Title:
BENZOXAZEPINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2005/012272
Kind Code:
A1
Abstract:
A compound represented by the formula [I]: [I] (wherein ring A and ring B each represents an optionally substituted benzene ring; ring C represents an optionally further substituted aromatic ring; R1 represents a lower alkyl optionally substituted by optionally substituted hydroxy; X1a represents a bond or optionally substituted lower alkylene; X1b represents a bond or optionally substituted lower alkylene; X2 represents a bond, -O-, or -S-; X3 represents a bond or an optionally substituted divalent hydrocarbon group; and Y represents optionally esterified or amidated carboxy) or a salt of the compound. The compound of the formula [I] is safer and has more potent lipid-lowering activity such as squalene synthase inhibitory activity (cholesterol-lowering activity) and triglyceride-lowering activity. The compound is useful as a medicine for, e.g., the prevention of and treatments for hyperlipemia.
Inventors:
MARUI SHOGO (JP)
MIKI TAKASHI (JP)
MIURA SHOUTAROU (JP)
NISHIMOTO TOMOYUKI (JP)
NAKADA YOSHIHISA (JP)
MIKI TAKASHI (JP)
MIURA SHOUTAROU (JP)
NISHIMOTO TOMOYUKI (JP)
NAKADA YOSHIHISA (JP)
Application Number:
PCT/JP2004/011293
Publication Date:
February 10, 2005
Filing Date:
July 30, 2004
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
MARUI SHOGO (JP)
MIKI TAKASHI (JP)
MIURA SHOUTAROU (JP)
NISHIMOTO TOMOYUKI (JP)
NAKADA YOSHIHISA (JP)
MARUI SHOGO (JP)
MIKI TAKASHI (JP)
MIURA SHOUTAROU (JP)
NISHIMOTO TOMOYUKI (JP)
NAKADA YOSHIHISA (JP)
International Classes:
A61P1/18; A61P3/00; A61P3/06; A61P3/10; A61P5/14; A61P7/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P13/12; A61P19/00; A61P19/10; A61P21/00; A61P25/28; A61P43/00; C07D417/06; (IPC1-7): C07D267/14; C07D417/06; C07D413/06; A61K31/553; A61K31/427; A61K31/4245; A61K45/00; A61P43/00; A61P3/06; A61P3/00; A61P13/12; A61P9/10; A61P9/06; A61P9/04; A61P7/00; A61P9/12; A61P3/10; A61P19/10; A61P1/18; A61P5/14; A61P25/28; A61P19/00; A61P21/00
Foreign References:
| JPH09136880A | 1997-05-27 | |||
| JPH07267939A | 1995-10-17 | |||
| JPH1059953A | 1998-03-03 | |||
| JP2002205956A | 2002-07-23 |
Other References:
See also references of EP 1650201A4
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 01, JP)
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