Title:
BICYCLIC DERIVATIVE INTEGRIN INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/083086
Kind Code:
A1
Abstract:
A bicyclic αvβ1, αvβ6 and αvβ8 integrin inhibitor compound represented by formula (I), and a racemate, stereoisomer, tautomer, solvate, polymorph, metabolite, ester, prodrug or pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same, a preparation method therefor, and a pharmaceutical use thereof. The structure of formula (I) is shown below.
Inventors:
HAO YU (CN)
HUANG YIAN (CN)
PEI CHENGKUI (CN)
HUANG YIAN (CN)
PEI CHENGKUI (CN)
Application Number:
PCT/CN2023/124799
Publication Date:
April 25, 2024
Filing Date:
October 16, 2023
Export Citation:
Assignee:
SHANGHAI RULINK BIOPHARMA CO LTD (CN)
International Classes:
C07D519/00; A61K31/41; A61K31/495; C07D471/10
Domestic Patent References:
| WO2005007656A1 | 2005-01-27 | |||
| WO2010129729A1 | 2010-11-11 | |||
| WO2008012623A1 | 2008-01-31 | |||
| WO2015200674A1 | 2015-12-30 |
Foreign References:
| CN109996541A | 2019-07-09 | |||
| CN101534822A | 2009-09-16 | |||
| CN108884096A | 2018-11-23 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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