BASE POLYMER FOR PERCUTANEOUSLY ABSORBABLE PREPARATION

WIPO Patent Application WO/1995/004094

A1

A base polymer for percutaneously absorbable preparations that is solid at ordinary temperatures but turns into a low-viscosity liquid near the human skin temperature, contains a hydrophilic segment, is responsive to heat and water, and enables drugs which have been difficult to compound into a percutaneously absorbable preparation to be stored stably for long and absorbed percutaneously with a high releasability and a high sustained releasability without causing much skin stimulation. The polymer comprises a heat-responsive segmented polyurethane represented by the general formula R-A-(U)-C-(U)-B-R1, wherein A and B represent each independently a polymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide, or a random or block copolymer thereof; R and R1 represent each H, CH3, C2H5, C3H7 or C4H9 as the terminal group of A and B, respectively; C represents a residue of a diisocyanate compound; and (U) represents a urethane linkage; and wherein at least one of A and B is hydrophilic and at the same time will melt near the human skin temperature.

WO/1996/011720	DRUG-RELEASING STENT
WO/1993/019746	TOPICAL ADMINISTRATION OF TOREMIFENE AND ITS METABOLITES
JP5507030	Methods of suppressing the decrease in percutaneous drug flow by inhibiting pathway closure

SHIKINAMI YASUO (JP)

PCT/JP1994/001253

February 09, 1995

July 29, 1994

Click for automatic bibliography generation  

TAKIRON CO (JP)
SHIKINAMI YASUO (JP)

A61K9/70; C08G18/28; C08G18/48; (IPC1-7): C08G18/48; A61K9/70; A61K47/30

WO1993008796A1

1993-05-13

JPS63146812A	1988-06-18
JPH0413618A	1992-01-17
JPH0413620A	1992-01-17
JPH01168716A	1989-07-04
JPS62275118A	1987-11-30

See also references of EP 0664307A4

View/Download PDF      PDF Help

Previous Patent: CATALYSTS FOR LOW TEMPERATURE CURE OF BLOCKED ISOCYANATES

Next Patent: GELLED REACTIVE RESIN COMPOSITIONS