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Title:
BICYCLIC COMPOUND ACTING AS RORΓ INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/024809
Kind Code:
A1
Abstract:
A bicyclic compound acting as a RORγ inhibitor. Provided are a compound of formula (I) or a pharmaceutically acceptable salt thereof, the compound having a structure as represented by formula (I-A) or formula (I-B). The provided compound of formula (I-A) or formula (I-B) or a pharmaceutically acceptable salt thereof has good RORγ inhibitory activities, being expected to be used for treating diseases mediated by RORγ receptors in a mammal.

Inventors:
CHEN KEVIN X (CN)
ZHOU KAI (CN)
YU YANXIN (CN)
HU BOYU (CN)
WU LINGHUI (CN)
CHEN XIAOYUAN (CN)
LIN JIANGFENG (CN)
CHEN HAOMIN (CN)
WANG XIANGJIAN (CN)
ZHANG XIQUAN (CN)
TIAN XIN (CN)
XU HONGJIANG (CN)
Application Number:
CN2018/097551
Publication Date:
February 07, 2019
Filing Date:
July 27, 2018
Export Citation:
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Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D515/04; A61K31/33; A61P37/00
Domestic Patent References:
WO2007009898A12007-01-25
WO2007113198A22007-10-11
WO2004007504A12004-01-22
WO2005074922A12005-08-18
WO2014179564A12014-11-06
WO2015116904A12015-08-06
WO2016061160A12016-04-21
WO2013045431A12013-04-04
WO2013160418A12013-10-31
WO2013160419A12013-10-31
Foreign References:
US20050026984A12005-02-03
Other References:
DATABASE Registry 4 April 2010 (2010-04-04), retrieved from STN Database accession no. 1216401-55-6
See also references of EP 3663299A4
BOUCHAUD, G. ET AL.: "Epidermal IL-15Ralpha acts as an endogenous antagonist of psoriasiform inflammation in mouse and man", J. EXP. MED., vol. 210, no. 10, 2013, pages 2105 - 17
QIN, S. ET AL.: "Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis", MOL MED REP, vol. 9, no. 6, 2014, pages 2097 - 104
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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