Title:
BENZOHETEROARYL DERIVATIVE AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/149205
Kind Code:
A1
Abstract:
The present invention relates to a benzoheteroaryl derivative and a preparation method and medical application thereof. In particular, the present invention relates to a novel benzoheteroaryl derivative represented by general formula (I), a preparation method thereof, a pharmaceutical composition comprising the derivative, and a use of the same as a therapeutic agent, especially as a PAR-4 antagonist. The definition of each substituent in general formula (I) is the same as the definition in the specification.
Inventors:
YANG FANGLONG (CN)
ZHANG LING (CN)
HAN JIHUI (CN)
HE FENG (CN)
TAO WEIKANG (CN)
ZHANG LING (CN)
HAN JIHUI (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2019/073815
Publication Date:
August 08, 2019
Filing Date:
January 30, 2019
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/433; C07D519/00; A61K31/4439; A61P7/02; C07D513/04
Domestic Patent References:
| WO2017066863A1 | 2017-04-27 |
Foreign References:
| CN104540835A | 2015-04-22 | |||
| CN104640869A | 2015-05-20 | |||
| CN104583218A | 2015-04-29 | |||
| CN107602589A | 2018-01-19 | |||
| CN102241621A | 2011-11-16 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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