DESCRIPTION

Beπzamide derivatives as vasopressln antagonists

TECHNICAL FIELD

This invention relates to new benzamide derivatives and pharmaceutically acceptable salts thereof which are useful as a medicament.

BACKGROUND ART

Some benzamide derivatives have been known as vasopressin antagonist, for example, in PCT International Publication No. WO 91/05549 and EP Application Publication No. 0620216.

DISCLOSURE OF INVENTION

This invention relates to new benzamide derivatives and pharmaceutically acceptable salts thereof.

More particularly, it relates to new benzamide derivatives and pharmaceutically acceptable salts thereof which possess activities as vasopressin antagonistic activity, vasodilating activity, hypotensive activity, activity for inhibiting saccharide release in liver, activity for inhibiting growth of mesangium cells, water diuretic activity, platelet agglutination inhibitory activity, oxytocin antagonistic activity and the like, to a pharmaceutical composition comprising the same and to a method for the treatment and/or prevention of hypertension, heart failure, renal insufficiency, edema, ascites, vasopressin parasecretion syndrome, hepatocirrhosis, hyponatremia, hypokalemia, diabetic, circulation disorder, cerebrovascuiar disease (e.g. cerebral edema, cerebral infarction, etc.), Meniere's syndrome (e.g. Meniere's disease, etc.), motion sickness and the like in human beings or animals.

One object of this invention is to provide new and useful benzamide derivatives which possess aforesaid activities.

Another object of this invention is to provide processes for the preparation of said benzamide derivatives and salts thereof.

A further object of this invention is to provide a pharmaceutical composition comprising, as an active ingredient, said benzamide derivatives and pharmaceutically acceptable salts thereof.

Still further object of this invention is to provide a therapeutical method for the treatment and/or prevention of aforesaid diseases in human beings or animals, using said benzamide derivatives and pharmaceutically acceptable salts thereof.

The object benzamide derivatives of this invention are new and can be represented by the following general formula (I) :

wherein

R ¹ is lower alkyl, aryl, cyclo (lower) alkyl or a heterocyclic group, each of which may be substituted with substituent (s) selected from the group consisting of halogen; hydroxy; nitro; amino; acyl; substituted acyl; acyl (lower) lkylsulfinyl; acyl (lower) alkylsulfonyl; acyloxy; lower alkyla ino (lower) alkylcarbamoyioxy; aryl; cyano;

a heterocyclic group; lower alkenyl optionally substituted with acyl or substituted acyl; lower alkynyl optionally substituted witn ammo, acylammo or substituted acylamino; lower alkyl optionally substituted with halogen, ammo, lower alkylammo, acylammo, substituted acylammo, hydroxy, acyloxy, acyl (lower) alkanoyloxy, acyl, substituted acyl or acyl (lower) alkoxyimmo; lower alkylthio optionally substituted with acyl or substituted acyl; alkoxy optionally substituted with aryl, substituted aryl, hydroxy, acyloxy, ammo, lower alkylammo, protected ammo, a heterocyclic group, acyl-substituted pyridyl, substituted acyl- substituted pyridyl, halogen, acyl (lower) alkylammo, N-protected-acyl (lower) alkylammo,

N-acyl (lower) alkyl-N-lower alκylammo, acyl, substituted acyl, acylammo, substituted acylamino, lower alkylhydrazmocarbonylammo, hydroxyimmo, acyl (lower) alkoxyimmo or substituted acyl (lower) alkoxyimmo; and lower alkenyloxy optionally substituted with acyl or substituted acyl;

R ² is lower alkyl optionally substituted with hydroxy, aryl or acyl; or cyclo (lower alkyl; R3 _1S hydrogen, halogen, lower alkyl, lower alkoxy, nitro or ammo;

R ⁴ is lower alkyl; aryl; or substituted aryl;

ana pharmaceutically acceptable salts thereof.

The oo]ect compound (I) for ts salt can be prepared oy the processes as illustrated ir. the following reaction scnemes .

Process 1

(III)

(II) or its rective derivative or its salt at the carboxy group or a salt thereof

(I) or its salt

Process 2

'

or its salt (V) or its reactive derivative at the carboxy group or a salt thereof

(I) or its salt

Process 3

deesterification

(la) or its salt

(lb) or its salt

Process 4

deacylation

(Ic) or its salt

(Id) or its salt

Process 5

elimination of the N-protective group

(If) or its salt

Process 6

a idation

(lb) or its reactive derivative at the carboxy group or a salt thereof

dg) its sal.

Process 7

(Ih) or its reactive derivative at the carboxy group or a salt thereof

(Ii) or its salt

Process 8

reduction

dj ⁾ or its salt

(Ik) or its salt

Process Q

reduction

(I ) or its salt

'

or its salt

Process 10

acylation

(Id) or its salt

(Ic) or its salt

Process 11

oxidation

dm) or its salt

(In) or its salt

Process 1?

(In) or its salt

do;

Process 13

dp) or its salt

dq) or its salt

Process 14

(Ir) (Is) or its salt or its salt

Process 15

(Is) (It) or its salt or its salt

Process 16

(Iu) (Iv) or its salt or its salt

Proπpss 1

(Iw)

(i ^χ ) or its salt or its salt

Process ii

dy) (Iz) or its salt or its salt

Prorpss 1 Q

(1-1) (1-2) or its salt or its salt

Process ?0

⁽ 1-1 ⁾ (1-3) or its salt or its salt

Process 21

(1-4) (1-5) or its salt or its salt

Process 7.7.

(1-6) (1-7) or its salt or its salt

Process 7 ^~

(1-8) (1-9) or its salt or its salt

Process 24

(1-10) or its reactive or its salt derivative

(1-11) or its salt

Process 25

(1-12) (1-13) or its salt or its salt

Process 26

(1-14) (1-15) or ts salt or its salt

Process 27

(1-16) (1-17) its salt or its salt

Process 28

(1-18) or its salt or its salt

Process 29

(1-19) (1-20) or its salt or its salt

Process 30

(1-21) (1-22) or its salt or its salt

Process ^~ l

(1-23) (1-24) or its salt its salt

Process ~7

(1-25) (1-26) or its salt or its salt

Process ^~~

(1-27) (1-28) Lts salt or its salt

Process 34

dees terif ication

(1-29) or its salt

(1-30) or its salt

Process 35

at the carboxy group or a salt thereof

wherein

R ¹ , R ² , R ³ , R ⁴ , X and Y are each as defined above, R is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted 5 with esterified carboxy; lower alkenyl substituted with esterified carboxy; lower alkyl substituted with esterified carboxy, esterified carboxy (lower) - alkanoyloxy or esterified carboxy(lower) alkoxyimino; lower alkylthio substituted with esterified carboxy;

10 alkoxy substituted with esterified carboxy- substituted aryl, esterified carboxy-substituted pyridyl, esterified carboxy (lower) alkylamino, N-protected-esterified carboxy(lower) alkylamino, N-esterified carboxy(lower) alkyl-N-lower alkylamino,

15 esterified carboxy or esterified carboxy(lower) alkoxyimino; or lower alkenyloxy substituted with esterfied carboxy; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted

20 with carboxy; lower alkenyl substituted with carboxy; lower alkyl substituted with carboxy, carboxy(lower) - alkanoyloxy or carboxy (lower) alkoxyimino; lower alkylthio substituted with carboxy; alkoxy substituted with carboxy-substituted aryl,

25 _. carboxy-substituted pyridyl, carboxy(lower) - alkylamino, N-protected-carboxy(lower) alkylamino, N-carboxy(lower) alkyl-N-lower alkylamino, carboxy or carboxy(lower) alkoxyimino; or lower alkenyloxy substituted with carboxy;

30 Ri is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with acyloxy; lower alkyl substituted with acyloxy or acyl (lower) alkanoyloxy; or alkoxy substituted with acyloxy;

35 R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or

a heterocyclic group, each of which is substituted with hydroxy; lower alkyl substituted with hydroxy; or alkoxy substituted with hydroxy; R _g is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with protected a ino, N-protected-acyl (lower) alkylamino, N-protected-N- containing heterocycliccarbonylamino or N-protected- N-containing heterocyclicsulfonyl-substituted aryl; Rf is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with amino, acyl (lower) - alkylamino, N-containing heterocycliccarbonylamino or N-containing heterocyclicsulfonyl-substituted aryl; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with substituted or unsubstituted N-containing heterocycliccarbonyl; carba oyl; substituted or unsubstituted lower alkylcarbamoyl; lower alkenyl substituted with substituted or unsubstituted

N-containing heterocycliccarbonyl, carbamoyl or substituted or unsubstituted lower alkylcarbamoyl; lower alkyl substituted with substituted or unsubstituted N-containing heterocycliccarbonyl, carbamoyl, substituted or unsubstituted lower alkylcarbamoyl, substituted or unsubstituted N-containing heterocycliccarbonyl (lower) alkanoyloxy, carbamoyl (lower) alkanoyloxy, substituted or unsubstituted lower alkylcarbamoyl (lower) alkanoyloxy, substituted or unsubstituted N-containing heterocycliccarbonyl (lower) alkoxyimino, carbamoyl- (lower) alkoxyimino or substituted or unsubstituted lower alkylcarbamoyl (lower) alkoxyimino; lower alkylthio substituted with substituted or unsubstituted N-containing heterocycliccarbonyl,

carbamoyl or substituted or unsubstituted lower alkylcarbamoyl; alkoxy substituted with substituted or unsubstituted N-containing heterocycliccarbonyl- substituted aryl, carbamoyl-substituted aryl, substituted or unsubstituted lower alkylcarbamoyl- substituted aryl, substituted or unsubstituted N-containing heterocycliccarbonyl-substituted pyridyl, carbamoyl-substituted pyridyl, substituted or unsubstituted lower alkylcarbamoyl-substituted pyridyl, substituted cr unsubstituted

N-containing heterocycliccarbonyl (lower) alkylamino, carbamoyl (lower) alkylamino, substituted or unsubstituted lower alkylcarbamoyl (lower) alkylamino, N-protected- (substituted or unsubstituted N-containing heterocyclic) carbonyl (lower) alkylamino, N-protected-carbamoyl (lower) alkylamino, N-protected substituted or unsubstituted lower alkylcarbamoyl- (lower) alkylamino, N- (substituted or unsubstituted N-containing heterocyclic) carbonyl (lower) alkyl-N- lower alkylamino, N-carbamoyl (lower) alkyl-N-lower alkylamino, substituted or unsubstituted N-lower alkylcarbamoyl-N-lower alkylamino, substituted or unsubstituted N-containing heterocycliccarbonyl, carbamoyl, substituted or unsubstituted lower alkylcarbamoyl, substituted cr unsubstituted

N-containing heterocycliccarbonyl (lower) alkoxyimino, carbamoyl (lower) alkoxyimino cr substituted or unsubstituted lower alkylcarbamoyl (lower) alkoxyimino; or lower alkenyloxy substituted with substituted or unsubstituted N-containing heterocycliccarbonyl, carbamoyl or substituted or unsubstituted lower alkylcarbamoyl; lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with carboxy;

R} is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with amino; R÷ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkenyl optionally substituted with acyl; lower alkynyl optionally substituted with acylamino; or lower alkenyloxy optionally substituted with acyl; R is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkyl optionally substituted with aryl or acylamino; or lower alkyloxy optionally substituted with acyl; R~ is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with lower alkanoyl; carboxy; esterified carboxy; or alkoxy substituted with esterified carboxy or esterified carboxy-substituted aryl; R is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with 1-hydroxy(lower)alkyl; or alkoxy substituted with hydroxy or hydroxymethyl-substituted aryl; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkanoyl; or alkoxy substituted with lower alkanoyl or formyl-substituted aryl; R _Q is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with 1- (lower alkyl) amino (lower) alkyl; or alkoxy substituted with N-acyl (lower)alkyl-N-lower alkylamino, acyl (lower) alkylamino or N-containing heterocyclic group-substituted methyl; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with mono(lower)-

alkylamino; or alkoxy substituted with amino optionally substituted with acyl (lower) alkyl or piperazinylsulfonyl-substituted aryl; R _g is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with di (lower) - alkylamino; or alkoxy substituted with lower alkylamino, N-acyl (lower) alkyl-N-lower alkylamino or N-lower alkylpiperazinylsulfonyl-substituted aryl; R ^* is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with methoxy substituted with aryl or substituted aryl; R _g is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with hydroxy;

R is alkyl optionally substituted with aryl, substituted aryl, hydroxy, acyloxy, amino, lower alkylamino, protected amino, a heterocyclic group, acyl- substituted pyridyl, halogen, acyl (lower) alkylamino, N-protected-acyl (lower) alkylamino, N-acyl (lower) - alkyl-N-lower alkylamino, acyl, substituted acyl, acylamino, substituted acylamino or lower alkylhydrazinocarbonylamino; Z ¹ is acid residue; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy optionally substituted with aryl, substituted aryl, hydroxy, acyloxy, amino, lower alkylamino, protected amino, a heterocyclic group, acyl-substituted pyridyl, halogen, acyl (lower) - alkylamino, N-protected-acyl : lower) alkylamino, N-acyl (lower) alkyl-N-lower alkylamino, acyl, substituted acyl, acylamino, substituted acylamino or lower alkylhydrazinocarbonylamino; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or

a heterocyclic group, each of which is substituted with alkoxy substituted with hydroxyimino; R is lower alkyl substituted witn acyl; 2 ^~ is acid residue; R^ is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with alkoxy suostituted with acyl (lower) alkyloxyi mo; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with halogen; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy suostituted with ammo, lower alkylammo, phthalimido or N-contammg neterocyclic group;

R _y is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with ammo; lower alkynyl substituted with ammo; or alkoxy substituted with ammo;

R^ is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with substituted or unsubstituted acylammo; lower alkynyl substituted with substituted or unsubstituted acylammo; or alkoxy substituted witn substituted or unsubstituted acylammo; R^ _a is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with substituted or unsubstituted aryloxycarbonylammo; lower alkynyl substituted with substituted or unsuostituted aryloxycarbonylammo; or alkcxy substituted with substituted or unsubstituted aryloxycarbonylammo; R^ _b is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or

a heterocyclic group, each of which is substituted with lower alkyl substituted with substituted or unsubstituted N-contammg neterocycliccarbonylammo or lower alkylhydrazmocarbonylammo; lower alkynyl substituted with substituted or unsubstituted

N-contammg heterocycliccarbonylamino or lower alkylhydrazmocarbonylammo; or alkoxy substituted with substituted or unsubstituted N-contammg heterocycliccarbonylamino or lower alkylhydrazmocaroonylammo;

R^ _c is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is unsubstituted with lower alkyl substituted with heterocyclicoxycarbonylammo; or alkoxy substituted with heterocyclicoxycarbonylammo;

R ^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with substituted or unsubstituted aryloxycarbonyloxy; lower alkyl substituted witn substituted or unsubstituted aryloxycarbonyloxy; or alkoxy substituted with substituted or unsubstituted aryloxycaroonyloxy; R^ _e is lower alkyl, aryl, haloaryl, cyclo (lower)alkyl or a heterocyclic group, each of which is substituted with N-contammg heterocycliccarbonyloxy; lower alkylammo (lower)alkylcarbamoyloxy; lower alkyl substituted with N-contammg heterocycliccarbonyloxy or lower alkylammo (lower)- alkylcarbamoyloxy; or alJoxy substituted with N-contammg neterocycliccaroonyloxy or lower alkylammo (lower) alkylcarbamoyloxy; R ⁴ is aryl substituteα witn nitre; R _j * is aryl substituted with ammc;

R ³ is nitro;

-> Ri is ammo;

R^ _f is lower alkyl, aryl, haloaryl, cyclo (lower)alkyl or a heterocyclic group, each of which is substituted with formyl; lower alkyl substituted with formyl; or lower alkoxy substituted with formyl; B is carboxy, esterified carboxy, di-esterified phosphono or triphenylphosphonium salt;

₇

R is lower alkyl optionally substituted with acyl; R^g is lower alkyl, aryl, haloaryl, cyclo(lower) alkyl or a heterocyclic group, each of which is substituted with lower alkenyl optionally substituted with acyl; lower alkenyloxy optionally substituted with acyl; R is lower alkyl substituted with carboxy or esterified carboxy; R£ is lower alkyl substituted with hydroxy; is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with esterified carboxy; or alkoxy substituted with esterified carboxy; R^_ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with formyl; or alkoxy substituted with formyl; R^- _j is lower alkyl, aryl, haloaryl, cyclo(lower)alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with formyl;

R^ is lower alkyl, aryl, haloaryl, cyclo (lower)alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with hydroxyimino; R ⁴ is aryl substituted with lower alkylamino; R^ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each cf which is substituted with cyano; R^ _j . is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each cf which is substituted with tetrazolyl;

R^ _n is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkylthio substituted with acyl; R^ ₀ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkylsulfinyl substituted with acyl; or lower alkylsulfonyl substituted with acyl; R^p is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with acyl (lower) alkylamino; Rj„ is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with N-protected- acyl (lower) alkylamino; R^ _r is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with hydroxy; or alkoxy substituted with hydroxy; Rg _s is lower alkyl, aryl, haloaryl, cyclo (lower) lkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with halogen; or alkoxy substituted with halogen; R^ _t is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with piperazinylcarbonyl;

R^ _u is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with alkoxy substituted with acylpiperazinylcarbonyl; R ² is lower alkyl substituted with esterified carboxy; R^ is lower alkyl substituted with carboxy; and

R| is lower alkyl substituted with substituted or unsubstituted N-containing heterocycliccarbonyl; carbamoyl; or substituted or unsubstituted lower alkylcarbamoyl.

In the above and subsequent description of the present specification, suitable examples of the various definitions to be included within the scope of the invention are explained in detail in the following.

The term "lower" is intended to mean a group having 1 to 6 carbon atom(s), unless otherwise provided.

The "higher" is intended to mean 7 to 20 carbon atoms, unless otherwise provided. The lower moiety in the term "cyclo (lower) alkyl is intended to mean a group having 3 to 6 carbon atoms.

The lower moiety in the terms "lower alkenyl", "lower alkenyloxy" and "lower alkynyl" is intended to mean a group having 2 to 6 carbon atoms . The term "alkoxy" may included lower alkoxy and higher alkoxy.

Suitable "lower alkoxy" and lower alkoxy moiety in the terms "acyl (lower) alkoxy", "acyl (lower) alkoxyimino", "esterified carboxy(lower) alkoxyimino", "carboxy(lower) alkoxyimino", "N-containing heterocycliccarbonyl (lower) alkoxyimino", "carbamoyl (lower) alkoxyimino", "lower alkylcarbamoyl (lower) alkoxyimino" and "lower alkoxycarbonyl" may be straight or branched ι_-C ₆ alkoxy such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, tert-butoxy, pentyloxy, hexyloxy or the like.

Suitable "higher alkoxy" may be straight or branched C -C20 alkoxy such as heptyloxy, octyloxy, nonyloxy, decyloxy, undecyloxy, dodecyioxy, tridecyloxy, tetradecyloxy, pentadecyloxy, hexadecyioxy, heptadecyloxy, octadecyloxy, nonadecyloxy, eicosyloxy, methylheptyloxy, ethyloctyloxy, methylnonyloxy, methyldecyloxy, ethylheptvloxy, ethyloctyloxy, et ylnonyloxy, ethyldecyloxy or the like, in which preferable cne is heptyloxy. Suitable "lower alkyl" and lower alkyl moiety in the

terms "acyl (lower)alkylsulfmyl", "acyl (lower)alkyl¬ sulfonyl", "lower alkylammo (lower)alkylcarbamoyloxy", "acyl (lower) alkylamino", "N-protected-acyl (lower)- alkylammo", "N-acyl (lower)alkyl-N-lower alkylammo", "lower alkylhydrazmocarbonylammo", "esterified carboxy(lower) alkylammo", "N-prctected-esterified carboxy(lower) alkylammo", "N-esterifled carboxy(lower) alkyl-N-lower alkylammo",

"carboxy(lower)alkylammo", "N-protected-carboxy(lower) - alkylammo", "N-carboxy(lower)alκyl-N-lower alkylam o", "lower alkylcarbamoyl", "lower alkylcarbamoyl (lower) alkanoyloxy", "lower alkylcarbamoyl (lower) alkoxyimmo", "lower alkylthio", "N-protected- (substituted or unsuostituted N-contammg heterocyclic)carbonyl (lower)alkylammo", "N-protected- carbamoyl (lower) alkylammo", "N-protected-substituted or unsubstituted lower alkylcarbamoyl (lower)alkylammo", "N- (substituted or unsubstituted N-contammg heterocyclic) carbonyl (lower) alkyl-N-lower alkylammo", "N-carbamoyl (lower)alkyl-N-lower alkylammo", "N-lower alkylcarbamoyl-N-lower alkylammo", "lower alkylcarbamoyl- (lower) alkoxyimmo", "1-hydroxy(lower) alkyl", "1- (lower alkyl)ammo(lower)alkyl", "mono(lower)alkylam o", "acyl (lower) alkyl", "di (lower) alkylammo", "lower alkylsulfmyl" and "lower alkylsulfonyl" may be straight or branched alkyl such as methyl, ethyl, propyl, isopropyl, butyl, lsonutyl, tert- utyl, pentyl, ethylpropyl, hexyl or the like.

Suitable "cycle (lower) alkyl" may be cyclo (C ₃ -Cg) alkyl such as cyclopropyi, cyclobutyl, c _/ clopentyl or cyclohexyl, which preferable or.e is cyclopentyl or cyclohexyl.

Suitable "lower alkenyl" anc lower alkenyl moiety in tne term "lower alkenyloxy" may oe straight and branched C ₆ -Cg aiκenyl such as etnenyi, prcpeπyl, pentenyl,

isopropenyl, butenyl, hexenyl or the like, in which preferable one is propenyl, pentenyl or hexenyl. Suitable "aryl" and aryl moiety in the term "haloaryl" may be phenyl, naphthyl, phenyl substituted with lower alkyl [e.g. tolyl, xylyl, mesityl, cumenyl, di (tert-butyl)phenyl, etc.] and the like, in which preferable one is phenyl, tolyl or xylyl.

Suitable "substituted aryl" may be aryl substituted with suitable substituent(s) such as acyl, N-protected piperazinylsulfonyl, piperazinylsulfonyl, N-lower alkylpiperazinylsulfonyl, hydroxy(lower)alkyl, a heterocyclic (lower) alkyl, halogen, nitro, amino, lower alkylamino or the like, in which preferable one for the substituent of alkoxy for R ¹ is aryl substituted with N-methylpiperazinylsulfonyl, N-t-butoxycarbonyl- piperazinylsulfonyl, piperazinylsulfonyl, carboxy, esterified carboxy, N-lower alkylpiperazinylcarbonyl, lower alkanoyl, hydroxy(lower) alkyl or N-lower alkyl- piperazinyl (lower) alkyl, and preferable one for R ⁴ is aryl substituted with halogen, nitro, amino or lower alkylamino.

Suitable "halogen" and halo moiety in the term "haloaryl" may be fluorine, chlorine, bromine and iodine, in which preferable one is chlorine or bromine. Suitable "lower alkylamino" and lower alkylamino moiety in the terms "lower alkylamino (lower)- alkylcarbamoyloxy", "acyl (lower) alkylamino", "esterified carboxy(lower) alkylamino", "carboxy(lower) alkylamino", "N-containing heterocycliccarbonyl (lower) alkylamino", "carbamoyl (lower) alkylamino" and "lower alkylcarbamoyl- (lower)alkylamino" may be mono or di (lower alkyl)amino such as methylamino, ethylamino, propylamino, isopropylamino, butylamino, tert-b tylamino, isobutylamino, pentylamino, hexyla ino, dimethylamino, diethylamino, dipropylamino, dibutylamino,

diisopropylam o, dipentylam o, dihexylammo, N-methylethylammo or the like, m which preferable one is methylammo, dimethylammo or d ethylammo.

Suitable "1-hydroxy(lower) alkyl" may be 1-hydroxy- (C^-Cg) alkyl such as hydroxymethyl, 1-hydroxyethyl,

1-hydroxypropyl, 1-hydroxybutyl, l-hydroxy-3-methylpropyl or the like, in which preferable one is hydroxymethyl or 1-hydroxyethyl.

Suitable "1- (lower alkyl) am o (lower) alkyl" may be 1-mono or dι(C_-Cg alkyl) ammo(C _j -Cg) alkyl such as methylammomethyl, dimethylam omethyl, 1-methylammoethyl, 1-dιmetnylamιnoethyl, ethylammomethyl, 1-ethylammoethyl or the like, m which preferable one is methylammomethyl, dimethylammomethyl, 1-methylammoethyl or 1-dιmethylammoethyl.

Suitable "heterocyclic group" may be one containing at least one hetero atom selected from nitrogen, sulfur and oxygen atom, and may include saturated or unsaturated, onocyclic or polycyclic heterocyclic group, and preferable heterocyclic group may oe N-contammg heterocyclic group such as unsaturated 3 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atoms, for example, pyrrolyl, pyrrolmyl, imidazolyl, pyrazolyl, pyridyl, pyπmidmyl, pyrazmyl, pyridaz yl, triazolyl [e.g. 4H-1,2,4-trιazolyl, 1H-1,2, 3-tπazolyl, 2H-1,2,3- tπazolyl, etc.], tetrazolyl [e.g. lH-tetrazolyl, 2H-tetrazolyl, etc.], etc.; saturated 3 to 7-membered heteromonocyclic group containing 1 to 4 nitrogen atoms [e.g. pyrrol dmyl, lmidazolidmyl, piperidyl, piperaz yl, homopiperazmyl, etc.]; unsaturated condensed heterocyclic group containing 1 to 5 nitrogen atoms, for example, dolyl, isomdolyl, mdolizmyl, benzimidazolyl, qumclyl, isoquinolyl, lmidazopyridyl, indazolyl, benzotriazolyl, tetrazolo- pyriαazmyl [e.g. tetrazolo[1, 5-b ^" pyridazmyl, etc.], etc.;

unsaturated 3 to 6-membered heteromonocyclic group containing an oxygen atom, for example, pyranyl, furyl, etc. ; saturated 3 to 6-membered heteromonocyclic group containing an oxygen atom, for example, lH-tetrahydropyranyl, tetrahydrofuran, etc.; unsaturated, 3 to 6-membered heteromonocyclic group containing 1 to 2 sulfur atoms, for example, thienyl, etc. unsaturated 3 to 6-membered heteromonocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms, for example, oxazolyl, isoxazolyl, oxadiazolyl [e.g.

1,2,4-oxadιazolyl, 1,3, 4-oxadιazolyl, 1,2, 5-oxadιazolyl, etc. ] , etc.; saturated 3 to 6-membered heteromonocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms

[e.g. orpholmyl, etc.]; unsaturated condensed heterocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms [e.g. benzofurazanyl, benzoxazolyl, benzoxadiazolyl, etc.]; unsaturated 3 to 6-membered heteromonocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms, for example, thiazolyl, thiadiazolyl [e.g.,

1,2,4-thιadιazolyl, 1,3,4-thιadιazolyl,

1,2, 5-thιadιazolyl, etc.], etc.; saturated 3 to 6-membered heteromonocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms

[e.g., thiazolidmyl, etc.]; unsaturated condensed heterocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms [e.g., benzothiazolyl, benzothiaαiazol l, etc.]; unsaturated condensed heterocyclic group containing 1 to 2 oxygen atoms [e.g. benzofuranyl, oenzodioxolyl, etc.] and the like.

Said "heterocyclic group" may be substituted with lower alkyl as exemplified aoove, m wnich preferable one

is N-methylpiperazmyl, tetrazolyl, morpholmyl, pyrrolidmyl, N-methylpipeπdyl,

N-methylhomopiperazmyl, IH-tetrahydropyranyl, thienyl, pyridyl or pipeπdyl. Suitable acyl and acyl moiety m the terms

"acyl (lower) alkylsulfmyl", "acyl (lower)alkylsulfonyl", "acyloxy", "acylammo", "acyl (lower) alkanoyloxy", "acyl (lower) alkoxyimmo", "acyl (lower) alkylammo", "N- protected-acyl (lower) alkylamino" and "N-acyl (lower)alkyl- N-lower alkylammo" may be carboxy, esterified carboxy, carbamoyl, lower alkylcarbamoyl, lower alkanoyl, aroyl, a heterocycliccarbonyl and the like.

The esterified carboxy may be substituted or unsubstituted lower alkoxycarbonyl [e.g. methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, utoxycarbonyl, tert-butoxycarbonyl, hexyloxycarbonyl, 2-ιodoethoxycarbonyl, 2,2,2-tπchloroethoxycarr.onyl, etc.], substituted or unsubstituted aryloxycarbonyl [e.g. phenoxycarbonyl, 4-nιtrophenoxycarbonyl, 2-naphthyloxycarbonyl, etc.], substituted or unsubstituted ar(lower)alkoxycarbonyl [e.g. benzyloxycarbonyl, phenethyloxycarbonyl, benzhydryloxycarbonyl, 4-nιtrobenzyloxycarbonyl, 3-methoxy-4-nιtrobenzyloxy- carbonyl, etc.], N-containmg heterocyclicoxycarbonyl [e.g. N-methylpiperidyloxycarbonyl, etc.] and the like, m which preferable one is lower alkoxycarbonyl or N-methylpipeπdyloxycarbonyl.

The lower alkylcarbamoyl may be mono or di (lower alkyl) carbamoyl such as methylcarr-amoyl, ethylcarbamoyl, propylcarbamoyl, oimethylcarbamoyl, diethylcarbamoyl, N-methyl-N-ethylcarbamoyl or tne like.

The lower alkanoyl may be substituted or unsubstituted C _] _-Cg alkanoyl sucn as formyl, acetyl, propionyl, butyryi, isobutyryi, valeryl, isovaleryl, pivaloyi, nexanoyl, tπfluoroacet _/ i or the like, m which

preferable one is formyl, acetyl or butyryl.

The aroyl may be benzoyl, naphthoyl, toluoyl, di (tert-butyl)benzoyl and the like, in which preferable one is benzoyl. 5 The heterocyclic moiety in the terms "a heterocyclic¬ carbonyl" "heterocyclicoxycarbonylammo" and "heterocyclicsulfonyl" may be one mentioned above as a heterocyclic group.

The "N-containing heterocycliccarbonyl" may be one

10 containing at least one nitrogen atom in heterocyclic group mentioned above, in which preferable one is N- (lower) alkyl)piperazinylcarbonyl (e.g. N-methyl- piperazinylcarbonyl, etc.), N- (lower alkyl) - homopiperazinylcarbonyl (e.g. N-methylhomopiperazinyl-

15 carbonyl, etc.), piperazinylcarbonyl, pyrrodinylcarbonyl or piperidylcarbonyl.

Suitable "substituted acyl" may be substituted lower alkylcarbamoyl [e.g. N-lower alkylamino-N-lower alkylcarbamoyl, pyridyl (lower) alkylcarbamoyl,

20 morpholino (lower) alkylcarbamoyl, etc.], substituted

N-containing heterocycliccarbonyl [e.g. trifluoroacetyl- piperazinylcarbonyl, pyridylpiperazinylcarbonyl, dimethylaminopiperazinylcarbonyl, hydroxyethoxyethyl- piperazinylcarbonyl, pyrrolidinylcarbonylmethyl-

25. piperazinylcarbonyl, etc.], n-protected-N-containing heterocycliccarbonyl [e.g. N-t-butoxycarbonylpiperidyl- carbonyl, etc.], and the like.

"N-Protective group" in "protected amino" may be common N-protective group such as substituted or

3C unsubstituted lower alkanoyl [e.g. formyl, acetyl, propionyl, trifluoroacetyl, etc.], phthaloyl, lower alkoxycarbonyl [e.g. tert-butoxycarbonyl, tert- amyloxycarbonyl, etc.], substituted or unsubstituted aralkyloxycarbonyl [e.g. benzyloxycarbonyl,

35 p-nitrobenzyloxycarbonyi, etc.], substituted or

unsubstituted arenesulfonyl [e.g. benzenesulfonyl, tosyl, etc.], nitrophenylsulfenyl, araikyl [e.g. trityl, benzyl, etc.] or the like, in which preferable one is phthaloyl or tert-butoxycarbonyl . 5 Suitable "acid residue" may be halogen [e.g. fluoro, chloro, bromo, iodo], arenesulfonyloxy [e.g. benzenesulfonyloxy, tosyloxy, etc.], alkanesulfonyloxy [e.g. mesyloxy, ethanesulfonyloxy, etc.], and the like, in which preferable one is halogen.

10 The substituent (s) on aryl for R ¹ may be plural and in such case the substituents may be the same or different.

Preferred "lower alkyl" for R^ may be ethylpropyl. Preferred "aryl" for R ¹ may be phenyl or phenyl

15 substituted with lower alkyl.

Preferred "cyclo (lower) alkyl" for R~ may be cyclopentyl.

Preferred "a heterocyclic group" for R ¹ may be pyridyl or thienyl.

20 Preferred compound (I) is one which has aryl, cyclo (lower) alkyl or a heterocyclic group, each of which may be substituted with substituent (s) selected from the group consisting of halogen; hydroxy; nitro; amino; acyl; acyloxy; aryl; lower alkenyl; acyl (lower) alkenyl; lower

25. alkoxy optionally substituted with amino, lower alkylamino, protected amino or acyl; and lower alkyl optionally substituted with hydroxy, lower alkylamino, acyl, acyloxy or acyl (lower) alkanoyloxy for R , lower alkyl or cyclo (lower) alkyl for R ² , hydrogen, halogen or

30 lower alkoxy for R , lower alkyl or aryl optionally substituted with amino for R ⁴ , CH or N for X and CH for Y. More preferred compound (I) is one which has pyridyl, thienyl substituted with esterified carboxy, cyclo (lower) - alkyl, or aryl which may be substituted with substituent (s)

35 selected from the group consisting of halogen; hydroxy;

nitro; amino; acyl; acyloxy; aryl; lower alkenyl; acyl (lower) alkenyl; lower alkoxy optionally substituted with amino, lower alkylamino or protected amino; and lower alkyl substituted with hydroxy, lower alkylamino, acyl, 5 acyloxy or acyl (lower) alkanoyloxy for R ¹ , lower alkyl or cyclo (lower) alkyl for R ² , hydrogen or halogen for R ³ , lower alkyl or aryl for R ⁴ , CH for X and CH for Y; aryl for R ¹ , lower alkyl for R ² , hydrogen for R ³ , aryl for R ⁴ , N fcr X and CH for Y; or aryl or haloaryl (more preferably phenyl,

10 tolyl or chlophenyl) , each of which is substituted with alkoxy substituted with acyl for R ¹ , lower alkyl for R ² , hydrogen or lower alkoxy for R , aryl (more preferably phenyl or tolyl) substituted with amino for R ⁴ , CH for X and CH for Y.

15 Most preferred compound (I) is one which has aryl or haloaryl (more preferably tolyl or chlorophenyl) , each of which is substituted with lower alkoxy substituted with N- (lower alkyl)piperazinylcarbonyl, esterified carboxy or carboxy for R ¹ , lower alkyl for R , hydrogen or lower

20 alkoxy for R , aryl (more preferably phenyl or tolyl) optionally substituted with amino for R ⁴ , CH for X and CH for Y.

Suitable pharmaceutically acceptable salts of the object compound (I) are conventional non-toxic salts and

25. include an acid addition salt such as an inorganic acid addition salt [e.g. hydrochloride, hydrobromide, sulfate, phosphate, etc.], an organic acid addition salt [e.g. formate, acetate, trifluoroacetate, maleate, tartrate, methanesulfonate, benzenesulfonate, toluenesulfonate,

30 etc.], a metal salt such as an alkali metal salt [e.g. sodium salt, potassium salt, etc.] and an alkaline earth metal salt [e.g. calcium salt, magnesium salt, etc.] and the like.

35 The processes for preparing the object compound (I)

are explained in detail in the following.

Process 1

The object compound (I) or its salt can be prepared by reacting a compound (II) or its salt with a compound

(III) or its reactive derivative at the carboxy group or a salt thereof.

Suitable salt of the compound (II) may be the same as those exemplified for the compound (I) . Suitable salts of the compound (III) and its reactive derivative at the carboxy group may be base salts as exemplified for the compound (I) .

Suitable reactive derivative at the carboxy group of the compound (III) may include an acid halide, an acid anhydride containing intramolecular, intermolecular and a mixed ones, an activated amide, an activated ester, and the like. Suitable examples of the reactive derivatives may be an acid chloride; an acid azide; a mixed acid anhydride with an acid such as substituted phosphoric acid [e.g. dialkylphosphoric acid, phenylphosphoric acid, diphenylphosphoric acid, dibenzylphosphoric acid, halogenated phosphoric acid, etc.], dialkylphosphorous acid, sulfurous acid, thiosulfuric acid, sulfuric acid, sulfonic acid [e.g. methanesulfonic acid, etc.], aliphatic carboxylic acid [e.g. acetic acid, propionic acid, butyric acid, isobutyric acid, pivalic acid, pentanoic acid, isopentanoic acid, 2-ethylbutyric acid, trichloroacetic acid, etc.] or aromatic carboxylic acid [e.g. benzoic acid, etc.]; a symmetrical acid anhydride; an activated amide with imidazole, 4-substituted imidazole, dimethylpyrazole, triazole or tetrazole; or an activated ester [e.g. cyanomethyl ester, methoxy ethyl ester, dimethyliminomethyl [ (CH ₃ ) ester, vinyl ester, propargyl ester, p-nitrophenyl ester, 2, 4-dinitrophenyl ester, trichlorophenyl ester, per.tachlorophenyl ester,

mesylphenyl ester, phenylazophenyl ester, phenyl thioester, p-nitrophenyl thioester, p-cresyl thioester, carboxymethyl thioester, pyranyl ester, pyridyl ester, piperidyl ester, 8-quinolyl thioester, etc.] or an ester 5 with an N-hydroxy compound [e.g.

N,N-dimethylhydroxylamine, l-hydroxy-2- (1H)-pyridone, N-hydroxysuccinimide, N-hydroxyphthalimide, 1-hydroxy-lH-benzotriazole, etc.], and the like. These reactive derivatives can optionally be selected from them

10 according to the kind of the compound (III) to be used.

The reaction is usually carried out in a conventional solvent such as water, alcohol [e.g. methanol, ethanol, etc.], acetone, dioxane, acetonitrile, chloroform, methylene chloride, ethylene chloride, tetrahydrofuran,

15 ethyl acetate, N,N-dimethylformamide, pyridine or any other organic solvent which does not adversely influence the reaction. These conventional solvents may also be used in a mixture with water.

In this reaction, when the compound (III) is used in

20 a free acid form or its salt form, the reaction is preferably carried out in the presence of a conventional condensing agent such as N,N'-dicyclohexylcarbodiimide; N-cyclohexyl-N'- orpholinoethy1carbodiimide; N-cyclohexyl-N'- (4-diethylaminocyclohexyl)carbodiimide;

25. N,N'-diethylcarbodiimide, N,N'-diisopropylcarbodiimide; N-ethyl-N'- (3-dimethylaminopropyi)carbodiimide; N,N'-carbonylbis- (2-methylimidazole) ; pentamethyleneketene-N-cyclohexyiimine; diphenylketene-N-cyclohexylimine; ethoxyacetylene;

30 1-alkoxy-l-chloroethylene; trial yl phosphite; ethyl polyphosphate; isopropyl polyphosphate; phosphorus oxychloride (phosphoryl chloride; ; phosphorus trichloride; diphenylphosphoryl azide; diphenyl chlorophosphate; diphenylphosphinic chloride; thienyl chloride; oxalyl

35 chloride; lower alkyl halofor ate [e.g. ethyl

chloroformate, isopropyl chloroformate, etc.]; triphenylphosphine; 2-ethyl-7-hydroxybenzisoxazolium salt; 2-ethyl-5-(m-sulfophenyl) isoxazolium hydroxide intramolecular salt; 1- (p-chlorobenzenesulfonyloxy)-6- chloro-lH-benzotriazole; so-called Vilsmeier reagent prepared by the reaction of N,N-dimethylformamide with thionyl chloride, phosgene, trichloromethyl chloroformate, phosphorus oxychloride, etc.; or the like.

The reaction may also be carried out in the presence of an inorganic or organic base such as an alkali metal bicarbonate, tri (lower) alkylamine, pyridine, 4-dimethylaminopyridine, N- (lower) alkylmorpholine, N,N-di (lower) alkylbenzylamine, or the like.

The reaction temperature is not critical, and the reaction is usually carried out under cooling to heating.

Prςςess 2

The object compound (I) or its salt can be prepared by reacting a compound (IV) or its salt with a compound (V) or its reactive derivative at the carboxy group or a salt thereof.

Suitable salts of the compounds (IV) and (V) and its reactive derivative at the carboxy group may be the same as those exemplified for the compound (I) . This reaction can be carried out in substantially the same manner as Process 1. and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 1.

Process 3

The object compound (lb) or its salt can be prepared by subjecting a compound (la) or its salt to deesterification reaction. Suitable salt of the compound (lb) may be the same as

those exemplified for the compound (I) .

Suitable salt of the compound (la) may be an acid addition salt as exemplified for the compound (I) .

The reaction is carried out m accordance with a conventional method such as hydrolysis, reduction or the like.

The hydrolysis is preferably carried out m the presence of a base or an acid including Lewis acid. Suitable base may include an inorganic base and an organic base such as an alkali metal [e.g. lithium, sodium, potassium, etc.], an alkaline earth metal [e.g. magnesium, calcium, etc.], the hydroxide or carbonate or bicarbonate thereof, tπalkylamme [e.g. trimethylam e, tnethylamine, etc.], picolme, 1,5-dιazabιcyclo[4.3.0]- non-5-ene, 1,4-dιazabιcyclo[2.2.2]octane,

1, 8-dιazabιcyclo[5.4.0]undec-7-ene, or the like. Suitable acid may mcluoe an organic acid [e.g. formic acid, acetic acid, propionic acid, trichloroacetic acid, tπfluoroacetic acid, etc.], an inorganic acid [e.g. hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, etc.] and Lewis acid [e.g. boron tπbromide, etc.].

The reaction is usually carried out in a solvent such as water, an alcohol [e.g. methanol, ethanol, etc.], xylene, diethylene glycol monometnyl ethyl, methylene chloride, tetrahydrofuran, a mixture thereof or any other solvent which does not adversely influence the reaction. A liquid base or acid can be also used as the solvent. The reaction temperature is not critical and the reaction is usually carried out under cooling to warming. The reduction can be applied preferably for elimination of the ester moiety such as 4-nιtrobenzyl, 2-ιodoethyl, 2,2,2-trιcnloroethyl, or the like. The reduction method applicable for tne elimination reaction mav include chemical reduction ar.d catalitic reduction.

Suitable reducing agents to be used in chemical reduction are a combination of metal [e.g. tin, zinc, iron, etc.] or metallic compound [e.g. chromium chloride, chromium acetate, etc.] and an organic or inorganic acid 5 [e.g. formic acid, acetic acid, propionic acid, trifluoroacetic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, etc.] .

Suitable catalysts to be used in catalytic reduction are conventional ones such as platinum catalysts [e.g.

10 platinum plate, spongy platinum, platinum black, colloidal platinum, platinum oxide, platinum wire, etc.], palladium catalyst [e.g. spongy palladium, palladium black, palladium oxide, palladium on carbon, colloidal palladium, palladium on barium sulfate, palladium on barium

15 carbonate, etc.], nickel catalyst [e.g. reduced nickel, nickel oxide, Raney nickel, etc.], cobalt catalyst [e.g. reduced cobalt, Raney cobalt, etc.], iron catalyst [e.g. reduced iron, Raney iron, etc.], copper catalyst [e.g. reduced copper, Raney copper, Uliman copper, etc.] or the

20 like.

The reduction is usually carried out in a conventional solvent which does not adversely influence the reaction such as water, an alcohol [e.g. methanol, ethanol, propanol, etc.], N,N-dimethylformamide, or a

25 _. mixture thereof. Additionally, in case that the above-mentioned acids to be used in chemical reduction are in liquid, they can also be used as a solvent. Further, a suitable solvent to be used in catalytic reduction may be the above-mentioned solvent, and other conventional

30 solvent such as diethyl ether, dioxane, tetrahydrofuran, etc., or a mixture thereof.

The reaction temperature of this reduction is not critical and the reaction is usually carried out under cooling to warming.

35 In this reaction, in case that the compound (la)

having lower alkyl substituted with esterified carboxy for R^ is used as a starting compound, the compound (lb) having lower alkyl substituted with carboxy for R ² may be obtained according to reaction condition. This case is included within the scope of this reaction.

Process 4

The object compound (Id) or its salt can be prepared by subjecting a compound (Ic) or its salt to deacylation reaction.

Suitable salt of the compound (Ic) may be an acid addition salt as exemplified for the compound (I).

Suitable salt of the compound (Id) may be the same as those exemplified for the compound (I) . This reaction can be carried out in substantially the same manner as hydrolysis in Process 3, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in hydrolysis in Process 3.

Process 5

The object compound (If) or its salt can be prepared by subjecting a compound (Ie) or its salt to elimination reaction of the N-protective group. Suitable salts of the compounds (Ie) and (If) may be acid addition salts as exemplified for the compound (I) .

This reaction is carried out in accordance with a conventional method such as hydrolysis, reduction or the like. The hydrolysis is preferably carried out in the presence of a base or an acid including Lewis acid.

Suitable base may include ar, inorganic base and an organic base such as an alkali metal [e.g. sodium, potassium, etc.], an alkaline earth metal [e.g. magnesium, calcium, etc.], the hydroxide or carbonate or bicarbonate

thereof, hydrazme, trialkylamme [e.g. trimethylamme, triethylamme, etc.], picolme, 1, 5-dιazabιcyclo[4.3.0]- non-5-ene, 1, 4-dιazabιcyclo[2.2.2]octane, 1, 8-dιazabιcyclo[5.4.0]undec-7-ene, or the like. Suitable acid may include an organic acid [e.g. formic acid, acetic acid, propicnic acid, trichloroacetic acid, trifluoroacetic acid, etc.], an inorganic acid [e.g. hydrochloric acid, hydrobro ic acid, sulfuric acid, hydrogen chloride, hydrogen bromide, hydrogen fluoride, etc.] and an acid addition salt compound [e.g. pyπdme hydrochloride, etc.].

The elimination using tπhaloacetic acid [e.g. trichloroacetic acid, trifluoroacetic acid, etc.] or the like is preferably carried out m the presence of cation trapping agents [e.g. amsole, pnenol, etc.].

The reaction is usually carried out in a solvent such as water, an alcohol [e.g. methanol, ethanol, etc.], methylene chloride, chloroform, tetrachloromethane, tetrahydrofuran, a mixture thereof or any other solvent which does not adversely influence the reaction. A liquid base or acid can be also used as the solvent. The reaction temperature is not critical and the reaction is usually carried out under cooling to heating.

The reduction method applicable for the elimination reaction may include chemical reduction and catalytic reduction.

Suitable reducing agents to be used in chemical reduction are a combination of metal [e.g. tin, zmc, iron, etc.] or metallic compound [e.g. chromium chloride, chromium acetate, etc.. and an organic or inorganic acid [e.g. formic acid, acetic acid, propionic acid, trifluoroacetic acid, p-toluenes_lfomc acid, hydrochloric acid, hydrobromic acid, etc.].

Suitable catalysts to Pe used m catalytic reduction are conventional ones such as platinum catalysts [e.g.

platinum plate, spongy platinum, platinum black, colloidal platinum, platinum oxide, platinum wire, etc.], palladium catalysts [e.g. spongy palladium, palladium black, palladium oxide, palladium on carbon, colloidal palladium, palladium on barium sulfate, palladium on barium carbonate, etc.], nickel catalysts [e.g. reduced nickel, nickel oxide, Raney nickel, etc.], cobalt catalysts [e.g. reduced cobalt, Raney cobalt, etc.], iron catalysts [e.g. reduced iron, Raney iron, etc.], copper catalysts [e.g. reduced copper, Raney copper, Uliman copper, etc.] and the like.

In case that the N-protective group is benzyl, the reduction is preferably carried out in the presence of a combination of palladium catalysts [e.g. palladium black, palladium on carbon, etc.] and formic acid or its salt [e.g. ammonium formate, etc.].

The reduction is usually carried out in a conventional solvent which does not adversely influence the reaction such as water, methanol, ethanol, propanol, N,N-dimethylformamide, or a mixture thereof.

Additionally, in case that the above-mentioned acids to be used in chemical reduction are in liquid, they can also be used as a solvent. Further, a suitable solvent to be used in catalytic reduction may be the above-mentioned solvent, and other conventional solvent such as diethyl ether, dioxane, tetrahydrofuran, etc. or a mixture thereof.

The reaction temperature of this reduction is not critical and the reaction is usually carried out under cooling to heating.

Process 6

The object compound (Ig) or its salt can be prepared by reacting a compound (lb) or its reactive derivative at the carboxy group or a salt thereof with an amine or its salt.

Suitable salt of amine may be an acid addition salt as exemplified for the compound (I) .

Suitable salts of the compounds (Ig) and (lb) and its reactive derivative at the carboxy group may be the same as those exemplified for the compound (I) .

Suitable "amine" may be ammonia, substituted or unsubstituted lower alkylamine, substituted or unsubstituted N-containing heterocyclic compound and the like. The substituted or unsubstituted lower alkylamine may be mono or di (lower) alkylamine (e.g. methylamine, ethylamine, propylamine, isopropylamine, butylamine, isobutylamine, pentylamine, hexylamine, dimethylamine, diethylamine, dipropylamine, dibutylamine, di-isopropylamine, dipentylamine, dihexylamine, etc.), pyridyl (lower) alkylamine, (e.g. pyridylmethylamine, etc.), lower alkylamino (lower) alkylamine (e.g. N-diethylaminoethyl-N-methylamine, etc.) , morpholino (lower) alkylamine (e.g. morpholinoethylamine, etc.) or the like.

The substituted or unsubstituted N-containing heterocyclic compound may be saturated 5 or 6-membered N-, or N- and S-, or N- and O-containing heterocyclic compound such as pyrrolidine, imidazolidine, piperidine, piperazine, lower alkylaminopiperidine (e.g. dimethylaminopiperidine, etc.),

N- (lower) lkylhomopiperazine (e.g. N-methylhomopiperazine, etc.), N- (lower) alkylpiperazine (e.g. N-methylpiperazine, N-ethylpiperazine, etc.), morpholine, thio orpholine, N-pyridylpiperazine, N-hydroxy (lower) alkoxy (lower) - alkylpiperazine (e.g. N-hydroxyethoxyethylpiperazine, etc.), N-pyrrolidinylcarbonyl (lower) alkylpiperazine (e.g. N-pyrrodidinylcarbonylmethylpiperazine, etc.), or the like, in which preferable one is N-methylpiperazine. This reaction can be carried out in substantially the

same manner as Process 1. and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained m Process 1.

Process 7

The object compound (Ii) or its salt can be prepared by the following method.

Namely, 1) the compound (Ih) or its reactive derivative at the carboxy group or its salt thereof is firstly reacted with an azide compound, and then 2) reacting the resultant product with an acid.

Suitable salts of the compound (Ih) and its reactive derivative at the carboxy group may be the same as those exemplified for the compound (I) .

Suitable salt of the compound (Ii) may be an acid addition salt as exemplified for the compound (I) .

Suitable reaction derivative at the carboxy group of the compound (Ih) is to be referred to those as explained in Process 1.

Suitable azide compound may be alkali metal azide [e.g. sodium azide, potassium azide, etc.], alkaline earth metal azide [e.g. calcium azide, etc.], hydrogen azide, diphenylphosphoryl azide and the like. In the first step, the reaction is preferably carried out m the presence of a base such as trialkylamme [e.g. triethylamme, etc.] or the like.

The reaction is usually carried out m a solvent which does not adversely influence the reaction such as tetrahydrofuran, oioxane, benzene or the like.

Tne reaction temperature is not critical and the reaction can be carried out under cooling to heating.

Additionally, case that tr.e above-mentioned azide compounds are alkali metal azide, alkaline earth metal azide and hydrogen azide, its reactive derivative at the

carboxy group of the compound (Ih) is preferably used.

The resultant is further reacted with an acid to give the object compound (Ii) or its salt.

Suitable acid may include an organic acid [e.g. formic acid, acetic acid, trifluoroacetic acid, etc.] and an inorganic acid [e.g. hydrochloric acid, hydrobromic acid, etc. ] .

The reaction is usually carried out in a solvent which does not influence the reaction such as tetrahydrofuran, dioxane, benzene, water, a mixture thereof or the like.

The reaction temperature is not critical and the reaction is usually carried out under warming to heating.

Process 8

The object compound (Ik) or its salt can be prepared by subjecting a compound (Ij) or its salt to reduction.

Suitable salts of the compounds (Ij) and (Ik) may be the same as those exemplified for the compound (I) . This reduction is carried out by catalytic reduction or a mixture of nickel chloride and sodium borohydride.

Suitable catalysts to be used in catalytic reduction are conventional ones such as platinum catalyst [e.g. platinum plate, spongy platinum, platinum black, colloidal platinum, platinum oxide, platinum wire, etc.], palladium catalyst [e.g. spongy palladium, palladium black, palladium oxide, palladium on carbon, colloidal palladium, palladium on barium sulfate, palladium on barium carbonate, etc.], nickel catalyst [e.g. reduced nickel, nickel oxide, Raney nickel, etc.] , cobalt catalyst [e.g. reduced cobalt, Raney cobalt, etc], iron catalyst [e.g. reduced iron, Raney iron, etc.], copper catalyst [e.g. reduced copper, Raney copper, Uliman copper, etc.] or the like. The reduction is usuallv carried out in a solvent. A

suitable solvent to be used may be water, an alcohol [e.g. methanol, ethanol, propanol, etc.], acetonitrile or any other conventional organic solvent such as diethyl ether, dioxane, tetrahydrofuran, etc. or a mixture thereof. The reaction temperature is not critical, and the reaction is preferably carried out under cooling to heating.

Process 9 The object compound (Im) or its salt can be prepared by reacting a compound (I.) or its salt with a reducing agent.

Suitable salts of the compound (1 or (Im) may be the same as those exemplified for the compound (I) . Suitable reducing agent may be diborane, lithium aluminum hydride, sodium borohydride and the like.

The reaction is usually carried out in a solvent which does not adversely influence the reaction such as diethyl ether, tetrahydrofuran, alcohol [e.g. methanol, ethanol, etc.] or the like.

In case that the compound (I.) having aryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with carboxy or esterified carboxy for R- ^* - is used as a starting compound, diborane or lithium aluminum hydride is used as a reducing agent.

Additionally, in case that diborane or lithium aluminum hydride is used as a reduced agent, alcohol can not be used as a solvent.

The reaction temperature is not critical and the reaction can be carried out under cooling to heating.

Process 10

The object compound (Ic) or ts salt can be prepared by reacting a compound (Id) or its salt with an acylating agent.

Suitable salts of the compounds (Ic) and (Id) may be the same as those exemplified for the compound (I) .

The acylating agent may include an organic acid represented by the formula : R ⁸ -OH, m which R ⁸ is acyl or acyl (lower) alkanoyl, acyl m wnich is illustrated above, or a reactive derivative thereof.

The suitable reactive derivative of organic acid may be a conventional one such as an acid halide [e.g. acid chloride, acid bromide, etc.], an acid azide, an acid anhydride containing intramolecular and mtermolecular ones, an activated amide, an activated ester or the like.

When free acid is used as an acylating agent, the acylat cn reaction may preferably be conducted m the presence of a conventional condensing agent such as N,N'-dιcyclohexylcarbodιιmιde or the like.

The reaction is usually carried out in a conventional solvent such as water, pyridme, acetone, dioxane, chloroform, methylene chloride, acetonitrile, ethylene chloride, tetrahydrofuran, ethyl acetate, N,N-dιmethylformamιde, pyridme or any other organic solvent which does not adversely influence the reaction, or a mixture thereof.

The reaction is also preferably carried out in the presence of a conventional base such as triethylamme, pyridme, sodium hydroxide or the like.

The reaction temperature is not critical, and the reaction can be carried out under cooling to heating.

Process 11 The object compound (In) or ts salt can be prepared by subjecting a compound (Im) or ts salt to oxidation reaction.

Suitable salts of the compounds (Im) and (In) may be the same as those exemplified for the compound (I) . Suitable oxidizing agent used m this reaction may be

manganese dioxide, dimethyl sulfoxide, a mixture of dimethyl sulfoxide and oxalyl chloride and the like.

The reaction is usually carried out in a conventional solvent such as pentane, hexane, benzene, diethyl ether, 5 dimethoxyethane, acetone, chloroform, dichloromethane or any other solvent which does not adversely influence the reaction.

Additionally in case that the above-mentioned oxidizing agent is liquid, it can be used as a solvent. 10 In this reaction, in case that dimethyl sulfoxide or a mixture of dimethyl sulfoxide and oxalyl chloride is used as an oxidizing agent, the reaction is preferably carried out in the presence of alkali metal iodide (e.g. sodium iodide, etc.) and alkali metal carbonate (e.g. 15 sodium carbonate) or tri (lower) alkylamine (e.g. triethylamine, etc.).

The reaction temperature is not critical, and the reaction is usually carried out under cooling to heating.

20 Process 12

The object compound (Io) or its salt can be prepared by reacting a compound (In) or its salt with mono or di (lower)alkylamine, N-acyl (lower) alkyl-N-lower alkylamine, N-containing heterocyclic compound, or a salt

25 _. thereof in the presence of a reducing agent.

Suitable salts of the compounds (In) and (Io), mono or di (lower) alkylamine, N-acyl (lower) alkyl-N-lower alkylamine and N-containing heterocyclic compound may be acid addition salts as exemplified for the compound (I) .

30 Suitable mono or di (lower) alkylamine may be mono or di (C- _[ _-Cg) alkylamine such as methylamine, ethylamine, dimethylamine, N-methyl-N-isopropyiamine or the like, in which preferable one is methylamine.

Suitable "N-acyl (lower) alkyl-N-iower alkylamine" may

35 be N-methylpiperazinylcarbonylmethyl-N-methylamine and the

like .

Suitable "N-containing heterocyclic compound" may be the same as aforementioned, in which preferable one is N- methylpiperazine. Suitable reducing agent may be diborane, borane-organic amine complex [e.g. borane-pyridine complex, etc.], alkali metal cyanoborohydride [e.g. sodium cyanoborohydride, lithium cyanoborohydride, etc.] and the like. The reaction is preferably carried out in the presence of molecular sieves.

The reaction is usually carried out in a conventional solvent such as water, an alcohol [e.g. methanol, ethanol, etc.], dioxane, tetrahydrofuran, a mixture thereof or any other organic solvent which does not adversely influence the reaction.

The reaction may also be carried out in an acidic condition [e.g. presence of acetic acid, etc.] and the reaction temperature is not critical, and the reaction is usually carried out under cooling to warming.

Process 13

The object compound (Iq) or its salt can be prepared by reacting a compound (Ip) or its salt with lower alkanal.

Suitable salts of the compounds (Ip) and (Iq) may be acid addition salts as exemplified for the compound (I) . Suitable lower alkanal may be C -Cg alkanal such as formaldehyde, ethanal, propanal or the like, in which preferable one is formaldehyde.

This reaction can be carried out in substantially the same manner as Process 12. and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reacticn are to be referred to those as explained m Process 12.

Process 1

The object compound (Is) or its salt can be prepared by subjecting a compound (Ir) or its salt to catalytic reduction. Suitable salts of the compounds (Ir) and (Is) may be the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as catalytic reaction in Process 5. and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in catalylic reaction in Process 5.

Process 15 The object compound (It) or its salt can be prepared by reacting a compound (Is) or its salt with a compound (VI) or its salt.

Suitable salts of the compounds (Is), (It) and (VI) may be the same as those exemplified for the compound (I) . When the compound (VII) having halogen for Z~ is used in this reaction, the reaction is preferably carried out in the presence of a base such as an alkali metal (e.g. sodium, potassium, etc.), an alkaline earth metal (e.g. magnesium, calcium, etc.), the hydride or hydroxide or carbonate or bicarbonate thereof.

The reaction is usually carried out in a conventional solvent which does not adversely influence the reaction such as water, dioxane, alcohol (e.g. methanol, ethanol, etc.), acetonitrile, tetrahydrofuran, acetic acid, N,N- dimethylformamide, or a mixture thereof.

The reaction temperature is not critical and the reaction can be carried out under cooling to heating.

Process 16 The object compound (Iv) or ts salt can be prepared

by reacting a compound (Iu) or its salt with a compound (VII) .

Suitable salts of the compounds (Iu) and (Iv) may be the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as Process 15, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred those as explained in Process 15.

Process 17

The object compound (Ix) or its salt can be prepared by reacting a compound (Iw) or its salt with an amine or potassium phthalimide. Suitable salts of the compounds (Ix) and (Iw) may be the same as those exemplified for the compound (I) .

Suitable "amine" may be ammonia, lower alkylamine, N- contammg heterocyclic compound and the like.

The lower alkylamine may be mono or di (lower)alkylamine such as methylamine, ethylamme, propylamme, isopropylamme, butylamine, lsobutylamme, pentylamme, hexylamme, dimethylamme, diethylamme, dipropylamme, dibutylamme, di-isopropylamme, dipentylam e, dihexylamme or the like. The N-contammg heterocyclic compound may be saturated 5 or 6-membered N-, or X- and S-, or N- and 0- contaimng heterocyclic compound such as pyrrolicine, lmidazolidme, piperidme, piperazme,

N- (lower)alkylpiperazine [e.g. N-itethylpiperazme, N- ethylpiperazme, etc.], morpholme, tniomorpholme or the like, in which preferable one is N-methylpiperazme. This reaction is preferably carried out m the presence of alkali metal carbonate or bicaroonate (e.g. potassium carbonate, potassium bicarbonate, etc.), alkali metal iodide [e.g. sodium iodide, potassium iodide, etc.]

and the like.

This reaction is usually carried out in a conventional solvent such as tetrahydrofuran, dioxane, aromatic hydrocarbon [e.g. benzene, toluene, xylene, etc.], N,N-dιmethylformamιde, acetone, a mixture thereof, or any other solvent which does not adversely influence the reaction.

The reaction temperature is not critical, and the reaction is usually carried out under cooling to heating.

Process 18

The object compound (Iz) or its salt can be prepared by reacting a compound (ly) or its salt with an acylating agent. Suitable salts of the compounds (ly) and (Iz) may be the same as those exemplified for the compound (I) .

The acylating agent may include an organic acid

Q Q represented by the formula : R -OH, m which R^ is acyl or substituted acyl as illustrated above, or its reactive derivative.

This reaction can be carried out in substantially the same manner as Process 10, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 10.

Process 19

The object compound (1-2) or its salt can be prepared by reacting a compound (I-l) or its salt with substituted or unsubstituted N-contammg heterocyclic compound or lower alkylhydrazme.

Suitable salts of the compounds (I-l) or (1-2) may be tne same as exemplified for the ccmpound (I) .

Suitable "substituted or unsuostituted N-contammg heterocyclic compound" may oe the same as those

exemplified in Process 6.

Suitable "lower alkylhydrazine" may be mono or di (lower) alkylhydrazine such as methylhydrazine, dimethylhydrazine, ethylhydrazine, diethylhydrazine or the like, in which preferable one is dimethylhydrazine.

This reaction is usually carried out in a conventional solvent which does not adversely influence the reaction such as diethyl ether, tetrahydrofuran, dioxane, N,N-dimethylformamide or the like. The reaction temperature of this reaction is not critical and the reaction is usually carried out under cooling to heating.

Process 20 The object compound (1-3) or its salt can be prepared by reacting a compound (I-l) or its salt with heterocyclic compound substituted with hydroxy.

Suitable salts of the compound (I-l) and (1-3) may be the same as those exemplified for the compound (I) . Suitable "heterocyclic compound substituted with hydroxy" may be N-containing heterocyclic compound afore¬ mentioned substituted with hydroxy and the like, in which preferable one is N-lower alkylpiperidine substituted with hydroxy. This reaction is usually carried out in a conventional solvent which does net adversely influence the reaction such as diethyl ether, tetrahydrofuran, dioxane, N,N-dimethylformamide cr the like.

The reaction temperature of this reaction is not critical and the reaction is usually carried out under cooling to heating.

Process 21

The object compound (1-5) or its salt can be prepared by reacting a compound (1-4) or its salt with

N-contammg heterocyclic compound or lower alkylammo (lower) alkylamine.

Suitable salts of the compounds (1-4) and (1-5) may be the same as those exemplified for the compound (I) . Suitable "N-contammg heterocyclic compound" may be the same as those exemplified in Process 17.

Suitable "lower alkylamino(lower) alkylamine" may be mono or di (lower)alkylamino(lower)alkylamine such as methylammomethylamme, dimethylammomethylamme, dimethylammoethylamme or the like, in which preferable one is dimethylethylamme.

This reaction is usually carried out in a conventional solvent which does not influence the reaction such as diethyl ether, tetrahydrofuran, dioxane, N,N-dιmethylformamιde or the like.

The reaction temperature of this reaction is not critical and the reaction is usually carried out under cooling to heating.

Process 22

The object compound (1-7) or its salt can be prepared by subjecting a compound (1-6) or its salt to reduction. Suitable salts of the compounds (1-6) and (1-7) may be the same as those exemplified for the compound (I) . The reduction may include chemical reduction and catalytic reduction, which are carried out m a conventional manner.

Suitable reducing agents to oe used in chemical reduction are a metal [e.g. tin, zinc, iron, etc.], a combination of sucn metal and/or metallic compound [e.g. chromium chloride, chromium acetate, etc.] and an organic or inorganic acid [e.g. formic ac d, acetic acid, propionic acid, trifluoroacetic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, etc.], a como ation cf such metal and/cr metallic compound and

base [e.g. ammonia, ammonium chloride, sodium hydroxide, etc.], a metal hydride compound such as aluminum hydride compound [e.g. lithium aluminum hydride, sodium aluminum hydride, aluminum hydride, lithium trimethoxyaluminum hydride, lithium tri-t-butoxyaluminum hydride, etc.], borohydride compound [e.g. sodium borohydride, lithium borohydride, sodium cyanoborohydride, tetramethylammoniiim borohydride, borane, diborane, etc.], a phosphorus compound [e.g. phosphorus trichloride, phosphorus tibromide, triphenylphosphine, triethylphosphine, etc.] and the like.

Suitable catalysts to be used in catalytic reduction are conventional ones such as platinum catalyst [e.g. platinum plate, spongy platinum, platinum black, colloidal platinum, platinum oxide, platinum wire, etc.], palladium catalyst [e.g. spongy palladium, palladium black, palladium oxide, palladium on carbon, colloidal palladium, palladium on barium sulfate, palladium on barium carbonate, etc.], nickel catalyst [e.g. reduced nickel, nickel oxide, Raney nickel, etc.], cobalt catalyst [e.g. reduced cobalt, Raney cobalt, etc.], iron catalyst [e.g. reduced iron, Raney iron, etc.], copper catalyst [e.g. reduced copper, Raney copper, Uliman copper, etc.], or the like. The reduction is usually carried out in a solvent. A suitable solvent to be used may be water, an alcohol [e.g. methanol, ethanol, propanol, etc.], acetonitrile or any other conventional organic solvent such as diethyl ether, dioxane, tetrahydrofuran, etc. or a mixture thereof.

The reaction temperature is not critical, and the reacting is preferably carried out under cooling to heating.

In this reaction, in case that the compound (1-6) having lower alkyl, aryl, chloroaryl, cyclo (lower) alkyl,

each of which is substituted with benzyloxy for R ¹ and/or nitro for R ³ is used as a starting compound, the compound (1-6) having lower alkyl, aryl, chloroaryl, cyclo (lower) alkyl, each of which is substituted with hydroxy for R ^~ and/or amino for R ³ may be obtained according to reaction condition. This case is included within the scope of this reaction.

Process 23 The object compound (1-9) or its salt can be prepared by subjecting a compound (1-8) or its salt to reduction. Suitable salts of the compounds (1-8) and (1-9) may be the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as Process 22, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 22.

In this reaction, in case that the compound (1-8) having aryl substituted with nitro for R ⁴ is used as a starting compound, the compound (1-9) having aryl substituted with amino may be obtained according to reaction condition. This case is included within the scope of this reaction.

Process 24

The object compound (1-11) or its salt can be prepared by reacting a compound (1-10) or its salt with a compound (VIII) or its reactive derivative. Suitable salts of the compounds (1-10) and (1-11) may be the same as those exemplified for the compound (I) .

Suitable reactive derivative of the compound (VIII) may be phosphorane derivative and the like.

This reaction is preferably carried out in the presence of an inorganic or organic base such as an alkali

metal [e.g. sodium, potassium, etc.], an alkaline earth metal [e.g. magnesium, calcium, etc.], the hydroxide or carbonate thereof, alkali metal hydride [e.g. sodium hydride, etc.], alkali metal amide [e.g. sodium amide etc.], alkaline earth metal hydride [e.g. calcium hydride, etc.], alkali metal alkoxide [e.g. sodium methoxide, sodium ethoxide, potassium tert-butoxide, etc.], alkaline earth metal alkoxide [e.g. magnesium methoxide, magnesium ethoxide, etc.], lower alkyl alkali metal [e.g. n-butyl lithium, etc.], trialkylamme [e.g. trimethylamme, triethylamme, etc.], pyridme, pipeπdme, picolme,

1, 5-dιazabιcyclo[4.3.0]non-5-ene,

1, 4-dιazabιcyclo[2.2.0]octane,

1, 8-dιazabιcyclo[5.4.0]undec-7-ene, or the like. The reaction is usually carried out in a solvent such as water, an alcohol [e.g. methanol, ethanol, etc.], acetonitrile, chloroform, metnylene chloride, nitromethane, benzene, tetrahydrofuran, diethyl ether, dimethylacetamide, N,N-dιmethylformamιde, dimethyl sulfoxide or any other organic solvent which does not adversely influence the reaction.

The reaction temperature is not critical, and the reaction can be carried out under cooling to heating.

Process 25

The object compound (1-13) or its salt can be prepared by reacting a compound (1-12) or its salt with a reducing agent.

Suitable salts of the compounds (1-12) and (1-13) may be the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as Process 9, and tnerefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of th s reaction are to be referred to those as explained m Process 9.

Process 26

The object compound (1-15) or its salt can be prepared by reacting a compound (1-14) or its salt with a reducing agent. Suitable salts of the compounds (1-14) and (1-15) may be the same as those exemplified for the compound (I) .

Suitable reducing agent may be diisobutylalummum hydride, sodium diisobutylalummum dihydride, sodium aluminum hydride, lithium tri-t-butoxyalummohydride, and the like.

The reaction is usually carried out in a conventional solvent such as dichloromethane, toluene, tetrahydrofuran, diethyl ether or the like.

The reaction temperature is not critical, and the reaction is usually carried out under cooling to warming.

Process 27

The object compound (1-17) or its salt can be prepared by reacting a compound (1-16) or its salt with hydroxylamme or its salt.

Suitable salts of the compounds (1-16) and (1-17) may be the same as those exemplified for the compound (I) .

Suitable salt of hydroxylamme may be an acid addition salt as exemplified for the compound (I) . The reaction is preferably carried out in the presence of alkali metal salt of acetic acid (e.g. sodium acetate, etc.) or alkali metal carbonate (e.g. sodium carbonate etc. ) .

The reaction is usually carried out in a solvent which does not adversely influence the reaction such as water, alcohol (e.g. metnanol, etnanol, etc.), tetrahydrofuran, dioxane, acetic acid or the like, or a mixture thereof.

The reaction temperature is not critical and the reaction can be carried out under cooling to heating.

Proces s ? 8

The object compound (1-18) or its salt can be prepared by reacting a compound (1-7) or its salt with lower alkanal. Suitable salts of the compounds (1-7) and (1-18) may be acid addition salts as exemplified for the compound (I) •

This reaction can be carried out in substantially the same manner as Process 13, and therefore the reaction, mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those explained in Process 13.

Process 29 The object compound (1-20) or its salt can be prepared by reacting a compound (1-19) or its salt with an azide compound.

Suitable salts of the compounds (1-19) and (1-20) may be the same as those exemplified for the compound (I) . Suitable azide compound may be alkali metal azide

[e.g. sodium azide, potassium azide, etc.], alkaline earth metal azide [e.g. calcium azide, etc.], hydrogen azide, trimethyltin azide and the like.

The reaction is usually carried out in a conventional solvent such as tetrahydrofuran, dioxane, toluene, xylene, N,N-dimethylformamide or any other organic solvent which does not adversely influence the reaction.

The reaction temperature is not critical, and the reaction can be carried out warming to heating.

Process 30

The object compound (1-22) or its salt can be prepared by subjecting a compound (1-21) or its salt with an oxidizing agent. Suitable salts of the compounds (1-21) and (1-22) may

be the same as those exemplified for the compound (I) .

The suitable oxidizing agent may be hydrogen peroxide, Jones reagent, peracid [e.g. peracetic acid, perbenzoic acid, m-chloroperbenzoic acid, etc.], chromic acid, potassium permanganate, alkali metal periodate [e.g. sodium periodate, etc.] and the like.

This reaction is usually carried out in a solvent which does not adversely influence the reaction such as acetic acid, dichloromethane, acetone, ethyl acetate, chloroform, water, an alcohol [e.g. methanol, ethanol, etc.], a mixture thereof or the like.

The reaction temperature is not critical, and the reaction is usually carried out under cooling to warming.

Process 31

The object compound (1-24) or its salt can be prepared by subjecting a compound (1-23) or its salt to introduction reaction of N-protective group.

Suitable salts of the compounds (1-23) and (1-24) may be the same as those exemplified for the compound (I) . Suitable N-protective group introducing agent in introduction reaction of N-protective group may be a halogen compound of N-protective group aforementioned such as acetyl chloride, tert-butoxycarbonyl chloride, benzyl chloride, benzyl bromide or the like, di-tert-butyl dicarbonate, or the like.

The reaction is preferably carried out in the presence of a base such as trilower alkylamine (e.g. triethylamine) or the like. The reaction is usually carried out in a conventional solvent such as water, an alcohci [e.g. methanol, ethanol, etc.], tetrahydrofuran, dioxane, pyridine, dichloromethane or any other organic solvent which does not adversely influence the reaction, or a mixture thereof. The reaction temperature is not critical, and the

reaction can be carried out under cooling to heating.

Process 32

The object compound (1-26) or its salt can be prepared by reacting a compound (1-25) or its salt with a halogenatmg agent.

Suitable salts of the compounds (1-25) and (1-26) may be the same as those exemplified for the compound (I) .

Suitable halogenatmg agent may be hydrogen halide, a mixture of triphenylphosphine ano carbon tetrahalide, and the like.

The reaction is usually carried out in a conventional solvent such as chloroform, dichloromethane, tetrahydrofuran or any other organic solvent which does not influence the reaction.

The reaction temperature is not critical, and the reaction is usually carried out under cooling to heating.

Process 33 The object compound (1-28) cr its salt can be prepared by reacting a compound '1-27) or its salt with an acylating agent.

Suitable salts of the compounds (1-27) and (1-28) may be the same as those exemplified for the compound (I) . This reaction can be carried out in substantially the same manner as Process 18, and tnerefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those explained m Process 18.

Process 34

The object compound (1-30) cr its salt can be prepared by subjecting a compound (1-29) or its salt to deesterificaticn reaction. Suitable salts of tne compounds (1-29) and (1-30) may

be the same as those exemplified for the compound (I) . This reaction can be carried out in substantially the same manner as Process 3, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those explained in Process 3.

In this reaction, ^' in case that the compound (1-29) having lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with esterified carboxy; lower alkenyl substituted with esterified carboxy; lower alkyl substituted with esterified carboxy, esterified carboxy(lower) alkanoyloxy or esterified carboxy(lower) alkoxyimino; lower alkylthio substituted with esterified carboxy; alkoxy substituted with esterified carboxy-substituted aryl, esterified carboxy-substituted pyridyl, esterified carboxy(lower) - alkylamino, N-protected-esterified carboxy(lower) - alkylamino, N-esterified carboxy(lower) alkyl-N-lower alkylamino, esterified carboxy or esterified carboxy(lower) alkoxyimino; or lower alkenyloxy substituted with esterfied carboxy for R- is used as a starting compound, the compound (1-30) having lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with carboxy; lower alkenyl substituted with carboxy; lower alkyl substituted with carboxy, carboxy (lower) alkanoyloxy or carboxy(lower) alkoxyimino; lower alkylthio substituted with carboxy; alkoxy substituted with carboxy-substituted aryl, carboxy-substituted pyridyl, carboxy(lower) - alkylamino, N-protected-carboxy (lower) alkylamino,

N-carboxy(lower) alkyl-N-lower alkylamino, carboxy or carboxy(lower) alkoxyimino; or lower alkenyloxy substituted with carboxy for R ¹ may be obtained according to reaction condition. This case is included within the scope of the Dresent reaction.

Process 35

The object compound (1-31) or its salt can be prepared by reacting a compound (1-30) or its reactive derivative at the carboxy group or a salt thereof with an amine or its salt.

Suitable salts of the compounds (1-31) and (1-30) and its reactive derivative at the carboxy group may be the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as Process 6, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 6.

The starting compound (II) or a salt thereof can be prepared by the following processes.

Process A

(IX) or its salt or its reactive derivative at the carboxy group or a salt thereof

(XI) or its salt

>rocess R

(XIa) (Xlb) or its salt or its salt

Process r.

deacylation

(XIc) (Xld) or its salt or its salt

Process D

acylation

(Xld) (XIc) or its salt or its salt

Process E

(Xld) or its salt

Process F

(Xlf) (ID or its salt or its salt

Process G

(xig) (Xlh) or its salt or its salt

Process H

oxidation

(Xli) (XIj) or its salt or its salt

Process I

acylation

(Xlk) (XI/) or its salt or its salt

Process .T

(Xlm) or its salt (XIn) or its salt

Process K

deesterification

(XII) or its salt

(V) or its salt

wherein

, ^* ^ ^* c;' ^R d' e' f' t' v' z' aa' ab' ' C < ^• X and Z- are each as defined above,

R ¹⁰ is hydrogen; lower alkyl optionally substituted with

5 aryl or acyl; or cyclo (lower) alkyl;

R ² ; is lower alkyl optionally substituted with acyl,

Z ³ is acid residue,

R^ _v is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted

10 with lower alkyl substituted with hydroxymethyl,

R^ _w is lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkyl substituted with lower alkoxycarbonyl, and

15 R ¹¹ is esterified carboxy.

The above-mentioned processes for preparing starting compound are explained in detail in the following.

20 Process A

The compound (XI) or its salt can be prepared by reacting a compound (IX) or its salt with a compound (X) or its reactive derivative at the carboxy group or a salt thereof. 25 Suitable salts of the compounds (IX), (XI) and (X) and its reactive derivative at the carboxy group may be the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as Process 1, and therefore the reaction mode 3C and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 1.

In this reaction, in case that the compound (IX) having lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a 35. heterocyclic group, each of which is substituted with

hydroxy for R ¹ is used as a starting compound, the compound (XI) having lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with the formula :

wherein R ^J and X are each as defined above

for R ¹ may be obtained according to reaction condition. This case is included within the scope of this reaction.

Process B

The compound (Xlb) or its salt can be prepared by reacting a compound (XIa) or its salt with a compound (XII) .

Suitable salts of the compounds (XIa) and (Xlb) may be the same as those exemplified for the compound (I) .

When the compound (XII) having halogen for Z ³ is used in this reaction, the reaction is preferably carried out in the presence of a base such as an alkali metal [e.g. sodium, potassium, etc.] or the hydride thereof.

The reaction is usually carried out in a conventional solvent which does not adversely influence the reaction such as dioxane, tetrahydrofuran, N,N-dimethylformamide, a mixture thereof or the like.

The reaction temperature is not critical and the reaction can be carried out under cooling to heating.

Process C

The compound (Xld) or its salt can be prepared by subjecting a compound (XIc) or its salt to deacylation

reaction.

Suitable salts of the compounds (XIc) and (Xld) may be the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as hydrolysis in Process 3, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in hydrolysis in Process 3.

Process D

The compound (XIc) or its salt can be prepared by subjecting a compound (Xld) or its salt with an acylating agent.

Suitable salts of the compounds (XIc) or (Xld) may be the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as Proceed 10, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 10.

Process E

The compound (Xle) or its salt can be prepared by reacting a compound (Xld) or its salt with a compound (VI) or its salt.

Suitable salts of the compounds (Xld) and (VI) may be the same as those exemplified for the compound (I) .

Suitable salt of the compound (Xle) may be an acid addition salt as exemplified for the compound (I) . When the compound (VI) having halogen for Z ¹ is used in this reaction, the reaction is preferably carried out in the presence of a base such as an alkali metal [e.g. sodium, potassium, etc.], an alkaline earth metal [e.g. magnesium, calcium, etc.], the hydride or hydroxide or carbonate or bicarbonate thereof.

The reaction is usually carried out in a conventional solvent which does not adversely influence the reaction such as water, dioxane, alcohol [e.g. methanol, ethanol, etc.], acetonitrile, tetrahydrofuran, acetic acid, N,N- dimethylformamide, or a mixture thereof.

The reaction temperature is not critical and the reaction can be carried out under cooling to heating.

Process F The compound (II) or its salt can be prepared by subjecting a compound (XIf) or its salt to reduction.

Suitable salts of the compounds (II) or (Xlf) may be the same as those exemplified for the compound (I) .

The reduction may include chemical reduction and catalytic reduction, which are carried out in a conventional manner.

Suitable reducing agents to be used m chemical reduction are a metal [e.g. thin, zinc, iron, nickel, etc.], a combination of such metal and/or metallic compound [e.g. nickel chloride, chromium chloride, chromium acetate, etc.] and an organic or inorganic acid [e.g. formic acid, acetic acid, propionic acid, trifluoroacetic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, etc.], a combination of such metal and/or metallic compound and base [e.g. ammonia, ammonium chloride, sodium hydroxide, etc.], a metal hydride compound such as aluminum hydride compound [e.g. lithium aluminum hydride, sodium aluminum hydride, aluminum hydride, lithium trimethoxyalum um hydride, lithium tπ- t-butoxyalummum hydride, etc.], oorohydπde compound [e.g. sodium borohydride, lithium borohydride, sodium cyanoborohydride, tetramethylammcnium borohydride, borane, diborane, etc.], a phosphorus compound [e.g. phosphorus trichloride, phosphorus tribromice, triphenylphosphine, tnethylphosphine, etc.] and the like.

Suitable catalysts to be used in catalytic reduction are conventional ones such as platinum catalysts [e.g. platinum plate, spongy platinum, platinum black, colloidal platinum, platinum oxide, platinum wire, etc.], palladium catalyst [e.g. spongy palladium, palladium black, palladium oxide, palladium on carbon, colloidal palladium, palladium on barium sulfate, palladium on barium carbonate, etc.], nickel catalyst [e.g. reduced nickel, nickel oxide, Raney nickel, etc.], cobalt catalyst [e.g. reduced cobalt, Raney cobalt, etc.], iron catalyst [e.g. reduced iron, Raney iron, etc.], copper catalyst [e.g. reduced copper, Raney copper, Uliman copper, etc.], or the like.

The reduction is usually carried out in a solvent. A suitable solvent to be used may be water, an alcohol [e.g. methanol, ethanol, propanol, etc.], acetonitrile or any other conventional organic solvent such as diethyl ether, dioxane, tetrahydrofuran, etc. or a mixture thereof.

The reaction temperature is not critical, and the reaction is preferably carried out under cooling to heating.

In this reaction, in case that the compound (Xlf) having lower alkyl, aryl, haloaryi, cyclo (lower) alkyl or a heterocyclic group each of which is substituted with lower alkenyl optionally substituted with acyl or substituted acyl for R- is used as a starting compound, the compound (II) having lower alkyl, aryl, haloaryl, cyclo (lower) alkyl or a heterocyclic group, each of which is substituted with lower alkyl optionally substituted with acyl for R ¹ may be obtained according to reaction condition. This case is included within the scope of the present reaction.

Process G

The compound (Xlh) or its salt can be prepared by subjecting a compound (Xlg* or ts salt to elimination

reaction of N-protective group.

Suitable salts of the compounds (Xlg) ano (XIn) may be acid addition salts as exemplified for the compound (I) •

This reaction can be carried out in substantially the same manner as Process 5, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 5.

Process H

The compound (XI ) or its salt can be prepared by subjecting the compound, which is prepared by reacting a compound (XIi) or its salt with an oxidizing, to esterification reaction.

Suitable salts of the compounds (XIi) and (XI ) may be acid addition salts as exemplified for the compound (I)

Suitable oxidizing agent may be Jones reagent, pyπdinium dichromate, potassium permanganate and the like.

Suitable agent used in esterification reaction may be diazo compound such as diazomethane, tπmethylsilyl diazomethane or the like.

The oxidation reaction is usually carried out in a solvent which does not adversely influence the reaction such as N,N-dιmethylformamιde, water or the like.

This oxidation reaction temperature is not critical, and the reaction is usually carried out under cooling to heating. The esterification reaction is usually carried out in a solvent which does net adversely influence tne reaction sucn as an alcohol (e.g. metnancl, ethanol, etc.), aromatic hydrocarbon (e.g. benzene, etc.), diethyl ether, or a mixture thereof. This esterification reacticr temperature is not

critical, and the reaction is usually carried out under cooling to warming.

Process I The object compound (XI?) or its salt can be prepared by reacting a' compound (Xlk) or its salt with an acylating agent.

Suitable salts of the compounds (Xlk) and (XIC) may be acid addition salts as exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as Process 18, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 18.

Process J

The compound (XIn) or its salt can be prepared reacting a compound (Xlm) or its salt with substituted or unsubstituted N-containing heterocyclic compound or lower alkylhydrazine.

Suitable salts of the compounds (Xlm) and (XIn) may be acid addition salts as exemplified for the compound

(I) - This reaction can be carried out in substantially the same manner as Process 19, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 19.

P ocess K

The compound (V) or its salt can be prepared by subjecting a compound (XII) or its salt to deesterification reaction. Suitable salts of the compounds (V) and (XII) may be

the same as those exemplified for the compound (I) .

This reaction can be carried out in substantially the same manner as Process 3, and therefore the reaction mode and reaction condition (e.g. solvent, reaction temperature, etc.) of this reaction are to be referred to those as explained in Process 3.

The compounds obtained by the above processes can be isolated and purified by a conventional method such as pulverization, recrystallization, column chromatography, reprecipitation, or the like.

It is to be noted that the compound (I) and the other compounds may include one or more stereoisomer(s) such as optical isomer(s) or geometrical isomer(s) due to asymmetric carbon atom(s) and double bond(s), and all of such isomers and mixture thereof are included within the scope of this invention.

The object compound (I) and pharmaceutically acceptable salts thereof possess activities as vasopressin antagonistic activity, vasodilatmg activity, hypotensive activity, activity for inhibiting saccharide release in liver, activity for inhibiting growth of mesangium cells, water diuretic activity, platelet agglutination inhibitory activity, oxytocm antagonistic activity and the like, and are useful for tne treatment and/or prevention of hypertension, heart failure, renal insufficiency, edema, ascites, vasopressin parasecretion syndrome, hepato- cirrhosis, hyponatremia, hypokalemia, diabetic, circulation disorder, cerebrovascular disease (e.g. cerebral edema, cerebral infarction, etc.), Meniere's syndrome (e.g. Meniere's disease, et.), motion sickness and the like in human beings and animals.

In order to illustrate the usefulness of the object compound (I), the pharmacological data of the compound (I) are shown in the following.

Test 1

Vasopressin 1 (VI) receptor binding

(i) Test Method :

Blood was obtained by venipuncture from normal subjects. Platelet-rich plasma (PRP) was prepared by centrifugation of whole blood at 200 xg for 10 minutes. PRP was centrifuged at 45,000 xg for 30 minutes. The remaining pellet was resuspended in 10 volume of ice cold 100 mM Tris-HCl (pH 7.4) buffer (containing 5 mM MgCl ₂ , 0.1% bovine serum albumin and 1 mM EGTA) , and centrifuged at 45,000 xg for 30 minutes again. The final pellet was resuspended in 100 mM Tris-HCl buffer. The resulting membrane preparation was used immediately for the binding assay.

Competition assays were conducted at equilibrium (15 minutes at 30°C) by using 1.5 nM ³ H-vasopressin (40-87 Ci/mmol; New England Nuclear) in 100 mM Tris-HCl (pH 7.4) buffer. Nonspecific binding was determined by using 1 μM vasopressin. After incubation, reaction was terminated by adding 5 ml of ice-cold 100 mM Tris-HCl (pH 7.4) buffer, and then filtered rapidly through Whatman glass filter (GF/C) . The filter was washed twice with the same buffer. The glass filter was mixed with liquid scintilation cocktail, and radioactivity was counted in a liquid scintilation counter. Competition activity of the test compound was represented by IC^g values.

;ii) Test Result

Test 2

Vasopressin 2 (V2) receptor binding

(i) Test Method :

For binding assays, the receptor cDNA was permanently expressed in Chinese hamster ovary (CHO) cells. CHO cells were transfected with a vector directing expression of the cDNA for the human V2 receptor and the clonal cell lines expressing human V2 receptor was established essentially as described previously (Nakajima, Y., et. al. J. Biol. Chem., 1992, 267, 2437) .

DNA-transfected cells were harvested and homogenized in ice cold 250 mM sucrose buffer containing 25 mM Tris-HCl

(pH 7.4), 10 mM MgCl ₂ , 1 mM EDTA and 5 μg/ml p-amidinophenylmethylsulfonyl fluoride (A-PMSF) . The homogenate was centrifuged at 500 xg for 10 minutes. The supernatant was centrifuged at 100,000 xg for 1 hour. The final pellet was suspended in 25 mM Tris-HCl (pH 7.4) buffer (containing 10 mM MgCl ₂ , 1 mM EDTA and 5 μg/ml A-PMSF), and stored in small aliquots at -80°C.

Competition assays were conducted at equilibrium (2 hours at 22°C) by using 0.5 nM ³ H-vasopressin (40-87 Ci/mmol, New England Nuclear) in 100 mM Tris-HCl (pH 7.4) buffer (containing 5 mM MgCl ₂ , 5 μg/ml A-PMSF, 4 μg/ml leupeptin, 40 μg/ml bacitracin, 20 μg/ml chymostatin and 0.1% bovine serum albumin) . Nonspecific binding was determined by using 1 μM vasopressin. After incubation, reaction mixture was rapidly filtered through Whatman glass filter (GF/C) . The filter was washed twice with the same buffer. The radioactivity was counted in a liquid scintilation counter. Competition activity of the test compound was represented by IC50 values.

.2 -

(ii i Test Result

For therapeutic purpose, the compound (I) of the present invention can be used in a form of pharmaceutical preparation containing one of said compounds, as an active ingredient, in admixture with a pharmaceutically acceptable carrier such as an organic or inorganic solid, semi-solid or liquid excipient suitable for oral, parenteral or external (topical) administration. The pharmaceutical preparations may be capsules, tablets, dragees, granules, suppositories, solution, lotion, suspension, emulsion, ointment, gel, or the like. If desires, there may be included in these preparations, auxiliary substances, stabilizing agents, wetting or emulsifying agents, buffers and other commonly used additives.

While the dosage of the compound (I) will vary ■ depending upon the age and condition of the patient, an average single dose of about 0.1 mg, 1 mg, 10 mg, 50 mg, 100 mg, 250 mg, 500 mg and 1000 mg of the compound (I) may be effective for treating the above-mentioned diseases. In general, amounts between 0.1 mg/body and about 1,000 mg/body may be administered per day.

The following Preparations and Examples are given for the purpose of illustrating this invention.

Preparation 1 To an ice bath cooled solution of N-methylaniline (536 mg) in dichloromethane (30 ml) were added triethylamine (0.837 ml) and p-nitrobenzoyl chloride (982 mg) and the mixture was stirred at ambient temperature for 3 hours. The solution was washed successively in IN hydrogen chloride, saturated aqueous sodium hydrogen carbonate solution and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was solidified with diethyl ether to give N-methyl-N- (4-nitrobenzoyl) aniline (1.11 g) as a pale yellow solid.

NMR (CDCI3, δ) : 3.53 (3H, s), 6.98-7.05 (2H, m) , 7.14-7.30 (3H, m) , 7.44 (2H, d, J=8.5Hz), 8.01 (2H, d, J=8.5Hz)

Preparation 2

The following compounds were obtained according to a similar manner to that of Preparation 1.

1) N-Ethyl-N- (4-nitrobenzoyl) aniline NMR (CDCI3, δ) : 1.25 (3H, t, J=7Hz) , 4.00 (2H, q,

J=7Hz), 6.98-7.05 (2H, m) , 7.14-7.30 (3H, m) , 7.42 (2H, d, J=8.5Hz) , 8.01 (2H, d, J=8.5Hz)

2) 2-Ξthoxycarbonyl-N- (4-nitrobenzoyl) aniline NMR (CDCI3, δ) : 1.44 (3H, t, J=7Hz) , 4.44 (2H, q,

J=7Hz), 7.17 (IH, dt, J=l, 8Hz), 7.63 (IH, dt, J=1.5, 8Kz), 8.13 (IH, dd, J=1.5, 8Hz) , 8.21 (2H, d, J=8.5Hz) , 8.35 (2H, d, J=8.5Hz) , 8.90 (IH, dd, J=l, 8Hz)

3) 2- [N- (4-Nitrobenzoyl) aminopyridine

NMR (CDC1 ₃ , δ) : 7.13-7.39 (2H, m) , 7.84 (IH, m) , 7.93 (2H, d, J=8.5Hz) , 8.14-8.38 (4H, m)

) 2-Chloro-N- (4-nitrobenzoyl) aniline

NMR (CDCI3, δ) : 7.14 (IH, dt, J=1.5, 8Hz), 7.36

(IH, dt, J=l, 8Hz), 7.46 (IH, dd, J=1.5, 8Hz), 8.09 (2H, d, J=8.5Hz), 8.38 (2H, d, J=8.5Hz. , 8.42 (IH, br) , 8.55 (IH, dd, J=l, 8Hz)

10

N-Methyl-N- (4-nitrobenzoyl) -p-toluidine NMR (CDCI3, δ) : 2.28 (3H, s), 3.48 (3H, s) , 6.89 (2H, d, J=8.5Hz), 7.50 (2H, d, J=8.5Hz) , 7.45 (2H, d, J=8.5Hz), 8.03 (2H, d, J=8.5Hz)

15

N-Methyl-N- (2-chloro-4-nitrobenzoyl) aniline

NMR (CDCI3, δ) : 3.51 (3H, s), 7.08-7.26 (5H, m) ,

7.31 (IH, d, J=8Hz) , 7.93 (IH, d, J=8Hz), 8.07

(IH, m)

20

N-Methyl-N- (4-nitrobenzoyl) -o-toluidine

NMR (CDCI3, δ) : 2.21 (3H, s), 3.40 (3H, s) , 6.98-

7.18 (4H, m) , 7.42 (2H, d, J=8.5Hz), 7.99 (2H, d, J=8.5Hz)

25.

2-Isopropyl-N- (4-nitrobenzoyl) aniline

NMR (CDCI3, δ) : 1.30 (6H, d, J=7Hz), 3.10 (IH, qq, J=7, 7Hz), 7.22-7.40 (4H, ) , 7.75 (IH, br) , 8.05 (2H, d, J=8.5Hz) , 8.34 (2H, d, J=8.5Hz)

30

9) N- (4-Nitrobenzoyl) -o-anisidine

NMR (CDCI3, δ) : 3.95 (3H, s), 6.94 (IH, dd, J=l, 8Hz), 7.03 (IH, ddd, J=l, 8, 8Hz), 7.14 (IH, ddd, J=l, 8, 8H2) , 8.04 (2H, d, J=8.5Hz) , 8.35 35 (IH, d, J=8.5Hz) , 8.50 (IH, dd, J=l, 8Hz) ,

8.58 (IH, br)

10) 3- (4-Nitrobenzoyl) aminopyridine

NMR (CDC1 ₃ + CD3OD, δ) : 7.39 (IH, dd, J=6, 9Hz) , 5 8.16 (2H, d, J=8.5Hz), 8.31-8.39 (3H, ) , 8.45

(IH, m) , 8.63 (IH, d, J=3Hz)

11) 2-Methoxycarbonyl-3- (4-nitrobenzoyl) aminothiophene NMR (DMSO-d ₆ , δ) : 3.88 (3H, s) , 8.01-8.08 (2K, m) ,

10 8.19 (2H, d, J=8.5Hz), 8.46 (2H, d, J=8.5Hz)

12) N-Methyl-N- (4-nitrobenzoyl) -m-toluidine

NMR (CDCI3, δ) : 2.27 (3H, s) , 3.49 (3H, s), 6.78 (IH, d, J=8Hz), 6.86 (IH, s), 6.99 (IH, d, 15 J=8Hz), 7.10 (IH, dd, J=8, 8Hz) , 7.45 (2H, d,

J=8.5Hz), 8.02 (2H, d, J=8.5Hz)

13) N- (4-Nitrobenzoyl) -2- (4-nitrobenzoyloxy) aniline

NMR (DMSO-d ₆ , δ) : 7.35-7.51 (3H, m) , 7.70 (IH, m) , 20 8.05 (2H, d, J=8.5Hz), 8.26-8.41 (6H, m)

14) N- (4-Nitrobenzoyl) -2-phenylaniline

NMR (CDCI3, δ) : 7.22-7.35 (2H, m) , 7.39-7.58 (6H, m) , 7.76 (2H, d, J=8.5Hz), 8.00 (IH, br) , 8.24 25. (2H, d, J=8.5Hz), 8.48 (IH, d, J=8Hz)

15) N-Cyclopentyl-N- (4-nitrobenzoyl) -p-anisidine

NMR (CDCI3, δ) : 1.34-1.71 (6H, ) , 1.91-2.12 (2H, m) , 3.74 (3H, s), 4.86-5.17 (IH, m) , 6.72 (2H,

30 d, J=8Hz), 6.92 (2H, d, J=8Hz), 7.38 (2H, d,

J=8Hz), 8.00 (2H, d, J=8Hz)

16) 2-Acetyl-N- (4-nitrobenzoyl, aniline

NMR (CDCI3, δ) : 2.74 (3H, s), 7.23 (IH, dt, J=l, 35 8Hz), 7.67 (IH, dt, J=l, 8Hz), 8.00 (IH, dd,

J=l, 8Hz), 8.23 (2H, d, J=8.5Hz), 8.39 (2H, d, J=8.5Hz), 8.95 (IH, dd, J=l, 8Hz)

17) 4-Nitro-N- (4-chlorophenyl) benzamide 5 mp : 150-153°C

18) 4-Nitro-N- (3-methoxyphenyl)benzamide mp : 144-146°C

10 19) 4-Nitro-N- (4-methoxyphenyl)benzamide mp : 146-150°C

20) 4-Nitro-N- (3-chlorophenyl) benzamide mp : 159-164°C

15

21) 4-Nitro-N- (2-methylphenyl)benzamide p : 155-158°C

22) 4-Nitro-N-benzyl-N- (2-methylphenyl)benzamide 20 mp : 107-111°C

23) 4-Nitro-N- (2-trifiuoromethylphenyl)benzamide mp : 126-128°C

NMR (CDC1 ₃ , δ) : 7.35 (IH, t, J=6Hz) , 7.68 (IH, t, 25. J=8Hz), 7.70 (IH, t, J=10Hz) , 8.06 (2H, dt,

J=l,10Hz), 8.16-8.24 (IH, br) , 8.33-8.42 (3H, m)

24) N-Ethyl-N- (3-pentyl) -4-nitrobenzamido slightly yellow oil

30

25) 4-Nitro-N- (2, 6-dimethylphenyl) benzamide mp : 192-195°C

26) N-Methyl-N- (4-tetrahydro-4H-pyranyl) -4-nitrobenzamide 35 mp : 87-91°C

27) 3-Methoxy-4-nitro-N- (2-ethoxycarbonylphenyl)benzamide NMR (CDC1 ₃ , δ) : 1.44 (3K, t, J=7.5Hz), 4.07 (3H, s), 4.43 (2H, q, J=7.5Hz), 7.16 (IH, dd, J=7, 7Hz), 7.60-7.67 (2H, m) , 7.72 (IH, s), 7.95 (IH, d, J=7Hz), 8.12 (IH, m) , 8.87 (IH, d, J=7Hz)

28) 4-Nitro-N-methyl- (2-cyano) phenylbenzamide

NMR (CDCI3, δ) : 3.54 (3H, s) , 7.22 (IH, m) , 7.35 (IH, m) , 7.46-7.65 (4H, m) , 8.00-8.12 (2H, m)

10

29) 3-Methyl-4-nitro-N-methyl-N- [2- (3-phthalimidoprop-l- yloxy)phenyl]benzamide

NMR (CDCI3, δ) : 2.21 (2H, m) , 2.48 (3H, s) , 3.39 (3H, s), 3.90-4.03 (4H, m) , 6.76-6.83 (2H, m) , 15 6.93 (IH, d, J=7Hz) , 7.10-7.26 (3H, m) , 7.40

(IH, s), 7.67-7.76 (2H, m) , 7.81-7.88 (2H, )

30) 3-Methoxy-4-nitro-N-methyl-N- [2- (3-phthalimidoprop-l- yloxy)phenyl]benzamide

20 NMR (CDCI3, δ) : 2.22 (2H, m) , 3.38 (3H, s), 3.78

(3H, s), 3.91 (2H, t, J=7.5Hz), 3.97 (2H, m) , 6.78-6.85 (2H, ) , 6.98 (IH, d, J=7.5Hz), 7.10 (IH, s), 7.19 (IH, t, J=7.5Hz), 7.61 (IH, d, J=7.5Hz), 7.69-7.64 (2H, m) , 7.80-7.86 (2H, m)

25 _.

31) 4-Nitro-N- [2- [ (E) -6-methoxycarbonyl-l-hexen-l- yl]phenyl]benzamide

NMR (CDCI3, δ) : 1.53 (2H, m) , 1.69 (2H, m) , 2.22- 2.37 (4H, m) , 3.65 (3H, s), 6.13 (IH, dt, J=15, 30 7.5Hz, , 6.50 (IH, d, J=15Hz), 7.20 (IH, t,

J=7Hz), 7.31 (IH, t, J=7Hz), 7.41 (IH, d, J=7Hz), 7.93-8.09 (3H, m) , 8.33-8.40 (2H, m)

32) 4-Nitro-N- [ 2- [ (Z) -6-methoxycarbonyl-l-hexen-l- 35 yl]phenyl]benzamide

NMR (CDCI3, δ) : 1.41 (2H, m) , 1.57 (2H, m) , 2.10 (2H, dt, J=7.7, 7.5Hz), 2.20 (2H, t, J=7.5Hz), 3.61 (3H, s), 5.97 (IH, dt, J=ll, 7.5Hz), 6.45 (IH, d, J=llHz) , 7.19 (2H, ) , 7.35 (IH, ) , 5 8.00-8.07 (2H, m) , 8.28-8.41 (2H, )

33) 4-Nitro-N- [2- [N- (3-ethoxycarbonylprop-l- yl) oxyi ino]methylphenyl]benzamide

NMR (CDCI3, δ) : 1.25 (3H, t, J=7.5Hz), 2.03 (2H, 10 tt, J=7.5, 7.5Hz), 2.43 (2H, t, J=7.5Hz), 4.13

(2H, q, J=7.5Hz), 4.27 (2H, t, J=7.5Hz), 7.19 (IH, dt, J=l, 7Hz), 7.31 (IH, dd, J=l, 7Hz) , 7.49 (IH, dt, J=l, 7Hz), 8.19 (2H, d, J=8.5Hz), 8.26 (IH, s), 8.38 (2H, d, J=8.5Hz), 8.84 (IH, 15 d, J=7Hz)

34) 4-Nitro-N- [2- (5-ethoxycarbonylpent-l- ylthio)phenyl]benzamide

NMR (CDCI3, δ) : 1.22 (3H, t, J=7.5Hz), 1.34-1.47 20 (2H, m) , 1.52-1.62 (4H, ) , 2.21 (2H, t,

J=7.5Hz), 2.78 (2H, t, J=7.5Hz), 4.10 (2H, q, J=7.5Hz), 7.13 (IH, t, J=7Hz) , 7.41 (IH, t, J=7Hz), 7.57 (IH, d, J=7Hz), 8.10 (2H, d, J=8.5Hz), 8.40 (2H, d, J=8.5Hz), 8.56 (IH, d, 25. J=7Hz), 9.50 (IH, br)

35) 4-Nitro-N- [2- (3-ethoxycarbonylprop-l- yloxy)phenyl]benzamide

NMR (CDCI3, δ) : 1.17 (3H, t, J=7.5Hz), 2.22 (2H, 30 ) , 2.50 (2H, t, J=7.5Hz), 4.00 (2H, q,

J=7.5Hz), 4.14 (2H, t, J=7.5Kz), 6.94 (IH, d,

J=7Hz), 7.00-7.15 (2H, m) , 8.12 (2H, d,

J=8.5Hz), 8.36 (2H, c, J=8.5Hz), 8.50 (IH, d, J=7Hz), 8.69 (IH, s) 35

36) 4-Nitro-N- [2- (5-ethoxycarbonylpent-l-yloxy)pyridi-3- yl] enzamide

NMR (CDC1 ₃ , δ) : 1.23 (3H, t, J=7.5Hz), 1.41 (2H, m) , 1.69 (2H, m) , 1.83 (2H, m) , 2.31 (2H, t, J=7.5Hz), 4.01 (2H, t, J=7.5Hz), 4.12 (2H, q,

J=7.5Hz), 6.31 (IH, dd, J=7, 7Hz) , 7.05 (IH, dd, J=l, 7Hz), 8.08 (2H, d, J=8.5Hz), 8.33 (2H, d, J=8.5Hz), 8.52 (IH, dd, J=l, 7Hz) , 9.31 (IH, s)

37) 4-Nitro-N-methyl-N- [3- (5-ethoxycarbonylpent-l- yloxy)pyrid-2-yl]benzamide

NMR (CDCI3, δ) : 1.25 (3H, t, J=7.5Hz), 1.49 (2H, m) , 1.64-1.82 (2H, m) , 2.35 (2H, t, J=7.5Hz), 3.43 (3H, s), 3.79 (2H, t, J=7.5Hz), 4.19 (2H, q, J=7.5Hz), 7.03 (IH, d, J=7Hz), 7.12 (IH, m) ,

7.48 (2H, d, J=8.5Hz), 7.95-8.02 (3H, m)

38) 3-Methyl-4-nitro-N-methyl-N- (4-chloro-2- benzyloxyphenyl)benzamide NMR (CDCI3, δ) : 2.40 (3H, s) , 3.35 (3H, s), 4.91

(IH, d, J=8.5Hz), 5.09 (IH, d, J=8.5Hz), 6.81- 6.89 (2H, m) , 6.96-7.10 (3H, ) , 7.30-7.47 (5H, m) , 7.67 (IH, d, J=7Hz)

39) 4-Nitro-N- (2-benzyloxy-4-chlorophenyl) -N- methylbenzamide

NMR (CDCI3, δ) : 3.37 (3H, s), 4.92 (IH, d, J=10Hz) , 5.04 (IH, d, J=10Hz), 6.80-6.92 (2H, m) , 7.01 (IH, d, J=9Hz), 7.28-7.50 (7H, m) , 7.98 (2H, d, J=9Hz)

40) 2-Chloro-4-nιtro-N- (2-benzyloxy-4-chlorophenyl) -N- methylbenza ide

NMR (CDCI3, δ) : 3.39 (3H, s), 5.00-5.14 (2H, m) , 6.79 (IH, d, J=8Hz), 6.90 (3H, s), 7.09-7.20

( IH, m) , 7 . 24 ( IH, d, J=8Hz ) , 7 . 33-7 . 52 ( 5H, m) , 7 . 84 ( IH, d, J=8Hz ) , 8 . 06 ( IH, s )

41) 2-Chloro-4-nitro-N- [2- (5-ethoxycarbonylpent-l- 5 yloxy)phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.24 (3H, t, J=7Hz), 1.42-1.56 (2H, m) , 1.62-1.76 (2H, m) , 1.76-1.91 (2H, m) , 2.30 (2H, t, J=7Hz), 4.01-4.16 (4H, m) , 6.92 (IH. d, J=9Hz), 7.04 (IH, dd, J=9, 9Hz), 7.13 (IH, dd, 10 J=9, 9Hz), 8.02 (IH, d, J=9Hz), 8.25 (IH, d,

J=9Hz), 8.36 (IH, s), 8.51 (IH, d, J=9Hz) , 8.68 (IH, br s)

42) 3-Methoxy-4-nitro-N- [2- (5-ethoxycarbonylpent-l- 15 yloxy) -4-methylphenyl]benzamide

NMR (CDCI3, δ) : 1.23 (3H, t, J=7Hz), 1.46-1.61 (2H, m) , 1.62-1.79 (2H, m) , 1.81-1.96 (2H, m) , 2.31 (2H, t, J=7Hz), 2.34 (3H, s), 4.04 (3H, s), 4.10 (2H, q, J=7Hz), 6.73 (IH, s), 6.81 (IH, d, 20 J=9Hz), 7.38 (IH, d, J=9Hz) , 7.73 (IH, s), 7.96

(IH, d, J=9Hz), 8.33 (IH, d, J=9Hz) , 8.54 (IH, s)

43) Ethyl 4- (4 '-methylbiphenyl-2-carboxamido) -2- 25. nitrobenzoate

NMR (CDCI3, δ) : 1.33 (3H, t, J=7Hz) , 2.42 (3H, s), 4.34 (2H, q, J=7Hz) , 7.16 (IH, br s), 7.24-7.40 (5H, ) , 7.41-7.63 (4H, m) , 7.67 (IH, d, J=9Hz) , 7.93 (IH, d, J=9Hz) 30

44) Ethyl 3-chioro-4- (4 '-methylb phenyl-2- carboxamido)benzoate

NMR (CDCI3, δ) : 1.37 (3H, t, J=7Hz), 2.35 (3H, s), 3.34 (2H, q, J=7Hz), 7.19 (2H, d, J=8Hz), 7.34 35 (2H, d, J=8Hz), 7.41-7.62 (3H, m) , 7.74 (IH, br

s ) , 7 . 83- 7 . 96 ( 3H , m) , 8 . 63 ( IH, br d, J=8Hz )

45) 3-Methyl-4-nιtro-N- (2-methylphenyl)benzamide mp : 154-156°C

46) 3-Methoxy-4-nιtro-N- (2-methylphenyl)benzamide mp : 135-137°C

47) N- (2-Benzyloxy-4-chlorophenyl) -3-metnoxy-N-methyl-4- nitrobenzamide

NMR (CDC1 ₃ , δ) : 3.37 (3H, s), 3.61 (3H, s), 4.89

(IH, d, J=llHz), 5.06 (IH, d, J=llHz), 6.80 (IH, d, J=9Hz), 6.85-6.94 (2H, m) , 7.01 (IH, s), 7.06 (IH, d, J=9Hz), 7.29-7.47 (5H, m) , 7.56 (IH, d, J=9Hz)

48) Ethyl 4- (methylphenyl-2-carboxamιdo) -2-nιtrobenzoate NMR (CDCI3, δ) : 1.34 (3H, t, J=7Hz) , 2.49 (3H, s),

4.33 (2H, q, J=7Hz) , 7.19-7.53 (4H, ) , 7.72- 7.89 (2H, m) , 8.04 (IH, br s), 8.19 (IH, br s)

Preparation 3

To a solution of 2-ethoxycaroonyl-N- (4- nitrobenzoyl) aniline (3.15 g) m N,N-dιmethylformamιde (30 ml) was added sodium hydride (60% in oil, 442 mg) and the solution was stirred at ambient temperature for 30 minutes. Iodomethane (1.56 g) was added to the solution and the mixture was stirred at ambient temperature for 4 hours. The solution was diluted with ethyl acetate and the solution was washed with successively with IN hydrochloric acid, water and brine. The organic phase was cried over magnesium sulfate and the solvent was evaporated in vacuo to give an oil. The oil was solidified with diethyl ether to give 2-ethoxycarbonyl-N- methyl-N- (4-nιtrobenzoyl) aniline (3.28 g) as a pale yellow

powder.

NMR (CDCI3, δ) : 1.36 (3H, t, J=7Hz), 3.44 (3H, s) , 4.35 (2H, q, J=7Hz) , 7.20-7.52 (5H, m) , 7.81 (IH, dd, J=8, 1.5Hz), 7.98 (2H, d, J=8.5Hz)

Preparation 4

The following compounds were obtained according to a similar manner to that of Preparation 3.

1) 2-Acetyl-N-methyl-N- (4-nitrobenzoyl) aniline

NMR (CDCI3, δ) : 2.37 (3H, s), 3.39 (3H, s) , 7.20-

7.50 (5H, m) , 7.61 (IH, dd, J=l, 8Hz), 7.96 (2H, d, J=8.5Hz)

2) 2- [N-Methyl-N- (4-nitrobenzoyl) ] aminopyridine

NMR (CDCI3, δ) : 3.95 (3H, s), 6.67 (IH, dt, J=l,

8Hz), 7.60-7.71 (2H, ) , 8.25 (2H, d, J=8.5Hz), 8.39-8.51 (3H, m)

3) 2-Chloro- [N-methyl-N- (4-nitrobenzoyl) ] aniline

NMR (CDCI3, δ) : 3.42 (3H, s), 7.08-7.25 (3H, m) , 7.32-7.40 (IH, ) , 7.50 (2H, d, J=8.5Hz), 8.02 (2H, d, J=8.5Hz)

4) 2-Isopropyl- [N-methyl-N- (4-nitrobenzoyl) aniline

NMR (CDCI3, δ) : 0.92 (3H, d, J=7Hz), 1.20 (3H, d, J=7Hz), 3.01 (IH, qq, J=7, 7Hz), 3.45 (3H, s), 7.08-7.22 (2H, m) , 7.06-7.29 (3H, m) , 7.45 (2H, d, J=8.5Hz), 8.00 (2H, d, J=8.5Hz)

5) [N-Methyl-N- (4-nitrobenzoyl) ] -o-anisidine

NMR (CDCI3, δ) : 3.39 (3H, s), 3.73 (3H, s), 6.76

(IH, dd, J=l, 8Hz), 6.81 (IH, ddd, J=l, 8, 8Hz), 7.05 (IK, dd, J=l, 8H∑), 7.18 (IH, ddd, J=l, 8, 8Hz), 7.45 (2H, d, J=8.5Hz), 7.99 (IH, d, J=8.5Hz!

6) 3- [N-Methyl-N- (4-nιtrobenzoyl) ] aminopyridine

NMR (CDC1 ₃ , δ) : 3.51 (3H, s) , 7.24 (IH, dd, J=5.5, 9Hz), 7.40 (IH, d, J=9Hz) , 7.42 (2H, d, J=8.5Hz), 8.07 (2H, d, J=8.5Hz), 8.33 (IH, s) , 8.43 (IH, d, J=5.5Hz)

7) 2-Methoxycarbonyl-3- [N-methyl-N- (4-nitrobenzoyl) ] - aminothiophene

NMR (CDCI3, δ) : 3.41 (3H, s) , 3.80 (3H, s) , 6.98 (IH, d, J=7.5Hz), 7.42-7.52 (3H, s), 8.03 (2H, d, J=8.5Hz)

8) [N-Methyl-N- (4-nitrobenzoyl) ] -2- (4- nitrobenzoyloxy) aniline NMR (DMSO-d _β , δ) : 3.33 (3H, s) , 7.30-7.42 (3H, m) ,

7.50 (2H, d, J=8.5Hz) , 7.65 (IH, m) , 8.11 (2H, d, J=8.5Hz), 8.31 (2H, d, J=8.5Hz), 8.50 (2H, d, J=8.5Hz)

9) [N-Methyl-N- (4-nitrobenzoyl) ] -2-phenylanιline

NMR (CDCI3, δ) : 3.53 (3H, s), 6.85-6.93 (4H, m) , 7.19-7.45 (7H, m) , 7.82 (2H, d, J=8.5Hz)

Pre ara ion 5 A mixture of N-methyl-N- (4-nιtrobenzoyl) aniline (1.18 g) and iron powder (2.57 g) in a mixture of ethanol (30 ml) and acetic acid (6 ml) was stirred at 80°C for 3 hours and the mixture was cooled to ambient temperature. The mixture was filtered through Celite and the filtrate was evaporated in vacuo. The residue was dissolved in chloroform and neutralized with saturated aqueous sodium hydrogen carbonate. The solution was filtered through Celite again and the organic phase of the filtrate was washed with brine, and dried over magnesium sulfate. The solvent was evaporated m vacuo and the residue was

solidified with diethyl ether to give N-methyl-N- (4- aminobenzoyl) aniline (754 mg) as a pale yellow solid.

NMR (CDC1 ₃ , δ) : 3.44 (3H, s), 3.77 (2H, br) , 6.40 (2H, d, J=8.5Hz), 7.01-7.30 (7H, m)

Preparation 6

The following compounds were obtained according to a similar manner to that of Preparation 5.

1) N-Ethyl-N- (4-aminobenzoyl) aniline

NMR (CDCI3, δ) : 1.17 (3H, t, J*=7Hz), 3.72 (2H, br) , 3.96 (2H, q, J=7Hz) , 6.39 (2H, d, J=8.5Hz), 6.98-7.27 (7H, m)

2) 2-Ethoxycarbonyl-N-methyl-N- (4-aminobenzoyl) aniline NMR (CDCI3, δ) : 1.34 (3H, t, J=7Hz) , 3.41 (3H, s) , 3.25 (2H, br), 4.30 (2H, q, J=7Hz) , 6.37 (2H, d, J=8.5Hz), 7.08 (2H, d, J=8.5Hz), 7.19-7.30 (2H, m) , 7.46 (IH, dt, J=l, 8Hz) , 7.77 (IH, d, J=8Hz)

3) 2- [N-Methyl-N- (4-aminobenzoyl) ] aminopyridine

NMR (CDCI3, δ) : 3.82 (3H, s), 3.92 (2H, br) , 6.42

(IH, dt, J=l, 8Hz) , 6.76 (2H, d, J=8.5Hz), 7.40- 7.53 (2H, m) , 8.13 (IH, d, J=8.5Hz) , 8.25 (IH, d, J=8Hz)

4) 2-Chloro-N-methyl-N- (4-aminobenzoyl) aniline

NMR (CDCI3, δ) : 3.35 (3H, s), 3.76 (2H, br) , 6.40 (2H, d, J=8.5Hz), 7.02-7.19 (5H, m) , 7.37 (IH, m)

5) N-Methyl-N- (4-aminobenzoyi) -p-toluidine

NMR (CDCI3, δ) : 2.28 (3H, s), 3.42 (3H, s), 3.77

(2H, br), 6.42 (2H, d, J=8.5Hz) , 6.93 (2H, d, J=8.5H∑), 7.04 (2H, d, J=8.5Hz) , 7.15 (2H, d,

J=8.5Hz)

6) N-Methyl-N- (4-amino-2-chlorobenzoyl) aniline NMR (CDC1 ₃ , δ) : 3.42 (3H, s), 3.73 (2H, br) , 6.32 (IH, d, J=8Hz), 6.48 (IH, s), 6.90 (IH, d,

J=8Hz), 7.01-7.25 (5H, m)

7) N-Methyl-N- (4-aminobenzoyl) -o-toluidine

NMR (CDCI3, δ) : 2.15 (3H, s) , 3.34 (3H, s), 3.74 (2H, br), 6.37 (2H, d, J=8.5Hz), 7.01-7.18 (6H, m)

8) 2-Isopropyl- [N-methyl-N- (4-aminobenzoyl) aniline NMR (CDCI3, δ) : 0.87 (3H, d, J=7Hz) , 1.17 (3H, d, J=7Hz), 3.00 (IH, qq, J=7, 7Hz) , 3.36 (3H, s) ,

3.73 (2H, br), 6.37 (2H, d, J=8.5Hz), 7.10-7.28 (6H, m)

9) [N-Methyl-N- (4-aminobenzoyl) ] -o-anisidine NMR (CDCI3, δ) : 3.30 (3H, s) , 3.70 (2H, br) , 3.71

(3H, s), 6.38 (2H, d, J=8.5Hz), 6.73-6.82 (2H, m) , 7.00 (IH, dd, J=l, 8Hz) , 7.02-7.06 (3H, m)

10) 3- [N-Methyl-N- (4-aminobenzoyl) ] aminopyridine NMR (CDCI3, δ) : 3.50 (3H, s), 3.83 (2H, br) , 6.42

(2H, d, J=8.5Hz), 7.11 (2H, d, J=8.5Hz), 7.20 (IH, dd, J=6, 9Hz), 7.38 (IH, m) , 8.38 (12H, m)

11) 2-Methoxycarbonyl-3- [N-methyl-N- (4- aminobenzoyl) ] aminothiophene

NMR (CDCI3, δ) : 3.37 (3H, s), 3.79 (2H, br) , 3.80 (3H, s), 6.42 (2H, d, J=8.5Hz), 6.84 (IH, d, J=5Hz), 7.14 (2H, d, J=8.5Hz), 7.37 (IH, d, J=5Hz)

- se ¬ ll) N-Methyl-N- (4-aminobenzoyl) -m-toluidine

NMR (CDCI3, δ) : 2.27 (3H, s) , 3.44 (3H, s), 3.76 (2H, br), 6.41 (2H, d, J=8.5Hz), 6.80 (IH, d, J=8Hz), 6.90 (IH, s) , 6.95 (IH, d, J=8Hz) , 7.10 (IH, dd, J=8Hz), 7.16 (2H, d, J=8.5Hz)

13) N-Methyl-N- (4-aminobenzoyl) -2-benzoyloxyanilme NMR (CDCI3, δ) : 3.37 (3H, s) , 3.75 (2H, br) , 6.90

(2H, d, J=8.5Hz), 7.11-7.30 (6H, m) , 7.50-7.70 (3H, m) , 8.22 (2H, d, J=8.5Hz)

14) N-Methyl-N- (4-aminobenzoyI) -2-phenylaniline

NMR (CDCI3, δ) : 3.31 (3H, s) , 3.72 (2H, br) , 6.28 (2H, d, J=8.5Hz), 6.82 (2H, d, J=8.5Hz), 7.09 (IH, ) , 7.19-7.48 (8H, m)

15) 2- (3-Phthalimidopropyloxy) - [N- (4-aminobenzoyl) -N- methyl] aniline

NMR (CDCI3, δ) : 2.17 (2H, tt, J=7.5, 7.5Hz), 3.32 (3H, s), 3.67 (2H, br) , 3.81-4.02 (4H, m) , 6.35

(2H, d, J=8.5Hz), 6.71-6.80 (2H, m) , 6.93-7.17 (4H, ) , 7.62 (2H, m) , 7.85 (2H, m)

16) 2-Acetyl-N- (4-aminobenzoyl) -N-methylaniline NMR (CDCI3, δ) : 2.28 (3H, s), 3.44 (3H, s), 3.80

(2H, s), 6.37 (2H, br) , 7.02 (2H, br) , 7.28 (2H, d, J=8.5Hz), 7.47 (2H, br t, J=8Hz)

17) 4-Ammo-N-methyl-N- [2-{3- (4-methyl-l-piperazmyl) - carbonylammoprop-1-yloxy _. phenyl]benzamide

Rf : 0.06 (10% methanol chloroform)

18) 4-Ammo-N-methyl-N- (4-chlcrophenyl)benzamide mp : 201-203°C NMR (CDCI3, δ) : 3.45 (3H, s), 3.76-3.85 (2H, br) ,

6 . 45 ( 2H, dd, J=l , 9Hz ) , 7 . 00 ( 2H, dd, J=l , 9Hz ) , 7 . 11 ( 2H, dd, J=l , 9Hz ) , 7 . 20 ( 2H, dd, J=l , 9Hz )

19) 4-Amino-N-methyl-N- (3-methoxyphenyl)benzamide NMR (CDC1 ₃ , δ) : 3.45 (3H, s), 3.70 (3H, s),

6.32-6.46 (2H, m) , 6.57-6.73 (3H, m) , 7.08-7.25 (3H, m)

20) 4-Amino-N-methyl-N- (4-methoxyphenyl)benzamide mp : 195-200°C NMR (CDCI3, δ) : 3.44 (3H, s), 3.78 (3H, s) ,

6.43 (2H, dd, J=l, 9Hz) , 6.78 (2H, dd, J=l, 9Hz), 6.96 (2H, dd, J=l, 9Hz) , 7.15 (2H, dd, J=l, 9Hz)

21) 4-Amino-N-methyl-N- (3-chlorophenyl)benzamide NMR (CDCI3, δ) : 3.48 (3H, s) , 3.78-3.85 (2H, br) , 6.35-6.50 (2H, m) , 6.95-6.96 (IH, m) , 7.10- 7.21 (13H, m)

22) 4-Amino-N-ethoxycarbonylmethyl-N- (2- methylphenyl)benzamide

NMR (CDCI3, δ) : 1.29 (3H, t, J=7Hz) , 2.22 (3H, s), 3.70-3.85 (2H, br) , 4.02 (IH, d, J=16Hz) ,

4.22 (2H, q, J=7Hz) , 4.78 (IH, d, J=16Hz), 6.38 (2H, d, J=8Hz), 7.05-7.32 (6H, m)

23) 4-Amino-N-benzyl-N- (2-methylphenyl)benzamide NMR (CDCI3, δ) : 1.88 (3H, s), 3.68-3.78 (2H, br) ,

4.70 (IK, d, J=14Hz), 5.29 (IH, d, J=14Hz), 6.36 (2H, d, J=9Hz), 6.90-7.20 (11H, m)

24) 4-Amino-N-methyl-N- (2-trifluoromethylphenyl) benzamide NMR (CDCI3, δ) : 3.38 (3H, s), 3.70-3.86 (2H, br) ,

6 .30- 6 . 58 ( 2H, br ) , 7 . 08-7 . 58 ( 5H, m) , 7 . 69 ( IH, d, J=7Hz )

25) 4-Amino-3-methyl-N-methyl-N- (2-methylphenyl)benzamide p : 139-144°C

26) N-Ethyl-N- (3-pentyl) -4-aminobenzamide mp : 132-135°C

27) 4-Amino-3-methoxy-N-methyl-N- (2-methylphenyl) - benzamide

NMR (CDC1 ₃ , δ) : 2.20 (3H, s) , 3.38 (3H, s) , 3.62 (3H, s), 3.84-3.95 (2H, br) , 6.40 (IH, d, J=9Hz), 6.74-6.87(2H, br) , 7.05-7.19 (4H, m)

28) 4-Amino-N-methyl-N- (2, 6-dimethylphenyl)benzamide mp: 158-160°C

29) N-Methyl-N- (4-tetrahydro-4H-pyranyl) -4-aminobenzamide mp : 130-133°C

30) 4-Amino-N-methyl-N- (2-ethoxycarbonylmethoxyphenyl) - benzamide

NMR (CDCI3, δ) : 1.30 (3H, t, J=8Hz) , 3.39 (3H, s), 3.68-3.72 (2H, br s), 4.26 (2H, q, J=8Hz) ,

4.60 (2H, s), 6.40 (2H, d, J=8Hz) , 6.70 (IH, d, J=8Hz), 6.80-6.86 (IH, m) , 6.96 (IH, d, J=8Hz) , 7.10-7.16 (IH, m) , 7.20 (2H, d, J=8Hz)

31) 4-Amino-N-methyl-N- (2-methoxycarbonylmethylphenyl) - benzamide Rf : 0.41 (10% methanol in chloroform)

32) 4-Amino-N-methyl-N- [ (2-ethoxycarbonylmethoxy-4- methyl) phenyl]benzamide

NMR (CDCI3, δ) : 1.32 (3H, t, J=8Hz) , 2.28 (3H, s), 3.36 (3H, s), 3.68-3.77 (2H, br s) , 4.28 (2H, q, J=8Hz), 4.60 (2H, s), 6.43 (2H, d, J=8Hz), 6.50 (IH, s), 6.63 (IH, d, J=8Hz) , 6.86 (IH, d, J=8Hz), 7.22 (2H, d, J=8Hz)

33) 4-Amino-3-methoxy-N-methyl-N- (2- ethoxycarbonylmethoxyphenyl)benzamide

NMR (CDCI3, δ) : 1.29 (3H, t, J=8Hz) , 3.38 (3H, s), 3.67 (3H, s), 3.83-3.88 (2H, br) , 4.26 (2H, q, J=8Hz), 4.60 (2H, s)

34) 4-Amino-3-methoxy-N-methyl-N- [4-methyl-2- [3- (4- methyl-1-piperazinyl) carbonylaminoprop-1- yloxy]phenyl]benzamide

Rf : 0.06 (10% methanol in chloroform)

35) N- (2-Benzyloxy-4-methylphenyl) -N-methyl-4- aminobenzamide NMR (CDCI3, δ) : 2.27 (3H, s) , 3.33 (3H, s), 3.70

(2H, s), 4.91-5.10 (2H, m) , 6.37 (2H, d, J=9Hz) , 6.63 (IH, d, J=9Hz), 6.68 (IH, s) , 6.91 (IH, d, J=9Hz), 7.14 (2H, d, J=9Hz) , 7.27-7.43 (5H, m)

36) N- (2-Benzyloxy-5-methylphenyl) -N-methyl-4- aminobenzamide

NMR (CDCI3, δ) : 2.19 (3H, s) , 3.34 (3H, s), 3.70 (2H, s), 6.37 (2H, d, J=9Hz) , 6.72 (IH, d, J=9Hz) ^' , 6.85-6.95 (2H, m) , 7.16 (2H, d, J=9Hz) , 7.24-7.40 (5H, m)

37) 4-Amino-N- (2-hydroxy-4-methylphenyl) -3-methoxy-N- methylbenzamide

NMR (CDCI3, δ) : 2.23 (3H, s), 3.26 (3H, s), 3.56 (3H, s), 6.42 (IH, d, J=9Hz) , 6.53 (IH, d,

J=9Hz ) , 6 . 63- 6 . 82 ( 3H, m) , 6 . 89 ( IH, d, J=9Hz )

38) 4-Amino-N- (2-hydroxyphenyl) -3-methoxy-N- methylbenzamide NMR (CDC1 ₃ , δ) : 1.71 (IH, br s) , 3.30 (3H, s),

3.56 (3H, s), 3.75-4.08 (IE, br s) , 6.34 (IH, d, J=9Hz), 6.61-6.80 (2H, m) , 6.80-7.02 (3H, m) , 7.1 (IH, dd, J=9, 9Hz)

39) 4-Amino-N- (2-benzyloxy-4-chlorophenyl)-3-methoxy-N- methylbenzamide NMR (CDCI3, δ) : 3.33 (3H, s) , 3.56 (3H, s) ,

4.83-5.16 (2H, m) , 6.38 (IH, d, J=9Hz), 6.72 (IH, dd, J=9.2Hz), 6.78-6.92 (3H, ) , 7.01 (IH, d, J=9Hz), 7.27-7.44 (5H, m)

40) 3-Methoxy-4-amino-N-methyl-N- (2- ethoxycarbonylphenyl)benzamide

NMR (CDCI3, δ) : 1.34 (3H, t, J=7.5Hz), 3.41 (3H, s), 3.59 (3H, s), 3.88 (2H, s) , 4.30 (2H, q,

J=7.5Hz), 6.38 (IH, d, J=7.5Hz), 6.68-6.77 (2H, m) , 7.20-7.29 (2H, m) , 7.45 (IH, t, J=7.5Hz), 7.78 (IH, d, J=7.5Hz)

- 41) 4-Amino-N-methyl-N- (3-methyl-2-methoxycarbonyl) - benzamide NMR (CDCI3, δ) : 2.32 (3H, s) , 3.33 (3H, s) , 3.77

(2H, br s), 3.88 (3H, s), 6.40 (2H, d, J=8.5Hz), 6.83 (IH, d, J=7.5Hz), 7.07 (IH, d, J=7.5Hz), 7.16 (IH, t, J=7.5Hz), 7.23 (2H, d, J=8.5Hz)

42) 4-Amino-N-methyl-N- [2- [3- (4-methylpiperazin-l- yl) carbonylamino-1-propyn-l-yl]phenyl] enzamide NMR (CDCI3, δ) : 2.32 (3H, s) , 2.47 (4H, t, J=6Hz), 3.33 (3H, s), 3.60 (4H, t, J=6Hz), 3.78

(2H, s), 4.24 (2H, m) , 5.47 (IH, br t, J=6.5Hz), 6.40 (2H, d, J=8.5Hz), 7.11-7.32 (6H, )

43) 4-Amino-N-methyl- (2-cyanophenyl) benzamide 5 NMR (CDC1 ₃ , δ) : 3.49 (3H, s) , 3.82 (2H, s) , 6.42

(2H, d, J=8.5Hz), 7.11-7.20 (2H, m) , 7.20-7.30 (2H, m) , 7.48 (IH, t, J=7Hz) , 7.61 (IH, d, J=7Hz)

10 44) 4-Amino-N-methyl-N- [2- [3- (4-dimethylaminopiperidin-l- yl ) carbonylaminoprop-1-yloxy ] phenyl ] benzamide MASS (m/z) : 454 (M+l)

45) 4-Amino-3-methyl-N- [1- (3-phthalimidoprop-l- 15 yloxy) phenyl] benzamide

NMR (CDCI3, δ) : 2.01 (3H, s) , 2.20 (IE, ) , 3.33 (3H, s), 3.63 (2H, s) , 3.86-4.0 (4H, m) , 6.32 (IH, d, J=7Hz), 6.74-6.81 (2H, ) , 6.90-6.98 (2H, m) , 7.08-7.17 (2H, m) , 7.66-7.72 (2H, m) , 20 7.78-7.86 (2H, m)

46) 4-Amino-3-methoxy-N-methyl-N- [2- (3-phthalimidoprop-l- yloxy)phenyl]benzamide

NMR (CDCI3, δ) : 2.20 (2H, m) , 3.32 (3H, s) , 3.63 25. (3H, s), 3.81-4.02 (6H, ) , 6.40 (IH, d, J=8Hz) ,

6.77-6.82 (4H, m) , 6.98 (IH, d, J=7.5Hz), 7.12 (IH, t, J=7.5Hz), 7.67-6.71 (2H, m) , 6.80-6.84 (2H, )

30 47) (E) -Methyl 7- (2-aminophenyl) -6-heptenoate

NMR (CDCI3, δ) : 1.52 (2H, m) , 1.70 (2H, m) , 2.26 (2H, dt, J=7.5, 7.5Hz), 2.37 (2H, t, J=7.5Hz), 3.68 (3H, s), 3.72 (2H, br) , 6.04 (IH, dt, J=15, 7.5Hz), 6.91 (IH, d, J=15Hz) , 6.67

35 (IH, d, J=7Hz), 6.73 (IH, dd, J=7, 7Hz) , 7.04

( IH, dd, J=7 , 7Hz ) , 7 . 22 ( IH, d, J=7Hz )

48) (Z) -Methyl 7- (2-aminophenyl) -6-heptenoate

NMR (CDC1 ₃ , δ) : 1.45 (2H, m) , 1.62 (2H, m) , 2.17 (2H, dt, J=7.5, 7.5Hz), 2.29 (2H, t, J=7.5Hz),

3.65(3H, s), 3.66 (2H, br) , 5.76 (IH, dt, J=ll, 7.5Hz), 6.30 (IH, d, J=llHz) , 6.70 (IH, d, J=7Hz), 7.74 (IH, d, J=7Hz) , 6.99-7.10 (2H, m)

49) 4-Amino-N-methyl-N- [2- [ (E) -6-methoxycarbonyl-l-hexen- 1-yl]phenyl]benzamide

NMR (CDCI3, δ) : 1.52 (2H, m) , 1.69 (2H, m) , 2.26 (2H, ) , 2.35 (2H, t, J=7.5Hz), 3.32 (3H, s) , 3.66 (3H, s), 3.73 (2H, s) , 6.18 (IH, dt, J=15, 7.5Hz), 6.36 (2H, d, J=8.5Hz), 6.49 (IH, d,

J=15Hz) , 6.92 (IH, d, J=7Hz) , 7.03-7.20 (4H, m) , 7.44 (7H, d)

50) 4-Amino-N-methyl-N- [2- [ (Z) -6-methoxycarbonyl-l-hexen- 1-yl]phenyl]benzamide

NMR (CDCI3, δ) : 1.39 (2H, m) , 1.76 (2H, m) , 2.01 (IH, m) , 2.13 (IH, ) , 2.30 (2H, t, J=7.5Hz), 3.32 (3H, s), 3.66 (3H, s) , 3.76 (2H, s) , 5.70 (IH, dt, J=ll, 7.5Hz), 6.28-6.38 (3H, ) , 7.03- 7.24 (6H, m)

51) 0- (3-Ethoxycarbonylprop-l-yl) - (2-amino)benzaldoxim NMR (CDCI3, δ) : 1.27 (3H, t, J=7.5Hz), 2.06 (2H, tt, J=7.5, 7.5Hz), 2.45 (2H, t, J=7.5Hz), 4.10- 4.21 (4H, m) , 5.50 (2H, s) , 6.64-6.71 (2H, m) ,

7.07-7.18 (2H, m) , 8.20 (IH, s)

52) 4-Amino-N-methyl-N- [2- [N- (3-ethoxycarbonylpropyl-l- yl) oxyimino]methylphenyl]benzamide NMR (CDCI3, δ) : 1.27 (3H, t, J=7.5Hz), 2.03 (2H,

tt, J=7.5, 7.5Hz), 2.43 (2H, t, J=7.5Hz), 3.37 (3H, s), 3.77 (2H, s), 4.13 (2H, q, J=7.5Hz), 4.20 (2H, t, J=7.5Hz), 6.36 (IH, d, J=7Hz) , 7.00-7.11 (3H, m) , 7.20-7.31 (2H, m) , 7.74 (IH, 5 d), 8.18 (IH, s)

53) 4-Amino-N-methyl-N-[2- (5-ethoxycarbonylpent-l- ylthio)phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.24 (3H, t, J=7.5Hz), 1.50 (2H, 10 m) , 1.61-1.75 (4H, m) , 2.31 (2H, t, J=7.5Hz),

2.90 (2H, m) , 3.30 (3H, s), 3.74 (2H, s), 4.13 (2H, q, J=7.5Hz), 6.49 (2H, d, J=8.5Hz), 6.92- 7.05 (2H, ) , 7.23-7.28 (4H, m)

15 54) 4- (4'-Methylbiphenyl-2-carboxamido)-N-methyl-N-[2- (3- ethoxycarbonylprop-1-yloxy)phenyl]benzamide NMR (CDCI3, δ) : 1.24 (3H, t, J=7.5Hz), 2.10 (2H, m) , 2.51 (2H, t, J=7.5Hz), 3.31 (3H, s), 2.71 (2H, m) , 3.97 (2H, br) , 4.15 (2H, q, J=7.5Hz), 20 5.40 (2H, d, J=8.5Hz), 6.77-6.84 (2H, m) , 7.01

(IH, d, J=7Hz), 7.13 (IH, m) , 7.17 (2H, d, J=8.5Hz)

55) 2- (5-Ethoxycarbonylpent-l-yloxy) -3-aminopyridine 25. MASS (m/z) : 253 (M+l)

56) 4-Amino-N-methyl-N- [2- (5-ethoxycarbonylpent-l- yloxy) pyrid-3-yl] benzamide

NMR (CDCI3, δ) : 1.24 (3H, t, 7.5Hz), 1.30 (2H, 30 m) , 1.61-1.77 (4H, m) , 2.30 (2H, t, J=7.5Hz),

3.29 (3H, s), 3.81 (2H, s) , 3.95 (2H, t, J=7.5Hz), 4.11 (2H, q, J=7.5Hz), 5.97 (IH, dd, J=7, 7Hz), 6.44 (2H, d, J=8.5Hz), 6.96 (2H, dd, J=l, 7Hz), 7.13 (IH, dd, J=l, 7Hz) , 7.20 (2H, d, 35 J=8.5Hz)

57) 3- (5-Ethoxycarbonylpent-l-yloxy) -2-aminopyridine NMR (CDC1 ₃ , δ) : 1.24 (3H, t, J=7.5Hz), 1.52 (2H, m) , 1.71 (2H, m) , 1.85 (2H, m) , 2.32 (2H, t, J=7.5Hz), 3.94 (2H, t) , 4.11 (2H, q, J=7.5Hz), 4.63 (2H, br) , 6.58 (IH, dd, J=7, 7.5Hz), 6.88

(IH, dd, J=l, 7.5Hz), 7.63 (IH, dd, J=l, 7Hz)

58) 4-Amino-N-methyl-N- [3- (5-ethoxycarbonylpent-l- yloxy)pyrid-2-yl]benzamide NMR (CDCI3, δ) : 1.25 (3H, t, J=7.5Hz), 1.49 (2H, m) , 1.64-1.82 (2H, m) , 2.35 (2H, t, J=7.5Hz), 3.43 (3H, s), 3.79 (2H, t, J=7.5Hz), 4.19 (2H, q, J=7.5Hz), 7.03 (IH, d, J=7Hz) , 7.12 (IH, m) , 7.48 (2H, d, J=8.5Hz), 7.95-8.02 (3H, m)

59) 3-Methyl-4-amino-N-methyl-N- (4-chloro-2- benzyloxyphenyl)benzamide

NMR (CDCI3, δ) : 1.98 (3H, s), 3.31 (3H, s) , 3.69 (2H, br), 5.00 (2H, br) , 6.31 (IH, d, J=7Hz), 6.77-6.89 (3H, m) , 6.96 (IH, d, J=7Hz) , 7.09

(IH, s), 7.38-7.40 (5H, m)

60) 4-Amino-N-methyl-N- [4-methyl-2- (5- methoxycarbonylpyrid-2-ylmethoxy)phenyl]benzamide NMR (CDCI3, δ) : 2.22 (3H, s), 3.30 (3H, s) , 3.70

(2H, s), 3.98 (3H, s), 5.29 (3H, s), 6.38 (2H, d, J=8.5Hz), 6.59 (IH, d, J=7Hz) , 6.73-6.82 (2H, m) , 7.16 (2H, d, J=8.5Hz), 7.28 (IH, m) , 8.50 (IH, ) , 9.10 (IH, )

61) 4-Amino-N-methyl-N- [2- (5-methoxycarbonylpyrid-2- yl ethoxy) phenyl]benzamide

NMR (CDCI3, δ) : 3.31 (3H, s), 3.70 (2H, s), 3.98 (3H, s), 5.31 (2H, ≤. , 6.39 (2H, d, J=8.5Hz), 6.77 (IH, dd, J=7, 7Hz), 6.93 (2H, d, J=8.5Hz),

7.07-7.23 (4H, m) , 8.49 (IH, m) , 9.10 (IH, m)

62) 4-Amino-N- (2-benzyloxy-4-chlorophenyl) -N- methylbenzamide 5 NMR (CDC1 ₃ , δ) : 3.33 (3H, s) , 3.75 (2H, br s) ,

4.92-5.10 (2H, m) , 6.38 (2H, d, J=9Hz), 6.79- 6.90 (2H, m) , 6.97 (IH, d, J=9Hz) , 7.10 (2H, d, J=9Hz) , 7.29-7.44 (5H, m)

10 63) 4-Amino-2-chloro-N- (2-benzyloxy-4-chlorophenyl) -N- methylbenzamide NMR (CDCI3, δ) : 3.36 (3H, s) , 3.71 (2H, br s),

5.07 (2H, br s), 6.24 (IH, dd, J=9, 2Hz) , 6.48

(IH, s), 6.76 (IH, dd, J=9, 2Hz) , 6.85 (2H, d,

15 J=9Hz), 7.06 (IH, d, J=9Hz) , 7.30-7.50 (5H, m)

64) 4-Amino-2-chloro-N- [2- (5-ethoxycarbonylpent-l- yloxy ) phenyl ] -N-methylbenzamide

NMR (CDCI3, δ) : 1.25 (3H, t, J=7Hz) , 1.43-1.63 20 (2H, m) , 1.63-1.79 (2H, m) , 1.79-1.94 (2H, m) ,

2.35 (2H, t, J=7Hz), 3.34 (3H, s) , 3.64 (2H, br s), 3.98 (2H, t, J=7Hz), 4.14 (2H, q, J=7Hz), 6.23 (IH, dd, J=9, 2Hz) , 6.47 (IH, d, J=2Hz) , 6.66-6.81 (2H, m) , 6.86 (IH, d, J=9Hz) , 7.03- 25. 7.14 (2H, m)

65) 4-Amino-3-methoxy-N- [2- (5-ethoxycarbonylpent-l- yloxy) -4-methylphenyl] -N-methylbenzamide

NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.41-1.55 30 (2H, ) , 1.59-1.86 (4H, m) , 2.26 (3H, s) , 2.31

(2H, t, J=7Hz), 3.29 (3H, s), 3.63 (3H, s), 3.75-4.01 (4H, m) , 4.13 (2H, q, J=7Hz), 6.41 (IH, d, J=9Hz), 6.55-6.64 (2H, ) , 6.77-6.89 (3H, m) 35

66) N- (2-Benzyloxy-4-methylphenyl)-N-methyl-4- aminobenzamide NMR (CDC1 ₃ , δ) : 2.27 (3H, s) , 3.33 (3H, s), 3.70

(2H, s), 4.91-5.10 (2H, m) , 6.37 (2H, d, J=9Hz) , 6.63 (IH, d, J=9Hz), 6.68 (IH, s) , 6.91 (IH, d,

J=9Hz), 7.14 (2H, d, J=9Hz) , 7.27-7.43 (5H, m) Preparation 7

A solution of p-anisidine (615 mg) , cyclopentancne

(420 mg) and acetic acid (2 ml) in methanol (30 ml) was cooled to 0°C, and sodium cyanoborohydride (315 mg) was added portionwise. The resulting solution was stirred at ambient temperature for 2 hours. The reaction mixture was then basified with IN aqueous sodium hydroxide, and extracted with ethyl acetate. The organic extract was washed with brine, dried over sodium sulfate, and concentrated. The residue was purified by column chromatography (Si0 ₂ 30 g, diethyl ether:n-hexane = 1:3) to give N-cyclopentyl-p-anisidine (530 mg) .

NMR (CDCI3, δ) : 1.21-2.12 (8H, m), ^' 3.74 (3H, s) , 3.69-3.85 (IH, m) , 6.57 (2H, d, J=8Hz), 6.78

(2H, d, J=8Hz), 7.04 (IH, br d, J=8Hz)

Preparation 8

A solution of N-cyclopentyl-N- (4-nitrobenzoyl)-p- anisidine (1.0 g) , 10% palladium on carbon (100 mg) and 2 drops of cone, hydrochloric acid in methanol (10 ml) was stirred under 3 atmospheric pressure of hydrogen at ambient temperature. After 4 hours, the reaction mixture was filtered through a bed of Celite, and concentrated to give N- (4-aminobenzoyl)-N-cyciopentyl-p-anisidine (870 mg) , which was used directly for the next step without further purification.

Preparation 9 A solution of [N-'methyl-N- (4-nitrobenzoyl) ]-2- (4-

nitrobenzoyloxy)aniline (1.76 g) in a mixture of methanol (20 ml) and IN sodium hydroxide (10 ml) was stirred at ambient temperature for 5 hours and the mixture was extracted with chloroform. The chloroform solution was washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was purified by silica gel column (lo methanol in chloroform) to give [N-methyl-N- (4- nitrobenzoyl) ]-2-hydroxyanιlme (982 mg) as a white powder.

NMR (DMSO-d ₆ , δ) : 3.23 (3H, s) , 6.65 (IH, ddd,

J=l, 8, 8Hz), 6.77 (IH, dd, J=l, 8Hz), 7.02 (IH, ddd, J=l, 8, 8Hz), 7.13 (IH, dd, J=l, 8Hz), 7.50 (2H, d, J=8.5Hz), 8.02 (2H, d, J=8.5Hz)

Preparation 10

To a mixture of [N-methyl-N- (4-nιtrobenzoyl) ]-2- hydroxyanilme (491 mg) and triethylamine (0.302 ml) in dichloromethane (20 ml) was added benzoyl chloride (0.202 ml) and the solution was stirred at ambient temperature for 4 hours. The solution was washed successively with IN hydrochloric acid, saturated sodium hydrogen carbonate, water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was solidified with n-hexane to give [N-methyl-N- (4- nitrobenzoyl) ]-2-benzoyloxyanιlme (652 mg) as a pale yellow solid .

NMR (CDC1 ₃ , δ) : 3.42 (3H, s) , 7.11-7.35 (4H, m) , 7.49 (2H, d, J=8.5Hz _/ , 7.58 (2H, d, J=8.5Hz), 7.70 (IH, d) , 8.03 (2H, d, J=8.5Hz), 8.13 (2H, d, J=8.5Hz)

Preparation 11

To a solution of 2-hydroxy- [N- ( 4-nιtrobenzoyl ) -N- methyl ] aniline ( 491 mg) m of N, N-dιmethylformamιde ( 20

ml) was added sodium hydride (60% in oil 72 mg) . After being stirred at ambient temperature for 30 minutes, N-(3- bromopropyDphthalimide (484 mg) was added to the solution and the mixture was stirred at ambient temperature for 4 hours. The mixture was diluted with ethyl acetate and the solution was washed successively with diluted hydrochloric acid, water and brine, dried over magnesium sulfate, and evaporated in vacuo to give an oil. The oil was purified by silica gel column (1% methanol in chloroform) to give 2-(3-phthalimidopropyloxy)-[N-(4-nitrobenzoyl)-N- ethyl]aniline (713 mg) as a pale yellow solid.

NMR (CDC1 ₃ , δ) : 2.23 (2H, tt, J=7.5, 7.5Hz), 3.40

(3H, s), 3.90-4.00 (4H, m) , 6.79 (2H, t, J=8Hz) , 6.98 (IH, dd, J=l, 8Hz), 6.98 (IH, dt, J=l, 8Hz), 7.53 (2H, d, J=8.5Hz), 7.73 (2H, m) , 7.86

(2H, m) , 8.01 (2H, d, J=8.5Hz)

Preparation 12

To a solution of 6-amino-m-cresol (5.0 g) and triethylamine (10.3 g) in dichloromethane (150 ml) was added 4-nιtrobenzoyl chloride (15.8 g) at ambient temperature. After 5 hours, the solid was filtered and washed with water and diethyl ether to give N,0-bis(4- nitrobenzoyl) -2-amino-5-methylphenol (12.5 g) as yellow crystal.

NMR (DMSO-d ₆ , δ) : 2.37 (3H, s) , 7.20 (IH, dd,

J=9, 2Hz), 7.28 (IH, d, J=2Hz) , 7.54 (IH, d, J=9Hz), 8.04 (2H, d, J=9Hz) , 8.28 (4H, d, J=9Hz), 8.36 (2H, d, J=9Hz)

Preparation 13

The following compounds were obtained according to a similar manner to that of Preparation 12.

1) N,O-Bis (4-nιtrobenzoyl)-2-ammophenethylalcohol

NMR (DMSO-d ₆ , δ) : 3.14 (2H, t, J=6Hz) , 4.53 (2H, t, J=6Hz), 7.28-7.48 (4H, m) , 8.10 (2H, d, J=8Hz), 8.20 (2H, d, J=8Hz), 8.30 (IE, d, J=8Hz), 8.36 (2H, d, J=8Hz) 5

2) 5-Methyl-N,0-bis (4-nitrobenzoyl) -2-aminophenol NMR (DMSO-d ₆ , δ) : 2.38 (3H, s) , 7.20 (IH, d,

J=9Hz), 7.28 (IH, s), 7.54 (IH, d, J=8Hz) , 8.04 (2H, d, J=9Hz), 8.29 (4H, d, J=9Hz) , 8.37 (2H, 10 d, J=9Kz)

3) N,0-Bis (3-methoxy-4-nitrobenzoyl) -2-aminophenol NMR (DMSO-d ₆ , δ) : 3.32 (3H, s) , 3.86 (3H, s),

7.38-7.57 (6H, m) , 7.70 (2H, d, J=llHz) , 7.81- 15 7.87 (IH, m) , 7.96-8.04 (IH, m)

4) N,O-Bis (3-methoxy-4-nitrobenzoyl) -2-amino-5- ethylphenol

Rf : 0.63 (10% methanol in chloroform) 20

5) N- [2- (4-Nitrophenylcarbonyloxy) -5-methylphenyl] -4- nitrobenzamide

NMR (DMSO-d ₆ , δ) : 2.38 (3H, s) , 7.18 (IH, dd,

J=9, 2Hz), 7.34 (IH, d, J=9Hz) , 7.50 (IH, d, 25. J=2Hz), 8.04 (2H, c, J=9Hz) , 8.30 (4H, d,

J=9Hz), 8.36 (2H, d, J=9Hz)

re ration 14

A solution of N- (2-benzyloxy-4-methylphenyl) -4-

30 nitrobenzamide (4.7 g) in N,N-dimethylformamide (50 ml) was treated with sodium hydride (623 mg, 60% w/w in mineral oil) at 0°C. After 3C minutes, iodomethane (1.21 ml) was added, and the reaction mixture was stirred for 3 hours. The reaction was quenched with water and the

35 mixture diluted with ethyl acetate. The organic phase was

washed with water and brine. The organic solution was dried over magnesium sulfate and concentrated to give N- (2-benzyloxy-4-methylphenyl) -N-methyl-4-nitrobenzamide (4.6 g) . NMR (DMSO-d ₆ , δ) : 2.21 (3H, s), 3.23 (3H, s) ,

5.00 (IH, d, J=12Hz), 5.10 (IH, d, J=12Hz) , 6.67 (IH, d, J=9Hz), 6.92 (IH, s), 7.16 (IH, d, J=9Hz), 7.32-7.47 (7H, m) , 8.01 (2H, d, J=9Hz)

Preparation 15

The following compounds were obtained according to a similar manner to that of Preparation 14.

1) N- (2-Benzyloxy-5-methylphenyl) -N-methyl-4- nitrobenzamide

NMR (DMSO-d ₆ , δ) : 2.15 (3H, s) , 3.26 (3H, s) ,

4.96 (IH, d, J=llHz), 5.06 (IH, d, J=llHz) , 6.91 (IH, d, J=9Hz), 6.98 (IH, d, J=9Hz) , 7.14 (IH, s), 7.30-7.48 (7H, m) , 8.03 (2H, d, J=9Hz)

2) 2-Benzyloxy-4-chloro-N-tert-butoxycarbonyl-N- methylaniline

NMR (CDC1 ₃ , δ) : 1.18-1.57 (9H, m) , 3.12 (3H, s) ,

5.09 (2H, s), 6.86-7.24 (3H, ) , 7.28-7.51 (5H, m)

3) 4-Nitro-N-methyl-N- (4-chiorophenyl)benzamide mp : 116-118°C

NMR (CDCI3, δ) : 3.50 (3H, s), 7.00 (2H, d, J=9Hz), 7.25 (2H, d, J=9Hz) , 7.46 (2H, d,

J=10Hz), 8.06 (2H, d, J=10Hz)

4) 4-Nitro-N-methyl-N- (3-methoxyphenyl) benzamide p : 83-87°C NMR (CDCI3, δ) : 3.50 (3H, s), 3.72 (3H, s),

- Ill -

6.58-6.63 (2H, m) , 6.75 (IH, dd, J=l, 9Hz) , 7.16 (IH, dd, J=l, 9Hz) , 7.50 (2H, d, J=10Hz) , 8.04 (2H, d, J=10Hz)

5) 4-Nitro-N-methyl-N- ( -methoxyphenyl)benzamide mp : 98-101 ^o C

NMR (CDC1 ₃ , δ) •: 3.49 (3H, s) , 3.75 (3H, s) , 6.78 (2H, d, J=9Hz), 6.95 (2H, d, J=9Hz) , 7.46 (2H, d, J=10Hz), 8.03 (2H, d, J=10Hz)

6) 4-Nitro-N-methyl-N- (3-chlorophenyl)benzamide

NMR (CDCI3, δ) : 3.52 (3H, s) , 6.83-6.92 (IH, m) , 7.12 (IH, s), 7.15-7.20 (2H, m) , 7.48 (2H, dd, J=l, 10Hz), 8.09 (2H, dd, J=l, 10Hz)

7) 4-Nitro-N-ethoxycarbonylmethyl-N- (2-methylphenyl) - benzamide mp : 121-124"C

NMR (CDCI3, δ) : 1.32 (3H, t, J=8Hz) , 2.27 (3H, s), 4.02 (IH, d, J=17Hz), 4.27 (2H, q, J=8Hz), 4.90

(IH, d, J-=17Hz), 7.03-7.18 (3H, m) , 7.26 (IH, d, J=8Hz), 7.48 (2H dd, J=l, 10Hz) , 8.02 (2H, dd, J=l, 10Hz)

8) 4-Nitro-N-methyl-N- (2-trifluoromethylphenyl)benzamide mp : 105-107°C

9) 3-Methyl-4-nitro-N-methyI-N- (2-methylphenyl)benzamide p : 75-77°C

10) 3-Methoxy-4-nitro-N-methyl-N- (2- methylphenyl)benzamide mp : 112-115°C

11) 4-Nitro-N-methyl-N- (2, 6-cimethylphenyl)benzamide

- 112 - mp : 113-116°C

12) N-Methyl-N,O-bis (4-nitrobenzoyl) -2- aminophenethylalcohol

NMR (CDC1 ₃ , δ) : 2.89 (IH, dt, J=7, 14Hz) , 3.07 (IH, dt, J=7, 1Hz), 3.49 (3H, s) , 4.56 (2H, q, J=7Hz), 7.15-7.28 (4H, m) , 7.44 (2H, d, J=9Hz) , 7.97 (IE, d, J=9Hz), 8.15 (2H, d, J=8Hz) , 3.29 (2H, d, J=8Hz)

13) 5-Methyl-N-methyl-N,O-bis (4-nitrobenzoyl) -2- aminophenol

NMR (CDCI3, δ) : 2.37 (3H, s) , 3.42 (3H, s) , 6.99- 7.11 (3H, ) , 7.48 (2H, d, J=9Hz) , 8.06 (2H, d, J=9Hz), 8.29 (2H, d, J=8Hz) , 8.42 (2H, d, J=8Hz)

14) N,0-Bis (3-methoxy-4-nitrobenzoyl) -N-methyl-2- a inophenol

NMR (CDCI3, δ) : 3.45 (3H, s) , 3.68 (3H, s), 4.07 (3H, s), 7.01-7.07 (2H, m) , 7.17 (IH, d, J=8Hz) ,

7.22-7.30 (2H, m) , 7.35-7.40 (IH, m) , 7.66 (IH, d, J=8Hz), 7.77-7.84 (2H, m) , 7.92 (IH, d, J=8Hz)

15) N,O-Bis (3-methoxy-4-nitrobenzoyl) -N-methyl-2-amino-5- methylphenol

NMR (CDCI3, δ) : 2.39 (3H, s), 3.42 (3H, s), 3.71 (3H, s), 4.07 (3H, s), 6.99-7.09 (5H, m) , 7.66 (IH, d, J=9Hz), 7.75-7.81 (2H, m) , 7.92 (IH, d, J=8Hz;

16) 3-Methoxy-4-nitro-N-methyi-N- (2- ethoxycarbonylphenyl)benzamide MASS (m/z) : 359 (M+l)

17) 4-Nitro-N-methyl-N- [2- [ (E) -6-methoxycarbonyl-l-hexen- 1-yl]phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.53 (2H, m) , 1.71 (2H, m) , 2.24- 2.40 (4H, m) , 3.40 (3H, s) , 3.69 (3H, s) , 6.18 (IH, dt, J=15, 7.5Hz), 6.44 (IH, d, J=15Hz) ,

6.96 (IH, d, J=7Hz), 7.09 (IH, t, J=7Hz) , 7.19 (IH, t, J=7Hz), 7.38-7.45 (3H, m) , 7.95-7.99 (2H, )

18) 4-Nitro-N-methyl-N-[2-[ (Z) -6-methoxycarbonyl-l-hexen- 1-yl]phenyl]benzamide

NMR (CDCI3, δ) : 1.43 (2H, m) , 1.61 (2H, m) , 1.94 (IH, m), 2.11 (IH, m) , 2.30 (2H, t, J=7.5Hz), 3.40 (3H, s), 3.67 (3H, s) , 5.80 (IH, dt, J=ll, 7.5Hz), 6.32 (IH, d, J=llHz) , 7.05 (IH, d,

J=7Hz), 7.13-7.23 (3H, m) , 7.41 (2H, d, J=8.5Hz), 7.98 (2H, d, J=8.5Hz)

19) 4-Nitro-N-methyl-N- [2- [N- (3-ethoxycarbonylprop-l- yl) oxyimino]methylphenyl]benzamide

NMR (CDCI3, δ) : 1.26 (3H, t, J=7.5Hz), 2.05 (2H, tt, J=7.5, 7.5Hz), 2.44 (2H, t, J=7.5Hz), 3.41 (3H, s), 4.15 (2H, q, J=7.5Hz), 4.21 (2H, t, J=7.5Hz), 7.08 (IH, dt, J=l, 7Hz) , 7.20-7.31 (2H, ) , 7.38 (2H, d, J=8.5Hz), 7.60 (IH, dd,

J=l, 7Hz), 7.99 (2H, d, J=8.5Hz), 8.10 (IH, s)

20) 4-Nitro-N-methyl-N- [2- (5-ethoxycarbonylpent-l- ylthio)phenyl]benzamide NMR (CDCI3, δ) : 1.27 (3H, t, J=7.5Hz), 2.52 (2H, ) , 1.63-1.77 (4H, ) , 2.31 (2H, t, J=7.5Hz), 2.90 (2H, m) , 3.39 (3H, s), 4.13 (2H, q, J=7.5Hz), 6.94-7.02 (2H, m) , 7.11-7.22 (2H, m) , 7.54 (2H, d, J=8.5Hz) , 8.00 (2H, d, J=8.5Hz)

21) 4-Nitro-N-methyl-N- [2- (3-ethoxycarbonylprop-l- yloxy)phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.28 (3H, t, J=7.5Hz), 2.23 (2H, m) , 2.52 (2H, m) , 3.37 (3H, s) , 3.96 (2H, m) , 4.16 (2H, q, J=7.5Hz), 6.75-6.84 (2H, m) , 7.01

(IH, d, J=7Hz), 7.17 (IH, dd, J=7, 7Hz) , 7.46 (2H, d, J=8.5Hz), 8.00 (2H, d, J=8.5Hz)

22) 4-Nitro-N-methyl-N- [2- (5-ethoxycarbonylpent-l- yloxy)pyrid-3-yl]benzamide

NMR (CDCI3, δ) : 1.23 (3H, t, J=7.5Hz), 1.30 (2H, m) , 1.57-1.69 (4H, m) , 2.29 (2H, t, J=7.5Hz), 3.33 (3H, s), 3.88 (2H, t, J=7.5Hz), 4.11 (2H, q, J=7.5Hz), 6.01 (IH, dd, J=7, 7Hz) , 7.09 (IH, dd, J=l, 7Hz), 7.18 (IH, dd, J=l, 7Hz) , 7.57

(2H, d, J=8.5Hz), 8.08 (2H, d, J=8.5Hz)

23) 2-Chloro-4-nitro-N- [2- (5-ethoxycarbonylpent-l- yloxy)phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.50-1.63 (2H, m) , 1.69-1.81 (2H, ) , 1.84-1.97 (2H, m) , 2.37 (2H, t, J=7Hz), 3.40 (3H, s), 3.94-4.06 (2H, ) , 4.15 (2H, q, J=7Hz) , 6.70-6.81 (2H, m) , 7.13 (IH, d, J=9Hz), 7.16 (IH, d, J=9Hz) , 7.31 (IH, d, J=9Hz), 7.87 (IH, d, J=9Hz) , 8.08 (IH, s)

24) 3-Methoxy-4-nitro-N- [2- (5-ethoxycarbonylpent-l- yloxy) -4-methylphenyl] -N-methylbenzamide

NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz), 1.43-1.59 (2H, m) , 1.65-1.90 (4H, m, , 2.27 (3H, s) , 2.34 (2H, t, J=7Hz), 3.33 (3H, s), 3.77 (3H, s), 3.82-3.99 (2H, m) , 4.13 (2H, q, J=7Hz), 6.59 (IH, d, J=9Hz), 6.60 (IH, s) , 6.86 (IH, d, J=9Hz), 6.94 (IH, d, J=9Hz), 7.0c (IH, s), 7.61 (IH, d, J=9Hz)

25) 2- [5- (Ethoxycarbonyl) pent-1-yloxy] -N-methyl-N-tert- butoxycarbonylaniline

NMR (CDC1 ₃ , δ) : 1.25 (3H, t, J=7Hz) , 1.33 (9H, br s), 1.40-1.58 (2H, m) , 1.58-1.86 (4H, m) , 2.32 (2H, t, J=7Hz), 3.12 (3H, s) , 3.96 (2H, t,

J=7Hz), 4.13 (2H, q, J=7Hz), 6.82-6.94 (2H, m) , 7.03-7.23 (2H, m)

26) N- (2-Benzyloxy-4-methylphenyl) -N-methyl-4- nitrobenzamide

NMR (DMSO-d ₆ , δ) : 2.21 (3H, s) , 3.23 (3H, s) , 5.00 (IH, d, J=12Hz), 5.10 (IH, d, J=12Hz) , 6.67 (IH, d, J=9Hz), 6.92 (IH, s) , 7.16 (IH, d, J=9Hz) , 7.32-7.47 (7H, ) , 8.01 (2H, d, J=9Hz)

Preparation 16

To a suspension of N- [2- (4-nitrophenylcarbonyloxy) -4- methylphenyl] -4-nitrobenzamide (12.5 g) was added IN sodium hydroxide (20 ml) at ambient temperature. After 3 hours, ethyl acetate (100 ml) and water (200 ml) was added to this solution and resulting solid was filtered and washed with water and diethyl ether to give N- (2-hydroxy- 4-methylphenyl) -4-nitrobenzamide (3.9 g) as yellow crystal. NMR (DMSO-d ₆ , δ) : 2.24 (3H, s), 6.65 (IH, dd, J=9,

2Hz), 6.74 (IH, d, J=2Hz) , 7.44 (IH, d, J=9Hz) , 8.18 (2H, d, J=9Hz), 8.36 (2H, d, J=9Hz) , 9.50- 9.90 (2H, m)

Preparation 1

The following compounds were obtained according to a similar manner to that of Preparation 16.

