Title:
BICYCLIC DERIVATIVES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/020523
Kind Code:
A1
Abstract:
A compound of Formula (I), (II) or (III), stereoisomer thereof, pharmaceutically acceptable salt thereof, pharmaceutically acceptable salt of the stereoisomer are disclosed.
Inventors:
YANG HONGWEI (CN)
MA CUNBO (CN)
GAO PANLIANG (CN)
HAN HUIFENG (CN)
WANG PENG (CN)
LI RUNZE (CN)
LIU XIAOYU (CN)
WANG YANPING (CN)
LONG WEI (CN)
ZHANG WEI (CN)
MA CUNBO (CN)
GAO PANLIANG (CN)
HAN HUIFENG (CN)
WANG PENG (CN)
LI RUNZE (CN)
LIU XIAOYU (CN)
WANG YANPING (CN)
LONG WEI (CN)
ZHANG WEI (CN)
Application Number:
PCT/CN2022/112931
Publication Date:
February 23, 2023
Filing Date:
August 17, 2022
Export Citation:
Assignee:
JACOBIO PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D403/14; A61K31/4375; A61P35/00; C07D401/14; C07D413/14; C07D417/14
Domestic Patent References:
| WO2021041671A1 | 2021-03-04 | |||
| WO2022132200A1 | 2022-06-23 | |||
| WO2022061251A1 | 2022-03-24 | |||
| WO2022042630A1 | 2022-03-03 | |||
| WO2022031678A1 | 2022-02-10 | |||
| WO2022184178A1 | 2022-09-09 | |||
| WO2022187528A1 | 2022-09-09 |
Other References:
DATABASE Registry STN; ANONYMOUS : "3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 3-[7-(8-chloro-1-naphthalenyl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H- pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]-6-fluoro-, 1,1-dimethylethyl ester, rel-", XP093037436, Database accession no. 2622024-36-4
DATABASE Registry ANONYMOUS : "6-Azaspiro[3.5]nonan-2-ol, 6-[7-[7,8-difluoro-3-(methoxymethoxy)-1- naphthalenyl]-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin- 7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]-", XP093037440, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 3-Azabicyclo[3.2.1]octan-6-ol, 3-[7-[8-ethyl-7-fluoro-3-(methoxymethoxy)-1- naphthalenyl]-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin- 7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]- ", XP093037438, retrieved from STN
DATABASE Registry ANONYMOUS : "6-Azaspiro[3.5]nonan-2-ol, 6-[7-[7,8-difluoro-3-(methoxymethoxy)-1- naphthalenyl]-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin- 7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]-", XP093037440, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 3-Azabicyclo[3.2.1]octan-6-ol, 3-[7-[8-ethyl-7-fluoro-3-(methoxymethoxy)-1- naphthalenyl]-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin- 7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]- ", XP093037438, retrieved from STN
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