Title:
BACTERIAL GLYCOLIPID ACTIVATION OF CD1D-RESTRICTED NKT CELLS
Document Type and Number:
WIPO Patent Application WO2006083671
Kind Code:
B1
Abstract:
Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.
Inventors:
TEYTON LUC (US)
BENDELAC ALBERT (US)
SAVAGE PAUL (US)
BENDELAC ALBERT (US)
SAVAGE PAUL (US)
Application Number:
PCT/US2006/002781
Publication Date:
April 12, 2007
Filing Date:
January 26, 2006
Export Citation:
Assignee:
UNIV BRIGHAM YOUNG (US)
SCRIPPS RESEARCH INST (US)
UNIV CHICAGO (US)
TEYTON LUC (US)
BENDELAC ALBERT (US)
SAVAGE PAUL (US)
SCRIPPS RESEARCH INST (US)
UNIV CHICAGO (US)
TEYTON LUC (US)
BENDELAC ALBERT (US)
SAVAGE PAUL (US)
International Classes:
C12Q1/00; C12N5/00; C12N5/02; C12N13/00; G01N33/567
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