1) N- (2-Hydroxy-5-methylphenyl) -4-nitrobenzamide NMR (DMSO-d ₆ , δ) : 2.23 :3H, s), 6.81 (IH, d,

J=9Hz), 6.88 (IH, dd, J=9, 2Hz) , 7.44 (IH, d, J=2Hz), 8.17 (2H, d, J=9Hz) , 8.35 (2H, d, J=9H ₂ )

2) 4-Nitro-N-methyl-N-[2- (2-hydroxyethyl) phenyl] - benzamide

NMR (CDC1 ₃ , δ) : 2.67 (IH, dt, J=6, 15Hz) , 2.85 (IH, dt, J=6, 15Hz) , 3.45 (3H, s) , 3.90 (2H, t, J=6Hz) , 7.08 (IH, d, J=7Hz) , 7.14-7.28 (3H, m) , 7.46 (2H, d, J=9Hz) , 7.98 (2H, d, J=9Hz)

3) 5-Methyl-N-methyl-N- (4-nitrobenzoyl) -2-aminophenol NMR (CDCI3, δ) : 2.22 (3H, s) , 3.38 (3H, s) , 5.83-

5.86 (IH, br s) , 6.56 (IH, dd, J=l, 9Hz) , 6.63 (IH, s) , 6.78 (IK, d, J=9Hz) , 7.49 (2H, d, J=8H2) , 8.00 (2H, dd, J=l, 8Hz)

4) N- (3-Methoxy-4-nitroben2oyl) -N-methyl-2-aminophenol NMR (CDCI3, δ) : 3.23 (3H, s) , 3.75 (3H, s) , 6.66-

6.72 (IH, ) , 6.82 (IH, d, J=8Hz) , 6.97-7.13 (3H, m) , 7.19 (IH, s), 7.70 (IH, d, J=8Hz)

5) N- (3-Methoxy-4-nitrobenzoyl) -N-methyl-2-amino-5- methylphenol

NMR (CDC1- ₃ , δ) : 2.10 (3H, s) , 3.18 (3H, s) , 3.74 (3H, s), 6.35 (IH, d, J=8Hz) , 6.58 (IH, s) , 6.87

(IH, d, J=8Hz), 7. CO (IH, d, J=9Hz), 7.26 (IH, s), 7.68 (IH, d, J=9Hz)

6) N- (2-Hydroxy-4-methylphenyl) -4-nitrobenzamide NMR (DMSO-d _β , δ) : 2.24 (3H, s) , 6.65 (IH, dd, J=9,

2Hz) , 6.74 (IH, d, J=2Hz) , 7.44 (IH, d, J=9Hz) , 8.18 (2H, d, J=9Hz) , 8.36 (2H, d, J=9Hz) , 9.50- 9.90 (2H, m)

Preparation 18

The following compounds were obtained according to a similar manner to that of Preparation 11.

1) 4-Nitro-N-methyl-N- (2-ethoxycarbonylmethoxyphenyl) - benzamide

NMR (CDC1 ₃ , δ) : 1.30 (3H, t, J=8Hz) , 3.42 (3H, s) , 4.28 (2H, q, J=8Hz) , 4.66 (2H, d, J=3Hz) , 6.67 (IH, d, J=9Hz), 6.81 (IH, t, J=8Hz) , 6.95 (IH, d, J=9Hz), 7.16 (IH, t, J=8Hz), 7.57 (2H, d, J=9Hz), 8.00 (2H, d, J=9Hz)

2) 4-Nitro-N-methyl-N- [ (2-ethoxycarbonylmethoxy-4- methyl)phenyl]benzamide

NMR (CDCI3, δ) : 1.33 (3H, t, J=8Hz) , 2.27 (3H, s) , 3.40 (3H, S), 4.30 (2H, q, J=8Hz) , 4.65 (2H, d,

J=3Hz), 6.47 (IH, s) , 6.62 (IH, d, J=8Hz) , 6.83 (IH, d, J=8Hz), 7.57 (2H, d, J=8Hz) , 8.01 (2H, d, J=8H2)

3) 3-Methoxy-4-nitro-N-methyl-N- (2- ethoxycarbonylmethoxyphenyl ) ben2amide

NMR {CDCI3, δ) : 1.30 (3H, t, J=8H2) , 3.43 (3H, s) ,

3.82 (3H, s), 4.27 (2H, q, J=8H2) , 4.66 (2H, d,

J=7Hz), 6.70 (IH, d, J=8Hz) , 6.81-6.88 (IH, m) , 6.98 (IH, d, J=8Hz) , 7.02 (IH, d, J=8Hz) , 7.14-

7.23 (2H, m) , 7.60 (IH, d, J=8Hz)

4 ) 4-Nitro-N-methyl-N- [2- (3-phthalimidoprop-l-yloxy) - phenyl]benzamide Rf : 0.18 (n-hexane: ethyl acetate = 1:2)

5) 3-Methoxy-4-nitro-N-methyl-N- [4-methyl-2- (3- phthalimidoprop-1-yloxy) phenyl]benzamide

NMR (CDCI3, δ) : 2.20 (2H, quint., J=7Hz), 2.27 (3H, s), 3.36 (3H, si , 3.80 (3H, s) , 3.88-3.98

(4H, m) , 6.60 (IH, s), 6.62 (IH, d, J=8Hz), 6.85 (IH, d, J=8Hz), 6.98 (IH, dd, J=l, 9Hz) , 7.10 (IH, d, J=1H2), 7.60 (IH, d, J=9H2), 7.69-7.74 (2H, ) , 7.82-7.87 (2H, m) 5

6) 2- (3-Ethoxycarbonylprop-l-yl) oxyaniline

NMR (CDC1 ₃ , δ) : 1.26 (3H, t, J=7.5H2), 2.15 (2H, tt, J=7.5, 7.5Hz), 2.51 (2H, t, J=7.5Hz), 3.79 (2H, br s), 4.04 (2H, t, J=7.5Hz), 4.15 (2H, q, 10 J=7.5H2), 6.65-6.82 (4H, m)

Preparation 1

To an ice bath cooled solution of 2-aminothiophenol (1.80 g) in N,N-dimethylformamide (35 ml) was added sodium 15 hydride (60% in oil, 575 mg) . After being stirred in an ice bath for 30 minutes, ethyl 6-bromohexanoate (3.21 g) was added and the mixture was stirred at ambient temperature for 3 hours. The mixture was diluted with ethyl acetate (100 ml) and the solution was washed with 20 water and brine. The organic phase was dried over magnesium sulfate and the solvent was evaporated in vacuo to give an oil. The oil was purified by silica gel column (1% methanol in chloroform) to give 2- (5- ethoxycarbonylpent-1-yl) thioaniline (3.20 g) as a pale 25. yellow amorphous.

NMR (CDCI3, δ) : 1.26 (3H, t, J=7.5H2), 1.35-1.47 (2H, ) , 1.53-1.67 (4H, m) , 2.28 (2H, t, J=7.5H2), 2.72 (2H, t, J=7.5H2), 4.12 (2H, q, J=7.5H2), 4.33 (2H, s), 6.65 (IH, d, J=7H2) , 30 7.71 (IH, d, J=7H2), 7.10 (IH, t, J=7H2) , 7.36

(IH, d, J=7H2)

Preparation 2 ^Q

To a solution of N- (2-hydroxy-4-methylphenyI) -4- 35 nitrobenzamide (3.8 g) in N,N-dimethylformamide (25 ml)

was added potassium carbonate (3.85 g) and benzyl bromide (2.63 g) . The reaction mixture was stirred at ambient temperature for 3 hours. The mixture was extracted with ethyl acetate and washed with water and brine. The organic solution was dried over magnesium sulfate. The solvent was removed by evaporation to give N- (2-benzyloxy- 4-methylphenyl) -4-nitrobenzamide (4.8 g) .

NMR (DMSO-d ₆ , δ) ^' : 2.32 (3H, s), 5.16 (3H, s) , 6.82 (IH, d, J=9Hz), 7.02 (IH, s), 7.24-7.40 (3H, m) , 7.47 (3H, d, J=9Hz) , 8.16 (2H, d, J=9H2) , 8.36

(2H, d, J=9Hz), 9.88 (IH, s)

Preparation 21

The following compounds were obtained according to a similar manner to that of Preparation 20.

1) N- (2-Benzyloxy-5-methylphenyl) -4-nitrobenzamide

NMR (DMSO-d _β , δ) : 2.26 (3H, s), 5.15 (2H, s), 6.97- 7.08 (2H, m) , 7.24-7.39 (3H, m) , 7.46 (3H, d, J=9Hz), 8.15 (2H, d, J=9Hz) , 8.36 (2H, d, J=9Hz)

2) N-.(2-Benzyloxy-4-methylphenyl) -4-nitrobenzamide

NMR (DMSO-d ₆ , δ) : 2.32 (3H, s), 5.16 (3H, s), 6.82 (IH, d, J=9Hz), 7.02 (IH, s) , 7.24-7.40 (3H, m) , 7.47 (3H, d, J=9Hz) , 8.16 (2H, d, J=9Hz) , 8.36

(2H, d, J=9Hz), 9.88 (IH, s)

3) 2- [5- (Ethoxycarbonyl) pent-1-yloxy] -N-tert- butoxycarbonylaniline NMR (CDC1 ₃ , δ) : 1.26 (3H, t, J=7Hz), 1.43-1.59

(11H, ) , 1.63-1.78 (2H, m) , 1.78-1.92 (2H, m) , 2.35 (2H, t, J=7Hz), 4.01 (2H, t, J=7Hz) , 4.12 (2H, q, J=7H2), 6.77-6.86 (IK, m) , 6.86-6.97 (2H, m) , 7.03 (IH, br s) , 7.99-8.10 (IH, m)

4) 4-Nitro-N-methyl-N- [ -methyl-2- (5- methoxycarbonylpyrid-2-yimethoxy)phenyl]benzamide NMR (CDC1 ₃ , δ) : 2.24 (3H, s) , 2.73 (3H, s), 3.99 (3H, s), 5.24 (IH, d, J=llHz), 5.31 (IH, d, J=llHz), 6.60 (IH, d, J=7Hz), 6.69 (IH, s) , 6.81

(IH, d, J=7Hz), 7.23 (IH, s), 7.47 (2H, d, J=8.5Hz), 7.99 (2H, d, J=8.5Hz) , 8.51 (IH, m) , 9.12 (IH, m)

5) 4-Nitro-N-methyl-N- [2- (5-methoxycarbonylpyrid-2- ylmethoxy ) phenyl ] ben2a1ru.de

NMR (CDCI3, δ) : 3.40 (3H, s), 3.99 (3H, s), 5.31 (2H, m) , 6.80 (IH, dd, J=7, 7Hz) , 6.91 (IH, d, J=7H2), 6.98 (IH, d, J=7Hz) , 7.16 (IH, dd, J=7, 7Hz), 7.28 (IH, s), 7.49 (2H, d, J=8.5Hz), 7.99

(2H, d, J=8.5Hz), 8.54 (IH, m) , 9.12 (IH, m)

6) 3- (5-Ethoxycarbonylpent-l-yloxy) -2-nitropyridine NMR (CDCI3, δ) : 1.25 (3H, t, J=7.5Hz), 1.51 (2H, ) , 1.70 (2H, m) , 1.87 (2H, m) , 2.31 (2H, t,

J=7.5Hz), 4.10 (2H, q, J=7.5Hz), 4.75-7.53 (2H, m) , 8.06 (IH, m)

7) 2- (5-Ethoxycarbonylpent-l-yloxy) -3-nitropyridine NMR (CDC1 ₃ , δ) : 1.23 (3H, t, J=7.5Hz), 1.40 (2H, m) , 1.68 (2H, ) , 1.82 (2H, m) , 2.30 (2H, t, J=7.5Hz), 4.10 (4H, m) , 6.29 (IH, dd, J=7, 7Hz) , 7.18 (7H, dd, J=lHz) , 8.30 (7H, dd, J=lHz)

8) 0- (3-Ethoxycarbonylprop-l-yl) - (2-nitro)benzaldoxim

NMR (CDCI3, δ) : 1.25 (3H, t, J=7.5Hz) 2.05 (2H, tt, J=7.5, 7.5Hz), 2.43 .2H, t, J=7.5Hz) , 4.13 (2H, q, J=7.5Hz), 4.24 (2H, t, J=7.5Hz), 7.52 (IH, dt, J=l, 7Hz), 7.62 'IH, dt, J=l, 7Hz) , 7.98 (IH, dd, J=l, 7Hz) , 6.04 (IH, dd, J=l, 7Hz) ,

8 . 61 ( IH, s )

9) 2- (5-Ethoxycarbonylpentyloxy) -[N-methyl-N- (4- nitroben∑oyl) ]aniline 5 NMR (CDC1 ₃ , δ) : 1.26 (3H, t, J=7.5H2), 1.45-1.58 (2H, m) , 1.67-1.76 (2H, m) , 1.79-1.88 (2H, m) , 2.34 (2H, t, J=7.5Hz), 3.38 (3H, s) , 3.84-4.00 (2H, m) , 4.13 (2H, q, J=7.5Hz), 6.72-6.82 (2H, m), 7.01 (IH, d, J=7Hz), 7.17 (IH, t, J=7Hz) , 10 7.45 (2H, d, J=8.5Hz), 7.98 (2H, d, J=8.5Hz)

10) 3-Methoxy-4-nitro-N-[2- (6-chlorohex-l-yloxy)-4- methylphenyl]-N-methylbenzamide

NMR (CDCI3, δ) : 1.41-1.61 (4H, m) , 1.71-1.90 (4H, 15 ), 2.27 (3H, s), 3.33 (3H, s), 3.56 (2H, t,

J=7Hz), 3.77 (3H, s), 3.82-3.98 (2H, m) , 6.58- 6.66 (2H, m) , 6.85 (IH, d, J=9Hz) , 6.92 (IH, d, J=9Hz), 7.06 (IH, s), 7.59 (IH, d, J=9Hz)

20 Preparation 11

To a solution of 4-nitro-N-methyl-N- [2- (3- phthalimidoprop-1-yloxy)phenyl]benzamide (760 mg) in ethanol (15 ml) was added hydrazine hydrate (828 mg) and the solution was stirred at ambient temperature for 1

25. days. After evaporation in vacuo, the residue was diluted with ethyl acetate and then the organic solution was washed successively with saturated sodium bicarbonate aqueous solution and brine. Drying, filtering and removal of solvents afforded 4-nitro- -methyl-N-[2- (3-aminoprop-l-

30 yloxy)phenyl]ben∑amide (422 mg) as a yellow oil. Rf : 0.06 (10% methanol in chloroform)

Preparation 23

The following compound was obtained according to a 35 similar manner to that of Preparation 22.

3-Methoxy-4-nitro-N-methyl-N- [4-methyl-2- (3- aminoprop-1-yloxy)phenyl]ben2amide

Rf : 0.06 (10% methanol in chloroform)

Preparation 24

To a solution of 4-nitro-N-methyl-N- [2- (2- hydroxyethyl)phenyl]ben2amide (686 mg) in N,N- dimethylformamide (12 ml) was added pyridinium dichromate (4.3 g) and the mixture was stirred at ambient temperature for 2 days. The mixture was diluted with water (80 ml) and the aqueous solution was extracted with ethyl acetate. The extract was washed with brine and dried over magnesium sulfate. Filtering and removal of solvents afforded a brown oil. To a solution of the brown oil in methanol (3 ml) and ben2ene (11 ml) was added trimethylsilyl dia2omethane (1.7 ml) and the resulting solution was stirred at ambient temperature for 30 minutes. The mixture was evaporated in vacuo to give 4-nitro-N-methyl- N- (2-methoxycarbonylmethylphenyl)ben2amide (517 mg) as a dark-green oil.

NMR (CDC1 ₃ , δ) : 3.42 and 3.45 (total 3H, s) , 3.47- 3.60 (2H, m) , 3.72 and 3.88 (total 3H, s), 7.18- 7.32 (3H, m) , 7.37-7.48 (3H, m) , 7.96-8.02 (2H, m)

Preparation 25

To an ice bath cooled mixture of 4-nitro-N-methyl-N- [2- [(E) and (Z) -6-methoxycarbcnyl-l-hexen-l- yl]phenyl]ben2amide (2.00 g) and nickel chloride hexahydrate (1.80 g) in a mixture of methanol (20 ml) and tetrahydrofuran (20 ml) was added sodium borohydride (954 mg) in small portions and the mixture was stirred in an ice bath for 1 hour. The solution was filtered through a bed of Celite and the filtrate was concentrated in vacuo. The residue was dissolved in ethyl acetate (100 ml) and

the solution was washed with water and brine. The organic phase was dried over magnesium sulfate and the solvent was evaporated in vacuo to give an oil. The oil was purified by silica gel column (1% methanol in chloroform) to give 5 4-amino-N-methyl-N- [2- (6-methoxycarbonylhex-l- yl)phenyl]benzamide (1.28 g) as a pale yellow amorphous. NMR (CDC1 ₃ , δ) : 1.24-1.30 (4H, m) , 1.50-1.64 (4K, m) , 2.28 (2H, t, J=7.5Hz), 2.33 (IH, m) , 2.48 (IH, ) , 3.33 (3H, s), 3.65 (3H, s) , 3.74 (2H, 10 s), 6.34 (2H, d, J=8.5Hz), 7.02-7.20 (6H, m)

Preparation 26

To a mixture of tetrahydro-4H-pyran-4-one (1.0 g) and methylamine (40% in methanol, 2.0 ml) in methanol (5 ml)

15 was added sodium cyanoborohydride (0.62 g) at ambient temperature. The mixture was stirred overnight. The mixture was quenched by adding of water, and methanol was evaporated. The resulting mixture was extracted with chloroform, and then the organic layer was washed with

20 brine. Drying and removal of solvents afforded 4- methylaminotetrahydro-4K-pyran (639 mg) as a slightly yellow oil.

Preparation 27

25. To a solution of 2-methyIaniline (1.0 g) and triethylamine (0.95 g) in N,N-dimethylformamide (15 ml) was added benzyl bromide (1.9 g) at ambient temperature and the mixture was stirred at ambient temperature overnight. The reaction mixture was diluted with ethyl

30 acetate and it was washed with water and brine. Drying, filtering and the removal of solvents afforded a crude product.

The crude product was chromatographed on silica gel (n-hexane:ethyl acetate = 10:1) to give N-benzyl-2-

35 methylaniline (795 mg) as a slightly yellow oil.

Preparation 28

2-Benzyloxy-4-chlorobenzoic acid (3.0 g) was heated under reflux in a mixture of benzene and t-butyl alcohol. Diphenylphosphoryl azide (3.14 g) and triethylamine (1.21 g) were added in one batch to the mixture and reflux was continued for a further 8 hours. Benzene was removed under reduced pressure and the residue taken up in ethyl acetate. An insoluble white solid was removed by filtration. The remaining organic filtrate was washed successively with diluted hydrochloric acid, water, saturated aqueous sodium hydrogen carbonate and brine. The organic layer was dried over magnesium sulfate and the solvent was evaporated to give 2-benzyloxy-4-chloro-N- tert-butoxycarbonylaniline (1.6 g) . NMR (CDC1 ₃ , δ) : 1.50 (9H, s), 5.08 (2H, s), 6.85-

7.04 (3K, m) , 7.31-7.49 (5H, m) , 8.04 (IH, d, J=9H2)

Preparation 29 The following compounds were obtained according to a similar manner to that of Example 48.

1) 2-Benzyloxy-4-chloro-N-methylaniline

NMR (CDCI3, δ) : 2.82 (3H, s) , 5.03 (2K, s) , 6.49 (IH, d, J=9Hz), 6.81 (IH, d, J=2Hz) , 6.87 (IH, dd, J=9, 2Hz), 7.31-7.46 (5H, m)

2) 2- [5- (Ethoxycarbonyl) pent-1-yloxy] -N-methylaniline NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.43-1.57 (2H, m) , 1.63-1.76 (2H, ) , 1.76-1.88 (2H, m) , 2.33

(2H, t, J=7Hz) , 2.86 (3H, s) , 3.97 (2H, t, J=7Hz), 4.13 (2H, q, J=7H2), 6.54-6.67 (2H, m) , 6.73 (IH, d, J=9H∑) , 6.88 (IH, dd, J=9, 9Hz)

Preparation 30

The following compounds were obtained according to a similar manner to that of Example 6.

1) 3-Chloro-4- (4 '-methylbiphenyl-2-carboxamido)benzoic acid

NMR (DMSO-d ₆ , δ) : 2.32 (3H, s) , 7.22 (2H, d,

J=8Hz), 7.37 (2H, d, J=8Hz) , 7.42-7.54 (2H, ) , 7.54-7.67 (2K, m) , 7.79-7.96 (3H, m)

2) 4- (Methylphenyl-2-carboxamido) -2-nitrobenzoic acid

NMR (DMS0-d ₆ , δ) : 2.41 (3H, s) , 7.29-7.38 (2H, m) , 7.44 (IH, dd, J=8, 8Hz), 7.49-7.56 (IK, ) , 7.89 (IH, d, J=8Hz), 7.98 (IH, d, J=8Hz) , 8.36 (IH, s)

3) 4- (4'-Methylbiphenyl-2-carboxamido) -2-nitrobenzoic acid NMR (CDC1 ₃ , δ) : 2.40 (3H, s) , 7.20-7.61 (9H, ) , 7.73 (IH, d, J=9Hz), 7.83 (IH, d, J=9Hz)

Preparation 31 To a solution of 4-nitro-N-methyl-N- [2- (3-aminoprop-l- yloxy)phenyl]benzamide (422 mg) and triethylamine (130 mg) in dichloromethane (10 ml) was added phenyl chloroformate (201 mg) and the solution was stirred at 0°C for 30 minutes. The reaction mixture was diluted with dichloromethane and then ■ the organic solution was washed successively with IN hydrochloric acid, saturated sodium bicarbonate aqueous solution and brine. Drying, filtering and removal of solvents afforded a crude product. The crude product was chromatographed on silica gel (eluent; 1% methanol in chloroform) to give 4-nitro- -methyl-N- [2- (3- phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide (383 mg) as a slightly yellow oil.

NMR (CDC1 ₃ , δ) : 2.12 '2H, quint., J=7Hz), 3.40 (3H, s), 3.50 (2H, q, J=7Hz), 3.96-4.07 (2H, m) , 5.22- 5.28 (IH, br), 6.79-6.88 (2H, m) , 7.01-7.23 (5H,

m) , 7 . 31-7 . 39 ( 2H, m) , 7 . 48 ( 2H, d, J=8Hz ) , 7 . 98 (2H, d, J=8Hz )

Preparation 37 The following compounds were obtained according to a similar manner to that cf Preparation 31.

1) 3-Methoxy-4-nιtro-N-methyl-N- [4-methyl-2- (3- phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide NMR (CDC1 ₃ , δ) : 2.10 (2H, quint., J=6Hz) , 2.30 (3H, s), 3.37 (3H, s) , 3.48 (2H, q, J=6Hz) , 3.78 (3H, s), 3.92-4.07 (2K, m) , 5.23-5.30 (IH, br) , 6.63- 6.68 (2H, m) , 6.90-6.99 (2H, m) , 7.09-7.14 (3H, m) , 7.17-7.23 (IH, m) , 7.31-7.39 (2H, m) , 7.60 (IH, d, J=8H2)

2) 4-Nitro-N-methyl-N- [2- (3-phenoxycarbonylamino-l-propyn- 1-yl)phenyl]ben2amide

NMR (CDCI3, δ) : 3.47 (3H, s) , 4.35 (2H, d, J=6.5H2), 5.55 (IH, br t, J=6.5H2), 7.10-7.28 (6H, m) , 7.22-7.41 (3H, ) , 7.54 (2H, d, J=8.5Hz), 8.01 (2H, d, J=8.5Hz)

Preparation 33 A mixture of 4-nitro-N-methyl-N- [2- (3- phenoxycarbonylammoprop-1-yloxy) phenyl]benzamide (383 mg) and piperazine (256 mg) in N, N-dimethylformamide (8 ml) was stirred at 80°C for 3 hours. The reaction mixture was diluted with ethyl acetate and then the organic solution was washed successively with saturated sodium bicarbonate aqueous solution and brine. Drying, filtering and removal of solvents afforded 4-nιtro-N-methyl-N- [2- { 3- (4-methyl-1- piperazinyl) carbonylammoprop-1-yloxy.phenyl]benzamide (357 mg) as a slightly yellow oil. NMR (CDCI3, δ) : 2.00-2.10 (2H, m) , 2.31 (3H, s),

2.38-2.44 (4H, m) , 3.37-3.45 (9H, m) , 3.90-4.01 (2H, m) , 4.69-4.75 (IH, m) , 6.85-6.95 (IH, m) , 7.00-7.25 (3H, m) , 7.47 (2H, d, J=9Hz) , 8.00 (2H, d, J=9Hz)

Preparation 34

The following compounds were obtained according to a similar manner to that of Preparation 33.

1) 3-Methoxy-4-nitro-N-methyl-N-[4-methyl-2-[3-(4- methyl-l-pipera2inyl) carbonylaminoprop-1- yloxy]phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.98-2.07 (2H, m) , 2.28 (3H, s), 2.31 (3H, s), 2.38-2.42 (4H, m) , 3.35 (3H, s) , 3.37-3.46 (6H, m) , 3.78 (3H, s), 3.88-4.00 (2H, m) , 4.70-4.75 (IH, br) , 6.80-6.84 (2H, m) , 7.08 (IH, s), 7.20-7.26 (2H, m) , 7.60 (IH, d, J=8H2)

2) 4-Nitro-N-methyl-N- [2- [3- (4-methylpiperazin-l- yl) carbonylamino-l-propyn-l-yl]phenyl]benzamide

NMR (CDCI3, δ) : 2.32 (3H, s), 2.44 (4H, t, J=6H2), 3.41 (3H, s), 3.54 (4H, t, J=6Hz), 4.32 (2H, m) , 5.10 (IH, br t, J=6.5Hz) , 7.13-7.32 (4H, m) , 7.55 (2H, d, J=8.5Hz), 8.00 (2H, d, J=8.5Hz) •

3) 4-Nitro-N-methyl-N- [2- [3- (4-dimethylaminopiperidin-l- yl) carbonylaminoprop-1-yloxy]phenyl]benzamide

MASS (m/z) : 484 (M+l)

repa ation 35

The following compound was obtained according to a similar manner to that of Example 20.

3- (5-Ethoxycarbonylpent-l-yloxy) -2-methylaminopyridine MASS (m/z) : 267 (M+l)

Example 1

To a solution of 2- (4-methylphenyl) benzoic acid (157 mg) dichloromethane (20 ml) were added oxalyl chloride (0.092 ml) and a few drop of N,N-dιmethylformamιde and the solution was stirred at ambient temperature for 2 hours. The solvent was evaporated vacuo to give an acid chloride as an oil and the oil was added to a mixture of N-methyl-N- (4-ammobenzoyl) aniline (150 mg) and triethylamine (0.14 ml) in dichloromethane (20 ml) . The mixture was stirred at ambient temperature for 2 hours ano washed successively with IN hydrochloric acid, water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was subjected to silica gel column (30 g, 1% methanol in chloroform) to give an oil. The oil was solidified with diethyl ether to give 4- (4 ' -methylbιphenyl-2-carboxamιdo) - N-methyl-N-phenylbenzamide (230 mg) .

NMR (CDC1 ₃ , δ) : 2.33 (3H, s), 3.46 (3H, s) , 6.89- 7.03 (5H, m) , 7.11-7.56 (11H, m) , 7.82 (IH, dd, J=1.5, 7.5Hz)

Example 2

The following compounds were obtained according to a similar manner to that of Example 1.

1) 4- (4 '-Methylbιphenyl-2-carboxamιoo) -N-ethyl-N- phenylbenzamide

NMR (CDCI3, δ) : 1.18 '3H, t, J=7Hz) , 2.32 (3H, s), 3.94 (2H, q, J=7Hz) , 6.84-7.02 (4H, m) , 7.11- 7.55 (13H, ) , 7.72 (IH, dd, J=1.5, 8Hz)

2) 4- ( '-Metnylbιphenyl-2-carboxamιdo) -N-methyl-N- (2- ethoxycaroonylpnenyl)benzamide

NMR (CDCI3, δ) : 1.33 (3H, t, J=7Hz) , 2.32 (3H, s) , 3.38 (3H, s), 4.28 '3H, q, J=7Hz), 6.90 (2H, m) ,

7 . 05-7 . 56 ( 13H, m) , 7 . 79 ( 2H, t , J=8Hz )

3) 4- ( ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- pyridyl) benzamide NMR (CDCI3, δ) : 2.39 (3H, s), 3.87 (3H, s), 6.50 (IH, dt, J=l, 7.5Hz), 7.07 (IH, br) , 7.17-7.27 (4H, m) , 7.36 (2H, d, J=8.5Hz), 7.43-7.58 (5H, m) , 7.91 (iH, dd, J=l, 7Hz) , 8.18 (2H, d, J=8.5Hz), 8.31 (IH, d, J=7.5Hz)

4- ( '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- chlorophenyl)benzamide

NMR (CDCI3, δ) : 2.35 (3H, s), 3.35 (3H, s), 6.88- 7.56 (16H, m), 7.81 (IH, d, J=8Hz)

5) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (4- methylphenyl)benzamide

NMR (CDCI3, δ) : 2.28 (3H, s), 2.33 (3H, s) , 3.43 (3H, s), 6.86-6.96 (5H, m) , 7.02 (2H, d, J=8.5H2), 7.17-7.55 (9H, m) , 7.94 (IH, d, J*=8Hz)

6) 2-Chloro-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N-phenylbenzamide

NMR (CDCI3, δ) : 2.36 (3H, s), 3.47 (3H, s) , 6.76- 7.55 (16H, m) , 7.80 (IH, d, J=8Hz)

7) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- methylphenyl)benzamide

NMR (CDCI3, δ) : 2.16 (3H, s), 2.35 (3H, s) , 3.31 (3H, s), 6.88-7.56 16H, ) , 7.82 (IH, d, J=8Hz)

8) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- isopropylphenyl)benzamide

NMR (CDCI3, δ) : 0.82 (3H, d, J=7Hz), 1.16 (3H, d, J=7Hz), 2.37 (3H, s, , 2.96 (IH, qq, J=7, 7Hz; ,

3.38 (3H, s), 6.72-6.95 (2H, m) , 7.07-7.55 (14H, m) , 7.81 (IH, d, J=8Hz)

4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- methoxyphenyl)benzamide

NMR (CDC1 ₃ , δ) : 2.35 (3H, s), 3.32 (3H, s) , 3.70

(3H, s), 6.78-6.93 (5H, m) , 6.99 (IH, d, J=8Hz) , 7.12-7.20 (5H, m) , 7.27-7.31 (2H, m) , 7.37-^.54 (3H, m) , 7.82 (IH, d, J=8Hz)

10) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- (3- pyridyl)benzamide

NMR (CDCI3, δ) : 2.37 (3H, s), 3.46 (3H, s), 6.95- 7.00 (3H, m) , 7.14-7.55 (11H, m) , 7.84 (IH, d, J=8Hz), 8.31 (IH, d, J=3Hz) , 8.38 (IH, d,

J=5.5Hz)

11) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [3- (2- methoxycarbonyl) thienyl]benzamide NMR (CDCI3, δ) : 2.37 (3H, s), 3.46 (3H, s) , 3.79

(3H, s), 6.86 (IH, d, J=8Hz), 6.95-7.02 (3H, m) , 7.18-7.56 (10H, m) , 7.83 (IH, dd, J=l, 8Hz)

12) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (3- methylphenyl)benzamide

NMR (CDCI3, δ) : 2.25 (3H, s), 2.34 (3H, s), 3.43 (3H, s), 6.77 (IH, d, J=8Hz) , 6.84-7.55 (15H, m) , 7.82 (IH, dd, J=i, 8Hz)

13 4- (4 ' -Metr.ylbιphenyl-2-carboxamιdo) -N-methyl-N- (2- benzoyloxyphenyl ) enzam e

NMR (CDC1 ₃ , δ) : 2.35 , 3H, s) , 3.37 (3H, s) , 6.90- 7.00 (3K, m) , 7.14- ^"7 .71 (16H, m) , 7.83 (IH, d, J=8Hz), 8.11 (2H, d, J=8.5Hz)

14) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- nitrophenyl)benzamide

NMR (DMSO-d ₆ , δ) : 2.28 (3H, s), 3.33 (3H, s), 7.01- 7.18 (3H, m) , 7.23-7.57 (11H, m) , 7.68-7.95 (3H, )

15) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- phenylphenyl)benzamide

NMR (CDC1 ₃ , δ) : 2.37 (3H, s) , 3.39 (3H, s), 6.70- 6.97 (6H, ) , 7.15-7.56 (15H, ) , 7.82 (IH, d,

J=8Hz)

16) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- allylphenyl)benzamide NMR (CDCI3, δ) : 2.36 (3H, s), 3.08-3.40 (2H, m) ,

3.35 (3H, s), 5.05 (IH, d, J=15Hz) , 5.09 (IH, d, J=10Hz), 5.66-5.90 (IK, ) , 6.83-7.6§6 (16H, m) , 7.80 (IH, d, J=8Hz)

17) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (3- phthalimidopropyloxy)phenyl]benzamide NMR (CDCI3, δ) : 2.14 (2H, tt, J=7.5, 7.5Hz), 2.30 (3H, s), 3.33 (3H, s), 3.84-3.99 (4H, m) , 6.73- 6.97 (6H, m) , 7.08-7.55 (9H, m) , 7.67 (2H, m) , 7.79-7.86 (4H, m)

18) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- acetylphenyl)benzamide

NMR (CDCI3, δ) : 2.20 (3H, s), 2.38 (3H, s), 3.41 (3H, s), 6.89 (2H, or), 7.04-7.54 (14H, m) , 7.82

(IH, d, J=8Hz)

19) 3-Methoxy-4- ( '-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-ethoxycarbonylphenyl) benzamide NMR (CDCI3, δ) : 1.34 (3H, t, J=7.5Hz), 3.41 (3H,

s), 3.59 (3H, s), 3.88 (2H, s) , 4.30 (2H, q, J=7.5Hz), 6.38 (IH, d, J=7.5Hz), 6.68-6.77 (2H, m) , 7.20-7.29 (2H, m) , 7.45 (IH, t, J=7.5Hz), 7.78 (IH, d, J=7.5Hz)

20) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N-[ (4- methyl-2-methoxycarbonyl)phenyl]benzamide NMR (CDC1 ₃ , δ) : 2.31 (3H, s), 2.37 (3H, s), 3.34 (3H, s), 3.90 (3H, s), 6.77 (IH, m) , 6.86-6.98 (3H, m) , 7.07-7.55 (10H, m) , 7.83 (IH, d,

J=7.5Hz)

2i) 4- (4'-Methylbiphenyl-2-carboxamido)-N-methyl-N-[2-[3- (4-methylpiperazin-l-yl) carbonylamino- (1-propyn-l- yl) ]phenyl]benzamide

NMR (CDCI3, δ) : 2.32 (3H, s), 2.39 (3H, s), 2.43 (4H, t, J=6Hz), 3.36 (3H, s) , 3.56 (4H, t, J=6Hz), 4.26 (2H, ) , 5.32 (IH, br t, J=6.5Hz), 6.90-6.98 (3H, m) , 7.10-7.32 (9H, m) , 7.38-7.55 (3H, m) , 7.82 (IH, d, J=7.5Hz)

22) 4- (4'-Methylbιphenyl-2-carboxamido)-N-methyl-N- (2- cyanophenyl)benzamide

NMR (CDCI3, δ) : 2.38 (3H, s), 3.48 (3H, s), 6.95- 7.00 (3H, m) , 7.14-7.54 (11H, m) , 7.60 (IH, d,

J=7Hz), 7.82 (IH, d, J=7Hz)

23) 4- ( ' -Methylbiphenyl-2-earboxamιdo) -N-methyl-N- [2- [3- ( 4-dimethylaminopιperιdm-l-yl ) carbonylammoprop-1- yloxy] phenyl] benzamide

NMR (CDCI3, δ) : 1.39 '2H, m) , 1.73-1.83 (4H, m) , 1.98 (2H, m) , 2.25 (6H, s), 2.37 (3H, s) , 2.74 (2H, m) , 3.32 (3H, s), 3.36 (2H, m) , 3.97 (2H, ) , 4.86 (IH, br) , 6.80-7.55 (15H, m) , 7.80 (IK, d, J=7Hz)

24) 4- (4 '-Chlorobiphenyl-2-carboxamido) -N-methyl-N- [2- [3- (4-methylpipera2in-l-yl) carbonylaminoprop-1- yloxy]phenyl]ben2amide

NMR (CDC1 ₃ , δ) : 1.99 (2H, m) , 2.28 (3H, s), 2.26 (4H, s), 3.33 (3H, s), 3.34-3.40 (6H, m) , 3.93

(2H, m) , 4.90 (IH, br) , 6.79-6.92 (2H, m) , 6.97- 7.10 (4H, ) , 7.14-7.57 (9H, m) , 7.75 (IH, d J=7H2)

25) 3-Methyl-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-phthalimidoprop-l-yloxy) phenyl] - benzamide NMR (CDCI3, δ) : 1.42 (3H, s), 2.20 (2H, ) , 2.34

(3H, s), 3.32 (3H, s), 3.86-4.02 (4H, m) , 6.73- 6.88 (2H, m) , 7.06-7.54 (11H, m) , 7.67-7.80 (2H, m) , 7.88-7.95 (2H, m) , 7.92 (IH, d, J=7H2)

26) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-phthalimidoprop-l-yloxy) phenyl] - benzamide

NMR (CDCI3, δ) : 2.19 (2H, m) , 2.22 (3H, s), 3.32

(3H, s), 3.40 (3H, s), 3.88-4.07 (5K, m) , 6.77- 6.95 (6H, m) , 7.10-7.18 (3H, m) , 7.26-7.53 (4H, m) , 7.63-7.72 (2H, m) , 7.76-7.82 (2H, m) , 8.18 (IH, d, J=7Hz)

27) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [(E) -6-methoxycarbonyl-l-hexen-l-yl]phenyl]benzamide NMR (CDCI3, δ) : 1.51 (2H, m) , 1.67 (2H, m) , 2.26 (2H, dt, J=7.5, 7.5Hz), 2.33 (2H, t, J*=7.5Hz),

2.33 (3H, s), 3.31 (3H, s), 3.66 (3H, s), 6.13 (IH, dt, J=15, 7.5Hz), 6.45 (IH, d, J=15Hz) , 6.85-6.93 (4H, m) , 7.05 (IH, dd, J=7, 7Hz), 7.10-7.17 (5H, m) , 7.26 (2H, d, J=8.5Hz), 7.33- 7.52 (3H, ) , 7.80 (IH, d, J=7Hz)

28) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N-[2-

[ (Z) -6-methoxycarbonyl-l-hexen-l-yl]phenyl]benzamide NMR (CDC1 ₃ , δ) : 1.36 (2H, m) , 7.53 (2H, m) , 1.90 (IH, m) , 2.10 (IH, m) , 2.28 (2H, d, J=7.5H2) , 2.35 (3H, s), 3.32 (3H, s) , 3.59 (3H, s), 5.69

(IH, dt, J=ll, 7.5Hz), 6.30 (IH, d, J=llHz) , 6.90 (2H, d, J=8.5H2), 7.01-7.42 (12H, m) , 7.50 (IH, t, J=7H2), 7.79 (IH, d, J=7H2)

29) 4- (4'-Methylbiρhenyl-2-carboxamido) -N-methyl-N- [2- (6- methoxycarbonylhex-1-yl) phenyl]ben2amide NMR (CDCI3, δ) : 1.25-1.39 (4H, m) , 1.46-1.63 (4H, ) , 2.26-2.27 (IH, m) , 2.29 (2H, t, J=7.5H2), 2.37 (3H, s), 2.49 (IH, m) , 2.36 (3H, s), 3.63 (3H, s), 6.92 (2H, d, J=8.5H2), 6.99-7.44 (12H, m) , 7.51 (IH, t, J=7H2), 7.80 (IH, d, J=7H2)

30) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [N- (3-ethoxycarbonylprop-l-yl) oxyimino]methylphenyl]- benzamide

NMR (CDCI3, δ) : 1.24 (3H, t, J=7.5Hz), 2.00 (2H, tt, J=7.5, 7.5Hz), 2.33 (3H, s), 2.40 (2H, t, J=7.5Hz), 3.34 (3H, s), 4.10 (2H, q, J=7.5Hz), 4.18 (2H, t, J=7.5Hz), 6.90-7.30 (11H, m) , 7.35- 7.51 (3H, ) , 7.68 (IH, d, J=7Hz) , 7.79 (IH, d,

J=7H2), 8.11 (IH, s)

31) 4- ( '-Methylbiphenyl-2-carboxamido) -N-methyl- [2- (5- ethoxycarbonylpent-1-ylthio)phenyl]benzamide NMR (CDCI3, δ) : 1.23 '3H, t, J=7.5Hz), 1.48 (2H, m) , 1.60-1.73 (4H, m) , 2.30 (2H, t, J=7.5Hz), 2.37 (3H, s), 2.89 (2H, m) , 3.31 (3H, s), 4.10 (2H, q, J=7.5Hz), 6.87-6.90 (4H, m) , 4.12-7.19 (4H, ) , 7.22-7.31 :4H, m) , 7.36-7.52 (3H, m) , 7.80 (IH, d, J=7Hz,

32) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (3- ethoxycarbonylprop-1-yloxy)phenyl] benzamide NMR (CDC1 ₃ , δ) : 1.24 (3H, t, J=7.5Hz), 2.09 (2H, m) , 2.33 (3H, s), 2.49 (2H, t, J=7.5Hz), 3.31 (3H, s), 3.96 (2H, m) , 4.13 (2H, q, J=7.5Hz),

6.74-6.81 (2H, m) , 6.86-6.98 (4H, m) , 7.10-7.21 (4H, m) , 7.23-7.31 (2H, ) , 7.35-7.53 (3H, m) , 7.82 (IH, d, J=7Hz)

33) 4- (4 ^l -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- ethoxycarbonylpent-l-yloxy)pyrid-3-yl]benzamide NMR (CDCI3, δ) : 1.20 (3H, t, J=7.5Hz), 1.50 (2H, m) , 1.57-1.73 (4H, m) , 2.28 (2H, t, J=7.5Hz), 2.36 (3H, s), 3.30 (3H, s), 3.91 (2H, t, J=7.5HZ), 4.06 (2H, q, J=7.5Hz), 5.98 (IH, dd,

J=7, 7Hz), 6.96-7.03 (3H, m) , 7.07-7.14 (2H, ) , 7.18 (2H, d, J=8.5Hz), 7.23-7.31 (3H, m) , 7.39- 7.55 (3H, m) , 7.82 (IH, d, J=7Hz)

34) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [3- (5- ethoxycarbonylpent-1-yloxy)pyrid-2-yl]benzamide NMR (CDCI3, δ) : 1.25 (3H, t, J=7.5Hz), 1.42 (2H, m) , 1.60-1.78 (4H, m) , 2.33 (2H, m) , 2.40 (3H, s), 3.40 (3H, s) , 3.70 (2H, ) , 4.12 (2H, q, - J=7.5Hz), 6.88-7.53 (13H, m) , 7.81 (IH, d,

J=7.5Hz), 8.02 (IH, d, J=7Hz)

35) 3-Methyl-4- ( ' -methylbiphenyl-2-carboxamido) -N- methyl-N- (4-chloro-2-ber_zyloxyphenyl) benzamide NMR (CDC! ₃ , δ) : 1.37 '3H, s), 2.34 (3H, s), 3.30

(3H, s), 4.97 (2H, m) , 6.77-6.99 (5H, ) , 7.02 (IH, s), 7.18 (2H, d, J=8.5Hz), 7.29-7.54 (10H, ) , 7.83 (IH, d, J=7Hz) , 7.99 (IH, d, J=7Hz)

36) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [4-

ethy1-2- (5-methoxycarbonylpyrid-2-ylmethoxy)phenyl] - benzamide

NMR (CDC1 ₃ , δ) : 2.28 (3H, s), 2.47 (3H, s) , 3.33

(3H, s), 3.99 (3H, s), 5.28 (2H, s), 6.58 (7H, d) , 6.71-6.79 (2H, m) , 6.85-6.94 (3H, m) , 7.16-

7.23 (4H, ) , 7.31 (2H, d, J=8.5Hz), 7.35-7.58

(3H, m) , 7.82 (IH, d, J=lEz) , 8.50 (IH, ) , 9.11

(IH, m)

37) 4- (4'-Nitrobiphenyl-2-carboxamido) -N-methyl-N- [2- (5- methoxycarbonylpyrid-2-ylmethoxy)phenyl]benzamide NMR (CDCI3, δ) : 3.31 (3H, s) , 3.98 (3H, s), 5.30

(2H, s), 6.78 (IH, dd, J=7, 7Hz) , 6.87-6.95 (2H, m) , 7.03-7.27 (6H, m) , 7.42 (IH, d, J=7Hz) , 7.48-7.63 (4H, ) , 7.71 (IH, d, J=7Hz), 9.21

(2H, d, J=8.5Hz), 8.51 (IH, ) , 9.10 (IH, m)

38) 3-Methoxy-4- (4 '-nitrobiphenyl-2-carboxamido) -N- methyl-N- [4-methyl-2- [6- (4-methylpiperazin-l-yl)hex- 1-yloxy]phenyl]benzamide

NMR (CDCI3, δ) : 1.28-1.59 (8H, m) , 1.69-1.88 (2H, m) , 2.27 (6H, s) , 2.27-2.65 (8H, m) , 3.28 (3H, s), 3.50 (3H, s), 3.75-4.00 (2H, m) , 6.51-6.66 (2H, m) , 6.74-6.91 (3H, m) , 7.42 (IH, d, J=9Hz) , 7.48-7.62 (4H, m) , 7.67-7.80 (2H, m) , 8.08 (IH, d, J=9Hz), 8.19 (2H, d, J=9Hz)

39) 4- (2-Phenylpyridine-3-carboxamido) -N- (4-chioro-2- benzyloxyphenyl ) -N-methylbenzamide NMR (CDCI3, δ) : 3.30 :3H, s) , 4.88-5.10 (2H, ) ,

6.77-7.03 (6H, m) , 7.14 (2H, d, J=9Hz) , 7.30- 7.47 (9H, ) , 7.59-7.68 (2H, m) , 8.14 (IH, d, J=9Hz), 8.73-8.80 IH, m)

40) 4- ( '-Methylbiphenyl-2-carboxamido) -N- [2-benzyloxy-4-

chlorophenyl] -N-methylbenzamide

NMR (CDCI3, δ) : 2.36 (3H, s) , 3.32 (3H, s), 4.86-

5.10 (2H, m) , 6.77-6.99 (6H, m) , 7.08-7.22 (4H, ) , 7.23-7.56 (10H, ) , 7.83 (IH, d, J=8Hz)

41) 2-Chloro-4- (4 '-methylbiphenyl-2-carboxamido) -N- [2- benzyloxy-4-chlorophenyI]-N-methylbenzamide

NMR (CDCI3, δ) : 2.40 (3H, s), 3.34 (3H, s) , 4.96-

5.11 (2H, ) , 6.69-6.99 (5H, ) , 7.06 (IH, d, J=9Hz), 7.14-7.59 (12H, m) , 7.76-7.91 (IH, m)

42) 2-Chloro-4- (4 '-methylbiphenyl-2-carboxamido) -N- [2- (5- ethoxycarbonylpent-1-yloxy)phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz), 1.45-1.60 (2H, m) , 1.66-1.79 (2H, m) , 1.79-1.94 (2H, m) , 2.35

(2H, t, J=7Hz), 2.36 (3H, s) , 3.33 (3H, s), 3.96 (2H, t, J=7Hz), 4.13 (2H, q, J=7Hz) , 6.65-6.79 (3H, m) , 6.81-7.00 (3H, m) , 7.00-7.56 (9H, m) , 7.89 (IH, d, J=9Hz)

43) 3-Methoxy-4- (2'-methylbiphenyl-2-carboxamido) -N- [2- (5-ethoxycarbonylpent-l-yloxy) -4-methylphenyl] -N- methylbenzamide

NMR (CDCI3, δ) : 1.24 (3H, t, J=7Hz), 1.40-1.56 (2H, m) , 1.56-1.86 (4H, m) , 2.12 (3H, s), 2.27 (3H, s), 2.32 (2H, t, J=7Hz), 3.28 (3H, s), 3.46 (3H, s), 3.69-3.98 (2H, m) , 4.12 (2H, q, J=7Hz) , 6.49-6.63 (2H, m) , 6.70-6.88 (3H, m) , 7.14-7.29 (4H, m) , 7.40-7.56 .2H, m) , 7.75 (IH, br s), 7.94 (IH, d, J=9Hz, , 8.16 (IH, br d, J=9H2)

44) 4- (2 ' , 4 '-Dimethylbiphenyl-2-carboxamido) -3-methoxy-N- [2- (5-ethoxycarbonylpent-l-yloxy) -4-methylphenyl] -N- methylbenzamide NMR (CDC1- ₅ , δ) : 1.26 ;3H, t, J=7Hz) , 1.41-1.56 (2H,

m) , 1.60-1.89 (4H, m) , 2.06 (3H, s), 2.28 (3H, s), 2.33 (3H, s), 2.33 (2H, t, J=7Hz) , 3.29 (3H, s), 3.48 (3H, s), 3.73-3.99 (2H, m) , 4.13 (2H, q, J=7Hz), 6.49-6.54 (2H, m) , 6.70-6.89 (3H, m) , 5 6.98-7.08 (2H, ) , 7.12 (IH, d, J=9Hz) , 7.21

(IH, d, J=9Hz), 7.41-7.56 (2K, m) , 7.81 (IH, s) , 7.96 (IH, d, J= 9Hz), 8.19 (IH, d, J=9Hz)

45) 3-Methoxy-4- (4'-nitrobiphenyl-2-carboxamido) -N- [2- (5- 10 ethoxycarbonylpent-1-yloxy) -4-methylphenyl] -N- methylbenzamide

NMR (CDC1 ₃ , δ) : 1.26 (3H, t, J=7Hz) , 1.41-1.57 (2H, m) , 1.62-1.87 (4H, m) , 2.30 (3H, s) , 2.33 (2H, t, J=7Hz), 3.29 (3H, s) , 3.51 (3H, s), 3.75-3.99 15 (2H, m) , 4.13 (2H, q, J=7Hz) , 6.52-6.65 (2H, m) ,

6.76-6.92 (3K, m) , 7.42 (IH, d, J=8Hz) , 7.49- 7.62 (4H, m) , 7.70-7.80 (2H, m) , 8.08 (IH, d, J=8Hz), 8.19 (2H, d, J=8Hz)

20 46) 4- (4 '-Nitrobiphenyl-2-carboxamido) -N- (2-benzyloxy-4- methylphenyl) -N-methylbenzamide NMR (CDCI3, δ) : 2.28 (3H, s), 3.33 (3H, s), 4.93

(IH, d, J=llHz), 5.05 (IH, d, J=llHz) , 6.63 (IH, d, J=9Hz), 6.70 (IH, s), 6.88 (IH, d, J=9Hz) , 25. 7.02-7.13 (3H, ) , 7.17-7.28 (2H, m) , 7.24-7.46

(5H, ) , 7.46-7.65 (4H, m) , 7.71 (IH, d, J=9Hz) , 8.21 (2H, d, J=9Hz,

47) 4- (2-Prop-2-ylbenzamido -N-methyl-N- [2- [3- (4- 30 methylpiperazin-1-yl) carbonylammoprop-1- yioxy] phenyl ] benzamide

NMR (CDCI3, δ) : 1.27 ^' 6H, d, J=7Hz), 2.02 (2H, m) , 2.28 (3H, s), 2.36 (4H, m) , 3.27-3.43 (7H, ) , 3.33 (3H, s), 3.98 (2H, m) , 4.88 (IH, br) , 35 6.79-6.91 (2H, ) , 7.02-7.23 (3H, m) , 7.30-7.42

( 6H, m) , 7 . 52 ( IH, m)

48) 4-(2-Methylbenzamido) -N-methyl-N- [2- [3- (4- methylpiperazin-1-yl) carbonylaminoprop-1- yloxy]phenyl]benzamide

NMR (CDC1 ₃ , δ) : 2.01 (2H, m) , 2.28 (3H, s), 2.34 (4H, m) , 2.46 (3H, s) , 3.30-3.40 (6H, m) , 3.32 (3H, s), 3.96 (2H, m) , 4.88 (IH, br) , 6.81-6.90 (2H, m) , 7.04-7.22 (3H, m) , 7.31-7.45 (6H, m) , 7.61 (IH, br)

49) 4- (2, 3-Dimethylbenzamido) -N-methyl-N- [2- [3- (4- methylpiperazin-1-yl) carbonylaminoprop-1- yloxy]phenyl]benzamide NMR (CDCI3, δ) : 2.00 (2H, m) , 2.27 (3H, s), 2.29

(3H, s), 2.32 (4H, m) , 3.30 (3H, s), 3.35 (6H, ) , 3.93 (2H, m) , 4.97 (IH, br) , 6.78-6.89 (2H, ) , 7.05-7.48 (8H, m) , 7.78 (IH, m)

50) 4- (l,2-Dimethylphenyl-3-carboxamido)-N- (2- benzyloxyphenyl) -N-methylbenzamide

NMR (CDCI3, δ) : 2.29 (3H, s) , 2.33 (3H, s), 3.37 (3H, s), 4.94-5.13 (2H, m) , 6.78-6.93 (2H, m) , 7.01-7.52 (15H, m) *

51) 2-Chloro-4- (methylphenyi-2-carboxamido) -N- [2- (5- ethoxycarbonyipent-1-yloxy)phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.47-1.63 (2H, m) , 1.66-1.80 (2H, m) , 1.80-1.95 (2H, m) , 2.35 (2K, t, J=7Hz), 2.44 (3H, s), 3.34 (3H, s), 3.99

(2H, t, J=7Hz), 4.13 (2H, q, J=7Hz), 6.69-6.81 (2H, m) , 7.02-7.42 (8H, ) , 7.51 (IH, s), 7.67 (IH, s)

52) 4- (Methylphenyl-2-carbcxamido) -N- (2-benzyloxy-4-

chlorophenyl) -N-methylbenzamide

NMR (CDCI3, δ) : 2.47 (3H, s), 3.34 (3H, s), 4.91-

5.11 (2H, m) , 6.83 (IH, d, J=9Hz), 6.89 (IH, s) , 6.98 (IH, d, J=9Hz), 7.17-7.51 (13H, m) 5

53) 4-(4'-Methylbiphenyl-2-carboxamido)-N-methyl-N-[2-{3- (4-methyl-l-piperazinyl) carbonylaminoprop-1- yloxy.phenyl]benzamide

NMR (CDCI3, δ) : 1.93-2.02 (2H, ) , 2.28 (3H, s), 10 2.33-2.40 (7H, ) , 3.33 (3H, s) , 3.34-3.40 (6H, m) , 3.87-3.98 (I , br) , 4.82-4.88 (IH, br) , 6.80-6.96 (4H, m) , 7.06-7.34 (8H, m) , 7.38-7.56 (3H, m) , 7.83 (IH, d, J=8Hz)

15 54) 4- (4 '-Methylbiphenyl) -2-carboxamido) -N-methyl-N- (4- chlorophenyl)benzamide mp : 153-155°C

NMR (CDC1 ₃ , δ) : 2.39 (3H, s), 3.45 (3H, s), 6.90- 7.00 (5H, m) , 7.12-7.58 (10H, m) , 7.85 (IH, dd, 20 J=l, 9Hz)

55) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (3- methoxyphenyl)benzamide mp : 147-150°C 25. NMR (CDCI3, δ) : 2.38 and 2.40 (total 3H, s) , 3.47

(3H, s), 3.69 (3H, s) , 6.51-6.64 (2H, m) , 6.70 (IH, dd, J=l, 8Hz) , 6.88-7.00 (3H, ) , 7.05-7.59 (9H, ) , 7.83 (IH, dd, J=l, 9Hz)

30 56) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (4- methoxyphenyl)benzamide mp : 170-173°C

NMR (CDCI3, δ) : 2.35 (3H, s), 3.41 (3H, s), 3.78

(3H, s), 6.75 (2H, d, J=9Hz), 6.88-7.00 (5H, m) , 35 7.14-7.58 (8H, m) , 7.81 (IH, dd, J=i, 8Hz)

57) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (3- chlorophenyl)benzamide mp : 115-118 ^β C

NMR (CDC1 ₃ , δ) : 2.38 (3H, s), 3.45 (3H, s), 6.82- 7.58 (15H, m) , 7.83 (IH, dd, J=l, 9Hz)

58) 4- (4 '-Methylbiphenyl-2-carboxamido) -N- ethoxycarbonylmethyl-N- (2-methylphenyl)benzamide mp : 72-75°C

NMR (CDCI3, δ) : 1.30 (3H, t, J=8Hz) , 2.22 (3H, s) , 2.38 (3H, s), 4.00 (IH, d, J=17Hz) , 4.24 (2H, q, J=8Hz), 4.82 (IH, d, J=17Hz), 6.84-6.96 (3H, ) , 7.05-7.58 (12H, m) , 7.80 (IH, d, J=8Hz)

59) 4- (4'-Methylbiphenyl-2-carboxamido)-N-benzyl-N- (2- methylphenyl)benzamide mp : 90-95°C

NMR (CDCI3, δ) : 1.86 (3H, s), 2.36 and 2.41 (total 3H, s), 4.70 (IH, d, J=15Hz), 5.28 (IH, d, J=15Hz), 6.80-7.60 (20H, m) , 7.80 (IH, d, J=6Hz)

60) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- trifluoromethylphenyl) enzamide mp : 90-93°C - NMR (CDCI3, δ) : 2.38 (3H, s), 3.30-3.42 (3K, br s),

6.85-7.00 (2H, br; , 7.10-7.55 (12H, m) , 7.60-7.70 (IH, br d, J=8Hz), 7.79-7.89 (IH, br d, J=8Hz)

61 ) 3-Methyl-4- ( ' -methylbiphenyl-2-carboxamido) -N- methyl-N- (2-methylphenyl) benzamide mp : 148-153°C

NMR (CDCI3, δ) : 1.40 (3H, s), 2.19 (3H, s) , 2.34 and 2.40 (total 3H, s), 3.35 (3H, s), 6.79 (IH, s) , 6.88-7.57 (12H, ) , 7.79 (IH, d, J=6Hz) , 7.90 (IH, d, J=9Hz)

62 ) N-Ethyl-N- (3-pentyl) -4- (4 '-methylbiphenyl-2- carboxamido)benzamide mp : 140-143°C

NMR (CDC1 ₃ , δ) : 0.85 (6H, t, J=8Hz), 0.90-1.05 (2H, br), 1.30 (3H, t, J=7Hz) , 1.38-1.60 (2H, m) ,

2.40 (3H, s), 3.15-3.52 (3H, m) , 7.00 (IH, s), 7.10-7.60 (10H, ) , 7.88 (IH, dd, J=l, 8Hz)

63) 4- (4 '-Methylbiphenyl-2-carboxamido) -3-methoxy-N- methyl-N- (2-methylphenyl)benzamide mp : 203-206°C

NMR (CDCI3, δ) : 2.20 (3H, s), 2.35 (3H, s), 3.34

(3H, s), 3.36 (3H, s) , 6.75-6.82 (2H, m) , 7.00- 7.34 (6H, m) , 7.35-7.57 (4H, m) , 7.68 (IH, s) , 7.79 (IH, d, J=7Hz), 8.18 (IH, d, J=10Hz)

64) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2, 6- dimethylphenyl)ben2amide mp : 225-228°C NMR (CDCI3, δ) : 2.17 (6H, s) , 2.36 (3H, s) , 3.30

(3H, s), 6.85-7.58 (14H, m) , 7.80 (IH, d, J=8H2)

65) N-Methyl-N- (4-tetrahydro-4H-pyranyl) -4- (4'- methylbiphenyl-2-carboxamido)ben2amide mp : 178-182°C

NMR (CDCI3, δ) : 1.56-1.75 (4H, br) , 1.80-2.00 (2H, ) , 2.40 (3H, s), 2.90 (3H, s) , 3.30-3.60 (IH, br), 3.95-4.10 (2H, m) , 7.05 (IH, s), 7.12-7.60 (10H, m) , 7.88 (IH, d, J=8Hz)

66) 4- (4 '-Methylbιphenyi-2-carboxamido) -N-methyl-N- (2- ethoxycarbonylmethoxyphenyl)benzamide

NMR (CDCI3, δ) : 1.29 '3H, t, J=8H2) , 2.37 (3H, s), 3.38 (3K, s), 4.26 (2H, q, J=8Hz), 4.60 (2H, s), 6.67 (IH, d, J=8HZ _' , 6.78-6.97 (4H, m) , 7.09-

7.34 (7H, m) , 7.36-7.55 (4H, ) , 7.82 (IH, d, J=8Hz)

67) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- methoxycarbonylmethylphenyl)benzamide NMR (CDC1 ₃ , δ) : 2.37 (3H, s), 3.36 (3H, s) , 3.40

(3H, s), 3.68 and 3.84 (total 2H, s), 6.90 (2H, d, J=8Hz), 7.08-7.30 (11H, ) , 7.37-7.52 (3H, m) , 7.82 (IH, d, J=8H2)

10

68) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [ (2- ethoxycarbonylmethyl-4-methyl)phenyl]benzamide

NMR (CDCI3, δ) : 1.30 (3H, t, J=8Hz) , 2.27 (3H, s) , 2.37 (3H, s), 3.35 (3H, s) , 4.26 (2H, q, J=8Hz) , 15 4.57 (2H, s), 6.47 (IH, s) , 6.60 (IH, d, J=8Hz) ,

6.78-6.96 (3H, m) , 7.17-7.32 (7H, m) , 7.36-7.55 (3H, m) , 7.83 (IH, d, J=8Hz)

69) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- 20 methyl-N- (2-ethoxycarbonylmethoxyphenyl) benzamide

NMR (CDCI3, δ) : 1.28 (3H, t, J=7Hz) , 2.34 (3H, s) ,

3.39 (3H, s), 3.40 and 3.42 (total 3H, s), 4.20-

4.29 (2H, m) , 4.59 (2H, s), 6.69-6.93 (5H, m) , 7.10-7.18 (3H, m) , 7.26-7.31 (2H, m) , 7.36-7.52

25. (3H, ) , 7.67-7.69 (IH, br s), 7.79 (IH, d,

J=8Hz), 8.16-8.20 (IH, m)

70) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [4-methyl-2- [3- (4-methyl-l-

30 piperazinyl) carbonylammoprop-1- yloxy ] phenyl ] benzamide NMR (CDCI3, δ) : 1.95-2.02 (2H, ) , 2.28 (3H, s),

2.30 (3H, s), 2.35-2.49 (7H, m) , 3.25-3.45 (9H, m) , 3.30 (3H, s), 3.80-3.98 (2H, m) , 4.75-4.82

35 (IH, ) , 6.60-6.92 (6H, m) , 7.12-7.54 (8H, m) ,

7.80 (IH, d, J=8Hz)

71) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- benzyloxy-4-methylphenyl)benzamide NMR (CDC1 ₃ , δ) : 2.28 (3H, s) , 2.36 (3H, s), 3.34 (3H, s), 4.94 (IH, d, J=llHz) , 5.04 (IH, d, J=llHz), 6.62 (IH, d, J=9Hz) , 6.68 (IH, br s) , 6.84-6.96 (4H, m) , 7.17 (4H, d, J=9H2) , 7.25- 7.56 (10H, m) , 7.84 (IH, d, J=9Hz)

72) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- benzyloxy-5-methylphenyl)benzamide

NMR (CDC1 ₃ , δ) : 2.19 (3H, s) , 2.35 (3H, s), 3.34 (3H, s), 4.89 (IH, d, J=llHz) , 5.01 (IH, d, J=llHz), 6.73 (IH, d, J=9H2) 6.82-6.99 (5H, ) ,

7.14-7.24 (4H, ) , 7.24-7.56 (10H, m) , 7.83 (IH, d, J=9H2)

73) 4- (Biphenyl-2-carboxamido) -N-methyl-N- (2- ben2yloxyphenyl)ben2amide

NMR (CDCI3, δ) : 3.35 (3H, s) , 4.95 (IH, br d,

J=11H2), 5.06 (IH, br d, J=llHz) , 6.76 (5H, m) , 7.02 (IH, br d, J=9Hz) , 7.08-7.21 (3H, m) , 7.27- 7.58 (13H, m) , 7.83 (IH, d, J=9Hz)

74) 3-Methoxy-4- (4 ' -methylb phenyl-2-carboxamιdo) -N- methyl-N- (2-hydroxy-4-methylphenyl) benzamide

NMR (CDCI3, δ) : 2.22 (3H, s), 2.31 (3H, s) , 3.30 (6H, s), 6.46-6.60 (IH, m) , 6.64-6.82 (2H, m) , 6.87-7.04 (2K, ) , 7.12 (2H, d, J=9Hz) , 7.27

(2H, d, J=9Hz), 7.34-7.46 (2H, m) , 7.50 (IH, dd, J=9, 9Hz), 7.70 (IH, br s), 7.78 (IH, d, J=9Hz), 8.14-8.30 (IH, m)

75) 3-Methoxy-4- ( ' -methylb phenyl-2-carboxamιdo) -N-

methyl-N- (2-hydroxyphenyl) benzamide

NMR (CDCI3, δ) : 2.31 (3H, s), 3.34 (6H, br s) ,

7.64-7.06 (4H, m) , 7.06-7.22 (3H, m) , 7.22-7.33 (3H, m) , 7.33-7.58 (3H, m) , 7.69 (IH, or s) , 7.79 (IH, d, J=9Hz), 8.16-8.35 (IH, br s)

76) 4- (Bιphenyl-2-carboxamιdo) -3-methoxy-N-methyl-N- (2- hydroxy-4-methylphenyl)benzamide

NMR (CDCI3, δ) : 2.23 (3H, s), 3.22-3.46 (6H, m) , 6.47-7.02 (5H, m) , 7.25-7.58 (7H, m) , 7.67 (IH, br s), 7.80 (IH, br d, J=9Hz) , 8.19 (IH, br d, J=9Hz)

77) 3-Methoxy-4- (4 '-methylbιphenyl-2-carboxamιdo) -N- methyl-N- (2-benzyloxy-4-chlorophenyl)benzamide

NMR (CDCI3, δ) : 2.32 (3H, s), 3.28 (3H, s) , 3.33 (3H, s), 4.78-5.12 (2H, ) , 6.71-6.81 (2H, m) , 6.81-6.91 (2H, m) , 7.00 (IH, d, J=9Hz) , 7.14 (2H, d, J=9Hz), 7.24-7.55 (10H, m) , 7.69 (IH, s), 7.81 (IH, d, J=9Hz) , 8.19 (IH, d, J=9Hz)

78) 4- (Methylphenyl-2-carboxamιdo) -N-methyl-N- (2- benzyloxy-4-methylphenyi)benzamide

NMR (CDCI3, δ) : 2.26 (3H, s), 2.46 (3H, s), 3.34 (3H, s), 4.96 (IH, d, J=12Hz) , 5.06 (IH, d,

J=12Hz), 6.64 (IH, d, J=9Hz), 6.71 (IH, s), 6.92 (IH, d, J=9Hz), 7.14-7.57 (14H, m)

Example 3 To a solution of N- (4-ar obenzoyl) -N-cyclopentyl-p- anisid e (870 mg) and pyric e (443 mg) in dichloromethane (20 ml) was added o-toluoyl chloride (868 mg) at 0°C. Tne the mixture was stirred for 3 hours at ambient temperature. The reaction mixture was concentrated and diluted w tn ethvl acetate and the

solution was washed with water, IN-hydrochloric acid and brine. The organic layer was dried over magnesium sulfate and filtered. The filtrate was concentrated and purified by silica gel column chromatography (S1O2 20 g, ethyl acetate:n-hexane = 1:2) . The eluent was concentrated and triturated with diethyl ether to give N-cyciopentyl-N-[4- (2-methylbenzoylammo)benzoyl] -p-anisidme (750 mg) .

NMR (CDCI3, δ) : 1.32-1.72 (6H, ) , 1.88-2.08 (2H, m) , 2.46 (3H, s), 3.76 (3H, s) , 4.85-5.09 (IH, m) , 6.77 (2H, d, J=8Hz) , 6.96 (2H, d, J=8Hz) ,

7.17-7.53 (9H, )

Example 4

To a solution of 6- [2- (4-methylphenyl)benzoyl) - ammonicotmic acid (333 mg) in dichloromethane (15 ml) were added oxalyl chloride (0.139 ml) and a few drop of N,N-dιmethylformamιde and the solution was stirred at ambient temperature for 2 hours. The solvent was evaporated in vacuo to give an acid chloride as an oil and the oil was added to a mixture of N-methyl-o-toluidme

(121 mg) and triethylamine (0.168 mg) in dichloromethane (15 ml) . The mixture was stirred at ambient temperature for 2 hours and washed successively with IN hydrochloric acid, water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was subjected to silica gel column (30 g, 1% methanol in chloroform) to give an oil. The oil was solidified with diethyl ether to give 2- (4 '-methylbιphenyl-2- carboxamido) -N-methyl-N- (2-methylphenyl) -5- pyridmecarboxamide (112 mg) .

NMR (CDCI3, δ) : 2.16 '3H, s), 2.29 (3H, s), 3.35 (3H, s), 6.98-7.27 (8H, m) , 7.34-7.44 (2H, ) , 7.48-7.57 (2H, m) , 7.65 (IH, m) , 7.88 (IH, s), 8.03 (2H, d, J=8.5Hz)

Example 5

To a mixture of 4- [2- (4-methylphenyl)benzoyl] - aminobenzoic acid (166 mg) and triethylamine (0.07 ml) in dichloromethane (10 ml) was added diphenylphosphoryl chloride (130 mg) and the solution was stirred at ambient temperature for 1 hour. To the resulting solution were added triethylamine (0.07 ml) and N-methylcyclohexylamine (56.6 mg) and the solution was stirred at ambient temperature for 4 hours. The solution was washed successively with IN hydrochloric acid, saturated aqueous sodium hydrogen carbonate and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was subjected to silica gel column (10 g, 1% methanol in chloroform) to give 4-(4'- methylbiphenyl-2-carboxamido) -N-methyl-N- cyclohexylbenzamide (102 g) as a colorless amorphous.

NMR (CDC1 ₃ , δ) : 1.08-1.88 (7H, m) , 1.64 (3H, s), 2.38 (3H, s), 2.75-2.97 (3H, s) , 3.47 (IH, m) , 7.02 (IH, s), 7.13-7.57 (9H, m) , 7.90 (IH, dd, J=l, 8Hz)

Example 6

A solution of 4- (4 *-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-ethoxycarbonylphenyl)benzamide (500 mg) in a mixture of ethanol (20 ml) and IN sodium hydroxide (2 ml) was heated at reflux for 4 hours and ethanol was evaporated in vacuo. Water (5 ml) was added to the residue and the aqueous solution was adjusted to pH 2 with IN hydrochloric acid. The precipitate was filtered to give 4- (4 '-methylbiphenyl-2-carboxamido) -N-methyl-N- (2- carboxyphenyl) benzamide (435 mg) as a white powder.

NMR (CDCI3 ^■ * ^■ CD3OD, δ) : 2.31 (3H, s), 3.41 (3H, s), 7.00 (2H, d, J=8.5Hz), 7.08-7.55 (13H, m) , 7.68 (IK, d, J=8Hz), 7.83 (IH, d, J=8Hz)

Example 7

To a solution of 4- (4 ' -methylbiphenyl-2-carboxamido) - N-methyl-N- (2-ben2oyloxyphenyl)ben2amide (350 mg) in methanol (10 ml) was added potassium carbonate (89.5 mg) and the mixture was stirred at ambient temperature overnight. Chloroform was added to the mixture and the solution was washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was subjected to silica gel column (30 g, 1% methanol in chloroform) to give an oil. The oil was solidified with diethyl ether to give 4— ( '— methylbiphenyl-2-carboxamido) -N-methyl-N- (2- hydroxyphenyl)benzamide (228 mg) as a white powder.

NMR (CDC1 ₃ , δ) : 2.33 (3H, s) , 3.32 (3H, s) , 6.70- 6.93 (4H, m) , 7.05-7.28 (9H, m) , 7.33-7.53 (4H, m) , 7.83 (IH, d, J=8Hz)

Example 8

A mixture of 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-phthalimidopropyloxy)phenyl]benzamide (545 mg) and hydrazine hydrate (0.212 ml) in ethanol (20 ml) was refluxed for 4 hours. After removal of insoluble material, the filtrate was evaporated in vacuo to give an oil and the oil was subjected to a silica gel column (5% - methanol in chloroform) to give 4- (4 '-methylbiphenyl-2- carboxamido) -N-methyl-N- [2- ' ^' 3-aminopropyloxy) - phenyl]benzamide (425 mg) .

NMR (CDCI3, δ) : 1.93 (2H, tt, J=7.5, 7.5Hz), 2.34 (3H, s), 2.92 (2K, t, J=7.5Hz), 3.31 (3H, s) , 3.98 (2H, m) , 6.73-6.83 (2H, ) , 6.90-7.01 (4H, ) , 7.09-7.54 (9H, m) , 7.79 (2H, m)

Example 9

To a solution of 4- (4 ' -methylbiphenyl-2-carboxamido) - N-methyl-N- (2-carboxyphenyl, enzamide (232 mg) in

dichloromethane (10 ml) were added oxalyl chloride (0.069 ml. and a few drop of N,N-dιmethylformamιde and the solution was stirred at amoient temperature for 2 nours. Dichloromethane was evaporated in vacuo to give an acid cnloride and cone, ammonia (5 ml) was added to the acid chloride. The mixture was stirred at ambient temperature for 1 hour and the precipitated solid was filtered. The solid was dissolved in chloroform and the solution was subjected to silica gel column (20 g, 2% methanol in cnloroform) . The product was solidified with diethyl ether to give 4- ( '-methylbιphenyl-2-carboxamιdo) -N- methyl-N- (2-carbamoylphenyl)benzamide (118 g) as a white powder.

NMR (CDC1 ₃ , δ) : 2.38 (3H, s) , 3.73 (3H, s) , 7.22- 7.60 (16H, m) , 7.78 (IH, m) , 7.90 (IH, dd, J=l,

8Hz), 8.39 (IH, dd, J=l, 8Hz)

Example 10

A mixture of 4- (4 '-methylbιphenyl-2-carboxamιdo) -N- methyl-N- (2-carboxyphenyl)benzamide (232 mg) , dipnenylphosphoryl azide (151 mg) , and triethylamine (0.084 ml) m benzene (10 ml) was refluxed for 5 hours and IN hydrochloric acid (4 ml) was added to the solution. The mixture was refluxed for 4 hours and the mixture was washed with aqueous saturated sodium hydrogen carbonate and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give crude oil. The oil was purified by silica gel column (10 g, 21 methanol in chloroform) and the product was solidified with diethyl etner to give 4-(4'- metnylbιphenyl-2-carboxamidc) -N-metnyl-N- (2- am ophenyl)benzamide (120 mg) .

NMR (CDCI3, δ) : 2.2C (3H, s), 3.34 (3H, s), 6.96- 7.57 (17H, m) , 9.C5 (2H, br)

Example 11

A solution of 4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- (2-allylphenyl) benzamide (100 g) and 10% palladium on carbon (20 mg) in methanol (15 ml) was stirred under an atmospheric pressure of hydrogen at ambient temperature. After 3 hours, the reaction mixture was filtered through a bed of Celite, concentrated and then triturated from ^' diethyl ether to give 4- (4 '- methylbiphenyl-2-carboxamido) -N-methyl-N- (2- propylphenyl)benzamide (70 mg) .

NMR (CDC1 ₃ , δ) : 0.95 (3H, t, J=7Hz) , 1.35-1.77 (2H, m) , 2.22-2.61 (2E, m) , 2.36 (3H, s) , 3.37 (3H, s), 6.80-6.98 (3K, m) , 6.99-7.60 (13H, m) , 7.81 (IH, d, J=8Hz)

Fx&mple 12

A solution of 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (5-carboxy-l-pentenyl)phenyl]benzamide (150 mg) in ethanol (10 ml) was shaken under hydrogen atmosphere (3 atm.) in the presence of 10% palladium on carbon (50 mg) for 4 hours. The catalyst was filtered off and the filtrate was evaporated in vacuo and the residue was subjected to silica gel column (2% methanol in chloroform) to give 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (5-carboxypentyl)phenyl]benzamide (150 mg) . NMR (CDCI3, δ) : 1.28-1.46 (3H, m) , 1.53-1.60 (3H, m) , 2.25-2.68 (4H, m) , 2.37 (3H, s) , 3.34 (3H, s), 6.92 (2H, d, J=8.5Hz), 7.02-7.52 (14H, ) , 7.77 (IH, d, J=8Kz)

Example 13

To a solution of 4- (4 '-methylbiphenyl-2-carboxamido) - N-methyl-N- (2-acetylphenyl) benzamide (200 mg) in methanol (15 ml) was added sodium borohydride (16.4 mg) and the solution was stirred at ambient temperature for 3 hours.

Chloroform was added to the mixture and the solution was washed successively with water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give a syrup and the crude product was purified by silica 5 gel column (chloroform) to give 4- (4 '-methylbiphenyl-2- carboxamido) -N-methyl-N- [2- (1-hydroxyethyl)phenyl] - benzamide (150 mg) as a white solid.

NMR (CDC1 ₃ , δ) : 1.12 (3H x 1/3, d, J=7Hz) , 1.41

(3H x 2/3, d, J=7Hz), 2.35 (3H, s), 2.35 (3H x 10 2/3, s), 3.42 (3H x 1/3, s) , 4.91 (IH, m) , 6.84-

6.95 (2H,, m) , 7.10-7.54 (14H, m) , 7.82 (IH, d, J=8Hz)

Example 14

15 A solution of 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-ethoxycarbonylphenyl)benzamide (493 mg) in tetrahydrofuran (20 ml) was cooled in an ice bath. Lithium aluminum hydride (IM solution in tetrahydrofuran, 2.5 ml) was added dropwise to the solution and the mixture

20 was stirred at the same temperature for 2 hours. Water was slowly added to the solution and resulting mixture was acidified with IN hydrochloric acid. The solution was extracted with chloroform and the organic solution was washed with water and brine, and dried over magnesium

25. sulfate. The solvent was evaporated in vacuo and the residue was subjected to silica gel column (20 g, 2% methanol in chloroform) . The product was solidified with diethyl ether to give 4- ( ' -methylbiphenyl-2-carboxamido) - N-methyl-N- (2-hydroxymethylphenyl)benzamide (245 mg) as a

30 white powder.

NMR (CDCI3 + CD3OD, δ) : 2.31 (3H, s), 3.35 (3H, s), 4.42 (IH, d, J=I3Kz), 4.57 (IH, d, J=13Hz), 6.99-7.68 (17H, m ^*

35 Example 15

A mixture of 4- ( '-methylbιphenyl-2-carboxamιdo) -N- methyl-N- (2-hydroxymethylpnenyl)benzamide (100 mg) and acetic anhydride (34 mg) in pyridme (5 ml) was stirred at ambient temperature for 3 days and the solvent was evaporated in vacuo. The residue was dissolved in chloroform and the organic solution was washed successively with IN hydrochloric acid, water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was solidified with diethyl ether to give 4-(4'- metnylbιphenyl-2-carboxamido) -N-methyl-N- (2- acetoxymethylphenyl)benzamide (105 mg) as a white powder. NMR (CDC1 ₃ , δ) : 2.08 (3H, s), 2.34 (3H, s) , 3.38 (3H, s), 4.92 (IH, d, J=12Hz) , 5.04 (IH, d, J=12Hz), 6.87-6.97 (2H, m) , 7.04-7.56 (14H, ) ,

7.82 (IH, d, J=8Hz)

Example 16

A mixture of 4- ( '-metnylbιphenyl-2-carboxamιdo) -N- methyl-N- (2-hydroxymethylphenyl)benzamide (100 mg) and glutaric anhydride (50.7 mg) m pyridme (5 ml) was stirred at 90°C for 10 hours and the solvent was evaporated in vacuo. The residue was dissolved in chloroform and washed successively with IN hydrochloric acid, water and brine. The organic layer was dried over magnesium sulfate and the solvent was evaporated in vacuo to give an oil. The oil was purified by preparative thin layer chromatography to give 4- (4 '-methylbιphenyl-2- carboxamido) -N-methyl-N- [2- 3-carboxypropιonyloxymethyl) - phenyl]benzamide (20 mg) as a white solid.

NMR (CDCI3, δ) : 1.93 (2H, tt, J=7, 7Hz), 2.29-2.42 (7H, ) , 3.35 (3H, s), 4.89 (IH, d, J=13Hz) , 5.04 (IH, d, J=13Hz), 6.91 (2H, d, J=S.5Hz), 7.05-7.54 (14H, , 7.29 (IH, d, J=8Hz)

29152

- 153 -

Example 17

A mixture of 4- (4'-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-hydroxymethylphenyl)benzamide (225 mg) and magnesium dioxide (651 mg) in chloroform (10 ml) was refluxed for 3 hours and the solution was filtered through Celite. The filtrate was evaporated in vacuo to give a crude oil and the oil was subjected to silica gel column (1% methanol in chloroform) . The product was solidified with diethyl ether to give 4-(4'-methylbiphenyl-2- carboxamido)-N-methyl-N- (2-formylphenyl)benzamide (209 mg) as a white powder.

NMR (CDC1 ₃ , δ) : 2.35 (3H, s) , 3.47 (3H, s), 6.84-

6.96 (2H, m) , 7.06-7.60 (13H, m) , 7.75-7.84 (2H, m) , 10.8 (IH, s)

Example 18

A mixture of 4- ( '-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-formylphenyl)benzamide (150 mg) , methylamine o

(38% in methanol, 0.5 ml) and 3A molecular sieves (500 mg) in methanol (10 ml) was stirred at ambient temperature overnight. Sodium borohydride (39 mg) was added to the solution and the mixture was stirred at ambient temperature for 4 hours. The mixture was diluted with chloroform and the solution was washed with saturated aqueous sodium hydrogen carbonate and brine. The organic phase was dried over magnesium sulfate and the solvent was evaporated in vacuo to give crude oil. The oil was purified by silica gel column (10 g, 21 methanol in chloroform) and the product was solidified with diethyl ether to give 4- (4'-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-methylaminomethylphenyl)benzamide (160 mg) as a white powder.

NMR (CDCI3, δ) : 2.31 '3H, s), 2.37 (3H, s), 3.36 (3H, s), 3.49 (IH, d, J=14Hz), 3.62 (IH, d, J=14Hz), 6.83-6.96 (3H, m) , 7.06-7.54 (13H, m) ,

7.82 (IH, d, J=8Hz)

Example 19

The following compound was obtained according to a similar manner to that of Example 18.

4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N-[2- (1- methylaminoethyl)phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.36 (3H, d, J=7Hz) , 2.17 (3H, s) , 2.32 (3H, s), 3.39 (3H, s), 3.77 (IH, q, J=7Hz) ,

6.54-6.66 (2H, m) , 6.83-7.57 (13H, m) , 7.73-7.87 (2H, m)

Example 20 To a solution of 4- (4 '-methylbiphenyl-2-carboxamido) - N-methyl-N- (2-methylaminomethylphenyl)benzamide (154 mg) in a mixture of methanol (10 ml) and acetic acid (0.5 ml) were added aqueous formaldehyde (0.2 ml) and sodium cyanoborohydride (20.9 mg) and the solution was stirred at ambient temperature for 4 hours. The mixture was diluted with chloroform and the solution was washed with saturated aqueous sodium hydrogen carbonate and brine. The organic phase was dried over magnesium sulfate and the solvent was evaporated in vacuo to give crude oil. The oil was purified by silica gel column (10 g, 2% methanol in chloroform) and the product was solidified with diethyl ether to give 4- (4'-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-dimethylaminomethylphenyl)benzamide (65 mg) as a white powder. NMR (CDCI3, δ) : 2.16 (6H, s), 2.35 (3H, s), 3.08

(IH, d, J=14Hz), 3.27 (IH, d, J=14Hz) , 3.38 (3H, s), 6.83-6.92 (3H, m) , 7.05-7.57 (13H, m) , 7.82 (IH, d, J=8Hz)

Example 21

The following compounds were obtained according to a similar manner to that of Example 20.

1) 4- (4'-Methylbiphenyl-2-carboxamido)-N-methyl-N-[2- (3- dimethylaminopropyloxy)phenyl]benzamide NMR (CDC1 ₃ , δ) : 1.95 (2H, tt, J=7.5, 7.5Hz), 2.23 (6H, s), 2.33 (3H, s), 2.42 (2H, t, J=7.5Hz), 3.32 (3H, s), 3.90-4.05 (4H, ) , 6.72-6.98 (5H, m) , 7.08-7.54 (10H, m) , 7.82 (2H, d, J=8.5Hz)

2) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (1- dimethylaminoethyl ) phenyl ] benzamide NMR {CDCI3, δ) : 0.51 (3H x 2/3, d, J=7Hz) , 1.17 (3H x 1/3, d, J=7Hz) , 2.08 (6H, s), 2.33 (3H, s), 2.99-3.23 (IH, m) , 3.38 (3H x 1/3, s) , 3.40

(3H x 2/3, s), 6.84-6.98 (4H, m) , 7.15-7.56 (11H, ) , 7.78 (2H, d, J=8.5Hz)

Example 22 The following compounds were obtained according to a similar manner to that of Example 4.

1) 6- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (3- phthalimidoprop-1-yloxy)phenyl]nicotinamide NMR (CDCI3, δ) : 2.07 (2H, m) , 2.32 (3H, s) , 3.36

(3H, s), 3.85-3.97 (4H, ) , 6.80 (2H, ) , 6.96 (IH, d, J=7Hz), 7.12-7.61 (10H, m) , 7.68 (2H, m) , 7.81 (2H, m) , 7.98-8.11 (2H, m)

2) 2-Methoxy-4- ( ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-phthalimidoprop-l- yloxy ) phenyl ] benzamide

NMR (CDCI3, δ) : 2.23 (2H, m) , 2.36 (3H, s), 3.38 (3H, s), 3.64 (3H, s), 3.84-4.01 (4H, m) , 6.18 (IH, d, J=7Hz), 6.64-7.55 (13H, m) , 7.70-7.74

( 2H, m) , 7 . 80-7 . 88 ( 3H, m)

3) 3-Chloro-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-phthalimidoprop-l-yloxy) phenyl] - benzamide

NMR (CDC1 ₃ , δ) : 2.21 (2H, m) , 2.33 (3H, s), 3.34 (3H, s), 3.86-4.03 (4H, m) , 6.77-6.82 (2K, m) , 6.95 (IH, m) , 7.09-7.55 (11H, m) , 7.68-7.72 (2H, m) , 7.80-7.85 (3H, )

4) 3-Chloro-4- (4 '-methylbiphenyl-2-carboxamido) -N- [2- benzyloxy-4-chlorophenyl] -N-methylbenzamide

NMR (CDCI3, δ) : 2.34 (3H, s), 3.31 (3H, s), 4.83- 5.10 (2H, m) , 6.80-6.93 (2H, m) , 6.93-7.07 (2H, m) , 7.14 (2H, d, J=8Hz), 7.21-7.59 (12H, m) ,

7.79 (IH, d, J=8Hz) , 8.28 (IH, br d, J=8Hz)

5) 2-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- [2- ben2yloxy-4-chlorophenyl] -N-methylben2amide NMR (CDCI3, δ) : 2.36 (3H, s), 3.32 (3H, s) , 3.60

(3H, s), 4.96 (IH, d, J=10Hz) , 5.04 (IH, d, J=10H2) , 6.20 (IH, d, J=9Hz) , 6.72 (IH, d, J=9Hz), 6.78-6.92 (4H, m) , 6.97 (IH, d, J=9Hz), 7.15-7.56 (12H, m) , 7.84 (IH, d, J=9Hz)

6) 4- (4 ' -Methylbiphenyl-2-carboxamido) -2-nitro-N- [2- (5- ethoxycarbonylpent-1-yloxy) phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.42-1.62 (2H, ) , 1.67-1.81 (2H, m) , 1.81-1.97 (2H, m) , 2.27- 2.34 (2H, m) , 2.39 (3H, s) , 3.37 (3H, s) , 3.96

(2H, t, J=7Hz), 4.13 (2H, q, J=7Hz) , 6.69 (IH, dd, J=9, 9Hz), 6.74 (IH, d, J=9Hz), 6.94-7.63

(13H, ) , 7.84 (IH, d, J=9Hz)

7) 2-Methoxy-4- (methylphenyl-2-carboxamido) -N- (2-

benzyloxy-4-chlorophenyl) -N-methylbenzamide NMR (CDCI3, δ) : 2.46 (3H, s), 3.33 (3H, s), 3.67 (3H, s), 4.99 (IH, d, J=10Hz), 5.06 (IH, d, J=10Hz), 6.68-6.79 (2H, m) , 6.85 (IH, d, J=2Hz) , 6.95-7.06 (2H, m) , 7.16-7.60 (11H, )

8) 2-Methoxy-4- (methylphenyl-2-carboxamido) -N- [2- (5- ethoxycarbonylpent-1-yloxy) phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.46-1.62 (2H, m) , 1.62-1.81 (2H, m) , 1.81-1.96 (2H, m) , 2.35

(2H, t, J=7Hz), 2.44 (3H, s), 3.31 (3H, s) , 3.70 (3H, s), 3.95 (2H, t, J=7Hz) , 4.12 (2H, q, J=7Hz), 6.64-6.79 (3H, m) , 6.97-7.45 (8H, m) , 7.58 (IH, s)

9) 4- (Methylphenyl-2-carboxamido) -2-nitro-N- [2- (5- ethoxycarbonylpent-1-yloxy) phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.46-1.65 (2H, m) , 1.67-1.82 (2H, m) , 1.82-1.98 (2H, m) , 2.37 (2H, t, J=7Hz) , 2.47 (3H, s), 3.35 (3H, s), 4.00

(2H, t, J=7Hz) , 4.13 (2H, q, J=7Hz) , 6.73 (IH, dd, J=9, 9Hz) , 6.79 (IH, d, J=9Hz) , 7.07-7.20 (2H, m) , 7.20-7.49 (5H, m) , 7.83 (IH, d, J=9Hz) , 8.03 (IH, br s) , 8.11 (IH, br s)

Example 23

The following compounds were obtained according to a similar manner to that of Example 6.

1) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-carbonylphenyl) benzamide NMR (CDCI3, δ) : 2.29 (3H, s) , 3.33 (3H, s), 3.40 (3H, s), 6.68-6.88 (3H, m) , 7.11 (2H, d, J=8.5Hz), 7.18-7.51 (6H, m) , 7.69 (IH, m) , 7.80 (IH, d, J=7.5Hz), 7.90 (IH, m) , 8.18 (IH, m)

2) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [ (E) -6-carboxy-l-hexen-l-yl]benzamide

NMR (CDC1 ₃ , δ) : 1.53 (2H, m) , 1.68 (2H, m) , 2.25 (2H, m) , 2.34 (3H, s) , 2.36 (2H, t, J=7.5Hz) , 3.33 (3H, s), 6.13 (IH, dt, J=15, 7.5Hz), 6.43

(IH, d, J=15Hz) , 6.75-7.42 (14H, m) , 7.50 (IH, t, J=7Hz), 7.80 (IH, d, J=7Hz)

3) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [ (Z) -6-carboxy-l-hexen-l-yl] phenyl]benzamide

NMR (CDCI3, δ) : 1.25-1.39 (4H, m) , 1.46-1.63 (4H, m) , 2.26-2.27 (IH, m) , 2.29 (2H, t, J=7.5Hz), 2.37 (3H, s), 2.49 (IH, ) , 2.36 (3H, s) , 3.63 (3H, s), 6.92 (2H, d, J=8.5Hz) , 6.99-7.44 (12H, m) , 7.51 (IH, t, J=7Hz) , 7.80 (IH, d, J=7Hz)

4) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (6- carboxyhex-1-yl) phenyl]benzamide

NMR (CDCI3, δ) : 1.27-1.90 (4H, m) , 1.48-1.66 (4H, m) , 2.30 (2H, ) , 2.33 (3H, s) , 2.47 (2H, m) ,

3.37 (3H, s), 6.87-6.96 (3H, m) , 7.04-7.53 (12H, m) , 7.80 (IH, d, J=7Hz)

5) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2-[N- (3-carboxyprop-l-yl) oxyimino]methylphenyl]benzamide

NMR (CDCI3, δ) : 2.02 (2H, tt, J=7.5, 7.5Hz), 2.33 (3H, s), 2.46 (2H, t, J=7.5Hz), 3.37 (3H, s), 4.19 (2K, t, J=7.5Hz), 6.88-6.98 (3H, m) , 7.02- 7.29 (8H, m) , 7.36-7.53 (3H, m) , 7.76 (IH, d, J=7Hz) , 7.80 (IH, d, J=7Hz) , 8.10 (IH, s)

6) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- carboxypent-1-ylthio) phenyl]benzamide

NMR (CDCI3, δ) : 1.50 (2H, m) , 1.61-1.73 (4H, m) , 2.33 (2H, m) , 2.34 (3H, s) , 2.88 (2H, m) , 3.30

(3H, s), 6.86-6.99 (5H, m) , 7.10-7.20 (4H, m) , 7.22-7.30 (3H, m) , 7.34-7.44 (2H, m) , 7.49 (IH, dd, J=7, 7Hz), 7.80 (IH, d, J=7Hz)

7) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- carboxy-4-penten-l-yloxy) phenyl]benzamide MASS (m/z) : 549 (M+l)

8) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [N- (2-carboxyethyl) -N- (t-butoxycarbonyl) aminoethyloxy] - phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.44 (9H, s) , 2.36 (3H, s), 2.63 (2H, m) , 3.32 (3H, s) , 3.42-3.43 (4H, m) , 3.83 (IH, br), 4.06 (IH, br) , 6.75-6.99 (4H, ) , 7.03-7.11 (2H, m) , 7.14-7.22 (4H, m) , 7.28 (2H, d, J=8.5Hz) , 7.36-7.46 (2H, m) , 7.51 (IH, dd, J=7, 7Hz) , 7.81 (2H, d, J=7Hz)

9) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [2- (carboxymethoxyimino) ethoxy]phenyl]benzamide

MASS (m/z) : 552 (M+l)

10) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- carboxyphenylmethoxy) phenyl]benzamide NMR (CDCI3, δ) : 2.32 (3H, s), 3.39 (3H, s), 5.03

(2H, m) , 6.80 (IH, d, J=7Hz) , 6.85-6.93 (3H, m) , 7.10-7.21 (6H, m) , 7.30 (2H, d, J=8.5Hz), 7.34- 7.52 (5H, m) , 7.82 (IH, d, J=7Hz) , 8.11 (2H, d, J=8.5Hz)

11) 4- (4 '-Methyl ^' biphenyl-2-carboxamido) -N-methyl-N- [2- (5- carboxypyrid-2-yl) methoxy]phenyl]benzamide

NMR (CDCI3, δ) : 2.35 (3H, s) , 3.37 (3H, s) , 5.28 (2H, s) , 6.78-7.02 (6H, m) , 7.12-7.24 (5H, m) , 7.30 (2H, d, J=8.5Hz) , 7.39-7.55 (3H, m) , 7.81

(IH, d, J=7Hz), 8.51 (IH, m) , 9.15 (IH, m)

12) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- carboxypent-1-yloxy) pyrid-3-yl]benzamide NMR (CDC1 ₃ , δ) : 1.31 (2H, m) , 1.61-1.79 (4H, m) , 2.34 (2H, t, J=7.5Hz), 2.37 (3H, s), 3.28 (3H, s), 3.96 (2H, br) , 5.97 (IH, dd, J=7, 7Hz) , 6.94 (IH, d, J=7H2), 7.00 (2H, d, J=8.5H2), 7.13-7.31 (8H, m) , 7.36-7.52 (3H, m) , 7.81 (IH, d, J=7H2)

13) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [3- (5- carboxypent-1 -yloxy) pyrid-2-yI]ben2amide

NMR (CDCI3, δ) : 1.45 (2H, ) , 1.63-1.75 (4H, m) ,

2.31-2.41 (2H, m. , 2.32 (3H, s), 3.39 (2H, s) , 3.72 (2H, m) , 6.90-7.55 (13H, m) , 7.81 (IH, d,

J=7.5H2), 8.03 (IH, d, J=7Hz)

14) 3-Methyl-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [3-chloro-2- (5-carboxypenten-l- yloxy) phenyl]benzamide

NMR (CDCI3, δ) : 1.41 (3H, s), 1.52 (2K, m) , 1.67- 1.85 (4H, m) , 2.34 (3H, s), 3.90 (2H, m) , 6.73- 7.02 (5H, m) , 7.09-7.18 (3H, m) , 7.30-7.54 (5H, m) , 7.83 (IH, d, J=7Hz), 7.97 (IH, d, J=7Hz)

15) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [4- methyl-2- (5-carboxypyrid-2-ylmethoxy)phenyl]benzamide NMR (CDCI3, δ) : 2.29 (3H, s), 2.35 (3H, s), 3.22

(3H, s), 5.22 (2H, m) , 6.61 (7H, d) , 6.72 (IH, s), 7.83 (IH, d) , 7.92 (2H, d, J=8.5Hz), 7.02

(IH, s), 7.14-7.23 (4H, m) , 7.28 (2H, d, J=8.5Hz), 7.34-7.53 (3H, m) , 7.81 (IH, d) , 8.50 (IH, m) , 9.13 (IH, m)

16) 4- (4'-Nitrobiphenyl-2-carboxamido) -N-methyl-N- [2- (5-

carboxypyrid-2-ylmethoxy)phenyl]ben2amide NMR (CDCI3, δ) : 3.31 (3H, s), 5.25 (2H, ) ,

6.80-6.99 (3H, ) , 7.06-7.22 (4H, m) , 7.34-7.54 (6H, m), 7.63 (2H, d, J=8.5H2), 8.14 (2H, d, J=8.5H2), 8.49 (IH, ) , 9.09 (IH, )

17) 4- (2-Phenylpyridine-3-carboxamido) -N- [2- (5- carboxypent-1-yloxy) -4-chlorophenyl] -N- methylbenzamide NMR (CDCI3, δ) : 1.36-1.55 (2H, m) , 1.56-1.82 (4H, m) , 2.31 (2H, t, J=7H2) , 3.28 (3H, s), 3.68-3.97 (2H, m) , 6.73-6.86 (2H, m) , 6.96 (IH, d, J=9H2) , 7.18 (2H, d, J=9H2), 7.30-7.58 (6H, m) , 7.72 (2H, d, J=9Hz), 7.77-7.91 (IH, m) , 8.44-8.54 (IH, m) , 8.72-8.83 (IH, )

18) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N- [2- (5- carboxypent-1-yloxy) -4-chlorophenyl] -N- methylbenzamide NMR (CDCI3, δ) : 1.44-1.58 (2H, ) , 1.63-1.86 (4H, m) , 2.36 (3H, s) , 2.38 (2H, t, J=7Hz) , 3.29 (3H, s), 3.76-3.97 (2H, ) , 6.74-6.82 (2H, m) , 6.87- 7.02 (4H, ) , 7.11-7.23 (4H, m) , 7.29 (2H, d, J=9Hz), 7.34-7.56 (3H, m) , 7.76-7.85 (IH, m)

19) 3-Chloro-4- (4 ' -methylbiphenyl-2-carboxamido) -N- [2- (5- carboxypent-1-yloxy) -4-chlorophenyl] -N- methylbenzamide

NMR (CDCI3, δ) : 1.46-1.60 (2H, m) , 1.65-1.76 (4H, m) , 2.36 (3H, s) , 2.40 (2H, t, J=7Hz), 3.28 and

3.33 (total 3H, s), 3.76-4.00 (2H, ) , 6.75-6.86 (2H, m) , 6.87-7.23 (4H, ) , 7.24-7.37 (3H, ) , 7.37-7.49 (2H, m. , 7.49-7.61 (2H, m) , 7.75-7.85 (IH, ) , 8.18-8.36 (IH, )

20) 2-Methoxy-4- (4'-methylbiphenyl-2-carboxamido) -N- [2- (5-carboxypent-l-yloxy) -4-chlorophenyl] -N- methylbenzamide

NMR (CDC1 ₃ , δ) : 1.48-1.63 (2H, m) , 1.64-1.90 (4H, m) , 2.28-2.44 (5H, ) , 3.25 and 3.29 (total 3H, s), 3.61 (3H, s) , 3.75-3.94 (2H, m) , 6.20-6.33 (IH, m) , 6.62-6.74 (2H, m) , 6.79 (IH, s) , 6.86- 7.33 (7H, ) , 7.33-7.56 (3H, m) , 7.77-7.86 (IH, m)

21) 2-Chloro-4- (4 '-methylbiphenyl-2-carboxamido) -N- [2- (5- carboxypent-1-yloxy) -4-chlorophenyl]-N- methylbenzamide

NMR (CDCI3, δ) : 1.48-1.64 (2H, m) , 1.67-1.79 (2H, m) , 1.79-1.93 (2H, m) , 2.33-2.45 (5H, m) , 3.30 and 3.34 (total 3H, s) , 3.90-3.99 (2H, m) , 6.66- 7.56 (14H, m) , 7.76-7.85 (IH, m)

22) 2-Chloro-4-(4'-methylbiphenyl-2-carboxamido)-N-[2- (5- carboxypent-1-yloxy)phenyl] -N-methylbenzamide

NMR (CDCI3, δ) : 1.49-1.67 (2H, m) , 1.67-1.97 (4H, m) , 2.33-2.47 (5H, m) , 3.34 (3H, s), 3.91-4.04 (2H, m) , 6.66-6.82 (2H, m) , 6.82-7.04 (4H, m) , 7.05-7.59 (9H, m) , 7.75-7.85 (IH, m)

23) 3-Methoxy-4- (2'-methylbiphenyl-2-carboxamido) -N- [2- (5-carboxypent-l-yloxy) -4-methylphenyl] -N- methylbenzamide

NMR (CDCI3, δ) : 1.42-1.58 (2H, m) , 1.63-1.83 (4H, m) , 2.11 (3H, s) , 2.27 (3H, s), 2.38 (2H, t,

J=7Hz), 3.30 (3H, s), 3.47 (3H, s), 3.70-3.96 (2H, m) , 6.58 (2H, br s), 6.73-6.90 (3H, m) , 7.14-7.28 (5H, m. , 7.40-7.56 (2H, m) , 7.77 (IH, s), 7.94 (IH, d, J=9Hz), 8.15 (IH, d, J=9Hz)

24) 4- (2' , 4'-Dimethylbiphenyl-2-carboxamido) -3-methyl-N- [2- (5-carboxypent-l-yloxy) -4-methylphenyl] -N- methylbenzamide

NMR (CDC1 ₃ , δ) : 1.43-1.59 (2H, m) , 1.64-1.86 (4H, ) , 2.06 (3H, s), 2.26 (3H, s) , 2.32 (3H, s),

2.39 (2H, t, J=7Hz), 3.30 (3H, s), 3.47 (3H, s) , 3.73-3.98 (2H, m) , 6.59 (2H, br s), 6.74-6.92 (3H, m) , 7.03 (2H, d, J=9Hz) , 7.11 (IH, d, J=9Hz), 7.21 (IH, d, J=9Hz), 7.39-7.54 (2H, m) , 7.83 (IH, ^' s), 7.96 (IH, d, J=9Hz), 8.18 (IH, d,

J=9H2)

25) 3-Methoxy-4- (4 ' -nitrobiphenyl-2-carboxamido) -N- [2- (5- carboxypent-1-yloxy) -4-methylphenyl] -N- methylben2amide

NMR (CDCI3, δ) : 1.43-1.57 (2H, m) , 1.63-1.83 (4H, m) , 2.30 (3H, s) , 2.38 (2H, t, J=7Hz) , 3.30 (3H, s), 3.50 (3H, s) , 3.71-3.97 (2H, m) , 6.56-6.65 (2H, m) , 6.81-6.93 (3H, m) , 7.42 (IH, d, J=9Hz), 7.48-7.62 (4H, m) , 7.70-7. ^' 80 (2H, ) , 8.09 (IH, d, J=9Hz) , 8.18 (2H, d, J=9Hz)

26) 4- (4 '-Aminobiphenyl-2-carboxamido) -N- [2- (5- carboxypent-1-yloxy) -4-methylphenyl] -N- methylbenza ide

NMR (CDCI3, δ) : 1.45-1.59 (2H, m) , 1.61-1.82 (4H, m) , 2.26 (3H, s) , 2.37 (2H, t, J=7Hz) , 3.28 (3H, s), 3.69-3.97 (2H, m) , 6.51-6.64 (2H, m) , 6.76 (2H, d, J=9Hz), 6.84-7.08 (4H, m) , 7.15-7.28 (4H, m) , 7.31-7.52 (3H, m) , 7.86 (IH, d, J=9Hz)

27) 4- (4'-Methylbiphenyl-2-carboxamido) -2-nitro-N- [2- (5- carboxypent-1-yloxy)phenyl] -N-methylbenzamide

NMR (CDCI3, δ) : 1.50-1.68 (2H, m) , 1.68-1.82 (2H, m) , 1.82-1.96 (2H, m) , 2.34-2.48 (2H, ) , 2.39

(3H, s), 3.36 (3H, s), 3.97 (2H, t, J=7Hz), 6.70 (IH, dd, J=9, 9Hz), 6.76 (IH, d, J=9Hz), 7.02- 7.64 (13H, m) , 7.83 (IH, d, J=9Hz)

28) 4-Methylphenyl-2-carboxamido) -N-methyl-N- [4-methyl-2- [5- (carboxypent-1-yloxy)phenyl]benzamide NMR (CDC1 ₃ , δ) : 1.44-1.59 (2H, m) , 1.62-1.86 (4K, ) , 2.28 (3H, s), 2.37 (2H, t, J=7Hz) , 2.45 (3H, s), 3.30 (3H, s), 3.76-3.98 (2H, m) , 6.55-6.66 (2H, m) , 6.91 (IH, d, J=9Hz) , 7.16-7.47 (8H, m) ,

7.67 (IH, br s)

29) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- carboxypentyloxy)phenyl]benzamide NMR (CDCI3, δ) : 1.46-1.61 (2H, m) , 1.64-1.86 (4H, m) , 2.36 (3H, s) , 2.39 (2H, t, J=7Hz) , 3.32 (3H, s), 3.78-3.98 (2H, m) , 6.74-6.84 (2H, m) , 6.87- 7.04 (4H, m) , 7.11-7.24 (5H, m) , 7.29 (2H, d, J=9Hz), 7.34-7.56 (3H, m) , 7.81 (IH, d, J=9H2)

30) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- carboxymethoxyphenyl) ben2amide

NMR (DMSO-d ₆ , δ) : 2.28 (3H, s), 3.22 (3H, s), 4.77 (2H, s), 6.76-6.82 (IH, m) , 6.89-7.00 (2H, m) , 7.10-7.36 (9H, m) , 7.40-7.57 (4H, m)

31) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- carboxymethylphenyl)ber.2amide

NMR (CDCI3, δ) : 2.33 (3H, s), 3.30-3.42 (2H, m) , 3.39 (3H, s), 6.90 (2H, d, J=8H2), 7.08-7.52

(14H, m) ^' , 6.69 and 7.74 (total IH, d, J=8Hz)

32) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [ (2- carboxymethoxy-4-methyl. phenyl]ben2amide Rf : 0.06 (n-hexane:ethyl acetate = 1:2)

33) 3-Methoxy-4- ( '-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-carboxymethoxyphenyl) benzamide Rf : 0.09 (10% methanol in chloroform)

34) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- carboxybutoxy) phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.73-1.88 (4H, m) , 2.84 (3H, s) , 2.92 (2H, t, J=7Hz), 3.31 (3H, s), 3.75-3.98 (2H, m) , 6.76 (IH, d, J=9H2), 6.81 (IH, d, J=9Hz), 6.92 (2H, br d, J=9H2) , 7.02 (2H, br d,

J=9H2), 7.09-7.23 (4H, m) , 7.23-7.32 (2H, m) , 7.33-7.53 (3H, m) , 7.79 (IH, d, J=9H2)

35) 4- ( '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (3- carboxypropoxy)phenyl]ben2amide

NMR (CDCI3, δ) : 1.99-2.16 (2H, m) , 2.34 (3H, s), 2.52 (3H, t, J=7H2), 3.33 (3H, s), 3.78-4.03 (2H, m) , 6.72-6.86 (2H, m) , 6.86-7.06 (4H, m) , 7.09-7.32 (7H, m) , 7.33-7.45 (2H, m) , 7.46-7.64 (IH, m) , 7.78 (IH, d, J=9H2)

36) 4- ( '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (7- carboxyheptyloxy)phenyl]ben2amide

NMR (CDCI3, δ) : 1.31-1.53 (6H, m) , 1.58-1.71 (2H, m) , 1.71-1.83 (2H, m) , 2.35 (2H, t, J=7H2), 2.36

(3H, s), 3.30 (3H, s), 3.78-3.97 (2H, m) , 6.72- 6.83 (2H, m) , 6.87-7.06 (4H, m) , 7.09-7.24 (5H, ) , 7.28 (2H, d, J=9Hz) , 7.34-7.56 (3H, m) , 7.79 (IH, d, J=9H2)

37) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- carboxypentyloxy) -4-methylphenyl] enzamide

NMR (CDCI3, δ) : 1.46-1.61 (2H, m) , 1.64-1.87 (4H, m) , 2.30 (3H, s), 2.38 (3H, s), 2.36-2.46 (2H, m) , 3.31 (3H, s), 3.77-3.99 (2H, m) , 4.12-4.80

(IH, br s), 6.60 (2H, br s) , 6.86 (IH, d, J=9Hz) , 6.90-7.04 (3H, m) , 7.13-7.26 (4H, m) , 7.31 (2H, d, J=9Hz), 7.36-7.56 (3H, m) , 7.82

(IH, d, J=9Hz)

38) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- carboxypentyloxy) -5-methylphenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.43-1.56 (2H, ) , 1.62-1.83 ( H, m) , 2.17 (3H, s), 2.36 (3H, s), 2.37 (2H, t, J=7Hz), 3.30 (3H, s), 3.71-3.94 (2H, m) , 6.66

(IH, d, J=9H2), 6.82 (IH, s), 6.87-7.00 (4H, m) , 7.14-7.25 (16H, ) , 7.29 (2H, d, J=9Hz), 7.35- 7.46 (2H, m) , 7.51 (IH, dd, J=9, 9Hz), 7.81 (IH, d, J=9Hz)

39) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (6- carboxyhexyloxy)phenyl]benzamide

NMR (CDCI3, δ) : 1.37-1.56 (4H, m) , 1.61-1.84 (4H, m) , 2.36 (3H, s), 2.37 (2H, t, J=7Hz), 3.33 (3H, s), 3.76-3.99 (2H, m) , 6.74-6.83 (2H, m) , 6.87-

7.03 (4H, m) , 7.10-7.24 (5H, m) , 7.29 (2H, d, J=9Hz), 7.34-7.56 (3H, ) , 7.81 (IH, d, J=9Hz)

40) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (5-carboxypentyloxy) -4- methylphenyl ] benzamide

NMR (CDCI3, δ) : 1.42-1.60 (2H, m) , 1.61-1.95 (4H, m) , 2.28 (3H, s) , 2.34 (3H, s), 2.31-2.45 (2H, m) , 3.30 (3H, s) , 3.43 (3H, s), 3.74-3.98 (2H, ) , 6.60 (2H, br d, J=9Hz) , 6.76-6.94 (3H, m) ,

7.15 (2H, d, J=9Kz) , 7.24-7.33 (2H, m) , 7.34- 7.55 (3H, m) , 7.69 (IH, s) , 7.79 (IH, d, J=9Hz) ,

8.16 (IH, d, J-=9Hz)

41) 4- (Biphenyl-2-carboxamido) -N-methyl-N- [2- (5-

carboxypentyloxy) phenyl]benzamide

NMR (CDCI3, δ) : 1.40-1.61 (2H, ) , 1.61-1.94 (4H, m) , 2.32-2.46 (2H, m) , 3.32 (3H, s), 3.76-3.98 (2H, m) , 6.72-6.84 (2H, m) , 6.84-7.04 (4H, m) , 7.09-7.24 (3H, ) , 7.30-7.58 (8H, m) , 7.82 (IH, d, J=9Hz)

42) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (5-carboxypentyloxy)phenyl]benzamide NMR (CDCI3, δ) : 1.42-1.60 (2H, m) , 1.61-1.89 (4H, m) , 2.33 (3H, s), 2.31-2.44 (2H, m) , 3.32 (3H, s), 3.39 (3H, s) , 3.76-4.00 (2H, m) , 6.73-6.90 (4H, m) , 6.99 (IH, d, J=9Hz) , 7.09-7.20 (3H, m) , 7.28 (2H, d, J=9Hz), 7.34-7.54 (3H, m) , 7.69 (IH, s), 7.80 (IH, d, J=9Hz), 8.17 (IH, d,

J=9Hz)

43) 4- (Biphenyl-2-carboxamido) -3-methoxy-N-methyl-N- [2- (5-carboxypent yloxy) - 4 -methylphenyl] benzamide NMR (CDCI3, δ) : 1.44-1.59 (2H, m) , 1.65-1.85 (4H, m) , 2.28 (3H, s) , 2.38 (2H, t, J=7H2) , 3.30 (3H, s), 3.41 (3H, s) , 3.73-3.86 (IH, m) , 3.86-3.98 (IH, m) , 6.55-6.63 (2H, m) , 6.77-6.89 (3H, m) , 7.24-7.57 (8H, ) , 7.66 (IH, s) , 7.80 (IH, d, J=9H2), 8.14 (IH, d, J=9H2)

44) 3-Methoxy-4- (4 ' -methyibiphenyl-2-carboxamido) -N- methyl-N- [2- (5-carboxypentyloxy) -4-chlorophenyl] - ben∑amide NMR (CDCI3, δ) : 1.45-1.59 (2H, m) , 1.65-1.86 (4H, m) , 2.32 and 2.33 (total 3H, s) , 2.38 (2H, t, J=7H2), 3.29 and 3.32 (total 3H, s), 3.40 and 3.42 (total 3H, s) , 3.77-3.99 (2H, m) , 6.74-7.03 (5H, m) , 7.10-7.18 (2H, m) , 7.24-7.32 (2H, m) , 7.35-7.54 (3H, m) , 7.69 (IH, br d, J=9Hz) , 7.80

(IH, dd, J=9, 9Hz) , 8.13-8.24 (IH, m)

45) 4- (2-Methylphenylbenzamido) -N-methyl-N- [4-chloro-2- (5-carboxypyrid-2-ylmethyloxy) phenyl]benzamide NMR (CDC1 ₃ , δ) : 2.33 (3H, s), 3.13 (3H, s) , 3.60

(3H, s), 5.32 (IH, d, J=llHz) , 5.43 (IH, d, J=11H2), 6.85 (IH, m) , 6.97-7.06 (3H, m) , 7.14 (IH, d, J=7H2), 7.20-7.47 (5H, ) , 8.52 (IH, ) , 9.06 (IH, )

46) 4- (1, 2-Dimethylphenyl-3-carboxamido) -N- [2- (5- carboxypent-1-yloxy) phenyl] -N-methylben2amide

NMR (CDCI3, δ) : 1.45-1.60 (2H, m) , 1.63-1.87 (4H, m) , 2.29 (3H, s) , 2.30 (3H, s), 2.36 (2H, t, J=7H2), 3.33 (3H, s), 3.77-4.00 (2H, m) , 6.75-

6.86 (2H, m) , 6.96-7.47 (10H, m) , 7.64 (IH, br s)

47) 2-Methoxy-4- (methylphenyl-2-carboxamido) -N- [2- (5- carboxypent-1-yloxy) -4-chlorophenyl] -N- methylbenzamide

NMR (CDCI3, δ) : 1.48-1.66 (2H, m) , 1.66-1.94 (4H, m) , 2.26-2.54 (5H, m) , 3.27 and 3.31 (total 3H, s), 3.70 (3H, br s), 3.83-4.00 (2H, m) , 6.64- 6.84 (3H, m) , 6.89-7.14 (3H, m) , 7.14-7.49 (5H, m) , 7.64-7.80 (IH, m)

48) 2-Chloro-4- (methylphenyl-2-carboxamido) -N- [2- (5- carboxypent-1-yloxy ) phenyl ] -N-methylbenzamide NMR (CDCI3, δ) : 1.49-1.66 (2H, m) , 1.66-1.80 (2H, m) , 1.80-1.96 (2H, m) , 2.38 (2H, t, J=7Hz) , 2.43 (3H, s) , 3.34 (3H, s) , 3.98 (2H, t, J=7Hz) , 6.68-6.81 (2H, m) , 7.00-7.41 (8H, ) , 7.51 (IH, br s) , 7.80 (IH, br s)

49) 2-Methoxy-4- (methylphenyl-2-carboxamido) -N- [2- (5- carboxypent-1-yloxy)phenyl] -N-methylbenzamide NMR (CDC1 ₃ , δ) : 1.48-1.94 (6H, m) , 2.39 (2H, t,

J=7Hz), 2.44 (3H, br s), 3.29 (3H, s), 3.68 (3H, br s), 3.84-4.04 (2H, m) , 6.63-6.82 (3H, m) ,

6.96-7.44 (8H, m) , 7.75 (IH, br s)

50) 4- (Methylphenyl-2-carboxamido) -2-nitro-N- [2- (5- carboxypent-1-yloxy) phenyl ] -N-1r.ethylben2am.ide NMR (CDCI3, δ) : 1.44-1.66 (2H, m) , 1.67-1.80 (2H, m) , 1.80-1.96 (2H, m) , 2.38 (2H, t, J=7H2) , 2.44 (3H, s), 3.33 (3H, s) , 3.98 (2H, t, J=7Hz) , 6.71 (IH, dd, J=9, 9Hz) , 6.78 (IH, d, J=9Hz) , 7.04- 7.46 (8H, m) , 7.80 (IH, br d, J=9Hz) , 8.06 (IH, br s) , 8.39 (IH, br s)

51) 4- (Methylphenyl-2-carboxamido) -N- [2- (5-carboxypent-l- yloxy) -4-chlorophenyl] -N-methylben2ami.de

NMR (CDCI3, δ) : 1.44-1.60 (2H, m) , 1.63-1.87 (4H, m) , 2.37 (2H, t, J=7H2), 2.44 and 2.47 (total

3H, s), 3.29 and 3.33 (total 3H, s), 3.75-4.00 (2H, m) , 6.75-6.86 (2H, m) , 6.92-7.07 (IH, m) , 7.07-7.51 (9H, m) , 7.59-7.76 (IH, m)

52) 4- ( '-Methylbiphenyl-2-carboxamido) -N-carboxymethyl-

N- (2-methylphenyl) benzamide mp : 189-192°C

NMR (CDCI3, δ) : 2.20 (3H, s), 2.37 (3H, s), 4.13

(IH, d, J=16Hz), 4.80 (IH, d, J=16Hz), 6.85-6.96 (3H, m) , 7.08-7.58 (12H, m) , 7.80 (IH, d, J-=9Hz)

Example 24

A suspension of 4- (4 ' -rr.ethylbiphenyl-2-carboxamido) - N-methyl-N- [2- (5-phthalimidcpentyloxy)phenyl]benzamide (1.1 g) in ethanol (20 ml) was stirred rapidly and treated

with hydrazine hydrate (844 mg) . The mixture was stirred at 60°C for 3 hours. After cooling, the reaction mixture was diluted with diethyl ether and filtered through Celite. The Celite was washed with diethyl ether, and the filtrate was concentrated. The residual milky oil was again dissolved in diethyl ether, filtered through Celite, washed with diethyl ether, and concentrated to give 4-(4'- methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- aminopentyloxy) phenyl] enzamide NMR (CDC1 ₃ , δ) : 1.42-1.59 (3H, m) , 1.71-1.87 (2H, ) , 1.92-2.11 (3H, m) , 2.36 (3H, s) , 2.72 (2H, t, J=7Hz), 3.32 (3H, s) , 3.77-4.00 (2H, m) , 6.73-6.84 (2H, m) , 6.86-7.05 (4H, m) , 7.08-7.24 (5H, m) , 7.28 (2H, d, J=9Hz), 7.34-7.56 (3H, m) , 7.80 (IH, d, J=9Hz)

Example 25

The following compounds were obtained according to a similar manner to that of Example 24.

1) 4- ( ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- aminobutoxy) phenyl]benzamide

NMR (CDCI3, δ) : 1.56-1.82 (4H, m) , 2.30 (3H, s) ,

2.40-2.86 (4H, m) , 3.27 (3H, s), 3.70-3.96 (2H, m) , 6.68-6.86 (2K, m) , 6.89-7.52 (16H, m) , 7.69

(IH, d, J=9H2)

2) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (3- aminoprop-1-yloxy)phenyl]benzamide Rf : 0.09 (101 methanol in chloroform)

3) 6- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (3- aminoprop-1-yloxy) phenyl] nicotinamide

NMR (CDCI3, δ) : 2.03 (2H, m) , 2.30 (3H, s) , 3.00 (2H, m) , 3.30 (3H, s) , 3.97 (2H, ) , 6.77-6.86

(2H, m) , 7.03 (IH, d, J=7H2) , 7.10-7.18 (3H, m) 7.24 (2H, d, J=8.5H2) , 7.34-7.42 (2H, m) , 7.50 (IH, t, J=7H2), 7.57-7.68 (2H, ) , 7.92-8.10 (2H, m)

) 3-Methyl-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-aminoprop-l-yloxy)phenyl]benzamide NMR (CDC1 ₃ , δ) : 1.41 (3H, s) , 1.92 (2H, m) , 2.34 (3H, s), 2.91 (2H, t, J=7.5Hz), 3.31 (3H, s), 3.96 (IH, m) , 4.03 (IH, ) , 6.74-6.84 (3H, ) ,

6.94-7.02 (2H, m) , 7.10-7.19 (4H, m) , 7.20-7.55 (4H, m) , 7.81 (IH, d, J=7Hz) , 7.93 (IH, d, J=7Hz)

5) 3-Methoxy-4- ( ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-aminoprop-l-yloxy)phenyl]benzamide NMR (CDCI3, δ) : 1.96 (2H, m) , 2.33 (3H, s) , 2.93 (2H, t, J=7.5Hz) , 3.33 (3H, s) , 3.41 (3H, s) , 3.97 (IH, m) , 4.08 (IH, m) , 6.78-6.90 (4H, m) , 7.00 (IH, d, J=7Hz) , 7.12-7.20 (3H, ) , 7.29

(IH, m) , 7.38-7.54 (3H, m) , 7.67 (IH, s) , 7.80 (IH, d, J=7Hz), 8.20 (IK, d, J=7Hz)

6) 2-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-aminoprop-l-yloxy) phenyl]benzamide

NMR (CDCI3, δ) : 1.99 (2H, m) , 2.35 (3H, s) , 2.94 (2H, t, J=7.5Hz) , 3.36 (3H, s) , 3.96 (IH, ) , 4.08 (IH, m) , 3.64 (3H, s), 3.84-4.01 (4H, ) , 6.18 (IH, d, J=7Hz), 6.64-7.55 (13H, m) , 7.82 (IH, d, J=7Hz)

7) 3-Chloro-4- (4 ' -methylbiphenyl) -2-carboxamido) -N- methyl-N- [2- (3-aminoprop-l-yloxy) phenyl] benzamide NMR (CDCI3, δ) : 1.93 (2H, m) , 2.35 (3H, s), 2.90 (2H, t, J=7.5Hz _; , 3.32 (3H, s), 3.95 (IH, ) ,

4 . 04 ( IH, m) , 6 . 83 ( 2H, d, J=8 . 5Hz ) , 6 . 98 -7 . 57 ( 11H, m) , 7 . 79 ( IH, d, J=7Hz ) , 8 . 27 ( IH, m)

Example 26 To a solution of 4- (4 '-methylbiphenyl-2-carboxamido) - N-methyl-N- (2-carboxymethoxyphenyl)ben2amide (295 mg) , N- methylpipera∑ine (60 mg) and l-hydroxyben2otria2ole hydrate (97 mg) in N,N-dimethylformamide (5 ml) was added N-ethyl-N'- (3-dimethylaminopropyl) carbodiimide hydrochloride (137 mg) at 0°C and the mixture was stirred at ambient temperature for 15 hours. The resulting mixture was diluted with ethyl acetate and then the organic layer was washed successively with saturated sodium bicarbonate aqueous solution and brine. Drying, filtering and removal of solvents afforded a crude product. The crude product was chromatographed on silica gel (eluent; 3% methanol in chloroform) to give 4-(4'- methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4-methyl-l- pipera2inyl) carbonylmethoxyphenyl]ben2amide (213 mg) as a white powder.

NMR (CDC1 ₃ , δ) : 2.31 (3H, s), 2.36 (3H, s), 2.30- 2.46 (4H, br), 3.37 (3H, s), 3.52-3.70 (4H, m) , 4.60 (2H, d, J=9H2), 6.80-7.00 (6H, m) , 7.12- 7.32 (6H, m) , 7.36-7.55 (3H, m) , 7.83 (IH, d, J=8Hz)

Example 27

The following compounds were obtained according to a similar manner to that of Example 26.

1) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- methyl-1-piperazinyl) carbonylmethylphenyl]benzamide NMR (CDCI3, δ) : 2.23-2.33 (4H, m) , 2.28 (3H, s),

2.38 (3H, s), 3.13-3.18 (IH, ) , 3.27-3.39 (4H, m) , 3.37 (3H, s) , 3.59-3.66 (IH, m) , 6.89-6.97

( 2H, m) , 7 . 10-7 . 53 ( 13H, m) , 7 . 82 ( IH , d, J=8Hz )

2) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [ {2- (4-methyl-l-piperazinyl) carbonylmethoxy-4- methyl}phenyl] benzamide

NMR (CDC1 ₃ , δ) : 2.28 (3H, s), 2.31 (3H, s), 2.34- 2.46 (4H, m) , 2.37 (3H, s) , 3.34 (3H, s) , 3.54- 3.68 (4H, m) , 4.59 (2H, d, J=8Hz), 6.60-6.66 (2H, br s), 6.84 (IH, d, J=8Hz), 6.87-6.98 (3H, m) , 7.17-7.23 (4H, m) , 7.25-7.33 (2H, m) , 7.37-

7.56 (3H, ) , 7.82 (IH, d, J=8Hz)

3) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (4-methyl-l-piperazinyl) - carbonylmethoxyphenyl]benzamide

NMR (CDCI3, δ) : 2.30 (3H, s), 2.36 (3H, s), 2.37-

2.46 (4H, br), 3.38 (3H, s) , 3.42 (3H, s), 3.52- 3.58 (2H, br), 3.60-3.68 (2H, br) , 4.58-4.63 (2H, br) , 6.80-6.88 (4H, m) , 6.95-7.02 (IH, m) , 7.12-7.20 (3H, m) , 7.26-7.32 (2H, m) , 7.36-7.54

(3H, m) , 7.68-7.72 (IH, br s) , 7.79 (IH, d, J=8Hz), 8.17-8.22 (IH, m)

) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- { (4-dimethylamino-l-pιperidinyl) carbonylmethoxy}- phenyl]ben2amide

Rf : 0.16 (chloroform:methanol: acetic acid = 8:2:1) .

5) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [4- (4-methylpipera2ine-l-carbonylamino) butoxy] phenyl] - ben∑amide

NMR (CDCI3, δ) : 1.60-1.86 (4H, m) , 2.29 (3H, s) ,

2.36 (3H, s), 2.33-2.43 (4H, ) , 3.20-3.35 (2H, m) , 3.32 (3H, s) , 3.35-3.46 (4H, m) , 3.72-3.84 (IH, m) , 3.84-3.96 (IH, m) , 4.84 (IH, br s),

6 . 72-7 . 01 ( 5H, m) , 7 . 02-7 . 33 ( 8H, m) , 7 . 36-7 . 57 ( 3H, m) , 7 . 81 ( IH, d, J=9H2 )

6) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [5- (4-methylpipera2in-l-yl) carbonylpentyloxy]phenyl] - benzamide

NMR (CDC1 ₃ , δ) : 1.40-1.59 (2H, m) , 1.60-1.91 (4H, m) , 2.30 (3H, s) , 2.26-2.45 (6H, m) , 2.35 (3H, s), 3.31 (3H, s), 3.49 (2H, t, J=6H2) , 3.60 (2H, t, J=6H2), 3.76-4.01 (2H, m) , 6.72-6.84 (2H, m) ,

6.88-7.06 (4H, m) , 7.08-7.57 (10H, m) , 7.80 (IK, d, J=9H2)

7) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [4- (4-methylpipera2in-l-yl) carbonylbutoxy]phenyl] - benzamide

NMR (CDCI3, δ) : 1.72-1.90 (4H, m) , 2.29 (3H, s) ,

2.35 (3H, s), 2.32-2.47 (6H, m) , 3.30 (3H, s), 3.46-3.53 (2H, m) , 3.68-3.76 (2H, m) , 3.80-3.99 (2H, m) , 6.78 (2H, d, J=9Hz) , 6.87-7.00 (4K, ) ,

7.08-7.22 (5H, m) , 7.27 (2H, d, J=9H2) , 7.33- 7.60 (3H, m) , 7.80 (IH, d, J=9H2)

8) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [3- (4-methylpiperazin-l-yl) carbonylpropoxy]phenyl] - benzamide

NMR (CDCI3, δ) : 2.04-2.18 (2H, m) , 2.30 (3H, s),

2.36 (3H, s), 2.34-2.36 (4H, ) , 2.50 (2H, t, J=7Hz), 3.32 (3H, s) , 3.45-3.54 (2H, m) , 3.59- 3.70 (2H, ) , 3.86-4.06 (2H, m) , 6.81 (2H, d,

J=9Hz) ^' , 6.86-6.97 (3H, ) , 7.00 (IH, d, J=9Hz) , 7.09-7.23 (5H, ) , 7.28 (2H, d, J=9Hz) , 7.33-7.56 (3H, ) , 7.79 (IH, d, J=9Hz)

9) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [4-

29152

- 175 - methyl-2- [5- (4-methylpiperazin-l-yl) - carbonylpentyloxy]phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.43-1.56 (2H, m) , 1.61-1.87 (4H, ), 2.27 (3H, s), 2.30 (3H, s), 2.36 (3H, s), 2.23-2.43 (6H, m) , 3.29 (3H, s) , 3.48 (2H, dd,

J=7, 7Hz), 3.61 (2H, dd, J=7, 7Hz), 3.73-3.85 (IH, m) , 3.85-3.96 (IH, m) , 6.57 (IH, d, J=9Hz) , 6.59 (IH, s), 6.83 (IH, d, J=9H2) , 6.94 (2K, d, J=9Hz), 7.02 (IH, s), 7.14-7.24 (4H, m) , 7.30 (2H, d, J=9H2), 7.36-7.67 (3H, m) , 7.81 (IH, d,

J=9Hz)

10) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [5- methyl-2- [5- (4-methylpipera2in-l-yl) - carbonylpentyloxy]phenyl]ben2amide

NMR (CDCI3, δ) : 1.40-1.55 (2H, ) , 1.59-1.83 (4H, m) , 2.16 (3H, s) , 2.30 (3H, s), 2.36 (3H, s), 2.28-2.44 (6H, m) , 3.31 (3H, s) , 3.48 (2H, dd, J=6, 6Hz), 3.60 (2H, dd, J=6, 6H2) , 3.67-3.80 (IH, ) , 3.80-3.95 (IH, m) , 6.66 (IH, d, J=9H2),

6.80 (IH, s), 6.39-6.99 (3H, m) , 7.02 (IH, s), 7.14-7.24 (4H, m, , 7.30 (2H, d, J=9Hz), 7.34- 7.56 (3H, m) , 7.81 (IH, d, J=9H2)

11) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [6- (4-methylpiperazin-l-yI) carbonyihexyloxy]phenyl] - benzamide

NMR (CDCI3, δ) : 1.34-1.53 (4H, m) , 1.56-1.70 (2H, m) , 1.70-1.82 (2H, m) , 2.28 (3H, s) , 2.35 (3H, s), 2.26-2.42 (6H, m) , 3.32 (3H, s), 3.46 (2H, dd, J=6, 6Hz), 3.57 (2H, dd, J=6, 6Hz), 3.76- 4.00 (2H, m) , 6.73-6.82 (2H, m) , 6.92-7.01 (3H, m) , 7.08-7.24 (6H, m) , 7.29 (2H, d, J=9Hz), 7.34-7.46 (2H, m) , 7.50 (IH, dd, J=9, 9Hz) , 7.79 (IH, d, J=9Hz)

12) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [4-methyl-2- [5- (4-methylpiperazin-l- yl) carbonylpentyloxy]phenyl]ben2amide NMR (CDCI3, δ) : 1.45-1.58 (2H, ) , 1.62-1.88 (4H, m) , 2.28 (3H, s) , 2.30 (3H, s) , 2.33 (3H, s) ,

2.26-2.43 (6H, ) , 3.30 (3H, s) , 3.42 (3H, s), 3.48 (2H, dd, J=7, 7Hz), 3.63 (2H, dd, J=7, 7Hz), 3.78-4.01 (2H, m) , 6.52-6.64 (2H, m) , 6.76-6.87 (3H, m) , 7.13 (2H, d, J=9Hz) , 7.28 (2H, d, J=9Hz), 7.34-7.55 (3H, m) , 7.69 (IH, s)

7.80 (IH, d, J=9Hz), 8.16 (IH, d, J=9Hz)

13) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- 4- [1- (t-butoxycarbonyl)piperidine-4- carbonylamino]butoxypheny1]benzamide

NMR (CDCI3, δ) : 1.44 (9H, s), 1.53-1.84 (8H, m) ,

2.18-2.37 (IH, m) , 2.35 (3H, s) , 2.60-2.81 (2H, m) , 3.19-3.36 (2H, m) , 3.32 (3H, s), 3.71-3.96

(2H, ) , 4.02-4.19 (2H, m) , 5.94-6.06 (IH, ) , 6.70-7.04 (5H, m) , 7.06-7.33 (8H, m) , 7.34-7.56

(3H, ) , 7.80 (IH, d, J=9Hz)

14) 4- (Biphenyl-2-carboxamido) -N-methyl-N- [2- [5- (4- methylpiperazin-1-yl) carbonylpentyloxy]phenyl] - benzamide

NMR (CDCI3, δ) : 1.42-1.56 (2H, m) , 1.59-1.87 (4H, m) , 2.29 (3H, s), 2.26-2.44 (6H, m) , 3.31 (3H, s), 3.48 (2H, dd, J=7, 7Hz) , 3.60 (2H, dd, J=7, 7Hz), 3.73-4.00 (2H, ) , 6.72-6.83 (2H, m) , 6.86-7.03 (4H, m) , 7.08-7.22 (3H, ) , 7.29-7.61

(8H, m) , 7.82 (IH, d, J=9Hz)

15 ) 3-Methoxy-4- ( 4 ' -methylbiphenyl-2-carboxamido ) -N- methyl-N- [2- [ 5- ( 4-methylpiperazin-l-yl ) - carbonylpentyloxy] phenyl ] ben2amide

NMR (CDCI3, δ) : 1.44-1.58 (2H, m) , 1.61-1.90 (4H, m) , 2.30 (3H, s), 2.34 (3H, s) , 2.25-2.45 (6H, m) , 3.33 (3H, s) , 3.38 (3H, s) , 3.49 (2H, dd, J=7, 7H2), 3.64 (2H, dd, J=7, 7Hz) , 3.78-4.02 (2H, ) , 6.72-6.89 (4H, m) , 6.94 (IH, d, J=9H2) ,

7.08-7.18 (3H, ) , 7.27 (2H, d, J=9H2) , 7.34- 7.54 (3H, m) , 7.67 (IH, s), 7.78 (IH, d, J=9H2) , 8.18 (IH, d, J=9Hz)

16) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [4- methyl-2- [5- (piperazin-1-yl) carbonylpentyloxy] - phenyl]benzamide NMR (CDCI3, δ) : 1.42-1.87 (6H, m) , 2.27 (3H, s),

2.30-2.38 (2H, ) , 2.36 (3H, s), 2.77-2.90 (4H, m) , 3.29 (3H, s), 3.44 (2H, dd, J=7, 7Hz) , 3.57

(2H, dd, J=7, 7Hz), 3.74-3.96 (2H, m) , 6.52-6.62 (2H, m) , 6.82 (IH, d, J=9Hz), 6.89-7.01 (3H, m) , 7.14-7.23 (4H, ) , 7.30 (2H, d, J=9Hz), 7.34- 7.56 (3H, m) , 7.81 (IH, d, J=9Hz)

17) 4- (Biphenyl-2-carboxamido) -3-methoxy-N-methyi-N- [2- [5- (4-methylpiperazin-l-yl) carbonylpentyloxy] - phenyl]benzamide

NMR (CDCI3, δ) : 1.44-1.58 (2H, m) , 1.58-1.86 (4H, m) , 2.27 (3H, s) , 2.29 (3H, s), 2.29-2.44 (6H, m) , 3.29 (3H, s) , 3.40 (3H, s), 3.49 (2H, dd, J=7, 7Hz), 3.64 (2H, dd, J=7, 7Hz) , 3.76-4.01 (2H, m) , 6.52-6.64 (2H, ) , 6.76-6.87 (3H, m) , 7.23-7.57 (8H, m) , 7.65 (IH, s), 7.80 (IH, d, J=9Hz), 8.16 (IH, d, J=9Hz)

18) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [4-chloro-2- ]5- (4-methylpiperazin-l- yl) carbonylpentyloxy] henyl]benzamide NMR (CDCI3, δ) : 1.42-1.59 (2H, m) , 1.61-1.92 (4H,

) , 2.23-2.47 (12H, ) , 3.28 and 3.32 (total 3H, s), 3.37 and 3.41 (total 3H, s) , 3.43-3.53 (2H, ) , 3.57-3.69 (2H, m) , 3.76-4.03 (2H, m) , 6.69- 6.98 (5H, m) , 7.06-7.19 (2H, m) , 7.21-7.33 (2H, ) , 7.33-7.55 (3H, m) , 7.68 (IH, br d, J=9Hz) ,

7.79 (IH, dd, J=9, 9H2), 8.20 (IH, dd, J=9, 9H2)

19) 4- (2-Methylben2amido) -N-methyl-N- [4-chloro-2- [5- (4- methylpipera2in-l-yl)pyrid-2-ylmethoxy]phenyl]- ben∑amide

NMR (CDC1 ₃ , δ) : 2.33 (IH, s), 2.42-2.53 (4H, m) ,

2.47 (3H, s), 3.31 (3H, s), 3.54 (2H, m) , 3.37 (3H, s), 4.00 (2H, m) , 5.27 (2H, m) , 6.69 (IH, d, J=7H2), 6.84 (IH, dd, J=l, 7Hz) , 6.94-6.99 (2H, ) , 7.08 (7H, d) , 7.20-7.27 (2H, m) , 7.33-

7.48 (3H, m) , 7.53 (IH, s), 8.00 (IH, m) , 8.59 (IH, )

20) 4- (l,2-Dimethylphenyl-3-carboxamido) -N-methyl-N- [2- [5- (4-methylpipera2in-l-ylcarbonyl)pent-1-yloxy] - phenyl]benzamide

NMR (CDCI3, δ) : 1.43-1.59 (2H, m) , 1.61-1.74 (2H, m) , 1.74-1.88 (2H, ) , 2.24-2.42 (6H, m) , 2.30

(6H, s), 2.33 (3H, s), 3.34 (3H, s) , 3.43-3.52 (2H, m) , 3.52-3.62 (2H, m) , 3.76-4.00 (2H, m) ,

6.76-6.86 (2H, ) , 7.01 (IH, d, J=9Hz) , 7.08- 7.28 (4H, m) , 7.33 (2H, d, J=9Hz) , 7.43 (2H, d, J=9Hz), 7.59 (IH, s)

21) 2-Methoxy-4- (methylphenyl-2-carboxamido) -N- [4-chloro-

2- [5- (4-methylpiperazin-l-ylcarbonyl) pent-1- yloxy] phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.45-1.63 (2H, m) , 1.63-1.95 (4H, m) , 2.24-2.56 (12H, ) , 3.28 and 3.32 (total 3H, s), 3.41-3.53 (2H, ) , 3.53-3.64 (2H, m) , 3.71

(3H, br s) , 3.83-4.03 (2H, m) , 6.64-6.82 (3H, m) , 6.90-7.14 (3H, ) , 7.14-7.47 (4H, ) , 7.61- 7.75 (IH, m)

22) 2-Chloro-4- (methylphenyl-2-carboxamido) -N-methyl-N- [2- [5- (4-methylpipera2in-l-ylcarbonyl) pent-1- yloxy]phenyl]ben∑amide

NMR (CDC1 ₃ , δ) : 1.46-1.63 (2H, m) , 1.63-1.96 (4H, ) , 2.25-2.47 (6H, m) , 2.30 (3H, s), 2.44 (3H, s), 3.33 (3H, s), 3.41-3.52 (2H, m) , 3.52-3.63

(2H, ) , 3.98 (2H, t, J=7H2) , 6.68-6.80 (2H, m) , 7.00-7.42 (8H, m) , 7.56 (IH, s), 7.88 (IH, s)

23) 2-Methoxy-4- (methylphenyl-2-carboxamido) -N-methyl-N- [2- [5- (4-methylpipera2in-l-ylcarbonyl)pent-1- yloxy]phenyl]benzamide

NMR (CDCI3, δ) : 1.48-1.66 (2H, m) , 1.66-1.96 (4H, m) , 2.24-2.52 (6H, m) , 2.31 (3H, s), 2.47 (3H, s), 3.34 (3H, s), 3.42-3.54 (2H, m) , 3.54-3.65 (2H, m) , 3.71 (3H, br s), 3.85-4.03 (2H, m) ,

6.62-6.80 (3H, m) , 6.95-7.46 (8H, ) , 7.64 (IH, br s)

24) 4- (Methylphenyl-2-carboxamido) -2-nitro-N-methyl-N- [2- [5- (4-methylpipera2in-l-ylcarbonyl)pent-l- yloxy]phenyl]ben2amide

NMR (CDCI3, δ) : 1.46-1.83 (4H, m) , 1.83-2.00 (2H, m) , 2.24-2.51 (6H, m) , 2.31 (3H, s), 2.47 (3H, s), 3.35 (3H, s), 3.42-3.63 (4H, ) , 3.90-4.06 (2H, ) , 6.67-6.82 (2H, ) , 7.06-7.49 (7H, ) ,

7.84 (IH, d, J=9H2), 8.18 (IH, br s), 8.27 (IH, br s)

25) 4- (Methylphenyl-2-carboxamido) -N- [4-chloro-2- [5- (4- methylpipera2in-l-ylcarbonyl)pent-1-yloxy]phenyl] -N-

methylben2amide

NMR (CDCI3, δ) : 1.40-1.58 (2H, m) , 1.59-1.89 (4H, m) , 2.31 (3H, s) , 2.23-2.42 (6H, m) , 2.46 and 2.48 (total 3H, s), 3.31 and 3.36 (total 3H, s), 3.42-3.52 (2H, m) , 3.52-3.63 (2H, m) , 3.75-4.01

(2H, m) , 6.75-6.86 (2H, m) , 6.91-7.05 (IH, m) , 7.08-7.52 (3H, m. , 7.63-7.73 (IH, m)

26) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (4-methylpipera2in-l-yl) carbonylphenyl] - ben2amide

NMR (CDCI3, δ) : 2.16-2.55 (10H, m) , 3.18-3.57 (8H, ) , 3.83 (2H, m) , 7.02-7.52 (11H, ) , 7.61-7.85 (3H, m) , 8.30 (IH, m)

27) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (4-dimethyIaminopiperid-l- yl) carbonylphenyl]ben2amide

NMR (CDCI3, δ) : 2.17-2.40 (13H, m) , 3.20-3.80 (10H, m) , 7.07-7.50 (11H, m) , 7.60-7.86 (3H, m) ,

8.30 (IH, )

28) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [ (Z) -6- (4-methylpipera2in-l-yl) carbonyl-l-hexen-1- yl]phenyl]ben2amide

NMR (CDCI3, δ) : 1.46 (2H, m) , 1.80 (IH, m) , 2.09 (IH, m) , 2.22-2.34 (6H, m) , 2.28 (3H, s), 2.33 (3H, s), 3.33 (3H, s), 3.43 (2H, m) , 3.49 (2H, m) , 5.64 (IH, dt, J=ll, 7.5Hz), 6.76 (IH, d, J=llHz), 6.98 (2H, d, J=8.5Hz), 7.06-7.41 (11H, m) , 7.48(1H, t, J=7Hz) , 7.57 (IH, s) , 7.74 (IH, d, J=7Hz)

29) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [ (E) -6- (4-methylpiperazin-l-yl) carbonyl-l-hexen-1-

yl ] phenyl ] benzamide

NMR (CDCI3, δ) : 1.52 (2H, m) , 1.64 (2H, m) , 2.20-

2.41 (8H, m) , 2.27 (3H, s) , 2.31 (3H, s) , 3.32

(3H, s), 3.48 (2H, m) , 3.58 (2H, m) , 6.11 (IH, dt, J=15, 7.5Hz), 6.42 (IH, d, J=15Hz) , 6.90-

6.98 (3H, m) , 7.04-7.52 (12H, m) , 7.80 (IH, d,

J=7.5Hz)

30) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [6- (4-methylpipera2in-l-yl) carbonylhex-1-yl]phenyl] - ben2amide

NMR (CDCI3, δ) : 1.18-1.33 (4H, m) , 1.42-1.56 (4H, m) , 2.23-2.44 (8H, m) , 2.28 (3H, s), 2.33 (3H, s), 3.36 (3H, s), 3.42-3.50 (4H, m) , 6.99 (2H, d, J=8.5H2), 7.11-7.42 (12H, m) , 7.50 (IH, t,

J=7H2), 7.77 (IH, d, J=7HZ)

31) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [N- [ (4-methylpiperazin-l-yl) carbonylprop-1-yl] oxyimino] - methylphenyl]benzamide

NMR (CDCI3, δ) : 1.98 (2H, m) , 2.29 (3H, s), 2.30- 2.44 (6H, m) , 2.36 (3H, s), 3.39 (3H, s), 3.48 (2H, m) , 3.54 (2H, m) , 4.18 (2H, t, J=7.5Hz), 6.95 (2H, m) , 7.03-7.30 (9H, m) , 7.36-7.53 (3H, m) , 7.68 (2H, d, J=7Hz) , 7.79 (IH, d, J=7Hz) ,

8.08 (IH, s)

32) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [5- (4-methylpiperazin-l-yl) carbonylpent-1-ylthio] - phenyl] benzamide

NMR (CDCI3, δ) : 1.48 (2H, ) , 1.55-1.72 (4H, m) , 2.27-2.40 (6H, m) , 2.19 (3H, s) , 2.33 (3H, s), 2.85 (2H, m) , 3.31 (3H, s), 3.46 (2H, m) , 3.53 (2H, m) , 6.92-7.02 (4H, ) , 7.11-7.18 (4H, m) , 7.21-7.30 (4H, m; , 7.34-7.42 (2H, )

33) 4- (4'-Methylbiphenyl-2-carboxamido)-N-methyl-N-[2-[5- (4-methylpiperazin-l-yl) carbonylpenten-1-yloxy]- phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.91 (2H, m) , 2.28 (3H, s) , 2.32 (3H, s), 2.32-2.42 (6H, m) , 3.33 (3H, s), 3.51

(2H, ) , 3.62 (2H, m) , 3.70-4.00 (2H, m) , 6.28 (IH, d, J=15Hz), 6.73-6.86 (2H, ) , 6.90-7.02 (2H, ) , 7.07-7.21 (4H, m) , 7.29 (2H, d, J=8.5Hz), 7.36-7.56 (4H, m) , 7.62-7.70 (2H, ) , 7.78 (IH, d, J=7Hz)

34) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N-[2-[N- [2- (4-methylpiperazin-l-yl) carbonylethyl]-N- (t- butoxycarbonyl)aminoethoxy]phenyl]benzamide MASS (m/z) : 734 (M+l)

35) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N-[2-[2- ( (4-methylpiperazin-l-yl) carbonylmethoxyimino) - ethoxy]phenyl]benzamide NMR (CDCI3, δ) : 2.28 (1.5H, s) , 2.30 (1.5H, s) ,

2.33 (3H, s), 2.33-2.45 (4H, m) , 3.33 (1.5H, s), 3.35 (1.5H, s), 3.43-3.69 (4H, m) , 4.44-4.86 (4H, m) , 6.71-6.98 (5H, m) , 7.03-7.22 (5H, m) , 7.30 (2H, d, J=8.5Hz), 7.34-7.54 (4H, m) , 7.80 (IH, m)

36) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [4- (4-methylpiperazin-l-yl) carbonylphenyl ]methoxy] - phenyl ] benzamide NMR (CDCI3, δ) : 2.31 (3H, s) , 2.33 (3H, s) , 2.33-

2.53 (4H, m) , 3.36 (3H, s), 3.47 (2H, m) , 4.80 (2H, ) , 5.00 (2H, ) , 6.83 (2H, d, J=8.5Hz), 6.85-6.93 (2H, m) , 6.98 (IH, s), 7.04 (IH, d, J=7Hz), 7.11-7.19 (5H, m) , 7.26-7.54 (7H, ) , 7.81 (7H, d)

37) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [5- (4-methylpiperazin-l-yl) carbonylpyrid-2-ylmethoxy] - phenyl]benzamide

NMR (CDC1 ₃ , δ) : 2.33 (3H, s), 2.36 (3H, s), 2.38- 2.55 (4H, m) , 3.34 (4H, s), 3.51 (2H, m) , 3.80 (2H, m) , 5.28 (2H, s), 6.78 (IH, dd, J=7, 7Hz), 6.87-7.00 (5H, m) , 7.11-7.21 (5H, m) , 7.29 (2H, d, J=8.5Hz), 7.28-7.54 (3H, m) , 7.82 (IH, d, J=7Hz), 8.00 (IH, m) , 8.55 (IH, s)

38) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [5- (4-methylpiperazin-l-yl) carbonylpent-l-yloxy]pyrid-3- yl]benzamide

NMR (CDCI3, δ) : 1.27 (2H, m) , 1.54-1.72 (4H, m) , 2.22-2.37 (6H, m) , 2.27 (3H, s), 2.35 (3H s), 3.31

(3H, s), 3.22 (2H, m) , 3.50 (2H, m) , 3.90 (2H, m) , 5.98 (IH, dd, J=7, 7Hz) , 6.99 (IH, d, J=7Hz), 7.08 (2H, d, J=8.5Hz), 7.12-7.20 (3H, m) , 7.26-7.31 (3H, m) , 7.38-7.53 (4H, m) , 7.78 (IH, d, J=7Hz)

39) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [3- [5- (4-methylpiperazin-l-yl) carbonylpent-1-yloxy]pyrid-2- yl]benzamide

NMR (CDCI3, δ) : 1.42 (2H, m) , 1.56-1.78 (4H, m) , 2.30 (3H, s), 2.30-2.44 (6H, m) , 2.36 (3H, s),

3.40 (3H, s), 3.48 (2H, m) , 3.58 (2H, m) , 3.68 (2H, m) , 6.90-7.56 (13H, m) , 7.81 (IH, d, J=7.5Hz), 8.02 (IH, d, J=7Hz)

40) 3-Methyl-4- (4 ' -methyibiphenyl-2-carboxamido) -N-methyl-

N- [4-chloro-2- [5- ( 4-methylpiperazin-l- yl) carbonylpenten-1-yloxy) phenyl] benzamide NMR (CDCI3, δ) : 1.41 (3H, s), 1.51 (2H, ) , 1.69 (2H, m) , 1.81 (2H, m) , 2.29 (3H, s) , 2.29-2.44 (6H, m) , 2.35 (3H, s), 3.27 (3H, s) , 3.49 (2H,

m) , 3.61 (2H, m) , 3.88 (2H, m) , 6.71-7.00 (5H, m) , 7.10 (IH, s) , 7.18 (2H, d, J=8.5Hz), 7.09- 7.54 (5H, ) , 7.83 (7H, d) , 7.99 (IH, d, J=7Hz)

41) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [4- methyl-2- [5- (4-methylpiperazin-l-yl) pyrid-2- ylmethoxy ] phenyl ] benzamide

NMR (CDC1 ₃ , δ) : 2.28 (3H, s), 2.33 (3H, s), 2.37 (3H, s), 2.39-2.53 (4H, m) , 3.30 (3H, s), 3.50 (2H, m) , 3.80 (2H, ) , 5.22 (2H, s), 6.56 (IH, d,

J=7Hz), 6.70-6.80 (2H, m) , 6.88-6.94 (3H, m) , 7.13-7.21 (4H, ) , 7.29 (2H, d, J=8.5Hz), 7.36- 7.53 (3H, m) , 7.82 (IH, d, J=7Hz) , 7.99 (IH, m) , 8.58 (IH, m)

42) ^" 4- (4'-Nitrobiphenyl-2-carboxamido) -N-methyl-N- [2- [5-

(4-methylpiperazin-l-ylcarbonyl)pyrid-2- ylmethoxy]phenyl]benzamide

NMR (CDCI3, δ) : 2.32 (3H, s), 2.42 (2H, ) , 2.50 (2H, m) , 3.31 (3H, s) , 3.50 (2H, m) , 3.79 (2H, ) , 5.27 (2H, s), 6.80 (IH, dd, J=7, 7Hz) , 6.89 (IH, d, J=7Hz), 6.99 (IH, d, J=7H2) , 7.07 (2H, d, J=8.5H2), 7.14-7.30 (4H, m) , 7.41 (IH, d, J=7H2) , 7.46-7.61 (4H, ) , 7.70 (IH, d, J=7H2) , 7.97 (IH, m) , 8.20 (2H, d, J=8.5H2), 8.52 (IH, )

43) 4- (2-Phenylpyridine-3-carboxamido) -N- [4-chloro-2- [5- (4-methylpipera2in-l-ylcarbonyl)pent-1-yloxy]phenyl] -

N-methylben2amide NMR (CDCI3, δ) : 1.33-1.51 (2H, m) , 1.51-1.83 (4H, m) , 2.25-2.43 (6H, m) , 2.30 (3H, s), 3.29 (3H, s), 3.41-3.50 (2H, m) , 3.50-3.59 (2H, m) , 3.59- 3.76 (IH, m) , 3.76-3.96 (IH, m) , 6.73-6.83 (2H, m) , 6.93 (IH, d, J=8H2) , 7.01 (2H, d, J=8Hz), 7.18 (2H, d, J=3H2) , 7.33-7.45 (5H, m) , 7.59-7.68

- 185 - ( 2H, m) , 8 . 11 ( IH, d, J=8Hz ) , 8 . 75- 8 . 80 ( IH, m)

44) 4- (4'-Methylbiphenyl-2-carboxamido)-N- [4-chloro-2- [5- (4-methylpiperazin-l-ylcarbonyl)pent-l-yloxy]phenyl] - N-methylbenzamide

NMR (CDC1 ₃ , δ) : 1.41-1.56 (2H, ) , 1.60-1.86 (4H, ), 2.23-2.43 (6H, ) , 2.30 (3H, s), 2.36 (3H, s), 3.27 (3H, s), 3.43-3.53 (2H, m) , 3.54-3.64

(2H, m) , 3.70-3.99 (2H, ) , 6.73-6.82 (2H, m) , 6.83-7.05 (4H, m) , 7.10-7.23 (4H, m) , 7.29 (2H, d, J=9Hz), 7.34-7.56 (3H, ) , 7.82 (IH, d, J=9Hz)

45) 4- (4'-Methylbiphenyl-2-carboxamido) -N- [4-chloro-2- [5- [N- (2-diethylaminoethyI) -N-methylcarbonyl]pent-l- yloxy]phenyl]-N-methylbenzamide

NMR (CDCI3, δ) : 1.00 (3H, t, J=7H2) , 1.02 (3H, t, J=7H2), 1.40-1.56 (2H, ) , 1.60-1.89 (4H, ) , 2.25-2.40 (2H, ) , 2.36 (3H, s) , 2.46-2.62 (6H, m) , 2.91 and 3.03 (total 3H, s) , 3.26 (3H, s) , 3.34 (IH, t, J=6Hz), 3.43 (IH, t, J=6H2) , 3.72-

3.98 (2H, ) , 6.70-6.80 (2H, ) , 6.80-7.06 (4H, ) , 7.06-7.23 (4H, m) , 7.29 (2H, d, J=8Hz) , 7.33- 7.56 (3H, m) , 7.81 (IH, d, J=8Hz)

46) 4- (4*-Methylbiphenyl-2-carboxamido)-N-[4-chloro-2-[5- (4-methylhomopiperazin-l-ylcarbonyl)pent-l- yloxy] henyl] -N-methylbenzamide

NMR (CDCI3, δ) : 1.39-1.56 (2H, ) , 1.61-2.01 (6H, ) , 2.27-2.40 (8H, m) , 2.48-2.67 (4H, m) , 3.28 (3H, s), 3.48-3.68 (4H, m) , 3.73-4.00 (2H, ) ,

6.73-6.83 (2H, m) , 6.83-7.08 (4H, m) , 7.09-7.34 (6H, m) , 7.34-7.56 (3H, m) , 7.82 (IH, d, J=8Hz)

47) 3-Chloro-4- (4 '-methylbiphenyl-2-carboxamido) -N- [4- chloro-2- [5- (4-methylpiperazin-l-ylcarbonyl)pent-l-

- 186 - yloxy]phenyl]-N-methylbenzamide

NMR (CDCI3, δ) : 1.43-1.60 (2H, ) , 1.64-1.94 (4H, ) , 2.27-2.46 (6H, m) , 2.31 (3H, s) , 2.35 (3H, s), 3.28 and 3.32 (total 3H, s) , 3.43-3.53 (2H, m) , 3.59-3.68 (2H, m) , 3.77-4.00 (2H, ) , 6.74-

7.23 (6H, m) , 7.24-7.36 (3H, ) , 7.37-7.49 (2H, ) , 7.49-7.60 (2H, ) , 7.75-7.85 (IH, m) , 8.19- 8.36 (IH, m)

48) 2-Methoxy-4-(4'-methylbiphenyl-2-carboxamido)-N-[4- chloro-2-[5-[ (4-methylpiperazin-l-ylcarbonyl)pent-1- yloxy]phenyl]-N-methylbenzamide NMR (CDCI3, δ) : 1.44-1.63 (2H, ) , 1.63-1.93 (4H, m) , 2.26-2.45 (12H, m) , 3.28 and 3.51 (total 3H, s), 3.44-3.55 (2H, ) , 3.56-3.67 (2H, ) , 3.62

(3H, s), 3.78-4.03 (2H, m) , 6.18-6.33 (IH, m) , 6.60-6.76 (2H, ) , 6.80-7.58 (11H, ) , 7.81 (IH, dd, J=8, 8Hz)

49) 2-Chloro-4- (4'-methylbiphenyl-2-carboxamido)-N-[4- chloro-2-[5- (4-methylpiperazin-l-ylcarbonyl)pent-1- yloxy]phenyl]-N-methylbenzamide

NMR (CDCI3, δ) : 1.46-1.63 (2H, ) , 1.63-1.80 (2H, m) , 1.80-1.96 (2H, ) , 2.26-2.46 (6H, m) , 2.32 (3H, s) , 2.38 (3H, s), 3.30 and 3.35 (total 3H, s), 3.43-3.53 (2H, m) , 3.56-3.68 (2H, m) , 3.87- 4.01 (2H, m) , 6.66-7.57 (14H, m) , 7.74-7.86 (IH, m)

50) 2-Chloro-4- (4 ' -methylbiphenyl-2-carboxamido) -N- [2- [5-

(4-methylpiperazin-l-ylcarbonyl) pent-1-yloxy] phenyl] - N-methylbenzamide

NMR (CDCI3, δ) : 1.46-1.63 (2H, ) , 1.63-1.79 (2H, ) , 1.79-1.94 (2H, m) , 2.26-2.47 (6H, ) , 2.31 (3H, s), 2.37 (3H, s) , 3.34 (3H, s), 3.43-3.54

(2H, m) , 3.57-3.66 (2H, m) , 3.96 (2H, t, J=7Hz) , 6.64-6.79 (2H, m) , 6.79-7.01 (4H, ) , 7.01-7.56 (9H, m), 7.79 (IH, d, J=9Hz)

51) 3-Methoxy-4- (2'-methylbiphenyl-2-carboxamido) -N- [4- methyl-2- [5- (4-methyipiperazin-l-ylcarbonyl)pent-1- yloxy]phenyl] -N-methylbenzamide NMR (CDC1 ₃ , δ) : 1.41-1.57 (2H, m) , 1.60-1.88 (4H, ) , 2.10 (3H, br s) , 2.24 (3H, s) , 2.30 (3H, s), 2.21-2.43 (6H, m) , 3.30 (3H, s), 3.38-3.52 (5H, ) , 3.56-3.68 (2H, m) , 3.73-3.98 (2H, m) , 6.47- 6.63 (2H, m) , 6.69-6.85 (3H, m) , 7.13-7.28 (5H, ) , 7.41-7.56 (2H, m) , 7.74 (IH, br s), 7.94 (IH, d, J=9Hz), 8.16 (IH, br d, J=9Hz)

52) 4- (2' , 4'-Dimethylbiphenyl-2-carboxamido) -3-methoxy-N- [4-methyl-2- [5- (4-methylpiperazin-l-ylcarbonyl)pent-1- yloxy]phenyl] -N-methylbenzamide

NMR (CDCI3, δ) : 1.41-1.58 (2H, m) , 1.58-1.87 (4H, ) , 2.06 (3H, s), 2.20-2.43 (15H, m) , 3.28 (3H, s), 3.39-3.53 (5H, m) , 3.57-3.67 (2H, m) , 3.72- 3.99 (2H, ) , 6.49-6.63 (2H, m) , 6.70-6.86 (3H, m) , 6.95-7.06 (2H, ) , 7.10 (IH, d, J=9Hz), 7.20 (IH, d, J=9Hz), 7.37-7.54 (2H, ) , 7.81 (IH, s), 7.96 (IH, d, J=9Hz) , 8.18 (IH, d, J=9Hz)

53) 3-Methoxy-4- (4 '-nitrobiphenyl-2-carboxamido) -N- [4- methyl-2- [5- (4-methylpiperazin-l-ylcarbonyl)pent-l- yloxy]phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.45-1.58 (2H, m) , 1.62-1.87 (4H, ) , 2.26-2.43 ' 6H, m) , 2.27 (3H, s) , 2.29 (3H, s), 3.31 (3H, s;, 3.45-3.54 (2H, ) , 3.50 (3H, s), 3.59-3.67 (2H, m) , 3.76-3.99 (2H, m) , 6.55- 6.65 (2H, m) , 6.76-6.91 (3H, ) , 7.42 (IH, d, J=9H2), 7.48-7.62 (4H, m) , 7.70-7.80 (2H, m) ,

- 188 - 8.09 (IH, br d, J=9H2) , 8.20 (2H, d, J=9Hz)

54) 3-Methoxy-4- (4 ' -nitrobiphenyl-2-carboxamido) -N- [2- [5- (4-dimethylaminopiperidin-l-ylcarbonyl)pent-l-yloxy]- 4-methylphenyl] -N-methylbenzamide

NMR (CDC1 ₃ , δ) : 1.29-1.57 (4H, m) , 1.61-1.96 (6H, m) , 2.29 (9H, s), 2.25-2.41 (3H, ) , 2.49-2.63

(IH, m) , 2.92-3.08 (IH, m) , 3.30 (3H, s) , 3.49

(3H, s), 3.75-3.99 (3H, m) , 4.56-4.68 (IH, m) , 6.53-6.66 (2H, ιr_) , 6.76-6.90 (3H, m) , 7.41 (IH, d, J=9Hz), 7.48-7.52 (4H, m) , 7.69-7.79 (2H, ) , 8.07 (IH, d, J=9Hz), 8.19 (2H, d, J=9H2)

55) 3-Methoxy-4- (4 ' -nitrobiphenyl-2-carboxamido) -N- [4- methyl-2- [5- [4- (4-pyridylpipera2in) -1-ylcarbonyl) pent-

1-yloxy ] phenyl ] -N-methylben2amide NMR (CDCI3, δ) : 1.45-1.87 (6H, ) , 2.29 (3H, s) ,

2.39 (2H, t, J=7H2), 3.30 (3H, s) , 3.28-3.41 (4H, m) , 3.50 (3H, s), 3.58-3.67 (2H, m) , 3.72-3.30 (2H, m) , 3.80-4.01 (2H, ) , 6.53-6.67 (4H, m) ,

6.76-6.91 (3H, ) , 7.42 (IH, d, J=9Hz) , 7.49-7.61 (4H, m) , 7.67-7.78 (2H, m) , 8.08 (IH, d, J=9H2) , 8.17 (2H, d, J=9H2), 8.27 (2H, d, J=9Hz)

56) 4- (4'-Aminobiphenyl-2-carboxamido) -N-methyl-N-[4- methyl-2-[5-[ (4-methylpiperazin-l-ylcarbonyl) ent-1- yloxy]phenyl]benzamide

NMR (CDCI3, δ) : 1.42-1.56 (2H, m) , 1.60-1.84 (4H, m) , 2.26 (3H, s), 2.30 (3H, s) , 2.28-2.43 (6H, ) , 3.28 (3H, s), 3.48 (2H, dd, J=6, 6H2) , 3.61

(2H, dd, J=6, 6Hz) , 3.71-3.97 (4H, ) , 6.53-6.60 (2H, m) , 6.67 (2H, d, J=9Hz) , 6.83 (IH, d, J=9Hz), 6.94-7.02 (2H, br d, J=9Hz) , 7.06 (IH, br s), 7.15-7.25 '3H, m) , 7.31-7.42 (2H, m) , 7.43- 7.52 (IH, m) , ^" .82 (IH, d, J=9Hz)

57) 4- (4'-Methylbiphenyl-2-carboxamido) -2-nitro-N- [2- [5- (4-methylpipera2in-l-ylcarbonyl)pent-1-yloxy]phenyl] - N-methylben2amide

NMR (CDC1 ₃ , δ) : 1.48-1.63 (2H, ) , 1.64-1.80 (2H, ) , 1.81-1.97 (2H, m) , 2.27-2.47 (9H, m) , 2.32 (3H, s), 3.36 (3H, s) , 3.44-3.56 (2H, ) , 3.57- 3.66 (2H, m) , 3.89-4.00 (2H, m) , 6.69 (IH, dd, J=9, 9H2) , 6.75 (IH, d, J=9H2) , 7.03-7.61 (13H, ) , 7.83 (IH, d, J=9Hz)

58) 4- (Methylphenyl-2-carboxamido) -N-methyl-N- [4-methyl-2- [5- (4-methylpiperazin-l-yl) carbonylpent-1-yloxy] - phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.42-1.57 (2H, m) , 1.58-1.87 (4H, m) , 2.28 (3H, s), 2.29 (3H, s) , 2.30-2.42 (6H, ) , 2.47 (3H, s), 3.33 (3H, s) , 3.47 (2H, dd, J=6, 6Hz) , 3.57 (2H, dd, J=6, 6Hz) , 3.74-3.99 (2H, m) , 6.56-6.64 (2H, m) , 6.88 (IH, d, J=9Hz) , 7.17-7.47 (8H, m) , 7.66 (IH, s)

59) 4- (4'-Methylbiphenyl-2-carboxamido) -N- dimethylaminocarbonylmethyl-N- (2-methylphenyl) - benzamide mp : 110-115°C NMR (CDCI3, δ) : 2.23 (3H, s), 2.37 (3H, s), 3.00

(3H, s), 3.06 (3H, s), 3.92 (IH, d, J==15Hz) , 5.10 (IH, d, J=15Hz) , 6.88 (3H, d, J=10Hz) , 7.04-7.56 (12H, ) , 7.80 (IH, d, J=6Hz)

Example 28

The following compounds were obtained by reacting the compounds, which were prepared according to a similar manner to that of Example 26, with hydrogen chloride.

1) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido) -N-

methyl-N- [4-methyl-2- [5- [4- (2- (2-hydroxyethoxy)ethyl) pipera2in-1-ylcarbonyl]pent-1-yloxy]phenyl]ben2amide hydrochloride

NMR (DMSO-d ₆ , δ) : 1.36-1.50 (2H, m) , 1.50-1.64 (2H, ) , 1.64-1.80 (2H, m) , 2.23 (3H, s) , 2.30 (3H, s), 2.38 (2H, t, J=7H2), 2.84-3.68 (18H, m) , 3.73-4.11 (5H, ) , 4.33-4.47 (IH, m) , 6.63 (IH, d, J=8H2), 6.74-6.79 (3H, m) , 7.00 (IH, d, J=8Hz), 7.16 (2H, d, J=8Hz) , 7.28 (2H, d, J=8Hz) , 7.35-7.49 (2H, ) , 7.50-7.61 (2H, m) , 7.70 (IH, d, J=8H2), 8.91 (IH, s)

2) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [4 -me thy 1-2- [5- [4- (4 -pyridyl) piperazin-1- ylcarbonyl ] pent- 1 -yloxy] phenyl] en2amide dihydrochloride

NMR (DMSO-d ₆ , δ) : 1.38-1.53 (2H, m) , 1.53-1.66 (2H, m) , 1.66-1.80 (2H, m) , 2.23 (3H, s) , 2.30 (3H, s), 2.38 (2H, t, J=7H2), 3.16 (3H, s) , 3.46 (3H, s), 3.53-3.77 (8H, m) , 3.78-4.01 (2H, ) , 6.64

(IH, d, J=8Hz) , 6.74-6.88 (3H, ) , 7.00 (IH, d, J=8Hz), 7.14 (4H, dd, J=8, 8Hz) , 7.26 (2H, d, J=8Hz), 7.33-7.45 (2H, ) , 7.53 (2H, dd, J=8, 8Hz), 7.69 (IH, d, J=8Hz) , 8.23 (2H, d, J=8Hz) , 8.89 (IH, s)

3) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [4-methyl-2- [5- (2-morpholinoethylcarbamoyl) - pent-1-yloxy] phenyl ] benzamide hydrochloride NMR (DMS0-d ₆ , δ) : 1.34-1.47 (2H, m) , 1.52-1.66 (2H, ) , 1.66-1.78 (2H, ) , 2.14 (2H, t, J=7Hz) , 2.23 (3H, s), 2.31 (3H, s), 2.98-3.21 (4H, m) , 3.18 (3H, s), 3.38-3.53 (7H, ) , 3.67-4.02 (6H, ) , 6.65 (IH, d, J=9Hz), 6.76-6.87 (3H, m) , 7.01 (IH, d, H=9Hz), 7.17 (2H, d, J=9Hz) , 7.29 (2H, d,

- 191 -

J=9Hz), 7.36-7.48 (2H, ) , 7.48-7.60 (2H, ) , 7.70 (IH, d, J=9H2), 8.14-8.24 (IH, ) , 8.92 (IH, s)

4) 3-Methoxy-4- (4'-methylbiphenyl-2-carboxamido) -N- methyl-N- [4-methyl-2- [5- (2-pyridylmethylcarbamoyl) - pent-1-yloxy] phenyl] en∑amide hydrochloride NMR (DMSO-d ₆ , δ) : 1.34-1.47 (2H, ) , 1.51-1.77 (4H, ) , 2.16-2.33 (2H, m) , 2.23 (IH, s), 2.28 (3H, s), 3.14 (3H, s , 3.46 (3H, s) , 3.76-4.01 (2H, m) , 4.55 (2H, d, J=6Hz) , 6.63 (IH, d, J=9Hz) , 6.74-6.88 (3H, ) , 6.99 (IH, d, J=9Hz) , 7.15 (2H d, J=9Hz), 7.28 (2H, d, J=9Hz) , 7.34-7.47 (2H, m) , 7.47-7.60 (2H, m) , 7.65-7.83 (3H, m) , 8.33 (IH, dd, J=9, 9Hz), 8.68-8.78 (2H, m) , 8.89 (IH, s)

5) 3-Methoxy-4-(4'-methylbiphenyl-2-carboxamido) -N- methyl-N-[4-methyl-2-[5-[4- (pyrrolidinocarbonyl- methyl)piperazin-l-ylcarbonyl]pent-l-yloxy]phenyl]- benzamide dihydrochioride

NMR (DMS0-d ₆ , δ) : 1.36-1.65 (4H, m) , 1.65-1.98 (6H, m) , 2.24 (3H, s), 2.30 (3H, s) , 2.33-2.45 (2H, ) , 2.90-4.50 (22H, m) , 6.64 (IH, d, J=8Hz) , 6.73-6.83 (3H, m) , 7.02 (IH, d, J=8Hz) , 7.17 (2H, d, J=8Hz) , 7.29 (2H, d, J=8Hz) , 7.35-7.50 (2H, ) , 7.50-7.63 (2H, m) , 7.71 (IH, d, J=8Hz) , 8.91 (IH, s)

6) 4- (4'-Methylbiphenyl-2-carboxamido)-N-methyl-N-[2-[7- (4-methylpiperazin-l-yl)carboxyheptyloxy]phenyl]- benzamide hydrochloride

NMR (CDC1 ₃ , δ) : 1.38-1.55 (6H, ) , 1.55-1.69 (2H, ) , 1.69-1.89 (2H, m) , 1.86 (3H, s), 2.35 (3H, s), 2.24-2.38 (2H, m) , 2.61-2.90 (4H, m) , 3.29

- 192 -

(3H, s), 3.23-3.49 (2H, m) , 3.75-4.01 (4H, ) , 6.78 (2H, br d, J=9Hz) , 6.90-7.04 (3H, m) , 7.11- 7.34 (7H, m) , 7.35-7.56 (3H, m) , 7.77 (IH, d, J=9Hz)

Example 29

A solution of 4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- (2-benzyloxy-4-methylphenyl)benzamide (2.2 σ) , 10% palladium hydroxide (220 mg) in methanol (50 ml) was stirred under atmospheric pressure of hydrogen at ambient temperature. After 5 hours, the reaction mixture was filtered through a bed of Celite, and then concentrated to give 4- (4 '-methylbiphenyl-2-carboxamido) -N-methyl-N- [2- hydroxy-4-methylphenyl]benzamide (1.71 g) . NMR (DMSO-d ₆ , δ) : 2.16 (3H, s) , 2.27 (3H, s) , 3.15

(3H, s), 6.47 (IH, d, J=9Hz) , 6.61 (IH, s) , 6.83 (IH, d, J=9Hz) , 7.10-7.24 (4H, m) , 7.24-7.38 (4H, m) , 7.43 (2H, dd, J=9, 9Hz) , 7.47-7.58 (2H, m) , 9.71 (IH, br s)

Example 30

The following compounds were obtained according to a similar manner to that of Example 29.

1) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- (2- hydroxy-5-methylphenyl)benzamide

NMR (DMS0-d ₆ , δ) : 2.08 (3H, s) , 2.27 (3H, s) , 3.16 (3H, s), 6.68 'IH, d, J=9Hz) , 6.77-6.88 (2H, ) , 7.10-7.68 (12H, ) , 9.56 (IH, s)

2) 4- (Biphenyl-2-carboxamido) -N-methyl-N- (2- hydroxyphenyl)benzamide

NMR (DMSO-d ₆ , δ) : 3.17 (3H, s) , 6.66 (IH, dd, J=9, 9Hz), 6.81 (IH, d, J=9Hz), 6.97 (IH, d, J=9Hz) , 7.03 (IH, dd, J=9, 9Hz) , 7.17 (2H, d, J=9Hz),

- 193 - 7.23-7.61 (11H, m) , 9.88 (IH, br s)

3) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- (4-chloro-2-hydroxyphenyl)benzamide

NMR (CDC1 ₃ , δ) : 2.31 (3H, s) , 3.28 (3H, s) , 3.33 (3H, s), 6.62-6.80 (2H, ) , 6.87-7.01 (2H, m) , 7.04-7.17 (3H, m) , 7.21-7.30 (2H, m) , 7.33-7.46 (2H, ) , 7.50 (IH, dd, J=9, 9Hz) , 7.64-7.83 (2H, ) , 8.13-8.28 (IH, )

4) 3-Chloro-4- ( ' -methylbiphenyi-2-carboxamido) -N- [4- chloro-2-hydroxyphenyl] -N-methylbenzamide

NMR (CDCI3, δ) : 2.32 (3H, s) , 3.29 and 3.33 (total

3H, s), 6.61-8.34 (15H, )

5) 2-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- [4- chloro-2-hydroxyphenyl] -N-methylbenzamide

NMR (DMSO-d ₆ , δ) : 2.28 (3H, s), 3.13 and 3.16 (total 3H, s), 3.54 (3H, s) , 6.51-6.69 (IH, ) , 6.70- 6.80 (IH, m) , 6.86-7.06 (3H, m) , 7.06-7.23 (3H, m) , 7.24-7.32 (2H, m) , 7.37-7.59 (4H, m)

6) 2-Chloro-4- (4 ' -methylbiphenyl-2-carboxamido) -N- [4- chloro-2-hydroxyphenyl ] -N-methylbenzamide NMR (CDCI3, δ) : 2.36 and 2.42 (total 3H, s) ,

3.20-3.41 (3H, m) , 6.63-7.94 (15H, m)

7) 4- (4'-Methylbiphenyl-2-carboxamido) -N- [4-chloro-2- hydroxyphenyl] -N-methylbenzamide NMR (DMSO-d _6/ δ) : 2.28 (3H, s) , 3.15 (3H, s) , 6.73

(IH, d, , 6.83 (IH, s) , 7.04 (IH, d, J=8H2) , 7.10-7.23 (4H, ) , 7.24-7.58 (9H, m)

8) 4- (2-Phenylpyridine-3-carboxamido) -N- (4-chIoro-2- hydroxyphenyl) -N-methylbenzamide

NMR (DMSO-d ₆ , δ) : 3.15 (3H, s) , 6.73 (IH, dd, J=8, 2H2) , 6.82 (IH, d, J=2H2), 7.04 (IH, d, J=8H2) , 7.20 (2H, d, J=8H2), 7.28-7.44 (6H, m) , 7.44-7.53 (IH, m) , 7.57-7.68 (2H, m) , 7.98 (IH, dd, J=8, 2H2), 8.70-8.79 (IH, m)

9) 4- (Methylphenyl-2-carboxamido) -N-methyl-N- (2-hydroxy- 4-methylphenyl)benzamide

NMR (DMSO-d ₆ , δ) : 2.14 (3H, s), 2.33 (3H, s), 3.16 (3H, s), 3.22-3.43 (2H, br s) , 6.47 (IH, d,

J=9Hz), 6.63 (IH, s), 6.84 (IH, d, J=9Hz), 7.19- 7.33 (4H, ) , 7.34-7.44 (2H, m) , 7.53 (2H, d, J=9Hz)

10) 3-Methyl-4- (4 '-methylbiphenyl-2-carboxamido) -N-methyl- N- (4-chloro-2-hydroxyphenyl)benzamide NMR (CDC1 ₃ , δ) : 1.43 (3H, s), 2.33 (3H, s), 3.27 (3H, s), 6.60-7.20 (7H, m) , 7.28-7.55 (5H, m) , 7.74-7.95 (3H, m)

11) 4- (1, 2-Dimethylphenyl-3-carboxamido) -N- (2- hydroxyphenyl) -N-methylbenzamide

NMR (DMSO-d ₆ , δ) : 2.20 (3H, s), 2.27 (3H, s), 3.20 (3H, s), 6.67 (IH, dd, J=8, 8Hz), 6.81 (IH, d, J=8Hz), 6.96-7.07 (2H, m) , 7.08-7.30 (5H, m) ,

7.53 (2H, d, J=8Hz), 9.86 (IH, s)

12) 2-Methoxy-4- (methylphenyl-2-carboxamido) -N- (4-chloro- 2-hydroxyphenyl) -N-methylbenzamide NMR (CDCI3, δ) : 2.35 and 2.49 (total 3H, s), 3.18 and 3.26 (total 3H, s), 3.65 and 3.92 (total 3H, br s), 6.52-6.67 (IH, m) , 6.67-7.69 (10H, m)

13) 4- (Methylphenyl-2-carboxamido) -N- (4-chloro-2- hydroxyphenyl) -N-methylbenzamide

NMR (CDCI3, δ) : 2.33 (3H, br s) , 3.24 and 3.30

(total 3H, br s) , 3.47 (IH, s) , 6.58-7.56 (11H, m) , 8.20-8.36 (IH, m)

E am le 31

To a solution of 4 '-methylbiphenyl-2-carboxamido-N- methyl-N- (2-hydroxyphenyl)benzamide (263 mg) in N,N- dimethylformamide (15 ml) was added potassium carbonate (250 mg) , ethyl 6-bromohexanoate (161 mg) and sodium iodide (cat.) at 60°C. The reaction mixture was stirred at same temperature for 13 hours. The reaction mixture was cooled in an ice bath and quenched with IN hydrochloric acid (4 ml) and water (20 ml) . The mixture was extracted with ethyl acetate. The organic phase was washed with water and brine. The organic solution was dried over magnesium sulfate. The solvent was removed by evaporation to give 4- (4 ' -methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- ethoxycarbonylpentyloxy)phenyl]benzamide (380 mg) .

NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.33-1.56 (2H, m) , 1.61-1.89 (4H, m) , 2.32 (2H, t, J=7Hz), 2.35

(3H, s), 3.32 (3H, s), 3.79-3.99 (2H, m) , 4.12 (2H, q, J=7Hz), 6.79 (2H, d, J=9Hz), 6.87-7.00 (4H, m) , 7.09-7.24 (5H, ) , 7.29 (2H, d, J=9H2) , 7.35-7.56 (3H, m) , 7.81 (IH, br d, J=9H2)

Example 32

The following compounds were obtained according to a similar manner to that of Example 31.

1) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (3- ethoxycarbonylpropoxy)phenyl]ben2amide NMR (CDCI3, δ) : 1.26 (3H, t, J=7H2) , 2.08 (2H, t, J=7Hz), 2.35 (3H, s) , 2.50 (2H, t, J=7Hz) , 3.32 (3H, s), 3.84-4.02 (2H, m) , 4.14 (2H, q, J=7Hz) , 6.80 (2H, d, J=9Hz) , 6.86-7.00 (4H, ) , 7.09-7.23

( 5H, m) , 7 . 28 ( 2H, d, J=9Hz ) , 7 . 34-7 . 56 ( 3H, ) ,

7 . 81 ( IH, d, J=9Hz )

2) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- chloropentyloxy) phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.55-1.69 (2H, m) , 1.76-1.94 (4H, m) , 2.36 (3H, s), 3.33 (3H, s), 3.57 (2H, t, J=7Hz), 3.81-4.00 (2H, m) , 6.75-6.84 (2H, m) , 6.86-7.03 (4H, ) , 7.10-7.25 (5H, ) , 7.30 (2H, d, J=9Hz), 7.35-7.56 (3H, m) , 7.83 (IH, d, J=9Hz)

3) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- hydroxybutoxy) phenyl]benzamide

NMR (CDCI3, δ) : 1.63-1.94 (4H, ) , 2.36 (3H, s) , 3.32 (3H, s), 3.44-3.76 (2H, m) , 3.81-4.01 (2H, m) , 6.74-6.86 (2H, m) , 6.88-7.07 (4H, m) , 7.10- 7.26(5H, ) , 7.29 (2H, d, J=9Hz) 7.35-7.56 (3H, ) , 7.81 (IH, d, J=9Hz)

4) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- ethoxycarbonylpentyloxy) -4-methylphenyl]benzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz), 1.41-1.55 (2H, m) , 1.61-1.84 (4H, m) , 2.28 (3H, s) , 2.34 (2H, t, J=7Hz), 2.36 (3H, s) , 3.29 (3H, s) , 3.76-3.97 (2H, m) , 4.12 (2H, q, J=7Hz) , 6.54-6.62 (2H, m) ,

6.82 (IH, d, J=9Hz), 6.86-6.99 (3H, m) , 7.14-7.23 (4H, m) , 7.30 (2H, d, J=9Hz) , 7.35-7.56 (3H, ) ,. 7.82 (IH, d, J=9Hz)

5) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5- ethoxycarbonylpentyloxy) -5-methylphenyl]benzamide NMR (CDCI3, δ) : 1.25 (3H, t, J=7Hz) , 1.38-1.54 (2H, m) , 1.60-1.82 (4H, m) , 2.16(3H, s) , 2.32 (2H, t, J=7Hz) , 2.36 (3H, s) , 3.29 (3H, s) , 3.70-3.94 (2H, m) , 4.12 (2H, q, J=7Hz) , 6.66(1H, d, J=9Hz) ,

6.79 (IH, s), 6.86-7.00 (4H, m) , 7.13-7.25 (4H, m) , 7.30 (2H, d, J=9Hz), 7.34-7.55 (3H, m) , 7.81 (IH, d, J=9H2)

6) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (5-ethoxycarbonylpentyloxy) -4- ethylphenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.26 (3H, t, J=lEz) , 1.40-1.58 (2H, ) , 1.59-1.94 (4H, m) , 2.28 (3H, s) , 2.34 (3H, s), 2.25-2.38 (2H, m) , 3.29 (3H, s) , 3.43 (3H,

S), 3.76-3.99 (2H, m) , 4.12 (2H, q, J=lEz) , 6.52- 6.66 (2H, ) , 6.74-6.90 (3H, m) , 7.14 (2H, d, J=9H2), 7.23-7.34 (2H, m) , 7.35-7.56 (3H, ) , 7.69 (IH, s), 7.80 (IH, d, J=9H2) , 8.17 (IH, d, J=9H2)

7) 4- (Biphenyl-2-carboxamido) -N-methyl-N- [2- (5- ethoxycarbonylpentyloxy)phenyl]ben2amide NMR (CDCI3, δ) : 1.26 (3H, t, J=7H2) , 1.38-1.56 (2H, m) , 1.56-1.93 (4H, m) , 2.33 (2H, t, J=7Hz) , 3.31

(3H, s), 3.75-3.99 (2H, m) , 4.11 (2H, q, J=7Hz) , 6.71-6.82 (2H, m) , 6.82-6.99 (4H, m) , 7.07-7.24 (3H, m) , 7.30-7.57 (8H, m) , 7.82 (IH, d, J=9H2)

8) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- ethoxycarbonylbutoxy)phenyl]ben2amide

NMR (CDCI3, δ) : 1.25 (3H, t, J=7H2) , 1.58-1.96 (4H, m) , 2.35 (3H, s) , 2.28-2.42 (2H, m) , 3.32 (3H, s), 3.77-4.00 (2H, m) , 4.14 (2H, q, J=lEz) , 6.78 (2H, br d, J=9H2) , 6.84-7.02 (4H, m) , 7.06-7.32

(7H, m) ,' 7.33-7.56 (3H, it.), 7.81 (IH, br s, J=9H2)

9) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (7- methoxycarbonylheptyloxy)phenyl]ben2amide

NMR (CDCI3, δ) : 1.29-1.53 (6H, ) , 1.54-1.69 (2H, ) , 1.70-1.83 (2H, m) , 2.30 (2H, t, J=7H2) , 2.35 (3H, s), 3.31 (3H, s), 3.64 (3H, s) , 3.78-3.97 (2H, m) , 6.71-6.83 (2H, m) , 6.86-7.04 (4H, m) , 7.07-7.22 (5H, ) , 7.29 (2H, d, J=9H2) , 7.33-7.56

(3H, m), 7.81 (IH, d, J=9Hz)

10) 3-Methoxy-4- (4 '-methylbiphenyl-2-carboxamido-N-methyl- N- [ 2- ( 5-ethoxycarbonylpent yloxy ) phenyl ] ben2amide NMR (CDCI3, δ) : 1.24 (3H, t, J=7H2) , 1.32-1.94 (6H, ) , 2.33 (3H, s), 2.26-2.38 (2H, m) , 3.32 (3H, s), 3.38 (3H, s), 3.77-4.01 (2H, m) , 4.12 (2H, q, J=7H2), 6.70-6.87 (4H, m) , 6.94 (IH, br d J=9H2) , 7.05-7.19 (3H, ) , 7.27 (2H, br d, J=9H2) , 7.32- 7.53 (3H, m) , 7.67 (IH, br s) , 7.79 (IH, d,

J=9H2), 8.17 (IH, br d, J=9H2)

11) 4- (Biphenyl-2-carboxamido) -3-methoxy-N-methyl-N-[2- (5- ethoxycarbonylpentyloxy) -4-methylphenyl]benzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.42-1.56 (2H, m) , 1.60-1.86 (4H, m) , 2.28 (3H, s) , 2.33 (2H, t, J=7H2), 3.29 (3H, s), 3.41 (3H, s), 3.76-3.99 (2H, m) , 4.13 (2H, q, J=7H2) , 6.52-6.65 (2H, m) , 6.76-6.88 (3H, ) , 7.23-7.57 (8H, m) , 7.65 (IH, br s), 7.81 (IH, d, J=9H2) , 8.16 (IH, d, J=9H2)

12) 3-Methoxy-4- (4'-methylbiphenyl-2-carboxamido)-N- methyl-N-[4-chloro-2- (5-ethoxycarbonylpentyloxy) - phenyl]ben∑amide NMR (CDCI3, δ) : 1.26 (3H, t, J=7H2) , 1.43-1.56 (2H, m) , 1.62-1.87 (4H, m) , 2.27-2.36 (5H, m) , 3.27 and 3.32 (total 3H, s), 3.39 and 3.42 (total 3H, s), 3.78-4.00 (2H, ) , 4.13 (2H, q, J=7H2) , 6.72- 6.97 (5H, ) , 7.08-7.18 (2H, ) , 7.25-7.33 (2H, m) , 7.34-7.55 (3H, m) , 7.68 (IH, br d, J=9H2) ,

7 . 79 ( IH, dd, J=9 , 9Hz ) , 8 . 13- 8 . 26 ( IH, )

13) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- phthalimidobutoxy)phenyl]ben2amide NMR (CDC1 ₃ , δ) : 1.53-1.96 (4H, m) , 2.34 (3H, s),

3.31 (3H, s), 3.66-3.80 (2H, m) , 3.83-4.04 (2H, m) , 6.73-6.83 (2H, m) , 6.85-7.00 (4H, ) , 7.07- 7.24 (5H, ) , 7.29 (2H, d, J=9H2) , 7.34-7.56 (3H, m) , 7.66-7.77 (2H, m) , 7.77-7.89 (3H, )

14) 4- (4 '-Methylbiphenyi-2-carboxamido) -N-methyl-N- [2- (3- phthalimidoprop-1-yloxy)phenyl]ben2amide

NMR (CDCI3, δ) : 2.19 (2H, quint., J=6H2), 2.35 (3H, s), 3.35 (3H, s), 3.86-3.98 (4H, m) , 6.75-6.85

(7H, m) , 7.10-7.34 (6H, m) , 7.38-7.55 (3H, m) , 7.68-7.88 (5H, )

15) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (3- hydroxypropoxy) phenyl]ben∑amide

NMR (CDCI3, δ) : 2.00 (2H, t, J=7H2) , 2.36 (3H, s) , 3.32 (3H, s), 3.76-3.86 (2H, m) , 3.88-4.14 (2H, m) , 6.76-7.06 (5H, m) , 7.11-7.34 (8H, m) , 7.34- 7.56 (3H, m) , 7.81 (IH, d, J=9H2)

16) 4- (4-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- methoxycarbonylphenylmethoxy) phenyl]ben2amide

NMR (CDCI3, δ) : 2.34 (3H, s), 3.38 (3H, s), 3.91

(3H, s), 4.91-5.13 (2H, m) , 6.78 (IH, s, J=7H2) , 6.82-6.92 (3H, ) , 7.07-7.19 (6H, ) , 7.27-7.54

(7H, m) , 7.82 (IH, d, J=7H2) , 8.02 (2H, d, J=8.5Hz)

17) 4- (4'-Methylbiphenyi-2-carboxamido) -N-methyl-N- [2- (5- methoxycarbonylpyrid-2-ylmethoxy)phenyl]ben2amide

NMR (CDCI3, δ) : 2.34 (3H, s) , 3.32 (3H, s) , 3.99

(3H, s), 5.30 (2H, s), 6.78 (IH, dd, J=7, 7Hz) , 7.85-7.94 (5H, m) , 7.10-7.23 (5H, m) , 7.30 (2H, d, J=8.5H2), 7.36-7.54 (5H, m) , 7.83 (IH, d, J=7H2), 8.50 (IH, ) , 9.10 (IH, m)

18) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [4- (4-t-butoxycarbonylpipera2in-l-yl) - sulfonylphenylmethoxy]phenyl]ben2amide NMR (CDCI3, δ) : 1.40 (9H, s), 2.32 (3H, s), 2.91-

3.02 (4H, m) , 3.37 (3H, s), 3.96-3.53 (4H, m) , 5.06 (2H, m) , 6.80 (IH, d, J=7H2), 6.87-6.94 (3H, ) , 7.11-7.20 (6H, m) , 7.24-7.51 (7H, m) , 7.72 (2H, d, J=8.5Hz), 7.82 (IH, d, J=7Hz)

19) 3-Methyl-4- (4 '-methylbiphenyl-2-carboxamido) -N-methyl- N- [3-chloro-2- (5-ethoxycarbonylpenten-l-yloxy) phenyl] - ben2amide

NMR (CDCI3, δ) : 1.23 (3H, t, J=7.5Hz) , 1.42 (3H, s), 1.48 (2H, m) , 1.70 (2H, ) , 1.79 (2H, m) , 2.31

(2H, t, J=7.5Hz) , 2.35 (3H, s), 3.26 (3H, s), 3.88 (2H, m) , 4.12 (2H, q, J=7.5Hz), 6.71-7.00 (4H, m) , 7.09 (IH, s), 7.28 (2H, d, J=8.5Hz), 7.29-7.53 (5H, m) , 7.82 (IH, d, J=7Hz), 7.98 (2H, d, J=7Hz)

20) 4- (4 '-Methylbiphenyl-2-carboxamido) -N- [4-chloro-2- (5- ethoxycarbonylpent-1-yloxy)phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz), 1.40-1.55 (2H, m) , 1.61-1.87 (4H, m) , 2.27-2.40 (5H, m) , 3.28 and 3.31 (total 3H, s), 3.75-3.98 (2H, m) , 4.11 (2H, q, J=7Hz), 6.72-6.80 (2H, m) , 6.84-7.00 (4H, m) , 7.09-7.24 (4H, ) , 7.30 (2H, d, J=9Hz), 7.34- 7.56 (3H, m) , 7.78-7.87 (IH, m)

21) 3-Chloro-4- (4 '-methylbiphenyl-2-carboxamido) -N- [4- chloro-2- (5-ethoxycarbonylpent-l-yloxy)phenyl] -N- methylben2amide

NMR (CDC1 ₃ , δ) : 1.26 (3H, t, J=7H2) , 1.40-1.57 (2H, m) , 1.63-1.88 (4H, m) , 2.27-2.42 (5H, m) , 3.28 and 3.32 (total 3H, s), 3.77-4.00 (2H, ) , 4.13 (2H, q, J=7H2), 6.75-6.85 (2H, ) , 6.85-7.36 (7H, m) , 7.36-7.50 (2H, m) , 7.50-7.60 (2H, m) , 7.75- 7.84 (IH, ) , 8.21-8.36 (IH, m)

22) 2-Methoxy-4- (4'-methylbiphenyl-2-carboxamido) -N- [4- chloro-2- (5-ethoxycarbonylpent-l-yloxy) phenyl] -N- methylben2amide

NMR (CDCI3, δ) : 1.26 (3H, t, J=7H2), 1.44-1.60 (2H, m) , 1.65-1.93 (4H, m) , 2.26-2.43 (5H, ) , 3.29 and 3.33 (total 3H, s), 3.64 (3H, s), 3.80-3.98 (2H, m) , 4.13 (2H, q, J=7Hz) , 6.16-6.28 (IH, m) , 6.60-6.76 (2H, m) , 6.80-7.12 (4H, ) , 7.13-7.24 (2H, m) , 7.24-7.33 (2H, m) , 7.33-7.56 (3H, m) , 7.78-7.87 (IH, )

23) 2-Chloro-4- ( ' -methylbiphenyl-2-carboxamido) -N- [4- chloro-2- (5-ethoxycarbonylpent-l-yloxy) phenyl] -N- methylben2amide NMR (CDCI3, δ) : 1.20-1.32 (3H, m) , 1.45-1.63 (2H, m) , 1.63-1.96 (4H, m) , 2.28-2.46 (5H, m) , 3.23- 3.37 (3H, m) , 3.88-4.00 (2H, ) , 4.07-4.20 (2H, m) , 6.66-7.60 fl4H, m) , 7.76-7.86 (IH, m)

24) 4- (4 '-Aminobiphenyl-2-carboxamido) -N- [2- (5- ethoxycarbonylpent-1-yloxy) -4-methylphenyl] -N- methylben2amide

NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.39-1.56 (2H, m) , 1.59-1.87 '4H, m) , 2.27 (3H, s) , 2.31 (2H, t, J=7Hz), 3.28 (3H, s), 3.72-3.97 (4H, m) , 4.12

(2H, q, J=7Hz), 6.51-6.61 (2H, m) , 6.68 (2H, d, J=9Hz), 6.82 (IH, d, J=9Hz) , 6.92-7.08 (3H, m) , 7.14-7.29 (4H, m) , 7.32-7.42 (2H, m) , 7.47 (IH, dd, J=9, 9Hz), 7.81 (IH, d, J=9Hz)

25) 4- (Methylphenyl-2-carboxamido) -N-methyl-N-[4-methyl-2- [5- (ethoxycarbonylpent-1-yloxy)phenyl]benzamide NMR (CDC1 ₃ , δ) : 1.24 (3H, t, J=7Hz) , 1.39-1.57 (2H, m) , 1.61-1.88 (4H, m) , 2.26 (3H, s), 2.34 (2H, t, J=7Hz), 2.45 (3H, s), 3.31 (3H, s), 3.77-3.98

(2H, m) , 4.10 (2H, q, J=7Hz), 6.52-6.66 (2H, m) , 6.86 (IH, d, J=9Hz), 7.16-7.50 (8H, ) , 7.58 (IH, br s)

26) 4- (2-Phenylpyridine-3-carboxamido) -N- [4-chloro-2- (5- ethoxycarbonylpent-i-yloxy) phenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.39-1.63 (2H, m) , 1.61-1.85 (4H, m) , 2.33 (2H, t, J=7Hz) , 3.29 (3H, s), 3.73-3.97 (2H, m) , 4.10 (2H, q, J=7Hz) , 6.74-6.81 (2H, m) , 6.89 (IH, d, J=9Hz) , 6.97 (2H, d, J=9Hz), 7.06 (IH, s) , 7.18 (2H, d, J=9Hz) , 7.34-7.46 (4H, m) , 7.59-7.68 (2H, m) , 8.16 (IH, d, J=9Hz), 8.76-8.82 (IH, )

27) 4- (2-Methylbenzamido) -N-methyl-N-[4-chloro-2-(5- methoxycarbonylpyrid-2-ylmethoxy)phenyl]benzamide NMR (CDCI3, δ) : 2.47 (3H, s) , 3.32 (3H, s) , 3.76 (3H, s), 3.99 (3H, s) , 5.30 (2H, m) , 6.67-6.76 (2H, m) , 6.90 (IH, m) , 6.99 (IH, d, J=7Hz), 7.10 (IH, d, J=7Hz), 7.20-7.48 (6H, m) , 8.53 (IH, m) ,

9.13 (ΪH, m)

28) 4- (l,2-Dimethylphenyl-3-carboxamido)-N-[2- (5- ethoxycarbonylpent-1-yloxy)phenyl]-N-methylbenzamide NMR (CDCI3, δ) : 1.26 (3H, t, J=7Hz) , 1.44-1.58 (2H,

m) , 1.58-1.89 (4H, m) , 2.25-2.39 (8H, m) , 3.33 (3H, s), 3.80-4.01 (2H, m) , 4.11 (2H, q, J=7Hz) , 6.74-6.86 (2H, ) , 7.00 (IH, d, J=8Hz) , 7.04-7.55 (9H, )

29) 4- (Methylphenyl-2-carboxamido) -N-[4-chloro-2- (5- ethoxycarbonylpent-1-yloxy)phenyl]-N-methylbenzamide NMR (CDC1 ₃ , δ) : 1.25 (3H, t, J=7Hz), 1.40-1.58 (2H, m) , 1.58-1.91 (4H, m) , 2.33 (2H, t, J=7Hz) , 2.45 and 2.46 (total 3H, s) , 3.30 and 3.34 (total 3H, s), 3.77-3.99 (2H, m) , 4.11 (2H, q, J=7Hz) , 6.75- 6.85 (2H, m) , 6.88-7.04 (IH, m) , 7.10-7.66 (9H, m)

Example 33

To a mixture of 4- (4'-methylbiphenyl-2-carboxamido)-N- methyl-N- [2- (2-hydroxyiminoethoxy)phenyl]benzamide (255 mg) and potassium carbonate (78.5 mg) in N,N-dimethylformamide (10 ml) was added ethyl bromoacetate (94.9 mg) and the mixture was stirred at ambient temperature for 5 hours.

The mixture was diluted with ethyl acetate (30 ml) and the solution was washed with water and brine. The organic phase was dried over magnesium sulfate and the solvent was evaporated in vacuo to give an oil. The oil was purified by silica gel column (chloroform) to give 4— (4 '— methylbiphenyl-2-carboxamido) -N-methyl-N- [2-[2- (ethoxycarbonylmethoxyimino) ethoxy]phenyl]benzamide (245 mg) as a colorless amorphous.

NMR (CDCI3, δ) : 1.29 (3H, ) , 2.34 (3H, s), 3.28- 3.90 (3H, m) , 4.21 (2H, ) , 4.45-4.87 (4H, m) ,

6.65-6.97 (6H, m) , 7.02-7.23 (5H, m) , 7.28 (2H, d, J=8.5Hz), 7.34-7.53 (3H, m) , 7.82 (IH, d, J=7Hz)

Example 34

1) To a solution of 4 '-methylbiphenyl-2-carboxamido-N- methyl-N- (2-hydroxyphenyl) benzamide (750 mg) in N,N- dimethylformamide (35 ml) was added potassium carbonate (1.42 g) , 1, 4-dibromobutane (1.11 g) . The reaction mixture was stirred at 60°C for 3 hours and to this mixture containing 4'-methylbiphenyl-2-carboxamido-N-methyl-N- [2- (4-bromobutoxy)phenyl]benzamide was added 1- ethylpiperazine (1.03 g) and stirring was continued additional 15 hours. The mixture was extracted with ethyl acetate and washed with water and brine. The organic solution was dried over sodium sulfate. The solvent was removed by evaporation and purified by silica gel column chromatography (Si0 ₂ ; 35 g, 5% methanol in dichloromethane) to give 4- (4 '-methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [4- (4-methylpiperazin-l-yl) butoxy]phenyl]benzamide.

2) The obtained compound was reacted with hydrogen chloride to give 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- [4- (4-methylpiperazin-l-yl)butoxy]phenyl] - benzamide dihydrochloride (480 mg) .

NMR (CDC1 ₃ , δ) : 1.72-1.95 (2H, m) , 1.95-2.12 (2H, m) , 2.35 (3H, s) , 2.88 (3H, s), 3.09-3.33 (2H, m) , 3.31 (3H, s), 3.52-4.19 (10H, m) , 6.70 (IH, d, J=9Hz), 6.86-7.55 (15H, m) , 7.76 (IH, br d, J=9Hz)

Example 35

The following compound was obtained according to a similar manner to that of Example 34-1) .

4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [6- (4-methylpiperazin-l-yl) hexyloxy]phenyl]benzamide

NMR (CDCI3, δ) : 1.31-1.61 (6H, m) , 1.72-1.86 (2H, ) , 2.29 (3H, s), 2.36 \ 1E, t, J=7Hz), 2.37 (3H, s), 2.38-2.66 (8K, ) , 3.32 (3H, s) , 3.80-4.00

(2H, m) , 6.73-6.84 (2H, m) , 6.88-7.00 (4H, m) , 7.11-7.24 (5H, m) , 7.30 (2H, d, J=9Hz) , 7.35-7.56 (3H, m) , 7.82 (IH, d, J=9Hz)

Example 36

The following compound was obtained according to a similar manner to that of Example 34.

4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [8- (4-methylpiperazin-l-yl) octyloxy]phenyl]ben∑amide dihydrochloride

NMR (CDC1 ₃ , δ) : 1.19-1.56 (8H, ) , 1.56-1.95 (4H, m) , 2.36 (3H, s), 2.88 (3H, s) , 2.90 (2H, t, J=7H2), 2.95-3.14 (2H, m) , 3.31 (3H, s), 3.42- 3.70 (4H, ) , 3.70-4.11 (4H, m) , 6.72-6.86 (2H, m) , 6.95-7.07 (3H, m) , 7.09-7.58 (11H, m) , 7.79 (IH, d, J=9H2)

Example 37 To a solution of 4- (1, 2-dimethylphenyl-3-carboxamido) - N- (2-hydroxyphenyl) -N-methylben2amide (710 mg) in N,N- dimethylformamide (25 ml) was added potassium carbonate (786 mg) , l-bromo-6-chlorohexane (757 mg) . The reaction mixture was stirred at 70°C for 12 hours and to this mixture was added 1-methyipiperazine (1.1 g) and catalytic amount of sodium iodide and stirring was continued additional 16 hours. The mixture was extracted with ethyl acetate and washed with water and brine. The organic solution was dried over sodium sulfate. The solvent was removed by evaporation and purified by silica gel column chromatography (Si0 ; 40 g, 5% methanol in chloroform) to give 4- (1, 2-dimethylphenyl-3-carboxamido) -N-methyl-N- [2- [6- (4-methylpipera2inyl) hex-1-yloxy]phenyl]ben2amide (200 mg) as amorphous. NMR (CDCI3, δ) : 1.30-1.60 (4H, m) , 1.72-1.94 (2H,

m) , 2.18-2.66 (19H, m) , 3.34 (3H, s), 3.83-4.00 (2H, m) , 6.76-6.87 (2H, m) , 6.99 (IH, d, J=9H2) , 7.07-7.53 (9H, m)

Example 38

To a solution of 4- (4 '-methylbiphenyl-2-carboxamido) - N-methyl-N- [2- (3-bromopropoxy)phenyl]ben2amide (520 mg) in N,N-dimethylformamide (15 ml) was added potassium carbonate (386 mg) and l-methylpipera2ine (280 mg) at ambient temperature. The reaction mixture was stirred at 60°C for 12 hours. The reaction mixture was cooled and extracted with ethyl acetate and washed with water, saturated sodium hydrogen carbonate and brine. The organic solution was dried over sodium sulfate. The solvent was removed by evaporation and subjected to silica gel column chromatography (Si0 ₂ ; 30 g, 10% methanol in chloroform) to give 4- (4 '-methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [3- (4-methylpiperazin-l-yl)propoxy]phenyl]ben2amide (180 mg) . NMR (CDC1 ₃ , δ) : 1.86-2.08 (2H, m) , 2.29 (3H, s) , 2.36 (3H, s), 2.39-2.67 (10H, ) , 3.31 (3H, s) ,

3.82-4.07 (2H, m) , 6.71-7.02 (5H, ) , 7.06-7.56 (11H, m) , 7.81 (IH, d, J=9H2)

Example 39 The following compounds were obtained according to a similar manner to that of Example 38.

1) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [5- (4-methylpiperazin-1-yl)pentyloxy]phenyl]ben2amide NMR (CDCI3, δ) : 1.41-1.63 (4H, m) , 1.74-1.86 (2H, m) , 2.32 (3H, s), 2.36 (3H, s), 2.20-2.65 (10H, m) , 3.32 (3H, s), 3.78-4.00 (2H, m) , 6.72-6.82 (2H, m) , 6.86-6.98 (4H, m) , 7.09-7.22 (5H, m) , 7.29 (2H, d, J=9H2), 7.34-7.56 (3H, m) , 7.82 (IH, d, J=9Hz)

2) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [4-chloro-2- [6- (4-methylpiperazin-l-yl) hex-1 ^* yloxy]phenyl]benzamide dihydrochloride

NMR (CDC1 ₃ , δ) : 1.41-1.58 (4H, m) , 1.72-1.83 (2H, ) , 1.83-1.97 (2H, m) , 2.34 and 2.35 (total 3H, s), 2.88 (3H, s), 3.06-3.16 (2H, ) , 3.28 and 3.32 (total 3H, s) , 3.39 and 3.43 (total 3H, s), 3.46-4.14 (10H, m) , 6.74-7.05 (5H, m) , 7.11-7.19 (2H, m) , 7.25-7.31 (2H, m) , 7.35-7.56 (3H, m) , 7.67-7.75 (IH, m) , 7.75-7.84 (IH, ) , 8.13-8.24

(IH, m)

3) 3-Methoxy-4-nitro-N- [2- [6- (4-methylpiperazin-l-yl) hex- 1-yloxy] -4-methylphenyl] -N-methylbenzamide NMR (CDCI3, δ) : 1.32-1.62 (6H, m) , 1.70-1.90 (4H, m) , 2.28 (3H, s), 2.29 (3H, s), 2.35 (2H, t, J=7Hz), 2.22-2.70 (6H, ) , 3.34 (3H, s), 3.77 (3H, s), 3.81-3.98 (2H, m) , 6.55-6.65 (2H, ) , 6.86 (IH, d, J=9Hz), 6.94 (IH, d, J=9Hz) , 7.06 (IH, s), 7.61 (IH, d, J=9Hz)

Example 40

To a solution of 4- (4 ' -methylbiphenyl-2-carboxamido) - N-methyl-N- [2- (5-chloropentyloxy) phenyl]benzamide (800 mg) in N,N-dimethylformamide (15 ml) was added potassium phthalimide (821 mg) and sodium iodide (cat.) at ambient temperature. The reaction mixture was stirred at 80°C for 18 hours. The reaction mixture was cooled and extracted with ethyl acetate and washed with water and brine. The organic solution was dried over magnesium sulfate. The solvent was removed by evaporation and subjected to silica gel column chromatography (Si0 ₂ ; 50 g, 0.5% methanol in chloroform) to give 4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (5-phthalimidopentyloxy) phenyl]benzamide (1.1 g) .

