Title:
Bcl-2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2021/083135
Kind Code:
A1
Abstract:
Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.
Inventors:
XUE HAI (CN)
GUO YUNHANG (CN)
WANG ZHIWEI (CN)
GUO YUNHANG (CN)
WANG ZHIWEI (CN)
Application Number:
PCT/CN2020/123939
Publication Date:
May 06, 2021
Filing Date:
October 27, 2020
Export Citation:
Assignee:
BEIGENE LTD (KY)
XUE HAI (CN)
XUE HAI (CN)
International Classes:
A61K31/437; C07D403/12; A61K31/496; A61K31/499; A61P35/00; C07D471/04; C07D519/00
Domestic Patent References:
| WO2002024636A2 | 2002-03-28 | |||
| WO2020140005A2 | 2020-07-02 | |||
| WO2019210828A1 | 2019-11-07 | |||
| WO2018192462A1 | 2018-10-25 | |||
| WO2017132474A1 | 2017-08-03 | |||
| WO2019040573A1 | 2019-02-28 |
Foreign References:
| CN102448959A | 2012-05-09 | |||
| CN106749233A | 2017-05-31 | |||
| CN110177788A | 2019-08-27 |
Other References:
See also references of EP 4051676A4
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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