Title:
BACILLUS VELEZENSIS CAPABLE OF PRODUCING COMPLEX ENZYME AT HIGH YIELD AND EFFICIENTLY DEGRADING MYCOTOXIN AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/087499
Kind Code:
A1
Abstract:
Bacillus velezensis capable of producing a complex enzyme at high yield and efficiently degrading a mycotoxin and an application thereof. The Bacillus velezensis is Bacillus velezensis LB-Y-1, the strain not only can effectively degrade AFB1, but also has the capability of producing proteases, cellulases and amylases at high yield. An in vivo experiment of a broiler indicates that the stain has potential probiotic characteristics of having high safety and strong stress resistance, being easy for intestinal colonization, improving intestinal flora structures, improving the growth performance, and the like. In addition, the strain can degrade AFB1 in mildewed peanut meal by means of fermentation treatment and increase the content of an acid soluble protein, so as to implement the biological detoxification and quality improvement of the peanut meal. The present invention has a comprehensive effect on eliminating and inhibiting the contamination by mycotoxins in feed and raw materials, reducing the content of crude fiber in the raw materials, increasing the content of a small peptide, and the like.
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Inventors:
DENG XUEJUAN (CN)
LI CHONG (CN)
CAI HUIYI (CN)
LI SHUANG (CN)
LI SHUZHEN (CN)
WANG TENGFEI (CN)
LI CHONG (CN)
CAI HUIYI (CN)
LI SHUANG (CN)
LI SHUZHEN (CN)
WANG TENGFEI (CN)
Application Number:
PCT/CN2021/142776
Publication Date:
May 25, 2023
Filing Date:
December 30, 2021
Export Citation:
Assignee:
TIANJIN BIOFEED TECH CO LTD (CN)
International Classes:
C12N1/20; A23K10/18; A23K50/75; A23L5/20; C12R1/07
Foreign References:
| CN110804570A | 2020-02-18 | |||
| CN112126601A | 2020-12-25 | |||
| CN111826295A | 2020-10-27 | |||
| CN112980751A | 2021-06-18 | |||
| US20180020676A1 | 2018-01-25 |
Other References:
SHU XIAN, WANG YUTING, ZHOU QING, LI MINGHAO, HU HAO, MA YUHAN, CHEN XUE, NI JUN, ZHAO WEIWEI, HUANG SHENGWEI, WU LIFANG: "Biological Degradation of Aflatoxin B1 by Cell-Free Extracts of Bacillus velezensis DY3108 with Broad PH Stability and Excellent Thermostability", TOXINS, vol. 10, no. 8, pages 330, XP093068185, DOI: 10.3390/toxins10080330
WANG LE, HUANG WEI, SHA YU, YIN HAICHENG, LIANG YING, WANG XIN, SHEN YAN, WU XINGQUAN, WU DAPENG, WANG JINSHUI: "Co-Cultivation of Two Bacillus Strains for Improved Cell Growth and Enzyme Production to Enhance the Degradation of Aflatoxin B1", TOXINS, vol. 13, no. 7, pages 435, XP093068188, DOI: 10.3390/toxins13070435
ZHANG D.F., XIONG X.L., WANG Y.J., GAO Y.X., REN Y., WANG Q., SHI C.B.: "Bacillus velezensis WLYS23 strain possesses antagonistic activity against hybrid snakehead bacterial pathogens", JOURNAL OF APPLIED MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 131, no. 6, 1 December 2021 (2021-12-01), GB , pages 3056 - 3068, XP055974775, ISSN: 1364-5072, DOI: 10.1111/jam.15162
WANG LE, HUANG WEI, SHA YU, YIN HAICHENG, LIANG YING, WANG XIN, SHEN YAN, WU XINGQUAN, WU DAPENG, WANG JINSHUI: "Co-Cultivation of Two Bacillus Strains for Improved Cell Growth and Enzyme Production to Enhance the Degradation of Aflatoxin B1", TOXINS, vol. 13, no. 7, pages 435, XP093068188, DOI: 10.3390/toxins13070435
ZHANG D.F., XIONG X.L., WANG Y.J., GAO Y.X., REN Y., WANG Q., SHI C.B.: "Bacillus velezensis WLYS23 strain possesses antagonistic activity against hybrid snakehead bacterial pathogens", JOURNAL OF APPLIED MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 131, no. 6, 1 December 2021 (2021-12-01), GB , pages 3056 - 3068, XP055974775, ISSN: 1364-5072, DOI: 10.1111/jam.15162
Attorney, Agent or Firm:
JEEKAI&PARTNERS (CN)
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