Title:
BICYCLIC FUSED RING DERIVATIVE OR SALT THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2023/055124
Kind Code:
A1
Abstract:
The present invention provides a bicyclic fused ring (for example, benzo[d]imidazole, benzo[d][1,2,3]triazole, or 8-oxo-8,9-dihydro-7H-purine) derivative or a pharmaceutically acceptable salt thereof, a method for preparing same, a pharmaceutical composition comprising same, and uses thereof. The bicyclic fused ring derivative or pharmaceutically acceptable salt thereof has inhibitory activity against the lysyl oxidase family, and may thus be usefully applied in the treatment and prevention of various diseases mediated by lysyl oxidase homologues, such as idiopathic pulmonary fibrosis (IPF), non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), or liver cirrhosis.
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Inventors:
KIM EUN-KYUNG (KR)
LIM CHEOL-HEE (KR)
LEE KANG-YO (KR)
CHOI HYUN-HO (KR)
LIM CHEOL-HEE (KR)
LEE KANG-YO (KR)
CHOI HYUN-HO (KR)
Application Number:
PCT/KR2022/014656
Publication Date:
April 06, 2023
Filing Date:
September 29, 2022
Export Citation:
Assignee:
YUHAN CORP (KR)
International Classes:
C07D235/04; A61K31/4184; A61P1/16; A61P11/00; A61P43/00
Domestic Patent References:
| WO2011113798A2 | 2011-09-22 |
Foreign References:
| KR20180134849A | 2018-12-19 | |||
| KR20180091770A | 2018-08-16 | |||
| US20080293936A1 | 2008-11-27 |
Other References:
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THEODORA W. GREENEPETER G. M. WUTS: "Protective groups in organic synthesis", 1999
W.C. STILL, J. ORG. CHEM., vol. 43, 1978, pages 2923
NAT REV CANCER, vol. 12, 2012, pages 540 - 552
LAB INVEST, vol. 78, no. 2, 1998, pages 143 - 151
J HEPATOL, vol. 43, no. 3, 2005, pages 499 - 507
INT J MOL SCI, vol. 20, 2019, pages 1634
GUT, vol. 66, no. 9, 2017, pages 1697 - 1708
NAT COMMUN, vol. 14, no. 7, pages 13710
MOL CELL BIOCHEM, vol. 307, no. 1-2, 2008, pages 159 - 167
CLIN CANCER RES, vol. 21, no. 21, 2015, pages 4892 - 4902
INVEST OPHTHALMOL VIS SCI, vol. 54, no. 8, 2013, pages 5788 - 5796
SCI REP, vol. 7, no. 1, 2017, pages 149
SCI REP, no. 11, 2021, pages 12437
INT. J. MOL. SCI, vol. 53, 2022, pages 5533
BIOCHIM BIOPHYS ACTA, vol. 1864, 2018, pages 1129 - 1137
FASEB J, vol. 30, 2016, pages 1599 - 1609
ESSAYS IN BIOCHEMISTRY, vol. 63, 2019, pages 349 - 364
PROC NATL ACAD SCI USA, vol. 75, 1978, pages 2945 - 2949
HEPATOLOGY, vol. 14, 1991, pages 1167 - 1173
KOREAN J GASTROENTEROL, vol. 69, no. 6, pages 353 - 358
NAT. MED., vol. 16, 2010, pages 1009 - 1017
J. BIOL. CHEM., vol. 291, 2016, pages 72 - 88
J. MED. CHEM., vol. 60, 2017, pages 4403 - 4423
J CELL MOL MED, vol. 23, no. 3, 2019, pages 1759 - 1770
THEODORA W. GREENEPETER G. M. WUTS: "Protective groups in organic synthesis", 1999
W.C. STILL, J. ORG. CHEM., vol. 43, 1978, pages 2923
Attorney, Agent or Firm:
OH, Kook-Jin (KR)
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