Title:
BENZOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/236263
Kind Code:
A1
Abstract:
The present invention provides a benzoxazole derivative, a preparation method therefor, and an application thereof. The benzoxazole derivative provided by the present invention has a structure as represented by formula (I). Experimental results show that the benzoxazole derivative provided by the present invention has good P2Y14 receptor antagonistic activity, and can be used for preparing a therapeutic drug for P2Y14 receptor related diseases.
Inventors:
LI HUANQIU (CN)
HU QINGHUA (CN)
ZHU YIFAN (CN)
ZHOU MENGZE (CN)
HU QINGHUA (CN)
ZHU YIFAN (CN)
ZHOU MENGZE (CN)
Application Number:
PCT/CN2022/101058
Publication Date:
December 14, 2023
Filing Date:
June 24, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07D263/56; A61K31/423; A61P1/16; A61P13/12; A61P19/02; A61P19/06; A61P25/04; C07D263/57
Domestic Patent References:
| WO2003055484A1 | 2003-07-10 | |||
| WO2020191227A1 | 2020-09-24 |
Foreign References:
| US20090239841A1 | 2009-09-24 | |||
| US20090082395A1 | 2009-03-26 | |||
| CN109574949A | 2019-04-05 | |||
| CN113831301A | 2021-12-24 | |||
| CN110885318A | 2020-03-17 |
Other References:
DATABASE Registry CAS; 22 June 2022 (2022-06-22), ANONYMOUS : "Urea, N-(4-methoxyphenyl)-N'-(2 -methyl-6-benzoxazolyl)-", XP093114393, retrieved from STN Database accession no. 2775967-93-4
DATABASE Registry CAS; 6 July 2015 (2015-07-06), ANONYMOUS : "Urea, N-6-benzoxazolyl-N'-(3-chl orophenyl)-", XP093114395, retrieved from STN Database accession no. 1795554-09-4
DATABASE Registry CAS; 29 June 2015 (2015-06-29), ANONYMOUS : "Urea, N-6-benzoxazolyl-N'-(4-chl orophenyl)-", XP093114396, retrieved from STN Database accession no. 1790669-03-2
DATABASE Registry CAS; 24 June 2015 (2015-06-24), ANONYMOUS : "Urea, N-(4-chlorophenyl)-N'-(2- methyl-6-benzoxazolyl)-", XP093114397, retrieved from STN Database accession no. 1787470-86-3
DATABASE Registry CAS; 29 June 2015 (2015-06-29), ANONYMOUS : "Urea, N-(3-chlorophenyl)-N'-(2- methyl-6-benzoxazolyl)-", XP093114399, retrieved from STN Database accession no. 1791131-22-0
DATABASE Registry CAS; 13 May 2016 (2016-05-13), ANONYMOUS : "Urea, N-(3-chlorophenyl)-N'-[2- (1-methylethyl)-6-benzoxaz olyl]-", XP093114401, retrieved from STN Database accession no. 1909946-17-3
DATABASE Registry CAS; 10 May 2016 (2016-05-10), ANONYMOUS : "Urea, N-(4-chlorophenyl)-N'-[2- (1-methylethyl)-6-benzoxaz olyl]-", XP093114404, retrieved from STN Database accession no. 1907660-60-9
DATABASE Registry CAS; 21 August 2005 (2005-08-21), ANONYMOUS : "Urea, N-(2-methyl-6-benzoxazol yl)-N'-(4-methylphenyl)-", XP093114406, retrieved from STN Database accession no. 861210-66-4
DATABASE Registry CAS; 6 July 2015 (2015-07-06), ANONYMOUS : "Urea, N-6-benzoxazolyl-N'-(3-chl orophenyl)-", XP093114395, retrieved from STN Database accession no. 1795554-09-4
DATABASE Registry CAS; 29 June 2015 (2015-06-29), ANONYMOUS : "Urea, N-6-benzoxazolyl-N'-(4-chl orophenyl)-", XP093114396, retrieved from STN Database accession no. 1790669-03-2
DATABASE Registry CAS; 24 June 2015 (2015-06-24), ANONYMOUS : "Urea, N-(4-chlorophenyl)-N'-(2- methyl-6-benzoxazolyl)-", XP093114397, retrieved from STN Database accession no. 1787470-86-3
DATABASE Registry CAS; 29 June 2015 (2015-06-29), ANONYMOUS : "Urea, N-(3-chlorophenyl)-N'-(2- methyl-6-benzoxazolyl)-", XP093114399, retrieved from STN Database accession no. 1791131-22-0
DATABASE Registry CAS; 13 May 2016 (2016-05-13), ANONYMOUS : "Urea, N-(3-chlorophenyl)-N'-[2- (1-methylethyl)-6-benzoxaz olyl]-", XP093114401, retrieved from STN Database accession no. 1909946-17-3
DATABASE Registry CAS; 10 May 2016 (2016-05-10), ANONYMOUS : "Urea, N-(4-chlorophenyl)-N'-[2- (1-methylethyl)-6-benzoxaz olyl]-", XP093114404, retrieved from STN Database accession no. 1907660-60-9
DATABASE Registry CAS; 21 August 2005 (2005-08-21), ANONYMOUS : "Urea, N-(2-methyl-6-benzoxazol yl)-N'-(4-methylphenyl)-", XP093114406, retrieved from STN Database accession no. 861210-66-4
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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