BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

Title:

BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

Document Type and Number:

WIPO Patent Application WO/1999/024425

Kind Code:

A1

Abstract:

Compounds represented by general formula (I) and having both an IL-4 production inhibitory activity and a PDE(IV) inhibitory activity; a medicinal composition comprising an effective amount of any of the compounds and a pharmaceutical carrier; a remedy or preventive for acute and chronic inflammatory diseases; and an antiallergic agent or antiphlogistic agent: wherein A is a triazole group; R¿1? and R¿2? are the same or different and each is an alicyclic hydrocarbon group or an aliphatic or alicyclic hydrocarbon group optionally having an aromatic hydrocarbon group; R¿3? is hydrogen or a substituent; and R¿4? is hydrogen or a group protecting the nitrogen atom. Also provided are methods of using the compounds represented by formula (I) for the production of the medicinal composition, the remedy or preventive for acute and chronic inflammatory diseases, and the antiallergic agent or antiphlogistic agent; and a method for the therapy and/or prevention of acute and chronic inflammatory diseases.

Inventors:

YAMADA SHOZO (JP)
HOSOYA TOSHIYUKI (JP)
KITAGAWA KAZUHIRO (JP)
INOUE SHIN-ICHI (JP)
KINIWA MAMORU (JP)
ASAO TETSUJI (JP)

Application Number:

PCT/JP1998/005011

Publication Date:

May 20, 1999

Filing Date:

November 06, 1998

Export Citation:

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Assignee:

TAIHO PHARMACEUTICAL CO LTD (JP)
YAMADA SHOZO (JP)
HOSOYA TOSHIYUKI (JP)
KITAGAWA KAZUHIRO (JP)
INOUE SHIN ICHI (JP)
KINIWA MAMORU (JP)
ASAO TETSUJI (JP)

International Classes:

A61P37/00; C07D403/04; C07D521/00; (IPC1-7): C07D403/04; A61K31/415

Foreign References:

JPH08109169A	1996-04-30
JPH08501318A	1996-02-13
JPH08134073A	1996-05-28

Other References: