BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE

Title:

BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE

Document Type and Number:

WIPO Patent Application WO/2010/072147

Kind Code:

A1

Abstract:

The invention provides benzisoxazole piperidinyl derivatives, their salts and their hydrates: Wherein R, X, Y, R’ and T have the same definition as that described in the description. The kind of compounds has antagonistic effect on 5-HT2A and has mediating effect on 5-hydroxytryptamine system such as reuptake inhibiting effect of 5-HT and so on. The compounds of the present invention possess excellent analgesia, sedation activity, minimal toxicity and side effects. The invention also provides pharmaceutical compositions comprising the derivatives and their use.

Inventors:

LI JIANQI (CN)
WANG GUAN (CN)
ZHANG GUISEN (CN)
LV NA (CN)
JIAO GUANGJUN (CN)
LIU SHICHENG (CN)
ZHOU SHIXIA (CN)

Application Number:

PCT/CN2009/075842

Publication Date:

July 01, 2010

Filing Date:

December 22, 2009

Export Citation:

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Assignee:

NHWA PHARMA CORP (CN)
LI JIANQI (CN)
WANG GUAN (CN)
ZHANG GUISEN (CN)
LV NA (CN)
JIAO GUANGJUN (CN)
LIU SHICHENG (CN)
ZHOU SHIXIA (CN)

International Classes:

C07D261/20; A61K31/435; A61P29/00

Foreign References:

CN1136275A	1996-11-20
US4352811A	1982-10-05

Other References:

JOSEPH T. STRUPCZEWSKI ET AL.: "Synthesis and neuroleptic activity of 3 -(1 -substituted-4-piperidinyl)-1,2-benzisoxazoles.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, no. 6, 1985, pages 761 - 769

Attorney, Agent or Firm:

NTD PATENT & TRADEMARK AGENCY LIMITED BEIJING OFFICE (Block A Investment Plaza,27 Jinrongdajie, Xicheng District, Beijing 0, CN)

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