NMR (CDCI3, δ) : 1.43-1.56 (2H, m) , 1.67-1.89 (4H, m) , 2.35 (3H, s), 3.29 (3H, s) , 3.70 (2H, t, J=7Hz), 3.79-3.96 (2H, ) , 6.74-6.84 (2H, m) , 6.88-7.04 (4H, m) , 7.09-7.24 (4H, m) , 7.29 (2H, d, J=9Hz), 7.34-7.55 (3H, ) , 7.66-7.92 (5H, )

Example 41

A solution of 4- (4'-methylbiphenyl-2-carboxamido) -N- methyl-N-[2- (5-aminopentyloxy)phenyl]benzamide (750 mg) in dichloromethane (30 ml) was treated with pyridine (681 mg) and phenyl chloroformate (675 mg) . After 18 hours, the solvent was removed and the residue was dissolved in ethyl acetate, washed with IN hydrochloric acid, water, saturated sodium hydrogen carbonate solution and brine, dried over sodium sulfate, concentrated, and purified by silica gel column chromatography (Si0 ; 50 g, 1% methanol in dichloromethane) to give 4- (4'-methylbiphenyl-2- carboxamido)-N-methyl-N- [2- (5-phenoxycarbonylamino- pentyloxy)phenyl]benzamide (590 mg) . NMR (CDCI3, δ) : 1.45-1.72 (4H, m) , 1.73-1.88 (2H, m) , 2.36 (3H, s), 3.23-3.39 (2H, m) , 3.33 (3H, s), 3.79-4.00 (2H, m) , 5.44-5.51 (IH, m) , 6.74- 6.87 (2H, m) , 6.88-6.99 (3H, m) , 7.01-7.56 (16H, ) , 7.82 (IH, d, J=9Hz)

Example 42

The following compounds were obtained according to a similar manner to that of Example 41.

1) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N-[2- (3- phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide NMR (CDCI3, δ) : 2.05 (2H, quint., J=6Hz) , 2.36 (3H, s), 3.36 (3H, s), 3.43 (2H, q, J=6Hz) , 3.85-4.06 (2H, m) , 5.32-5.40 (IH, br) , 6.80-6.96 (4H, m) , 7.05-7.55 (17H, m) , 7.80 (IH, d, J=8Hz)

2) 4- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- ( - phenoxycarbonyla inobutoxy) phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.66-1.91 (4H, m) , 2.34 (3H, s) ,

3.25-3.40 (2H, m) , 3.34 (3H, s), 3.77-4.00 (2H, m) , 5.36 (IH, br t, J=7Hz), 6.72-7.00 (5H, m) ,

7.00-7.56 (16H, m) , 7.81 (IH, d, J=9Hz)

3) 6- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [3- (phenoxycarbonylamino)prop-l-yloxy]phenyl]nicotinamide MASS (m/z) : 615 (M+l)

4) 3-Methyl-4- (4 ' -methylbiphenyl-2-carboxamido) -N-methyl- N- [2- (3-phenoxycarbonylaminoprop-l- yloxy ) phenyl ] benzamide NMR (CDCI3, δ) : 1.45 (3H, s), 2.04 (2H, m) , 2.34

(3H, s), 3.35 (3H, s), 3.42 (2H, ) , 3.92 (IH, m) , 4.03 (IH, m) , 5.42 (IH, br) , 6.80-6.92 (3H, m) , 7.03-7.54 (15H, m) , 7.83 (IH, d, J=7Hz), 7.91 (IH, m)

5) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-phenoxycarbonylaminoprop-l- yloxy) phenyl] benzamide

NMR (CDCI3, δ) : 2.06 (2H, m) , 2.32 (3H, s) , 3.31- 3.48 (2H, ) , 3.35 (3H, s) , 3.40 (3H, s) , 3.90

(IH, m) , 4.04 (IH, m) , 5.33 (IH, br) , 6.79-6.90 (4H, m) , 7.03-7.21 (6H, m) , 7.27-7.53 (7H, m) , 7.68 (IH, s), 7.79 (IH, d, J=7Hz) , 8.20 (IH, m)

6) 2-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-phencxycarbonylaminoprop-l- yloxy) phenyl]benzamide

NMR (CDCI3, δ) : 2.13 (2H, m) , 2.36 (3H, s), 3.36 (3H, s), 3.61 (2H, m) , 3.63 (3H, s) , 4.02 (2H, m) , 5.41 (IH, br) , 6.22 (IH, d, J=7Hz) , 6.70-6.78

( 2H, m) , 6 . 82 ( IH, s ) , 6 . 94 -7 . 53 ( 15H, m) , 1 . 82 ( IH, d, J=7Hz )

7) 3-Chloro-4- (4'-methylbiphenyl-2-carboxamido)-N-methyl- N-[2- (3-phenoxycarbonylaminoprop-l-yloxy)phenyl]- benzamide

NMR (CDC1 ₃ , δ) : 2.07 (2H, m) , 2.33 (3H, s) , 3.35 (3H, s), 3.45 (2H, m) , 3.92 (IH, m) , 4.03 (IH, m) , 5.30 (IH, br), 6.80-6.90 (2H, m) , 7.02-7.53 (16H, m) , 7.78 (IH, d, J=7Hz), 8.28 (IH, m)

Example 43

To a solution of 4- (4'-methylbiphenyl-2-carboxamido)- N-methyl-N-[2- (5-phenoxycarbonylaminopentyloxy)phenyl]- ben2amide (290 mg) in N,N-dimethylformamide (15 ml) was added l-methylpipera2ine (271 mg) at ambient temperature. The reaction mixture was stirred at 80°C for 10 hours. The reaction mixture was cooled and extracted with ethyl acetate and washed with saturated sodium hydrogen carbonate and brine. The organic solution was dried over sodium sulfate. The solvent was removed by evaporation and subjected to silica gel column chromatography (Si0 ₂ ; 30 g, 5% methanol in chloroform) to give 4- (4'-methylbiphenyl-2- carboxamido)-N-methyl-N- [2-[5- (4-methylpiperazin-l- carbonylamino)pentyloxy]phenyl]benzamide (190 mg) .

NMR (CDCI3, δ) : 1.37-1.66 (4H, m) , 1.68-1.83 (2H, m) , 2.26 (3H, s), 2.29-2.39 (4H, m) , 2.34 (3H, s), 3.11-3.29 (2H, m) , 3.32 (3H, s), 3.33-3.43 (4H, br t, J=7Hz), 3.76-3.96 (2H, m) , 5.00 (IH, br t, J=7H2), 6.76 (IH, d, J=9Hz) , 6.83 (IH, dd,

J=9, 9Hz), 6.96 (2H, br d, J=9Hz) , 7.02-7.33 (9H, m) , 7.35-7.56 (3H, m) , 7.78 (IH, d, J=9Hz)

Example 44 The following compounds were obtained according to a

similar manner to that of Example 43.

1) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyi-N- [2-{3- (N,N-dimethylhydrazino) carbonylaminoprop-1- yloxy.phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.95-2.05 (2H, m) , 2.35 (3H, s) , 2.88 (6H, s), 3.33 (3H, s), 3.34-3.42 (2H, m) , 3.85-4.02 (2H, ) , 6.80-7.06 (6H, ) , 7.15-7.32 (6H, m) , 7.38-7.56 (4H, m) , 7.82 (IH, d, J=8Hz)

2) 6- (4 ' -Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [3- (4-methylpiperazin-i-yl) carbonylaminoprop-1- yloxy]phenyl]nicotinamide

NMR (CDCI3, δ) : 1.98 (2H, m) , 2.29 (3H, s) , 2.33 (3H, s), 2.39 (4H, m) , 3.34 (3H, s) , 3.34-3.40

(6H, m) , 3.92 (2H, m) , 4.77 (IH, br) , 6.76-6.90 (2H, m) , 7.08 (IH, d, J=7Hz), 7.12-7.20 (2H, m) , 7.24-7.29 (2H, m) , 7.38-7.45 (2H, m) , 7.48-7.77 (4H, m) , 7.97-8.10 (2H, m)

3) 3-Methyl-4- (4 ' -methylbiphenyl-2-carboxamido) -N-methyl- N- [2- [3- (4-methylpiperazin-l-yl) carbonylaminoprop-1- yloxy]phenyl]benzamide

NMR (CDCI3, δ) : 1.42 (3H, s) , 1.92 (2H, m) , 2.20 (3H, s), 2.27 (4H, ) , 2.32 (3H, s) , 3.25 (3H, s) , 3.37-3.42 (6H, ) , 3.89 (2H, m) , 5.21 (IH, br) , 6.73-7.83 (2H, m) , 6.95-7.18 (6H, m) , 7.25- 7.50 (4H, m) , 7.70-7.82 (2H, m)

4) 3-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- [3- (4-methylpiperazin-l-yl) - carbonylaminoprop-1-yloxy]phenyl]benzamide NMR (CDCI3, δ) : 2.00 (2H, m) , 2.27 (3H, s) , 2.35 (3H, s), 2.37 (4H, m) , 3.33 (3H, s) , 3.34 (3H, s) , 3.34-3.41 ( 6H, ) , 3.93 (2H, m) , 4.82 (IH,

br), 6.80-6.92 (3H, m) , 7.05-7.55 (10H, m) , 7.70 (IH, s), 7.80 (IH, d, J=7Hz)

5) 2-Methoxy-4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- [3- (4-methylpiperazin-l-yl) - carbonylaminoprop-1-yloxy] phenyl] benzamide NMR (CDC1 ₃ , δ) : 2.02 (2H, m) , 2.23 (3H, s) , 2.31 (3H, s), 2.34 (4H, m) , 3.28 (3H, s) , 2.32-2.42 (6H, m) , 3.55 (3H, s), 3.97 (2H, m) , 5.13 (IH, br), 6.30 (IH, d, J=7H2), 6.63-6.73 (2H, ) , 6.80

(IH, s), 6.90-7.52 (9H, ) , 7.73 (IH, d, J=7H2) , 7.94 (IH, s)

6) 3-Chloro-4- (4 ' -methylbiphenyl-2-carboxamido) -N-methyl- N- [2- [3- (4-methylpiperazin-l-yl) carbonylaminoprop-1- yloxy]ben2amide

NMR (CDCI3, δ) : 2.00 (2H, m) , 2.30 (3H, s) , 2.37 (3H, s), 2.39 (4H, m) , 3.32 (3H, s) , 3.35-3.41 (6H, m) , 3.83-4.01 (2H, m) , 4.83 (IH, br) , 6.80- 6.90 (2H, m) , 7.02-7.57 (11H, m) , 7.80 (IH, d,

J=7H2), 8.28 (IH, m)

Example 45

The following compound was obtained according to similar manners to those of Example 41 and 43.

4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [3- [l-methyl-4-piperidyloxycarbonylamino) propoxy]phenyl] - ben2amide NMR (CDCI3, δ) : 1.63-1.79 (2H, m) , 1.86-2.06 (4H, m) , 2.21-2.40 (2H, m) , 2.30 (3H, s) , 2.35 (3H, s), 2.68 (2H, br s) , 3.33 (3H, s) , 3.27-3.40 (2H, m) , 3.81-4.06 (2H, m) , 4.68 (IH, br s) , 5.03 (IH, br s), 6.75-7.07 (6H, ) , 7.10-7.25 (5H, m) , 7.29 (2H, d, J=9H2), 7.35-7.66 (3H, m) , 7.81 (IH, d,

J=9H2)

Example 46

A solution of 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-hydroxypropoxy)phenyl]ben2amide (300 mg) in dichloromethane (15 ml) was treated with pyridine (95.8 mg) and p-nitrophenyl chloroformate (183 mg) . After 4.5 hours, l-methylpipera2ine (303 mg) was added to the reaction mixture and stirred for a further 1 hour at ambient temperature. After concentration, the residue was dissolved in ethyl acetate and washed with saturated sodium hydrogen carbonate solution and brine, dried over sodium sulfate, concentrated, and purified by silica gel column chromatography (Si0 ₂ ; 30 g, 3% methanol in dichloromethane) to give 4- (4 '-methylbiphenyl-2- carboxamido) -N-methyl-N- [2- [3- (4-methylpiperazin-l- carbonyloxy)propoxy]phenyl]ben2amide (200 mg) as white amorphous.

NMR (CDC1 ₃ , δ) : 2.06-2.17 (2H, m) , 2.30 (3H, s), 2.36 (3H, s), 2.33-2.42 (4H, m) , 3.33 (3H, s),

3.48 (4H, br t, J=7H2), 3.86-4.06 (2H, m) , 4.26 (2H, t, J=7H2), 6.76-7.02 (6H, m) , 7.10-7.33 (7H, ) , 7.35-7.56 (3H, m) , 7.82 (IH, d, J=9H2)

Example 47

The following compounds were obtained according to a similar manner to that of Example 46.

1) 4- ( '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [2- (N,N-dimethylamino) ethylcarbamoyloxy]phenyl] enzamide NMR (CDCI3, δ) : 2.28 (6H, s) , 2.35 (3H, s), 2.22-

2.34 (2H, m) , 2.47 (2H, t, J=7Hz) , 3.35 (3H, s), 3.26-3.39 (2H, m) , 5.66 (IH, m) , 6.86-7.33 (13H, m) , 7.33-7.56 (3H, m) , 7.80 (IH, d, J=9Hz)

4- (4'-Methylbiphenyl-2-carboxamido)-N-methyl-N- [2-[4-

(4-methylpiperazin-l-carbonyloxy)butoxy]phenyl]- benzamide

NMR (CDC1 ₃ , δ) : 1.74-1.93 (4H, br s) , 2.29 (3H, s), 2.34 (3H, s), 2.31-2.50 (4H, ) , 3.32 (3H, s) , 3.39-3.62 (4H, ) , 3.78-4.00 (2H, m) , 4.13 (2H, br t, J=7Hz), 6.74-6.84 (2H, m) , 6.86-7.01 (4H, m) , 7.06-7.34 (6H, m) , 7.34-7.56 (3H, m) , ^.βl (IH, br d, J=9H2)

Example 48

To a solution of 4- ( '-methylbiphenyl-2-carboxamido) - N-methyl-N-[2-[4-[1-(t-butoxycarbonyl)piperidine-4- carbonylamino]butoxy]phenyl]benzamide (440 mg) in dichloromethane (15 ml) was added trifluoroacetic acid (1 ml) at 0°C. The reaction mixture was allowed to warm to ambient temperature and stirred for 2 hours. The solution was evaporated to remove excess trifluoroacetic acid. The residue was diluted with dichloromethane and washed with saturated sodium hydrogen carbonate and brine. The organic layer was dried over sodium sulfate, concentrated, and purified by silica gel column chromatography (Si0 ₂ ; 20 g, 1% ammonia solution (28%) -10% methanol in dichloromethane) to give 4- (4'-methylbiphenyl-2-carboxamido) -N-methyl-N-[2- [4- (piperidine-4-carbonylamino)butoxyphenyl]benzamide (310 mg) .

NMR (CDCI3, δ) : 1.50-1.90 (8H, m) , 2.17-2.37 (IH, m) , 2.34 (3H, s), 2.59 (2H, dd, J=ll, 11Hz) , 3.08 (2H, br d, J=llHz), 3.31 (3H, s) , 3.19-3.39 (2H, m) , 3.73-3.97 (2H, m) , 5.94 (IH, br s), 6.71-7.34

(13H, m) , 7.34-7.57 (3H, m) , 7.80 (IH, d, J=9Hz)

Example 49 The following compounds were obtained according to a

similar manner to that of Example 48.

1) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [2- (4-methylpiperazin-l-yl) carbonylethyl] a inoethoxy] - phenyl]benzamide

NMR (CDC1 ₃ , δ) : 2.28 (3H, s) , 2.32-2.41 (4H, m) ,

2.37 (3H, s), 2.56 (2H, t, J=7.5Hz) , 3.00 (2H, t, J=7.5Hz), 3.03 (2H, m) , 3.32 (3H, s), 3.47 (2H, m) , 3.59 (2H, m) , 3.91 (IH, br) , 4.06 (IH, br) , 6.78-6.94 (2H, m) , 6.89-7.02 (4H, ) , 7.10-7.22

(4H, ) , 7.28 (2H, d, J=8.5Hz), 7.37-7.54 (3H, m) , 7.82 (IH, d, J=7Hz)

2) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [4- (piperazin-1-yl) sulfonylphenylmethoxy]phenyl]benzamide

NMR (CDCI3, δ) : 2.32 (3H, s), 2.88-3.01 (8H, m) ,

3.37 (3H, s), 5.03 (2H, m) , 7.80 (IH, d, J=7Hz) , 7.86-7.92 (3H, m) , 7.10-7.20 (7H, m) , 7.26-7.54 (7H, m) , 7.75 (2H, d, J=8.5Hz), 7.81 (IH, d, J=7Hz)

Example 50

A solution of 3-methoxy-4- (4 ' -nitrobiphenyl-2- carboxamido) -N- [4-methyl-2- [5- (4-methylpiperazin-l- ylcarbonyl) pent-1-yloxy]phenyl] -N-methylbenzamide (910 mg) , 20% palladium hydroxide (200 mg) in methanol (30 ml) was stirred under atmospheric pressure of hydrogen at ambient temperature. After 5 hours, the reaction mixture was filtered through a bed of Celite, and the solvent was removed by evaporation and the crude product was purified by silica gel column chromatography (Si0 ₂ ; 30 g, 5% methanol in chloroform) to give free product. To a solution of this product (810 mg) in ethanol (20 ml) was added IN hydrochloric acid (2.39 ml) and stirred at ambient temperature for 10 minutes. The solvent was removed to

give 4- (4 '-aminobiphenyl-2-carboxamido) -3-methoxy-N- [4- methyl-2- [5- (4-methylpiperazin-l-ylcarbonyl)pent-l- yloxy]phenyl] -N-methylbenzamide dihydrochloride as amorphous. NMR (DMSO-d ₆ , δ) : 1.37-1.50 (2H, m) , 1.50-1.64 (2H, m) , 1.67-1.80 (2H, ) , 2.24 (3H, s) , 2.38 (2H, t, J=7Hz), 2.74 (3H, s) , 2.80-3.50 (4H, m) , 3.17 (3H, s), 3.54 (3H, s), 3.73-4.55 (6H, m) , 6.63 (IH, d, J=9Hz) , 6.81 (3H, br s), 6.96-7.04 (IH, m) , 7.30 (2H, d, J=9Hz) , 7.38-7.71 (7H, m) , 9.16

(IH, s)

Example 51

The following compounds were obtained according to a similar manner to that of Example 50.

1) 4- (4 '-Aminobiphenyl-2-carboxamido) -3-methoxy-N- [2- [5- (4-dimethylaminopiperidin-l-ylcarbonyl)pent-1-yloxy] - 4-methylphenyl] -N-methylbenzamide NMR (CDC1 ₃ , δ) : 1.33-2.08 (10H, m) , 2.27 (3H, s),

2.30-2.45 (8H, m) , 2.45-2.66 (IH, m) , 2.94-3.08 (IH, m) , 3.29 (3H, s), 3.46 (3H, s), 3.70-4.01 (4H, m) , 4.60-4.75 (IH, m) , 6.50-6.67 (4H, m) , 6.72-6.89 (3H, ) , 7.18 (2H, d, J=9Hz) , 7.30-7.41 (2H, m) , 7.42-7.52 (IH, m) , 7.71-7.82 (2H, m) ,

8.16 (IH, d, J=9Hz)

2) 4- (4 '-Aminobiphenyl-2-carboxamido) -3-methoxy-N- [4- methyl-2- [5- [4- (4-pyridyl) piperazin-l-ylcarbonyl]pent- 1-yloxy] phenyl ] -N-methylbenzamide

NMR (CDCI3, δ) : 1.46-1.61 (2H, m) , 1.65-1.91 (6H, m) , 2.27 (3H, s), 2.40 (2H, t, J=7Hz) , 3.31 (3H, s), 3.30-3.41 '4H, m) , 3.47 (3H, s), 3.56-3.68 (2H, m) , 3.70-.3.80 (2H, m) , 3.80-4.01 (2H, m) , 6.52-6.67 (6H, m) , 6.74-6.84 (2H, m) , 6.86 (IH,

s), 7.17 (2H, d, J=9Hz) , 7.33-7.40 (2H, m) , 7.43- 7.51 (IH, m) , 7.72-7.81 (2H, m) , 8.17 (IH, br d, J=9Hz) , 8.27 (2H, d, J=9Hz)

3) 4- (4 '-Aminobiphenyl-2-carboxamido) -3-methoxy-N- [2- (5- carboxypent-1-yloxy) -4-methylphenyl] -N-methylbenzamide NMR (CDC1 ₃ , δ) : 1.45-1.58 (2H, m) , 1.60-1.84 (4H, m) , 2.27 (3H, s), 2.35 (2H, t, J=7H2) , 3.29 (3H, s), 3.44 (3H, s), 3.70-3.84 (IH, m) , 3.85-3.98 (IH, m) , 6.54-6.63 (2H, m) , 6.66 (2H, d, J=9Hz) ,

6.80-6.90 (3H, m) , 7.20 (2H, d, J=9Hz) , 7.30-7.41 (2H, m) , 7.42-7.51 (IH, m) , 7.73-7.86 (2H, m) , 8.17 (IH, br d, J=9Hz)

4) 4- (4 '-Aminobiphenyl-2-carboxamido) -3-methoxy-N-methyl- N- [4-methy1-2- [6- (4-methylpiperazin-l-yl) hex-1- yloxy]phenyl]benzamide

NMR (CDCI3, δ) : 1.30-1.65 (5H, m) , 1.69-1.84 (2H, m) , 2.25 (3H, s), 2.36 (3H, s), 2.30-2.84 (15H, m) , 3.29 (3H, s), 3.47 (3H, s), 3.66-4.02 (4H, m) , 6.50-6.67 (4H, m) , 6.79 (2H, d, J=9Hz), 6.87 (IH, s), 7.17 (2H, d, J=9H2) , 7.36 (2H, dd, J=9, 9H2), 7.47 (IH, dd, J=9, 9Hz) , 7.70-7.82 (2H, m) , 8.17 (IH, d)

5) 2-Amino-4- (4 ' -methyibiphenyl-2-carboxamido) -N- [2- [5- (4-methylpiperazin-l-ylcarbonyl) pent-l-yloxy]phenyl] - N-methylben2amide

NMR (CDCI3, δ) : 1.40-1.57 (2H, m) , 1.57-1.76 (2H, m) , 1.76-1.91 (2H, m) , 2.29 (3H, s) , 2.35 (3H, s), 2.24-2.43 (6H, m) , 3.29 (3H, s) , 3.40-3.53 (2H, m) , 3.53-3.66 (2H, m) , 3.82 (2H, t, J=7Hz) , 4.77 (2H, br s) , 5.76 (IH, br d, J=9Hz), 6.63 (IH, br d, J=9Ez), 6.71-6.86 (4H, m) , 6.96 (IH, d, J=9H2), 7.06-7.54 (8H, ) , 7.76 (IH, d, J=9Hz)

6) 2-Amino-4- (methylphenyl-2-carboxamido) -N-methyl-N-[2- [5- (4-methylpiperazin-1-ylcarbonyl)pent-1- yloxy]phenyl]benzamide

NMR (CDC1 ₃ , δ) : 1.42-1.58 (2H, m) , 1.59-1.77 (2H, m) , 1.78-1.84 (2H, m) , 2.28 (3H, s), 2.26-2.43

(6H, m) , 2.46 (3H, s) , 3.33 (3H, s) , 3.41-3.52 (2H, m) , 3.54-3.66 (2H, m) , 3.96 (2H, t, J=7Hz) , 4.90 (2H, br s), 6.33 (IH, br d, J=9Hz) , 6.31 (3H, dd, J=9, 9Hz), 7.01 (IH, d, J=9Hz) , 7.08-7.44 (8H, m)

Example 52

A solution of 4- (4'-nitrobiphenyl-2-carboxamido)-N- (2- ben2yloxy-4-methylphenyl) -N-methylben2amide (430 mg) , 20% palladium hydroxide (80 mg) in methanol (20 ml) and 1,4- dioxane (30 ml) was stirred under atmospheric pressure of hydrogen at 30°C. After 5 hours, the reaction mixture was filtered through a bed of Celite, and the solvent was removed by evaporation and the crude product was purified by silica gel column chromatography (Si0 ₂ ; 30 g, 3% methanol in chloroform) to give 4- (4 '-aminobiphenyl-2- carboxamido) -N- (2-hydroxy-4-methylphenyl) -N-methylbenzamide (350 mg) as amorphous.

NMR (CDC1 ₃ , δ) : 2.20 (3H, s), 3.31 (3H, s) , 3.63- 3.89 (2H, br s), 6.40-6.84 (5H, ) , 6.85-7.04

(2H, m) , 7.05-7.31 (5H, m) , 7.31-7.40 (2H, m) , 7.48 (IH, dd, J=9, 9Hz) , 7.64-7.78 (IH, m)

Example 53 A mixture of 4- ( '-nitrobiphenyl-2-carboxamido) -N- methyl-N-[2-[5- (4-methylpiperazin-l-ylcarbonyl)pyrid-2- yl ethoxy]phenyl]benzamide (300 mg) and iron powder (122 mg) in a mixture of ethanol (10 ml) and acetic acid (1 ml) was refluxed for 3 hours and the mixture was evaporated in vacuo. The residue was stirred in a mixture of chloroform

(20 ml) and saturated aqueous sodium hydrogen carbonate (20 ml) at ambient temperature for 30 minutes and the mixture was filtered through a bed of Celite. The organic phase of the filtrate was separated and washed with brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give a syrup. The crude product was purified by silica gel column (chloroform: ethanol:cone, ammonia = 10:1:0.1) to give 4- (4'-aminobiphenyl-2-carboxamido)-N-methyl-N- [2-[5- (4- methylpiperazin-l-ylcarbonyl)pyrid-2-ylmethoxy]phenyl]- benzamide (157 mg) as a pale yellow amorphous.

NMR (CDC1 ₃ , δ) : 2.32 (3H, s), 2.42 (2H, m) , 2.50 (2H, m) , 3.33 (3H, s), 3.50 (2H, m) , 3.71-3.95 (4H, ) , 5.28 (3H, s), 6.63 (2H, d, J=8.5Hz), 6.87 (IH, dd, J=7, 7Hz) , 6.87-7.01 (4H, m) , 7.11-

7.28 (5H, m) , 7.32-7.50 (3H, m) , 7.79 (IH, d, J=7Hz), 7.97 (IH, ) , 8.55 (IH, )

Example 54 To an ice bath cooled solution of (4- carboxybutyl) triphenylphosphonium bromide (371 mg) in N,N- dimethylacetamide (15 ml) was added potassium t-butoxide (188 mg) and the mixture was stirred at the same temperature for 30 minutes. To the resulting mixture was added 4- (4'-methylbiphenyl-2-carboxamido) -N-methyl-N- (2- formylphenyl)benzamide (250 mg) and the mixture was stirred in an ice bath for 3 hours. The mixture was diluted witr ethyl acetate (40 ml) and the solution was washed successively with IN hydrochloric acid (30 ml) , water (20 ml) and brine (20 ml) . The organic phase was dried over magnesium sulfate and the solvent was evaporated in vacuo to give an oil. The crude oil was purified by silica gel column (1% methanol in chloroform) to give 4-(4'- methylbiphenyl-2-carboxamido)-N-methyl-N-[2- (5- carboxypenten-1-yl)phenyl]benzamide (201 mg) as a colorless

amorphous.

MASS (m/z) : 533 (M+l)

Example 55 A mixture of 4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (3-formylprop-l-yloxy)phenyl]benzamide (507 mg) and (carbethoxymethylene) triphenylphosphorane (418 mg) in tetrahydrofuran (20 ml) was stirred at ambient temperature overnight and the solvent was evaporated in vacuo. The oily residue was purified by silica gel column (chloroform) to give 4- (4 ' -methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (5-ethoxycarbonyl-4-penten-1-yloxy)phenyl]benzamide (435 mg) as a colorless amorphous.

NMR (CDC1 ₃ , δ) : 1.26 (3H, t, J=7.5Hz), 1.93 (2H, m) , 2.35 (3H, s), 2.39 (2H, m) , 3.31 (3H, s), 3.77-

3.97 (2H, m) , 4.16 (2H, q, J=7.5Hz), 5.84 (IH, dt, J=15, 1Hz) , 6.73-6.82 (2H, m) , 6.88-7.01 (4H, m) , 7.10-7.21 (4H, m) , 7.29 (2H, d, J=8.5Hz), 7.33-7.55 (4H, m) , 7.82 (IH, d, J=7Hz)

Example 56

The following compound was obtained according to a similar manner to that of Preparation 11.

4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (2- acetoxyethoxy)phenyl]benzamide

NMR (CDCI3, δ) : 2.06 (3H, s), 2.35 (3H, s) , 3.33 (3H, s), 4.10 (2H, m) , 4.39 (2H, m) , 6.78-6.99 (6H, m) , 7.10-7.29 (6H, m) , 7.36-7.53 (3H, ) , 7.82 (IH, d, J=7Hz)

Example 57

A mixture of 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (2-acetoxyethoxy) phenyl]benzamide and potassium carbonate (129 mg) in methanol (15 ml) was stirred at

ambient temperature for 2 hours and the mixture was diluted with ethyl acetate (30 ml) . The solution was washed with water and brine and the organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give 4- (4 '-methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (2-hydroxyethoxy)phenyl]benzamide (450 mg) as an oil.

NMR (CDC1 ₃ , δ) : 2.34 (3H, s), 3.32 (3H, s) , 3.88

(2H, m) , 3.99 (2H, m) , 6.77-6.99 (4H, m) , ^" \08- 7.30 (8H, m) , 7.38 (IH, ) , 7.43 (IH, d, J=7H2), 7.52 (IH, d, J=7H2), 7.82 (IH, d, J=7H2)

Example 58

A solution of 4- (4 ' -methylbiphenyl-2-carboxamido) -N- methyl-N- [2- (6-methoxycarbonyl-5-hexenyloxy)phenyl] - ben2amide (360 mg) and nickel chloride hexahydrate (594 mg) in methanol (15 ml) and tetrahydrofuran (15 ml) was treated at 0°C with sodium borohydride (283 mg) and stirred at 0°C for 4 hours. The reaction mixture was diluted with tetrahydrofuran and filtered through a bed of Celite and then concentrated. The residue was diluted with ethyl acetate and washed with water and brine. The organic layer was dried over magnesium sulfate, concentrated to give 4- (4 ' -methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (6- methoxycarbonylhexyloxy) phenyl]ben2amide (340 mg) . NMR (CDCI3, δ) : 1.32-1.54 (4H, m) , 1.60-1.85 (4H, m) , 2.33 (2H, t, J=7H2) , 2.36 (3H, s), 3.33 (3H, s), 3.65 (3H, s), 3.79-3.99 (2H, m) , 6.76 (IH, d, J=9H2), 6.79 (IH, d, J=9H2) , 6.86-7.00 (4H, m) , 7.10-7.23 (5H, m) , 7.30 (2H, d, J=9H2) , 7.34-7.56 (3H, m) , 7.82 (IH, d, J=9H2)

Example 59

To an ice cooled mixture of 4- (4 '-methylbiphenyl-2- carboxamido) -N-methyl-N- [2- [3- (4-methylpipera2in-l- yl) carbonylamino- (1-propyn-l-yl) ]phenyl]ben2amide (250 mg)

and nickel chloride hexahydrate (297 mg) in a mixture of tetrahydrofuran (5 ml) and methanol (5 ml) was added sodium borohydride in small portions and the mixture was stirred at the same temperature for 1 hour. The mixture was filtered through bed of Celite and the filtrate was evaporated in vacuo. The residue was dissolved in chloroform (20 ml) and washed with water and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give a syrup. The residue was solidified with diethyl ether to give 4-(4'- methylbiphenyl-2-carboxamido)-N-methyl-N-[2-[3- (4- methylpiperazin-1-ylcarbonyl) aminoprop-1- yl]phenyl]ben2amide (75.0 mg) as a powder.

NMR (CDC1 ₃ , δ) : 2.12-2.56 (8H, ) , 2.27 (3H, s), 2.36 (3H, s), 3.00-3.38 (6H, m) , 3.40 (3H, s),

6.84-6.93 (2H, m) , 7.10-7.57 (13H, m) , 7.80 (IH, d, J=7.5H2)

Example 60 A solution of 4- (4'-methylbiphenyl-2-carboxamido-N- methyl-N- [2- (4-ethoxycarbonylbutoxy)phenyl]benzamide (1.26 g) and dry tetrahydrofuran (30 ml) was cooled to 0°C, and lithium aluminum hydride (93.5 mg) was added. The reaction mixture was maintained at 0°C for 1 hour, and then was quenched by adding IN hydrochloric acid. The resulting mixture was filtered through a bed of Celite, diluted with ethyl acetate, washed with brine, dried over magnesium sulfate, and concentrated to give 4- (4'-methylbiphenyl-2- carboxamido) -N-methyl-N- [2- (5-hydroxypentyloxy)phenyl]- ben∑amide (1.18 g) .

NMR (CDC1 ₃ , δ) : 1.45-1.70 (4H, m) , 1.72-1.86 (2H, m) , 2.36 (3H, s), 3.32 (3H, s), 3.67 (2H, t, J=7H2), 3.76-3.99 (2H, m) , 6.74-6.84 (2H, ) , 6.87-7.06 (4H, m) , 7.09-7.24 (5H, m) , 7.28 (2H, d, J=9H2), 7.34-7.46 (2H, m) , 7.51 (IH, dd, J=9,

9Hz), 7.80 (IH, d, J=9Hz)

Example 61

The following compound was obtained according to a similar manner to that of Example 60.

4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (4- hydroxy ethylphenylmethoxy)phenyl]benzamide

NMR (CDC1 ₃ , δ) : 2.33 (3H, s) , 3.34 (3H, s), 4.80 (IH, d, J=6Hz), 5.30 (2H, m) , 6.76-7.00 (6H, ) ,

7.07-7.19 (5H, m) , 7.24-7.53 (8H, ) , 7.81 (IH, d, J=7Hz)

Example 62 To a solution of 4- (4'-methylbiphenyl-2-carboxamido) - N-ethoxycarbonylmethyl-N- (2-methylphenyl)benzamide (100 mg) in ethanol (5 ml) was added sodium borohydride (37 mg) at 0°C and the mixture was stirred for 2 hours at ambient temperature. Since the reaction was not completed and it was so slow, sodium borohydride (220 mg) was added to the mixture at 0°C and stirred overnight. The reaction mixture was neutralized with IN hydrochloric acid and diluted with ethyl acetate. The organic layer was washed with brine and dried over magnesium sulfate. Filtering and the removal of solvents afforded 4- (4'-methyibiphenyl-2-carboxamido) -N- (2- hydroxyethyl) -N- (2-methyiphenyl)benzamide (70 mg) as a colorless prisms. mp : 115-118°C

NMR (CDCI3, δ) : 2.20 (3H, s), 2.38 (3H, s), 3.68- 3.90 (4H, ) , 4.08-4.30 (IH, m) , 6.90 (3H, d,

J=6Hz), 7.10-7.58 (12H, ) , 7.80 (IH, d, J=7Hz)

Example 63 The following compound was obtained according to a

similar manner to that of Example 17.

4- (4'-Methylbiphenyl-2-carboxamido)-N-methyl-N- [2- (4- formylphenylmethoxy)phenyl]benzamide

This compound was used for further reaction without purification.

Example 64 To a solution of oxalyl chloride (174 mg) in dichloromethane (15 ml) was added dimethyl sulfoxide (107 mg) at -78°C and the solution was stirred at the same temperature for 10 minutes. A solution of 4-(4'- methylbiphenyl-2-carboxamido)-N-methyl-N-[2- (2- hydroxyethoxy)phenyl]benzamide (440 mg) in dichloromethane (5 ml) was added to the mixture at -78°C. After being stirred at -78°C for 20 minutes, triethylamine (0.51 ml) was added to the mixture at the same temperature and the cooling bath was removed. The mixture was stirred at ambient temperature for 3 hours and the solution was washed successively with IN hydrochloric acid, water and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give 4-(4'- methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (formylmethoxy)phenyl]benzamide (420 mg) as an amorphous. NMR (CDC1 ₃ , δ) : 2.35 (3H, s), 3.39 (3H, s), 5.30

(2H, s), 6.61 (IH, d, J=7Hz), 7.86-6.97 (3H, m) , 7.10-7.31 (8H, m) , 7.37-7.54 (3H, m) , 7.82 (IH, d, J=7Hz), 9.56 (IH, s)

Example 65

To a mixture of 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N-[2- (formylmethoxy)phenyl]benzamide (400 mg) and 4-methyl-l- (N-methylamino)methylcarbonylpiperazme (143 mg) in a mixture of methanol (15 ml) and acetic acid (0.5 ml)

was added sodium cyanoborohydride (52.4 mg) and the mixture was stirred at ambient temperature for 4 hours. The solution was diluted with ethyl acetate (30 ml) and washed successively with saturated aqueous sodium hydrogen carbonate, water and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo. The residue was purified by silica gel column (chloroform:methanol:cone, ammonia = 10:1:0.1) to give 4- (4'-methylbiphenyl-2-carboxamido) -N-methyl-N-[2-[2- [N- methyl-N- (4-methylpiperazin-l-yl) carbonylmethylamino]- ethoxy]phenyl]benzamide (310 mg) as a colorless amorphous. NMR (CDC1 ₃ , δ) : 2.27 (3H, s), 2.30-2.38 (4H, m) ,

2.36 (3H, s), 2.43 (3H, s), 2.90 (2H, m) , 3.28- 3.32 (2H, m) , 3.31 (3H, s), 3.55 (2H, m) , 3.60 (2H, m) , 3.89 (IH, m) , 4.07 (IH, ) , 6.78 (2H, m) , 6.86-6.98 (4H, m) , 7.10-7.30 (5H, m) , 7.37- 7.53 (4H, m) , 7.82 (IH, d, J=7Hz)

Example 66 The following compound was obtained according to a similar manner to that of Example 65.

4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [4- (4-methylpiperazin-l-yl)methylphenylmethoxy]phenyl]- benzamide

NMR (CDCI3, δ) : 2.19 (3H, s), 2.34 (3H, s), 2.39- 2.60 (8H, m) , 3.35 (3H, s), 3.50 (2H, s), 4.98 (2H, m) , 6.77-6.91 (5H, m) , 7.00 (IH, d) , 7.10- 7.20 (5H, m) , 7.25-7.53 (8H, m) , 7.82 (IH, d, J=7Hz)

Example 67

The following compound was obtained according to similar manners to those of Examples 64 and 65.

4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [2- (2-methoxycarbonylethyl) a inoethoxy]phenyl]benzamide

NMR (CDC1 ₃ , δ) : 2.35 (3H, s) , 2.53 (2H, t, J=7.5H2), 2.97 (2H, t, J=7.5Hz), 2.99 (2H, ) , 3.32 (3H, s), 3.68 (3H, s), 3.90-4.02 (2H, m) , 6.75-6.83

(2H, m) , 6.88-7.01 (4H, m) , 7.10-7.24 (4H, m) , 7.30 (2H, d, J=8.5Hz), 7.36-7.53 (3H, m) , 7.80 (IH, d, J=7Hz)

Example 68

The following compound was obtained according to similar manners to those of Examples 64 and 55.

4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (6- methoxycarbonyl-5-hexenyloxy)phenyl]benzamide

NMR (CDCI3, δ) : 1.55-1.70 (2H, m) , 1.73-1.86 (2H, m) , 2.28 (2H, dt, J=7, 7Hz) , 2.36 (3H, s), 3.33 (3H, s), 3.73 (3H, s), 3.78-3.99 (2H, m) , 5.86 (IH, d, J=15Hz), 6.78 (IH, d, J=9H2) , 6.81 (IH, d, J=9H2), 6.88-7.04 (5H, m) , 7.10-7.23 (4H, m) ,

7.30 (2H, d, J=9Hz), 7.34-7.56 (3H, m) , 7.82 (IH, d, J=9H2)

Example 69 To a solution of 4- ( ' -methylbiphenyl-2-carboxamido) - N-methyl-N- [2- (3-ethoxycarbonylprop-l-yloxy)phenyl] - ben2amide (1.10 g) in dichloromethane (20 ml) was added dropwise a solution of diisobutylalummum hydride in toluene (1.5 M solution, 2 ml) at -78°C and the mixture was stirred at the same temperature for 2 hours. The reaction was quenched with addition of water and the resulting mixture was warmed to ambient temperature. The mixture was extracted with dichloromethane and the organic phase was washed successively with IN hydrochloric acid, water and brine. The organic solution was dried over magnesium

sulfate and the solvent was evaporated in vacuo to give 4- (4'-methylbiphenyl-2-carboxamido) -N-methyl-N-[2- (3- formylprop-1-yloxy)phenyl]benzamide (987 mg) as a syrup. The unstable aldehyde was immediately used for next step.

Example 70

To a solution of oxalyl chloride (127 mg) in dichloromethane (20 ml) was added dimethyl sulfoxide (78 mg) at -78°C and the solution was stirred at the same temperature for 10 minutes. A solution of 4-(4'- methylbiphenyl-2-carboxamido) -N-methyl-N-[2- (2- hydroxyethoxy)phenyl]benzamide (400 mg) in dichloromethane (5 ml) was added to the mixture at -78°C. After being stirred at -78°C for 20 minutes, triethylamine (0.50 ml) was added to the mixture at the same temperature and the cooling bath was removed. The mixture was stirred at ambient temperature for 3 hours and the solution was washed successively with IN hydrochloric acid, water and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give 4-(4'- methylbiphenyl-2-carboxamido) -N-methyl-N- [2- (formylmethyloxy)phenyl]benzamide (399 mg) as an amorphous. To a mixture of the crude obtained aldehyde (399 mg) and hydroxylamine hydrochloride (174 mg) in ethanol (20 ml) was added potassium carbonate (173 mg) in water (2 ml) and the solution was stirred at ambient temperature for 2 hours. The mixture was diluted with ethyl acetate (30 ml) and the solution was washed with water and brine. The organic phase was dried over magnesium sulfate and the solvent was evaporated in vacuo to give 4- (4'-methylbiphenyl-2- carboxamido) -N-methyl-N- [2- (2-hydroxyiminoethoxy)phenyl]- benzamide (288 mg) as an amorphous.

NMR (CDC1 ₃ , δ) : 2.34 (3H, s), 3.34 (1.5H, s), 3.36

(1.5H, s), 4.52 (0.5H, br) , 4.73 (0.5H, br) , 6.78- 6.95 (6H, m) , 7.05-7.21 (7H, m) , 7.28 (2H, d,

J=8.5Hz), 7.36-7.53 (3H, ) , 7.80 (IH, d, J=7Hz)

Example 71

The following compounds were obtained according to a similar manner to that of Example 20

1) 4- (4'-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [2- [N- [ 2- (4-methylpiperazin-l-yl) carbonylethyl] -N- methylaminoethoxy]phenyl]ben2amide NMR (CDC1 ₃ , δ) : 2.11 (1.5H, s), 2.16 (1.5H, s) , 2.28

(1.5H, s), 2.30 (1.5H, s) , 2.30-2.40 (4H, m) , 2.61 (2H, t, J=7.5Hz), 3.30 (1.5H, s), 3.32 (1.5H, s), 3.39-3.87 (9H, m) , 4.03 (IH, ) , 6.74- 7.01 (4H, m) , 7.06 (IH, d, J=7H2) , 7.12-7.20 (5H, m) , 7.30 (2H, d, J=8.5H2), 7.37-7.53 (3H, m) ,

7.79 (IH, m)

2) 4- (4 '-Methylbiphenyl-2-carboxamido) -N-methyl-N- [2- [4- (4-methylpipera2in-l-yl) sulfonylphenylmethoxy]phenyl] - ben2amide

NMR (CDCI3, δ) : 2.23 (3H, s), 2.32 (3H, s) , 2.41- 2.50 (4H, m) , 2.97-3.08 (4H, m) , 3.38 (3H, s), 5.03 (2H, m) , 6.78 (IH, d, J=7H2) , 7.86-7.93 (3H, m) , 7.11-7.22 (6H, ) , 7.31 (2H, d, J=8.5H2), 7.37-7.53 (5H, ) , 7.76 (2H, d, J=8.5H2), 7.84

(IH, d, J=7H2)

Example 72

To a solution of 4- (4 ' -aminobiphenyl-2-carboxamido) -3- methoxy-N- [2- [5- (4-dimethylaminopiperidin-l- ylcarbonyl)pent-l-yloxy] -4-methylphenyl] -N-methylben2amide (180 mg) and 37% formalin (3 ml) in methanol (20 ml) and acetic acid (0.5 ml) was added sodium cyanoborohydride (80 mg) at ambient temperature. The mixture was stirred at same temperature for 3 hours and quenched with saturated

sodium hydrogen carbonate. The mixture was extracted with ethyl acetate and washed with saturated sodium hydrogen carbonate, brine and dried over sodium sulfate. The solvent was removed by evaporation and the crude product was purified by preparative thin layer chromatography (10% methanol in chloroform) to give free product. To a solution of this product (120 mg) in ethanol (10 ml) was added IN hydrochloric acid (0.33 ml) and stirred at ambient temperature for 10 minutes. The solvent was removed to give 4- (4'-dimethylaminobiphenyl-2-carboxamido) -3-methoxy- N-[2- [5- (4-dimethylaminopiperidin-l-ylcarbonyl)pent-l- yloxy]-4-methylphenyl]-N-methylbenzamide dihydrochloride (130 mg) as amorphous.

NMR (DMSO-d ₆ , δ) : 1.25-2.10 (10H, m) , 2.26 (3H, s), 2.20-2.40 (2H, m) , 2.63 (3H, s), 2.64 (3H, s),

2.99 (6H, s), 3.16 (3H, s), 3.20-3.50 (2H, m) , 3.49 (3H, s), 3.50-4.10 (4H, m) , 4.47-4.60 (IH, m) , 6.64 (IH, d, J=9Hz) , 6.74-6.90 (3H, m) , 7.01 (IH, d, J=9Hz), 7.04-7.25 (IH, ) , 7.31-7.48 (4H, m) , 7.49-7.62 (2H, m) , 7.68-7.78 (IH, ) , 8.96

(IH, br s)

Example 73

A mixture of 4- (4'-methylbiphenyl-2-carboxamido) -N- methyl-N- (2-cyanophenyl)benzamide (350 mg) and trimethyltin azide (453 mg) in xylene (15 ml) heated at 120°C for 2 days and cooled to ambient temperature. The solution was directly applied to silica gel column (the column was pre¬ packed with chloroform as a solvent) . The column was eluted with 2% methanol in chloroform and the solvent was evaporated in vacuo. The residue was solidified with diethyl ether to give 4- (4'-methylbiphenyl-2-carboxamido) - N-methyl-N-[2- (tetrazol-5-yl)phenyl]benzamide (233 mg) as a white powder. NMR (DMSO-d ₆ , δ) : 2.28 (3H, s), 3.19 (3H, s), 6.93

( 2H, d, J=8 . 5Hz ) , 7 . 10-7 . 53 ( 13H, m) , 7 . 74 ( IH, d, J=7Hz )

Example 74 A mixture of 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N-[2- [5- (4-methylpiperazin-l-yl) carbonylpent-1- ylthio]phenyl]benzamide (500 mg) and m-chloroperbenzoic acid (133 mg) in dichloromethane (20 ml) was stirred in an ice bath for 2 hours and the solution was washed successively with saturated aqueous sodium hydrogen carbonate, water and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give a syrup. The crude product was solidified with diethyl ether to give 4- (4'-methylbiphenyl-2- carboxamido) -N-methyl-N- [2-[5- (4-methylpiperazin-l- yl) carbonylpent-1-ylsulfinyl]phenyl]benzamide (423 mg) as a white powder.

MASS (m/z) : 665 (M+l)

Example 75

A mixture of 4- (4 '-methylbiphenyl-2-carboxamido) -N- methyl-N-[2-[5- (4-methylpiperazin-l-yl) carbonylpent-1- ylthio]phenyl]ben2amide (500 mg) and m-chloroperben2θic acid (332 mg) in dichloromethane (20 ml) was stirred at ambient temperature for 4 hours and the solution was washed successively with saturated aqueous sodium hydrogen carbonate, water and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give a syrup. The crude product was solidified with diethyl ether to give 4- (4'-methylbiphenyl-2- carboxamido) -N-methyl-N- [2- [5- (4-methylpiperazin-l- yl) carbonylpent-1-ylsulfonyl]phenyl]ben2amide (455 mg) as a white powder.

MASS (m/z) : 681 (M+l)

9152

- 231 -

Example 76

A mixture of 4- (4 '-methylbiphenyl-2-carboxamido)-N- methyl-N-[2-[2- (2-methoxycarbonylethyl) aminoethoxy]- phenyl]benzamide (409 mg) , di-tert-butyl dicarbonate (189 mg) and triethylamine (87.8 mg) in dichloromethane (20 ml) was stirred in an ice bath for 6 hours and the mixture was washed successively with IN hydrochloric acid, water and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give 4- (4'-methylbiphenyl-2-carboxamido) -N-methyl-N-[2-[2-[N-(2- methoxycarbonylethyl)-N- (t-butoxycarbonyl)amino]ethyloxy]- phenyl]benzamide (450 mg) as a colorless amorphous.

NMR (CDC1 ₃ , δ) : 1.44 (9H, s), 2.35 (3H, s) , 2.58 (2H, m) , 3.31 (3H, s), 3.68 (2H, t, J=7.5Hz), 3.66 (2H, m) , 3.82-5.13 (2H, m) , 6.76-7.02 (6H, m) , 7.11-7.22 (4H, m) , 7.28 (2H, d, J=8.5Hz), 7.35-7.53 (3H, m) , 7.81 (IH, d, J=7Hz)

Example 77 To a solution of 4- (4'-methylbiphenyl-2-carboxamido) - N-methyl-N- [2- (3-hydroxypropoxy)phenyl]benzamide (520 mg) in dichloromethane (20 ml) was added triphenylphosphine (827 mg) and carbon tetrabromide (1.39 g) at ambient temperature. The mixture was stirred for 2 hours and diluted with ethyl acetate and washed successively with saturated sodium hydrogen carbonate and brine, and dried over magnesium sulfate. The solid was removed and the solvent was removed by evaporation to give crude product. The crude material was subjected to a silica gel column chromatography (Si0 ₂ ; 50 g, 0.5% methanol in chloroform) to give 4- ( '-methylbiphenyl-2-carboxamido) -N-methyl-N-[2- (3- bromopropoxy)phenyl]benzamide (540 mg) as white amorphous. NMR (CDCI3, δ) : 2.24-2.33 (2H, m) , 2.36 (3H, s) ,

3.33 (3H, s), 3.59 (2H, t, J=7Hz) , 3.93-4.17 (2H, m) , 6.78-6.96 (5H, m) , 7.02 ^' (IH, br d, J=9Hz),

7 . 12-7 . 24 ( 4H, m) , 7 . 30 (2H, d, J=9Hz ) , 7 . 35-7 . 56 ( 3H, m) , 7 . 82 ( IH, d, J=9Hz )

Example 78 A solution of 4- (4'-methylbiphenyl-2-carboxamido)-N- methyl-N-[4-methyl-2- [5- (piperazin-1-yl) carbonylpentyloxy]- phenyl]benzamide (150 mg) in dichloromethane (15 ml) was treated with pyridine (0.04 ml) and trifluoroacetic anhydride (0.04 ml) at 0°C. After 30 minutes, the mixture was allowed to warm to ambient temperature and stirred for 1.5 hours. The reaction mixture was diluted with ethyl acetate and washed with water, saturated sodium bicarbonate solution and brine, dried over magnesium sulfate, concentrated, and purified by column chromatography (Si0 ₂ ; 30 g, ethyl acetate:n-hexane = 1:1) to give 4— (4'— methylbiphenyl-2-carboxamido)-N-methyl-N-[4-methyl-2-[5- (4- trifluoroacetylpiperazin-1-yl) carbonylpentyloxy]phenyl]- benzamide (80 mg) .

NMR (CDC1 ₃ , δ) : 1.46-1.59 (2H, m) , 1.64-1.86 (4H, m) , 2.27 (3H, s), 2.36 (3H, s), 2.32-2.43 (2H, m) , 3.28 (3H, s), 3.48-3.74 (8H, m) , 3.74-3.9 (2H, m) , 6.54-6.63 (2H, m) , 6.84 (IH, d, J=9Hz) , 6.94 (3H, br d, J=9Hz) , 7.18 (4H, br d, J=9Hz) , 7.29 (2H, d, J=9Hz), 7.34-7.56 (3H, m) , 7.81 (IH, d, J=9Hz)