BCL-2 PROTEIN APOPTOSIS-INDUCING AGENT AND APPLICATION THEREOF

WIPO Patent Application WO/2022/089463

A1

Disclosed is a BCL-2 protein apoptosis-inducing agent. Also disclosed are the compound and an application of a pharmaceutical composition comprising the compound in preparing a drug for treating diseases related to anti-apoptotic protein BCL-2 such as infectious diseases, immune diseases, inflammatory diseases, and abnormal cell proliferation diseases. The compound of the present invention has potent BCL2/BAK blocking activity, potent inhibitory activity on BCL-2(G101V) and BCL-2(D103Y), and potent proliferation inhibitory activity on mutant cell strains. The compound can be applied to individually treat or treat in combination with other drugs infectious diseases, immune diseases, inflammatory diseases, or abnormal cell proliferation diseases, etc. which benefit from the inhibition of the anti-apoptotic protein BCL-2.

LIU XINGGUO (CN)
SU MINGBO (CN)
WU YIZHE (CN)
GAO ANHUI (CN)
ZHOU XINGLU (CN)
ZHONG LI (CN)
HU MIAO (CN)
HUANG JINGLAI (CN)
JING HANGHUI (CN)
JIN XINXIN (CN)
ZHU JIANRONG (CN)

PCT/CN2021/126588

May 05, 2022

October 27, 2021

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HANGZHOU HEALZEN THERAPEUTICS CO LTD (CN)
BIOPOLAR HONGYE NANTONG PHARMACEUTICAL CO LTD (CN)

C07D471/04; A61K31/496; A61P35/00

WO2020140005A2	2020-07-02
WO2019210828A1	2019-11-07
WO2021083135A1	2021-05-06
WO2021223736A1	2021-11-11

CN102448959A	2012-05-09
CN110546151A	2019-12-06

HANGZHOU ZHIXIAN PATENT AGENCY (CN)

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