Title:
BENZAMIDE DERIVATIVES WITH ANTI-PROLIFERATIVE ACTIVITY, PHARMACEUTICAL PREPARATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/113255
Kind Code:
A1
Abstract:
Novel benzamide derivatives of formula I, wherein the definition of substituents
Het, G1, G2, G3, Y, X1, X2,
X3 and X4 see also in the description. Preparation processes
for these compounds, pharmaceutical compositions containing these compounds,
and the use of these compounds as active ingredients in medicament for the treatment
of diseases associated with proliferation, such as leukaemia and solid tumor.
Inventors:
LI SHUXIN (CN)
LIU YONGXUE (CN)
ZHAO YANJIN (CN)
HAN CHUNGUANG (CN)
KUANG XIANZHAO (CN)
HUANG LINYI (CN)
XIAO WENSONG (CN)
SUN XIAOMEI (CN)
DENG XIAODONG (CN)
XUE YANG (CN)
YE QINGQUAN (CN)
LIU YONGXUE (CN)
ZHAO YANJIN (CN)
HAN CHUNGUANG (CN)
KUANG XIANZHAO (CN)
HUANG LINYI (CN)
XIAO WENSONG (CN)
SUN XIAOMEI (CN)
DENG XIAODONG (CN)
XUE YANG (CN)
YE QINGQUAN (CN)
Application Number:
PCT/CN2008/000500
Publication Date:
September 25, 2008
Filing Date:
March 14, 2008
Export Citation:
Assignee:
INST RADIATION MED AMMS PLA (CN)
LI SHUXIN (CN)
LIU YONGXUE (CN)
ZHAO YANJIN (CN)
HAN CHUNGUANG (CN)
KUANG XIANZHAO (CN)
HUANG LINYI (CN)
XIAO WENSONG (CN)
SUN XIAOMEI (CN)
DENG XIAODONG (CN)
XUE YANG (CN)
YE QINGQUAN (CN)
LI SHUXIN (CN)
LIU YONGXUE (CN)
ZHAO YANJIN (CN)
HAN CHUNGUANG (CN)
KUANG XIANZHAO (CN)
HUANG LINYI (CN)
XIAO WENSONG (CN)
SUN XIAOMEI (CN)
DENG XIAODONG (CN)
XUE YANG (CN)
YE QINGQUAN (CN)
International Classes:
C07D495/04; A61K31/343; A61K31/36; A61K31/40; A61K31/428; A61K31/4439; A61K31/455; A61K31/496; A61K31/505; A61K31/5377; A61K35/00; C07C237/40; C07D209/14; C07D213/38; C07D277/68; C07D401/04; C07D403/04; C07D413/10; C07D413/12; C07D471/04
Domestic Patent References:
| WO2006122319A2 | 2006-11-16 | |||
| WO2006115845A1 | 2006-11-02 | |||
| WO2005030705A1 | 2005-04-07 | |||
| WO2005030704A1 | 2005-04-07 | |||
| WO2001002369A2 | 2001-01-11 | |||
| WO2003064385A2 | 2003-08-07 | |||
| WO2007002559A1 | 2007-01-04 | |||
| WO2005092899A1 | 2005-10-06 |
Foreign References:
| US20070015809A1 | 2007-01-18 | |||
| US20050187300A1 | 2005-08-25 | |||
| JPH06128276A | 1994-05-10 |
Other References:
KRAL'OVA K. ET AL.: "Inhibition of oxygen evolution rate in fresh water algae Chlorella vulgaris by some anilides of substituted pyridine-4-carboxylic acids", CHEMICAL PAPERS, vol. 55, no. 4, 2001, pages 251 - 253
DATABASE CHEMICAL ABSTRACTS [online] 2001, Database accession no. (134:353234)
NAZAROV V.N. ET AL.: "Acylation of amines by diphenic anhydride", VESTNIK NATSIONAL'NOGO TEKHNICHESKOGO UNIVERSITETA "KHPI", no. 12, 2006, pages 27 - 34
MILETIN M. ET AL.: "Some anilides of 2-alkylthio- and 2-chloro-6-alkylthio-4-pyridinecarboxylic acids: synthesis and photosynthesis-inhibiting activity", MOLECULES, vol. 6, no. 7, 2001, pages 603 - 613, XP055014285, Retrieved from the Internet DOI: doi:10.3390/60700603
MILETIN M. ET AL.: "Inhibition of oxygen evolution rate in spinach chloroplasts by some anilides of substitutedpyridine-4-carboxylic acids", FOLIA PHARMACEUTICA UNIVERSITATIS CAROLINAE, vol. 26, 2001, pages 27 - 32
DATABASE CHEMICAL ABSTRACTS [online] 2001, Database accession no. (134:353234)
NAZAROV V.N. ET AL.: "Acylation of amines by diphenic anhydride", VESTNIK NATSIONAL'NOGO TEKHNICHESKOGO UNIVERSITETA "KHPI", no. 12, 2006, pages 27 - 34
MILETIN M. ET AL.: "Some anilides of 2-alkylthio- and 2-chloro-6-alkylthio-4-pyridinecarboxylic acids: synthesis and photosynthesis-inhibiting activity", MOLECULES, vol. 6, no. 7, 2001, pages 603 - 613, XP055014285, Retrieved from the Internet
MILETIN M. ET AL.: "Inhibition of oxygen evolution rate in spinach chloroplasts by some anilides of substitutedpyridine-4-carboxylic acids", FOLIA PHARMACEUTICA UNIVERSITATIS CAROLINAE, vol. 26, 2001, pages 27 - 32
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (Haidian, Beijing 5, CN)
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