Title:
BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2008/016132
Kind Code:
A1
Abstract:
Disclosed is a benzyl phenyl glucopyranoside derivative having excellent inhibitory
effect on human SGLT1 and/or SGLT2 activity. Specifically disclosed is a compound
represented by the general formula (I) or a pharmacologically acceptable salt
thereof. (I) wherein R1 represents a hydrogen atom, an amino group,
a hydroxy C1-C6 alkyl group, or the like; R2 represents
a hydrogen atom, or the like; R3 represents a C1-C6
alkyl group, a hydroxy C1-C6 alkyl group, or the like; R4
represents a hydrogen atom, a C2-C7 acyl group, or the like;
R5, R6, R7 and R8 independently represent
a hydrogen atom, a C1-C6 alkyl group, or the like (provided
that all of R5, R6, R7 and R8 do not represent
a hydrogen atom in a molecule); R9 represents a halogen atom; n represents
a number ranging from 0 to 4; and X represents CH or N.
Inventors:
HONDA TAKESHI
OGUCHI MINORU
YOSHIDA MASAO
OKUYAMA RYO
OGATA TSUNEAKI
ABE MANABU
UEDA KENJIRO
OHSUMI JUN
IZUMI MASANORI
OGUCHI MINORU
YOSHIDA MASAO
OKUYAMA RYO
OGATA TSUNEAKI
ABE MANABU
UEDA KENJIRO
OHSUMI JUN
IZUMI MASANORI
Application Number:
PCT/JP2007/065231
Publication Date:
February 07, 2008
Filing Date:
August 03, 2007
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
HONDA TAKESHI
OGUCHI MINORU
YOSHIDA MASAO
OKUYAMA RYO
OGATA TSUNEAKI
ABE MANABU
UEDA KENJIRO
OHSUMI JUN
IZUMI MASANORI
HONDA TAKESHI
OGUCHI MINORU
YOSHIDA MASAO
OKUYAMA RYO
OGATA TSUNEAKI
ABE MANABU
UEDA KENJIRO
OHSUMI JUN
IZUMI MASANORI
International Classes:
C07H15/203; A61K31/7034; A61K31/7036; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P19/06; A61P25/02; A61P27/02; A61P27/12; A61P31/00; A61P43/00; C07H17/02
Domestic Patent References:
WO2005095429A1 | 2005-10-13 | |||
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WO2002044192A1 | 2002-06-06 | |||
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Foreign References:
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EP1405859A1 | 2004-04-07 | |||
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GREENE T.H.; WUTS P.G.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
GREENE T.H.; WUTS P.G.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC
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See also references of EP 2048150A4
J. CLIN. INVEST., vol. 93, 1994, pages 397 - 404
AM. J. CLIN. NUTR., vol. 59, no. 3, 1994, pages 690S - 698S
NATURE, vol. 350, 1991, pages 354 - 356
GREENE T.H.; WUTS P.G.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
GREENE T.H.; WUTS P.G.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC
CHEM. BER, vol. 71, 1938, pages 1843 - 1849
CARBOHYDR. RES., vol. 273, 1995, pages 249 - 254
BULL. CHEM. SOC. JPN., vol. 55, 1982, pages 938 - 942
BULL. CHEM. SOC. JPN., vol. 49, 1976, pages 788 - 790
ORG. LETT., vol. 5, 2003, pages 3419 - 3421
ORG. BIOMOL. CHEM, vol. 1, 2003, pages 767 - 771
J. CHEM. SOC., 1956, pages 2124 - 2126
LIEBIGS ANN. CHEM. GE., vol. 7, 1992, pages 747 - 758
ORG. MAGN. RESON., vol. 13, 1980, pages 372 - 375
See also references of EP 2048150A4
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (LIMITED1-16-13, Kitakasa, Edogawa-ku Tokyo 81, JP)
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