US)
KOBAYASHI TETSUYA (US)
LI XIAOFEN (US)
PERRY THAO (US)
ZABLOCKI JEFF (US)
Application Number:
PCT/US2009/062381
Publication Date:
July 08, 2010
Filing Date:
October 28, 2009
Export Citation:
Assignee:
GILEAD PALO ALTO INC (US)
ABELMAN MATTHEW (US)
ELZEIN ELFATIH (US)
JIANG ROBERT (US)
KALLA RAO (US)
KOBAYASHI TETSUYA (US)
LI XIAOFEN (US)
PERRY THAO (US)
ZABLOCKI JEFF (US)
ABELMAN MATTHEW (US)
ELZEIN ELFATIH (US)
JIANG ROBERT (US)
KALLA RAO (US)
KOBAYASHI TETSUYA (US)
LI XIAOFEN (US)
PERRY THAO (US)
ZABLOCKI JEFF (US)
International Classes:
C07C311/08; A61K31/18; A61P3/10; A61P9/00; A61P25/02; C07C311/14; C07C311/29; C07C317/32; C07D213/38; C07D213/82; C07D257/04; C07D295/13; C07F9/40
Domestic Patent References:
| WO2007146824A2 | 2007-12-21 | |||
| WO2005066166A2 | 2005-07-21 | |||
| WO2007025575A1 | 2007-03-08 | |||
| WO2004113279A1 | 2004-12-29 |
Foreign References:
| US20060223837A1 | 2006-10-05 | |||
| US6800651B2 | 2004-10-05 | |||
| DE4238233A1 | 1994-05-19 | |||
| US20060270686A1 | 2006-11-30 |
Other References:
A. ZAZA, ET AL.: "Pathophysiology and pharmacology of the cardiac ''late sodium current''", PHARMACOLOGY AND THERAPEUTICS, vol. 119, no. 3, 1 July 2008 (2008-07-01), ELSEVIER, US, pages 326 - 339, XP024528635, ISSN: 0163-7258
M.P. JOHNSON, ET AL.: "Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)", PSYCHOPHARMACOLOGY, vol. 179, no. 1, 17 February 2005 (2005-02-17), SPRINGER, BERLIN, DE, pages 271 - 283, XP019326360, ISSN: 1432-2072
J.A. CHRISTOPHER, ET AL.: "The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 14, 29 April 2007 (2007-04-29), ELSEVIER SCIENCE, OXFORD, GB, pages 3972 - 3977, XP022119992, ISSN: 0960-894X
C.A. PARRISH, ET AL.: "Novel ATP-competitive kinesin spindle protein inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, no. 20, 29 August 2007 (2007-08-29), AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, pages 4939 - 4952, XP002570426, ISSN: 0022-2623
M.P. JOHNSON, ET AL.: "Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)", PSYCHOPHARMACOLOGY, vol. 179, no. 1, 17 February 2005 (2005-02-17), SPRINGER, BERLIN, DE, pages 271 - 283, XP019326360, ISSN: 1432-2072
J.A. CHRISTOPHER, ET AL.: "The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 14, 29 April 2007 (2007-04-29), ELSEVIER SCIENCE, OXFORD, GB, pages 3972 - 3977, XP022119992, ISSN: 0960-894X
C.A. PARRISH, ET AL.: "Novel ATP-competitive kinesin spindle protein inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, no. 20, 29 August 2007 (2007-08-29), AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, pages 4939 - 4952, XP002570426, ISSN: 0022-2623
Attorney, Agent or Firm:
HARTRUM, J., Elin et al. (Inc.333 Lakeside Driv, Foster City CA, US)
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