Title:
HDAC/MAO-B DUAL INHIBITOR, PREPARATION THEREOF, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/061101
Kind Code:
A1
Abstract:
Disclosed are an HDAC/MAO-B dual inhibitor, the preparation thereof, and an application in the preparation of a drug and neuroprotective antioxidant for preventing and treating related diseases by inhibiting monoamine oxidase and histone deacetylase. The HDAC/MAO-B dual inhibitor has the following general formula (I) or (II): in the formulas (I) and (II): each R is independently an aromatic group or a substituted aromatic group. The HDAC/MAO-B dual inhibitor has both an HDAC inhibitory effect and an MAO-B inhibitory effect, being a multi-target hydroxamic acid/anthranilamide propargyl amine-type derivative that achieves neuroprotection and anti-oxidation by means of the synergy of a propynylamine group and hydroxamic acid or an anthranilamide group.
Inventors:
XIE TIAN (CN)
BAI RENREN (CN)
YE XIANGYANG (CN)
YAO CHUANSHENG (CN)
BAI RENREN (CN)
YE XIANGYANG (CN)
YAO CHUANSHENG (CN)
Application Number:
PCT/CN2022/116933
Publication Date:
April 20, 2023
Filing Date:
September 05, 2022
Export Citation:
Assignee:
UNIV HANGZHOU NORMAL (CN)
International Classes:
C07C259/10; A61K31/166; A61K31/167; A61P25/16; A61P25/28; A61P29/00; C07C231/12; C07C237/40
Domestic Patent References:
| WO2004092177A1 | 2004-10-28 | |||
| WO2010086860A2 | 2010-08-05 |
Foreign References:
| CN113956182A | 2022-01-21 | |||
| CN102036955A | 2011-04-27 | |||
| CN112552232A | 2021-03-26 | |||
| CN106946854A | 2017-07-14 |
Other References:
YAO CHUANSHENG, JIANG XIAOYING, ZHAO RUI, ZHONG ZHICHAO, GE JIAMIN, ZHU JUNLONG, YE XIANG-YANG, XIE YUANYUAN, LIU ZHEN, XIE TIAN, : "HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids", BIOORGANIC CHEMISTRY, vol. 122, 1 May 2022 (2022-05-01), US , pages 1 - 17, XP093056820, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2022.105724
SHAIMAA M. ABOUKHATWA; THOMAS W. HANIGAN; TAHA Y. TAHA; JAYAPRAKASH NEERASA; RAJEEV RANJAN; EMAN E. EL‐BASTAWISSY; MOHAMED A. ELKE: "Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue", CHEMMEDCHEM COMMUNICATIONS, vol. 14, no. 11, 10 April 2019 (2019-04-10), DE , pages 1096 - 1107, XP072419666, ISSN: 1860-7179, DOI: 10.1002/cmdc.201900114
SHAIMAA M. ABOUKHATWA; THOMAS W. HANIGAN; TAHA Y. TAHA; JAYAPRAKASH NEERASA; RAJEEV RANJAN; EMAN E. EL‐BASTAWISSY; MOHAMED A. ELKE: "Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue", CHEMMEDCHEM COMMUNICATIONS, vol. 14, no. 11, 10 April 2019 (2019-04-10), DE , pages 1096 - 1107, XP072419666, ISSN: 1860-7179, DOI: 10.1002/cmdc.201900114
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
Download PDF: