Title:
BENZO-CONDENSED RING COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/222856
Kind Code:
A1
Abstract:
A benzo-condensed ring compound of formula (I), a pharmaceutical composition comprising same, a preparation method therefor and a use thereof as an HDAC6 inhibitor.
Inventors:
ZHANG GUIPING (CN)
LI JIAPENG (CN)
WANG KUIFENG (CN)
ZHU RONG (CN)
LI JIAPENG (CN)
WANG KUIFENG (CN)
ZHU RONG (CN)
Application Number:
PCT/CN2022/087060
Publication Date:
October 27, 2022
Filing Date:
April 15, 2022
Export Citation:
Assignee:
SUZHOU GENHOUSE BIO CO LTD (CN)
International Classes:
C07D279/14; A61K31/5415; A61K31/554; A61P25/00; A61P35/00; A61P35/02; A61P37/02; C07D279/16; C07D281/10
Domestic Patent References:
| WO2021208945A1 | 2021-10-21 | |||
| WO2021067859A1 | 2021-04-08 |
Foreign References:
| US20190255046A1 | 2019-08-22 | |||
| CN110621317A | 2019-12-27 |
Other References:
SHEN SIDA, PICCI CRISTINA, USTINOVA KSENIYA, BENOY VERONICK, KUTIL ZSÓFIA, ZHANG GUIPING, TAVARES MAURÍCIO T., PAVLÍČEK JIŘÍ, ZIMP: "Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 8, 22 April 2021 (2021-04-22), US , pages 4810 - 4840, XP055979146, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c02210
GUO ZHENG; ZHANG ZIXUE; ZHANG YI; WANG GUAN; HUANG ZIYI; ZHANG QINWEI; LI JIANQI: "Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 218, 17 March 2021 (2021-03-17), AMSTERDAM, NL , XP086560134, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113383
SHEN, SIDA ET AL.,: "Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease,", ACS CHEMICAL NEUROSCIENCE,, vol. 7, no. 2, 24 November 2015 (2015-11-24), pages 240 - 258, XP055416603, DOI: 10.1021/acschemneuro.5b00286
"Medicinal Chemistry (3rd edition)", 31 January 2000, PEOPLE'S HEALTH PUBLISHING HOUSE, CN, ISBN: 7-117-00009-0, article LI, ZHENGHUA: "Bioisosterism Principles", pages: 97 - 98, XP009543974
GUO ZHENG; ZHANG ZIXUE; ZHANG YI; WANG GUAN; HUANG ZIYI; ZHANG QINWEI; LI JIANQI: "Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 218, 17 March 2021 (2021-03-17), AMSTERDAM, NL , XP086560134, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113383
SHEN, SIDA ET AL.,: "Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease,", ACS CHEMICAL NEUROSCIENCE,, vol. 7, no. 2, 24 November 2015 (2015-11-24), pages 240 - 258, XP055416603, DOI: 10.1021/acschemneuro.5b00286
"Medicinal Chemistry (3rd edition)", 31 January 2000, PEOPLE'S HEALTH PUBLISHING HOUSE, CN, ISBN: 7-117-00009-0, article LI, ZHENGHUA: "Bioisosterism Principles", pages: 97 - 98, XP009543974
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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