Title:
BENZAZEPINE HETEROCYCLIC COMPOUND AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2023/274396
Kind Code:
A1
Abstract:
A class of benzazepine heterocyclic compounds that can be used as RORγt agonists and an application thereof in medicine, as well as a pharmaceutical composition comprising this class of compound and an application thereof in medicine. Specifically, a compound as shown in formula (I), or a stereoisomer, tautomer, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or prodrug of the compound shown in formula (I), and a pharmaceutical composition comprising said class of compound. Said class of compound and pharmaceutical composition can be used to prevent, treat or alleviate RORγt-mediated disease in patients.
Inventors:
LIU BING (CN)
ZHANG YINGJUN (CN)
HE WEI (CN)
MA CHAOQUN (CN)
ZHANG YINGJUN (CN)
HE WEI (CN)
MA CHAOQUN (CN)
Application Number:
PCT/CN2022/103288
Publication Date:
January 05, 2023
Filing Date:
July 01, 2022
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D413/12; A61K31/435; A61K31/538; A61P31/04; A61P31/10; A61P35/00; C07D215/58; C07D265/36; C07D279/16; C07D401/04; C07D401/06; C07D401/12; C07D413/06; C07D413/14; C07D417/12
Domestic Patent References:
| WO2015171610A2 | 2015-11-12 | |||
| WO2020108538A1 | 2020-06-04 | |||
| WO2011057892A1 | 2011-05-19 |
Foreign References:
| CN107980042A | 2018-05-01 | |||
| CN109568321A | 2019-04-05 | |||
| CN111635373A | 2020-09-08 | |||
| CN111499591A | 2020-08-07 |
Download PDF: