Title:
BERBERRUBINE DERIVATIVES HAVING ANTIFUNGAL ACTIVITIES
Document Type and Number:
WIPO Patent Application WO/2007/094548
Kind Code:
A3
Abstract:
The present invention relates to a berberrubine derivative having superior antifungal activity, more particularly to a berberrubine derivative having inhibitory activity against chitin synthase, which participates in the synthesis of chitin and is essential in the growth of fungi, and having a potent antifungal activity against human pathogenic fungi.
Inventors:
KIM SUNG UK (KR)
PARK KI DUK (KR)
MOON JAE SUN (KR)
KANG TAE HOON (KR)
KIM YOUNG-KOOK (KR)
PARK KI DUK (KR)
MOON JAE SUN (KR)
KANG TAE HOON (KR)
KIM YOUNG-KOOK (KR)
Application Number:
PCT/KR2006/004607
Publication Date:
October 21, 2010
Filing Date:
November 06, 2006
Export Citation:
Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
KIM SUNG UK (KR)
PARK KI DUK (KR)
MOON JAE SUN (KR)
KANG TAE HOON (KR)
KIM YOUNG-KOOK (KR)
KIM SUNG UK (KR)
PARK KI DUK (KR)
MOON JAE SUN (KR)
KANG TAE HOON (KR)
KIM YOUNG-KOOK (KR)
International Classes:
C07D455/03; A61K31/4375
Domestic Patent References:
| WO2003051875A1 | 2003-06-26 | |||
| WO2000037468A1 | 2000-06-29 |
Other References:
PARK K D ET AL.: "Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents.", BIOORG MED CHEM LETT., vol. 16, no. 15, 1 August 2006 (2006-08-01), pages 3913 - 3916
DATABASE CA MIZUTA ET AL.: "Smiles rearrangement in isoquinolinium salts.", Database accession no. 108:112180
DATABASE CA MIZUTA ET AL.: "Smiles rearrangement in isoquinolinium salts.", Database accession no. 108:112180
Attorney, Agent or Firm:
PAIK, Nam-Hoon (KTB Network Building 826-14Yeoksam-dong, Kangnam-ku, Seoul 135-769, KR)
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