Title:
BENZAMIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2002/081448
Kind Code:
A1
Abstract:
A benzamidine derivative having the general formula: (1) wherein R?1¿ represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group, R?2¿ represents a hydrogen atom or a halogen atom, R?3¿ represents a hydrogen atom, an alkyl group optionally substituted, an aralkyl group, an alkylcarbonyl group optionally substituted, an alkylsulfonyl group optionally substituted, or the like, R?4¿ and R?5¿ each represent a hydrogen atom, a halogen atom, an alkyl or carbamoyl group optionally substituted, or the like, R?6¿ represents a heteroring or the like, R?7¿ and R?8¿ each represent a hydrogen atom, an alkyl group, or the like, and n represents 0,1 or 2; or a salt thereof being pharmacologically acceptable. The benzamidine derivative and the salt have excellent inhibition action for activated blood coagulation factor X, and are useful as a medicine for therapy or prevention of a disease of blood coagulation.
Inventors:
FUJIMOTO KOICHI (JP)
TANAKA NAOKI (JP)
SHIMADA IKUKO (JP)
ASAI FUMITOSHI (JP)
TANAKA NAOKI (JP)
SHIMADA IKUKO (JP)
ASAI FUMITOSHI (JP)
Application Number:
PCT/JP2002/003355
Publication Date:
October 17, 2002
Filing Date:
April 03, 2002
Export Citation:
Assignee:
SANKYO CO (JP)
FUJIMOTO KOICHI (JP)
TANAKA NAOKI (JP)
SHIMADA IKUKO (JP)
ASAI FUMITOSHI (JP)
FUJIMOTO KOICHI (JP)
TANAKA NAOKI (JP)
SHIMADA IKUKO (JP)
ASAI FUMITOSHI (JP)
International Classes:
A61K31/402; A61K31/422; A61K31/427; A61K31/435; A61K31/437; A61K31/4439; A61K31/445; A61K31/454; A61K31/4545; A61K31/55; A61P7/02; A61P9/00; A61P9/10; A61P43/00; C07D207/12; C07D207/22; C07D207/48; C07D211/46; C07D211/72; C07D211/96; C07D223/08; C07D223/12; C07D401/04; C07D401/06; C07D403/04; C07D413/04; C07D417/04; C07D451/06; C07D471/04; C07D487/04; C07D487/08; (IPC1-7): C07D211/46; C07D211/72; C07D401/04; C07D401/06; C07D413/04; C07D417/04; C07D451/06; C07D471/04; A61K31/435; A61K31/445; A61K31/454; A61K31/4545; A61K31/46; A61P7/02; A61P9/00; A61P43/00; A61P9/10
Domestic Patent References:
| WO2001009093A1 | 2001-02-08 | |||
| WO2001030756A1 | 2001-05-03 |
Other References:
See also references of EP 1375482A4
Attorney, Agent or Firm:
Ohno, Akio c/o SANKYO COMPANY (LIMITED 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, JP)
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