Title:
BACILLUS COAGULANS FOR AMELIORATING CONSTIPATION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/173899
Kind Code:
A1
Abstract:
Provided are Bacillus coagulans for ameliorating constipation and an application thereof. The strain is preserved in China General Microbiological Culture Collection Center on 10 November 2021, and has a preservation number of CGMCC No.23766. According to the strain, the propulsion effect of the small intestine of a mouse is promoted, so that water content of excrement is increased, achieving a good bowel relaxing effect. By adjusting a gastrointestinal motility-related biomarker, the strain can regulate intestinal functions of a constipated mouse and relieve intestinal inflammation.
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Inventors:
YU YANG (CN)
MA XIN (CN)
YU XUEPING (CN)
MA XIN (CN)
YU XUEPING (CN)
Application Number:
PCT/CN2022/143703
Publication Date:
September 21, 2023
Filing Date:
January 16, 2023
Export Citation:
Assignee:
THANKCOME BIOLOGICAL SCIENCE AND TECH CO LTD (CN)
International Classes:
C12N1/20; A61K35/742; A61P1/00; A61P1/10; C12R1/07
Foreign References:
| CN114480218A | 2022-05-13 | |||
| CN112029674A | 2020-12-04 | |||
| CN111004732A | 2020-04-14 | |||
| CN111004733A | 2020-04-14 | |||
| KR20110116344A | 2011-10-26 |
Other References:
LIU WENYING, ZHAI QIXIAO, TIAN FENGWEI, ZHAO JIANXIN, ZHANG HAO, CHEN WEI: "The effects of Bacillus coagulans B.C-39 compound microecological preparation against constipation in mice ", FOOD AND FERMENTATION INDUSTRIES, vol. 45, no. 13, 1 January 2019 (2019-01-01), pages 85 - 91, XP093090075, DOI: 10.13995/j.cnki.11-1802/ts.020212
KANG SEUNGHEE, PARK MIN YOUNG, BROOKS ISABEL, LEE JAEKYUNG, KIM SU HWAN, KIM JI YEON, OH BUMJO, KWON ORAN: "Spore-forming Bacillus coagulans SNZ 1969 improved intestinal motility and constipation perception mediated by microbial alterations in healthy adults with mild intermittent constipation: A randomized controlled trial", FOOD RESEARCH INTERNATIONAL, ELSEVIER, AMSTERDAM, NL, vol. 146, 1 August 2021 (2021-08-01), AMSTERDAM, NL , pages 110428, XP093090081, ISSN: 0963-9969, DOI: 10.1016/j.foodres.2021.110428
KANG SEUNGHEE, PARK MIN YOUNG, BROOKS ISABEL, LEE JAEKYUNG, KIM SU HWAN, KIM JI YEON, OH BUMJO, KWON ORAN: "Spore-forming Bacillus coagulans SNZ 1969 improved intestinal motility and constipation perception mediated by microbial alterations in healthy adults with mild intermittent constipation: A randomized controlled trial", FOOD RESEARCH INTERNATIONAL, ELSEVIER, AMSTERDAM, NL, vol. 146, 1 August 2021 (2021-08-01), AMSTERDAM, NL , pages 110428, XP093090081, ISSN: 0963-9969, DOI: 10.1016/j.foodres.2021.110428
Attorney, Agent or Firm:
BEIJING SHENGXUN IP AGENCY CO., LTD. (CN)
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